author keywords: right asymmetry; Stomach; Morphogenesis; Pitx2; Sim2; Down syndrome; Frog

MeSH headings : Animals; Anura; Basic Helix-Loop-Helix Transcription Factors / genetics; Basic Helix-Loop-Helix Transcription Factors / metabolism; Body Patterning; Embryo, Nonmammalian; Endoderm / embryology; Endoderm / metabolism; Gene Expression Regulation, Developmental; Homeodomain Proteins / genetics; Homeodomain Proteins / metabolism; Morphogenesis; Stomach / embryology; Transcription Factors / genetics; Transcription Factors / metabolism

TL;DR: It is demonstrated that sim2 functions downstream of LR patterning cues to regulate key cellular properties and behaviors in the left stomach epithelium that drive asymmetric curvature, and has implications for dose-dependent roles of laterality factors in non-laterality-related birth defects. (via Semantic Scholar)