Works Published in 2017
Displaying works 121 - 140 of 280 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2017 journal article
New frontiers for mass spectrometry based upon structures for lossless ion manipulations
Analyst, 142(7), 1010–1021.
Contributors: Y. Ibrahim *, A. Hamid *, L. Deng *, S. Garimella *, I. Webb *, E. Baker* , R. Smith *
TL;DR:
The evolution of SLIM devices developed over the last three years is reviewed and the basis for previously impractical manipulations, such as very long path length ion mobility separations where ions traverse a serpentine path multiple times are provided.
(via Semantic Scholar)
europepmc.org (repository)
Source: ORCID
Added: December 5, 2019
2017 journal article
PIXiE: an algorithm for automated ion mobility arrival time extraction and collision cross section calculation using global data association
Bioinformatics (Oxford, England), 33(17), 2715–2722.
Contributors: J. Ma *, C. Casey *, X. Zheng *, Y. Ibrahim *, C. Wilkins*, R. Renslow *, D. Thomas*, S. Payne *
MeSH headings : Algorithms; Computational Biology / methods; Mass Spectrometry / methods; Software
TL;DR:
To automatically extract arrival times for molecules measured by DTIMS at multiple electric fields and compute their associated collisional cross sections (CCS), the PNNL Ion Mobility Cross Section Extractor (PIXiE) is created.
(via Semantic Scholar)
Source: ORCID
Added: December 5, 2019
2017 journal article
Profiling microbial lignocellulose degradation and utilization by emergent omics technologies
Critical Reviews in Biotechnology, 37(5), 626–640.
Contributors: J. Rosnow*, L. Anderson *, R. Nair *, E. Baker* & A. Wright *
author keywords: Genomics; proteomics; transcriptomics; NMR; fluorescence-activated cell sorting; metabolomics; activity-based probes
MeSH headings : Biofuels; Lignin / metabolism
TL;DR:
New technologies are yielding important insights into microbial functions and strategies employed to degrade lignocellulose, providing a mechanistic blueprint in order to advance biofuel production.
(via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: December 5, 2019
2017 journal article
Lipid and Glycolipid Isomer Analyses Using Ultra-High Resolution Ion Mobility Spectrometry Separations
International Journal of Molecular Sciences, 18(1).
Contributors: R. Wojcik *, I. Webb *, L. Deng *, S. Garimella *, S. Prost*, Y. Ibrahim *, E. Baker* , R. Smith *
author keywords: lipids; glycolipids; isomers; ion mobility spectrometry
MeSH headings : Glycolipids / chemistry; Glycolipids / isolation & purification; Isomerism; Mass Spectrometry / methods
Source: ORCID
Added: December 5, 2019
2017 journal article
Ligand induced structural isomerism in phosphine coordinated gold clusters revealed by ion mobility mass spectrometry
Chemical Communications, 53(53), 7389–7392.
Contributors: M. Ligare*, E. Baker* , J. Laskin * & G. Johnson *
TL;DR:
These ligand-dependant structure-property relationships are critical to theoretical modeling of clusters as well as their applications in catalysis and photovoltaics.
(via Semantic Scholar)
Source: ORCID
Added: December 5, 2019
2017 journal article
Identification of Hip BMD Loss and Fracture Risk Markers Through Population-Based Serum Proteomics
Journal of Bone and Mineral Research, 32(7), 1559–1567.
Contributors: C. Nielson *, J. Wiedrick*, J. Shen *, J. Jacobs *, E. Baker* , A. Baraff*, P. Piehowski *, C. Lee *
author keywords: BIOCHEMICAL MARKERS OF BONE TURNOVER; OSTEOPOROSIS; GENERAL POPULATION STUDIES
MeSH headings : Aged; Aged, 80 and over; Biomarkers / blood; Bone Density; Hip; Hip Fractures / blood; Humans; Male; Osteoporosis / blood; Osteoporosis / pathology; Peptides / blood; Proteome / metabolism; Proteomics
TL;DR:
Some proteins have been previously associated with fracture risk (eg, CD14 and SHBG), whereas others have roles in cellular senescence and aging and complement activation and innate immunity (CO7, CO9, CFAD).
(via Semantic Scholar)
Source: ORCID
Added: December 5, 2019
2017 journal article
Integrating ion mobility spectrometry into mass spectrometry-based exposome measurements: what can it add and how far can it go?
Bioanalysis, 9(1), 81–98.
Contributors: T. Metz *, E. Baker* , E. Schymanski *, R. Renslow *, D. Thomas*, T. Causon *, I. Webb *, S. Hann *, R. Smith *, J. Teeguarden *
author keywords: collision cross section; exposome; ion mobility spectrometry; mass spectrometry; metabolome
MeSH headings : Animals; Chromatography, Liquid / methods; Computational Biology / methods; High-Throughput Screening Assays / methods; Humans; Mass Spectrometry / methods; Metabolome; Workflow
TL;DR:
The state-of-the-art in measuring the exposome is reviewed, the potential use for IMS-MS and the physico-chemical property of collisional cross section in both exposure assessment and molecular identification is discussed.
(via Semantic Scholar)
Source: ORCID
Added: December 5, 2019
2017 journal article
Distinguishing D- and L-aspartic and isoaspartic acids in amyloid β peptides with ultrahigh resolution ion mobility spectrometry
Chemical Communications, 53(56), 7913–7916.
Contributors: X. Zheng *, L. Deng *, E. Baker* , Y. Ibrahim *, V. Petyuk * & R. Smith *
MeSH headings : Amyloid beta-Peptides / chemistry; Aspartic Acid / chemistry; Ion Mobility Spectrometry / methods; Isoaspartic Acid / chemistry; Peptide Fragments / chemistry; Protein Conformation; Stereoisomerism
TL;DR:
An ultrahigh resolution ion mobility spectrometry platform coupled with mass Spectrometry (IMS-MS) is utilized to separate amyloid β (Aβ) peptides containing l-aspartic acid, d-as Partic acid; the results illustrate how IMS-MS could be used to better understand age-related diseases or protein folding disorders resulting from amino acid modifications.
(via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: December 5, 2019
2017 journal article
Compression Ratio Ion Mobility Programming (CRIMP) Accumulation and Compression of Billions of Ions for Ion Mobility-Mass Spectrometry Using Traveling Waves in Structures for Lossless Ion Manipulations (SLIM)
Analytical Chemistry, 89(12), 6432–6439.
Contributors: L. Deng *, S. Garimella *, A. Hamid *, I. Webb *, I. Attah *, R. Norheim*, S. Prost*, X. Zheng *
MeSH headings : Ion Mobility Spectrometry / instrumentation; Ions / chemistry; Mass Spectrometry / instrumentation; Peptides / analysis
TL;DR:
It is shown that extended ion accumulation in conjunction with CRIMP compression and multiple passes through the serpentine path provides the basis for a highly desirable combination of ultrahigh sensitivity and SLIM SUPER high-resolution IM separations.
(via Semantic Scholar)
Source: ORCID
Added: December 5, 2019
2017 journal article
Characterizing the lipid and metabolite changes associated with placental function and pregnancy complications using ion mobility spectrometry-mass spectrometry and mass spectrometry imaging
Placenta, 60, S67–S72.
Contributors: K. Burnum-Johnson *, E. Baker* & T. Metz *
author keywords: Deep placentation; Pregnancy complications; Mass spectrometry imaging; Metabolome; Lipidome; Ion mobility spectrometry-mass spectrometry; Nano-DESI
MeSH headings : Animals; Chromatography, High Pressure Liquid; Embryo Implantation; Female; Humans; Ion Mobility Spectrometry; Lipid Metabolism; Metabolomics / methods; Metabolomics / trends; Models, Biological; Placenta / metabolism; Placenta / physiology; Placenta / physiopathology; Placentation; Pregnancy; Pregnancy Complications / metabolism; Pregnancy Complications / physiopathology; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Secondary Ion
TL;DR:
Current analytical techniques for metabolomic and lipidomic characterization of pregnancy complications are described and the potential for new technologies to contribute to a better understanding of the molecular changes that affect the placenta and pregnancy outcomes is discussed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: December 5, 2019
2017 journal article
An Interlaboratory Evaluation of Drift Tube Ion Mobility-Mass Spectrometry Collision Cross Section Measurements
Analytical Chemistry, 89(17), 9048–9055.
Contributors: S. Stow*, T. Causon *, X. Zheng *, R. Kurulugama*, T. Mairinger*, J. May *, E. Rennie*, E. Baker*
MeSH headings : Calibration; Ion Mobility Spectrometry / methods; Laboratories / standards; Lipids / chemistry; Mass Spectrometry / methods; Molecular Structure; Nitrogen / chemistry; Proteins / chemistry; Reproducibility of Results
TL;DR:
Improvements on the measurement accuracy of experimental parameters influencing IM separations provide standardized drift tube, nitrogen CCS values (DTCCSN2) for over 120 unique ion species with the lowest measurement uncertainty to date.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Source: ORCID
Added: December 5, 2019
2017 journal article
A structural examination and collision cross section database for over 500 metabolites and xenobiotics using drift tube ion mobility spectrometry
Chemical Science, 8(11), 7724–7736.
Contributors: X. Zheng *, N. Aly*, Y. Zhou *, K. Dupuis*, A. Bilbao *, V. Paurus *, D. Orton *, R. Wilson*
TL;DR:
The DTIMS collision cross section database for metabolites and xenobiotics shows clear trends in both the number of xenobiotic molecules and the proportions of these molecules in the blood stream are increasing.
(via Semantic Scholar)
Source: ORCID
Added: December 5, 2019
2017 journal article
Enhancing glycan isomer separations with metal ions and positive and negative polarity ion mobility spectrometry-mass spectrometry analyses
Analytical and Bioanalytical Chemistry, 409(2), 467–476.
Contributors: X. Zheng *, X. Zhang *, N. Schocker*, R. Renslow *, D. Orton *, J. Khamsi*, R. Ashmus *, I. Almeida *
author keywords: Ion mobility spectrometry; Mass spectrometry; Glycans; O-Glycans; Isomers
MeSH headings : Chemistry Techniques, Analytical / methods; Ion Mobility Spectrometry; Ions / chemistry; Isomerism; Mass Spectrometry; Metals / chemistry; Polysaccharides / chemistry; Polysaccharides / isolation & purification
TL;DR:
Ims-MS results showed significant differences for the glycan structural isomers when analyzed in positive and negative polarity and complexed with different metal cations, and suggest that specific metal ions or ion polarities could be used to target and baseline separate glycan isomers of interest with IMS-MS.
(via Semantic Scholar)
Source: ORCID
Added: December 5, 2019
2017 book
Coupling front-end separations, ion mobility spectrometry, and mass spectrometry for enhanced multidimensional biological and environmental analyses
In Annual Review of Analytical Chemistry (Vol. 10, pp. 71–92).
Contributors: X. Zheng *, R. Wojcik *, X. Zhang *, Y. Ibrahim *, K. Burnum-Johnson *, D. Orton *, M. Monroe *, R. Moore *, R. Smith *, E. Baker*
author keywords: drift tube IMS; gas chromatography; supercritical fluid chromatography; liquid chromatography; solid-phase extraction; capillary electrophoresis; field asymmetric ion mobility spectrometry; microfluidics; structure for lossless ion manipulations
MeSH headings : Bacterial Toxins / analysis; Chromatography, Liquid; Chromatography, Supercritical Fluid; Environmental Monitoring; Gases / chemistry; Ions / chemistry; Mass Spectrometry / instrumentation; Mass Spectrometry / methods; Microfluidics / methods; Pharmaceutical Preparations / analysis
TL;DR:
This review highlights three-dimensional separations using IMS-MS in conjunction with a range of front-end techniques, such as gas chromatography, supercritical fluidchromatography, liquid Chromatography, solid-phase extractions, capillary electrophoresis, field asymmetric ion mobility spectrometry, and microfluidic devices.
(via Semantic Scholar)
Source: ORCID
Added: December 5, 2019
2017 journal article
Comparing identified and statistically significant lipids and polar metabolites in 15-year old serum and dried blood spot samples for longitudinal studies
Rapid Communications in Mass Spectrometry, 31(5), 447–456.
Contributors: J. Kyle *, C. Casey *, K. Stratton *, E. Zink *, Y. Kim *, X. Zheng *, M. Monroe *, K. Weitz *
TL;DR:
The difference in the number of statistically significant polar metabolites and lipids indicated that the lipids did not degrade to as great of a degree as the polar metabolites in the DBS samples and lipid quantitation was still possible.
(via Semantic Scholar)
Source: ORCID
Added: December 5, 2019
2017 journal article
A Carbon Nanotube Optical Sensor Reports Nuclear Entry via a Noncanonical Pathway
ACS Nano.
author keywords: helical polymer; hyperspectral imaging; cervical cancer; near-infrared sensor; biosensor; polycation; nuclear pore complex
MeSH headings : Active Transport, Cell Nucleus; Cell Nucleus / metabolism; HeLa Cells; Humans; Luminescent Agents / chemistry; Luminescent Agents / metabolism; Microscopy, Fluorescence; Molecular Structure; Nanotubes, Carbon / analysis; Nanotubes, Carbon / chemistry; Optical Imaging; Polymers / chemistry; Tumor Cells, Cultured
TL;DR:
A carbon nanotube based hybrid material is developed that elucidate a distinct mechanism of nuclear translocation of a nanomaterial in cultured cells and provides a reporter for the study of nucleus-related pathologies.
(via Semantic Scholar)
Source: ORCID
Added: August 27, 2019
2017 journal article
Polymer cloaking modulates the carbon nanotube protein corona and delivery into cancer cells
J. Mater. Chem. B.
TL;DR:
This work modulated functional moieties on a helical polycarbodiimide polymer backbone that non-covalently suspended the nanotubes in aqueous media and obtained nanotube complexes that present net surface charges of opposite polarity at physiological pH.
(via Semantic Scholar)
Source: ORCID
Added: August 27, 2019
2017 journal article
Control of Carbon Nanotube Solvatochromic Response to Chemotherapeutic Agents
ACS Applied Materials & Interfaces.
author keywords: nanosensor; fluorescence; photoluminescence; cis-diammineplatinum(II) dichloride; antineoplastic; mustard agent
MeSH headings : Adsorption; Antineoplastic Agents; DNA, Single-Stranded; Nanotubes, Carbon
TL;DR:
A new approach to control the direction and magnitude of solvatochromic responses of carbon nanotubes is described and it is found that the alkylation of DNA on the nanotube surface can result in small changes in DNA conformation that allow the adsorption of amphiphiles to produce large differences in response to different drugs.
(via Semantic Scholar)
Source: ORCID
Added: August 27, 2019
2017 journal article
A Carbon Nanotube Optical Reporter Maps Endolysosomal Lipid Flux
ACS Nano.
author keywords: single-walled carbon nanotubes; single-cell sensing live-cell imaging; near-infrared fluorescence; hyperspectral microscopy
MeSH headings : Atherosclerosis / blood; Atherosclerosis / pathology; DNA, Single-Stranded / blood; DNA, Single-Stranded / chemistry; Endosomes / chemistry; Humans; Lipids / chemistry; Luminescent Measurements; Lysosomes / chemistry; Lysosomes / metabolism; Macrophages / chemistry; Macrophages / metabolism; Monocytes / chemistry; Monocytes / metabolism; Nanotubes, Carbon / chemistry; Niemann-Pick Disease, Type C; Optics and Photonics / instrumentation; Single-Cell Analysis / methods; Transport Vesicles / chemistry; Transport Vesicles / metabolism
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: August 27, 2019
2017 journal article
Creating 3D Physical Models to Probe Student Understanding of Macromolecular Structure
BIOCHEMISTRY AND MOLECULAR BIOLOGY EDUCATION, 45(6), 491–500.
author keywords: active learning; assessment and the design of probes for student understanding and learning; judging quality of macromolecular models; molecular visualization; protein structure function and folding; visual literacy
MeSH headings : DNA / chemistry; Humans; Macromolecular Substances / chemistry; Models, Molecular; Molecular Structure; Proteins / chemistry; Students / psychology; Universities
TL;DR:
Four different physical models are designed to address student understanding of electrostatics and noncovalent interactions and their relationship to macromolecular structure to engage students at an appropriate level of difficulty and focus student attention on the principles of electrostatic attractions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
4. Quality Education
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
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