Works (3)

Updated: July 5th, 2023 14:29

2022 journal article

Tissue-reactive drugs enable materials-free local depots


By: S. Pandit n, S. Palvai n, N. Massaro n, J. Pierce n & Y. Brudno n

author keywords: Sustained release; Materials-free delivery; Paclitaxel; Pancreatic cancer; Extracellular matrix; N-hydroxysuccinimide ester
MeSH headings : Animals; Cell Line, Tumor; Drug Delivery Systems; Drug Liberation; Hydrogels; Mice; Paclitaxel; Pancreatic Neoplasms / drug therapy
TL;DR: It is demonstrated that locally injected TRAPs create dispersed, stable intratumoral depots deep within mouse and human pancreatic tumor tissues, and had better solubility than free paclitaxel and enabled sustained in vitro and in vivo drug release. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: May 2, 2022

2021 journal article

On-Demand Drug Release from Click-Refillable Drug Depots


By: S. Palvai n, C. Moody n, S. Pandit n & Y. Brudno n

author keywords: drug delivery; bioorthogonal; stimuli-responsive; photocleavage; click chemistry
MeSH headings : Animals; Antineoplastic Agents / administration & dosage; Antineoplastic Agents / pharmacokinetics; Cell Line, Tumor; Click Chemistry / methods; Delayed-Action Preparations; Doxorubicin / administration & dosage; Doxorubicin / pharmacokinetics; Drug Delivery Systems / methods; Drug Liberation; Fluorescent Dyes; Humans; Mice
TL;DR: An on- demand drug delivery paradigm that combines bioorthogonal click chemistry to locally enrich protodrugs at a prelabeled site and light-triggered drug release at the target tissue is reported, establishing a novel method for in vivo targeting and on-demand delivery of cytotoxic drugs at target tissues. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: October 26, 2021

2020 journal article

In Vivo Targeting Using Arylboronate/Nopoldiol Click Conjugation

BIOCONJUGATE CHEMISTRY, 31(10), 2288–2292.

By: S. Palvai n, J. Bhangu*, B. Akgun*, C. Moody n, D. Hall* & Y. Brudno n

MeSH headings : Animals; Boronic Acids / chemical synthesis; Boronic Acids / chemistry; Click Chemistry / methods; Crystallography, X-Ray; Magnetic Resonance Spectroscopy; Mice; Models, Molecular; Semicarbazides / chemical synthesis; Semicarbazides / chemistry
TL;DR: A detailed structural analysis of the arylboronate/nopoldiol adduct is reported that the bioorthogonal reactants form, unexpectedly, a tetracyclic adduct through the cyclization of the distal nitrogen into the semithiocarbazone leading to a strong B-N dative bond and two new 5-membered rings. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: December 21, 2020

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