Michael K Dush

Works (8)

Updated: April 25th, 2025 17:23

2023 article

Rare variants in CAPN2 increase risk for isolated hypoplastic left heart syndrome

Blue, E. E., White, J. J., Dush, M. K., Gordon, W. W., Wyatt, B. H., White, P., … Bamshad, M. J. (2023, August 11). Human Genetics and Genomics Advances, Vol. 4.

By: E. Blue *, J. White *, M. Dush n, W. Gordon *, B. Wyatt n, P. White *, C. Marvin*, E. Helle * ...

MeSH headings : Animals; Humans; Hypoplastic Left Heart Syndrome / genetics; Alleles; Aorta; Calpain / genetics; Cerebral Ventricles
topics (OpenAlex): Congenital heart defects research; RNA modifications and cancer; Cardiac Valve Diseases and Treatments
TL;DR: The findings show that iHLHS is typically not a Mendelian condition, demonstrate that CAPN2 variants increase risk of i HLHS, and identify a novel pathway involved in HLHS pathogenesis. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: October 16, 2023

2021 article

Single-minded 2 is required for left-right asymmetric stomach morphogenesis

Wyatt, B. H., Amin, N. M., Bagley, K., Wcisel, D. J., Dush, M. K., Yoder, J. A., & Nascone-Yoder, N. M. (2021, July 1). Development, Vol. 9.

By: B. Wyatt n, N. Amin n, K. Bagley n, D. Wcisel n, M. Dush n, J. Yoder n , N. Nascone-Yoder n 

author keywords: right asymmetry; Stomach; Morphogenesis; Pitx2; Sim2; Down syndrome; Frog
MeSH headings : Animals; Anura; Basic Helix-Loop-Helix Transcription Factors / genetics; Basic Helix-Loop-Helix Transcription Factors / metabolism; Body Patterning; Embryo, Nonmammalian; Endoderm / embryology; Endoderm / metabolism; Gene Expression Regulation, Developmental; Homeodomain Proteins / genetics; Homeodomain Proteins / metabolism; Morphogenesis; Stomach / embryology; Transcription Factors / genetics; Transcription Factors / metabolism
topics (OpenAlex): Congenital heart defects research; Developmental Biology and Gene Regulation
TL;DR: It is demonstrated that sim2 functions downstream of LR patterning cues to regulate key cellular properties and behaviors in the left stomach epithelium that drive asymmetric curvature, and has implications for dose-dependent roles of laterality factors in non-laterality-related birth defects. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: September 27, 2021

2019 article

Vangl2 coordinates cell rearrangements during gut elongation

Dush, M. K., & Nascone‐Yoder, N. M. (2019, May 13). Developmental Dynamics, Vol. 248, pp. 569–582.

By: M. Dush n & N. Nascone‐Yoder n 

author keywords: Vangl2; endoderm; gut; Xenopus; morphogenesis; elongation
MeSH headings : Animals; Body Patterning; Cell Adhesion; Cell Movement; Cell Polarity; Endoderm / cytology; Intestines / anatomy & histology; Intestines / growth & development; Membrane Proteins / metabolism; Membrane Proteins / physiology; Morphogenesis; Xenopus Proteins / metabolism; Xenopus Proteins / physiology; Xenopus laevis / growth & development
topics (OpenAlex): Hippo pathway signaling and YAP/TAZ; Pluripotent Stem Cells Research
TL;DR: The embryonic gut tube undergoes extensive lengthening to generate the surface area required for nutrient absorption across the digestive epithelium in Xenopus, a process that concomitantly opens the gut lumen and facilitates epithelial morphogenesis. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: July 22, 2019

2017 article

Acetylcholinesterase plays a non-neuronal, non-esterase role in organogenesis

Pickett, M. A., Dush, M. K., & Nascone-Yoder, N. M. (2017, July 7). Development, Vol. 144, pp. 2764–2770.

By: M. Pickett n, M. Dush n & N. Nascone-Yoder n 

author keywords: Acetylcholinesterase; Morphogenesis; Gut; Intestine; Fibronectin; Xenopus laevis
MeSH headings : Acetylcholine / metabolism; Acetylcholinesterase / genetics; Acetylcholinesterase / metabolism; Animals; Cell Adhesion / physiology; Embryo, Nonmammalian / metabolism; Endoderm / cytology; Endoderm / metabolism; Fibronectins / genetics; Fibronectins / metabolism; Immunohistochemistry; Nervous System / embryology; Nervous System / metabolism; Organogenesis / genetics; Organogenesis / physiology; RNA, Messenger / genetics; Xenopus laevis / embryology; Xenopus laevis / genetics; Xenopus laevis / metabolism
topics (OpenAlex): Cholinesterase and Neurodegenerative Diseases; Medicinal Plants and Neuroprotection; Nicotinic Acetylcholine Receptors Study
TL;DR: A non-classical function of acetylcholinesterase in the polarization, rearrangement and adhesion of endoderm cells during Xenopus gut morphogenesis is identified and has wide-reaching implications for development and toxicology. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2013 article

Jun N-terminal kinase maintains tissue integrity during cell rearrangement in the gut

Dush, M. K., & Nascone-Yoder, N. M. (2013, March 6). Development, Vol. 140, pp. 1457–1466.

By: M. Dush n & N. Nascone-Yoder n 

author keywords: JNK; Rho kinase; Endoderm; Gut; Intestine; Morphogenesis; Xenopus
MeSH headings : Animals; Animals, Genetically Modified; Body Patterning / genetics; Body Patterning / physiology; Cell Adhesion / genetics; Cell Movement / genetics; Cell Movement / physiology; Embryo, Nonmammalian; Endoderm / embryology; Endoderm / metabolism; Gastrula / cytology; Gastrula / embryology; Gastrula / metabolism; Gene Expression Regulation, Developmental; Intestinal Mucosa / cytology; Intestinal Mucosa / metabolism; Intestinal Mucosa / physiology; JNK Mitogen-Activated Protein Kinases / genetics; JNK Mitogen-Activated Protein Kinases / metabolism; JNK Mitogen-Activated Protein Kinases / physiology; Microtubules / genetics; Microtubules / metabolism; Models, Biological; Permeability; Xenopus / embryology; Xenopus / genetics; Xenopus / metabolism
topics (OpenAlex): Cellular Mechanics and Interactions; Cancer Cells and Metastasis; Hippo pathway signaling and YAP/TAZ
TL;DR: It is shown that JNK activity is indispensable for the rearrangement of endoderm cells that underlies the elongation of the Xenopus gut tube, and sheds new light on the means by which intra- and intercellular forces are balanced to promote topological change, while preserving structural integrity, in numerous morphogenetic contexts. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2011 article

Heterotaxin: A TGF-β Signaling Inhibitor Identified in a Multi-Phenotype Profiling Screen in Xenopus Embryos

Dush, M. K., McIver, A. L., Parr, M. A., Young, D. D., Fisher, J., Newman, D. R., … Nascone-Yoder, N. (2011, February 1). Chemistry & Biology, Vol. 18, pp. 252–263.

By: M. Dush n, A. McIver n, M. Parr n, D. Young n, J. Fisher n, D. Newman n, P. Sannes n, M. Hauck n, A. Deiters n, N. Nascone-Yoder n 

MeSH headings : Animals; Cell Line; Drug Evaluation, Preclinical; Embryo, Nonmammalian / abnormalities; Embryo, Nonmammalian / cytology; Embryo, Nonmammalian / drug effects; Embryo, Nonmammalian / metabolism; Humans; Intracellular Space / drug effects; Intracellular Space / metabolism; Neovascularization, Physiologic / drug effects; Phenotype; Pyridines / chemistry; Pyridines / pharmacology; Signal Transduction / drug effects; Stereoisomerism; Structure-Activity Relationship; Transforming Growth Factor beta / metabolism; Xenopus laevis
topics (OpenAlex): Congenital heart defects research; Developmental Biology and Gene Regulation
TL;DR: A small molecule screen for left-right asymmetry phenotypes in Xenopus embryos is performed and a pyridine analog, heterotaxin, is discovered, which disrupts both cardiovascular and digestive organ laterality and inhibits TGF-β-dependent left- right asymmetric gene expression. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2010 journal article

Photocaged Morpholino Oligomers for the Light-Regulation of Gene Function in Zebrafish and Xenopus Embryos

Journal of the American Chemical Society, 132(44), 15644–15650.

By: A. Deiters n, R. Garner n, H. Lusic n, J. Govan n, M. Dush n, N. Nascone-Yoder n , J. Yoder n 

MeSH headings : Animals; Cells, Cultured; Embryo, Nonmammalian / metabolism; Gene Expression; Morpholines / chemistry; Oligonucleotides / genetics; Oligonucleotides / metabolism; Ultraviolet Rays; Xenopus laevis / genetics; Xenopus laevis / metabolism; Zebrafish / genetics; Zebrafish / metabolism
topics (OpenAlex): Photochromic and Fluorescence Chemistry; RNA Interference and Gene Delivery; Advanced biosensing and bioanalysis techniques
TL;DR: A novel and efficient synthetic route for incorporating photocaged monomeric building blocks directly into morpholino oligomers is reported and the utility of these caged morpholinos in the light-activated control of gene function in both cell culture and living embryos is demonstrated. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2009 article

Morphogenesis of the primitive gut tube is generated by Rho/ROCK/myosin II–mediated endoderm rearrangements

Reed, R. A., Womble, M. A., Dush, M. K., Tull, R. R., Bloom, S. K., Morckel, A. R., … Nascone‐Yoder, N. M. (2009, November 18). Developmental Dynamics, Vol. 238, pp. 3111–3125.

By: R. Reed n, M. Womble n, M. Dush n, R. Tull n, S. Bloom n, A. Morckel n, E. Devlin*, N. Nascone‐Yoder n 

author keywords: gut; Xenopus; morphogenesis; endoderm, intercalation; elongation
MeSH headings : Animals; Animals, Genetically Modified; Body Patterning / genetics; Cell Polarity / genetics; Cell Shape / genetics; Embryo, Nonmammalian; Endoderm / cytology; Endoderm / embryology; Endoderm / metabolism; Gastrointestinal Diseases / congenital; Gastrointestinal Diseases / embryology; Gastrointestinal Tract / abnormalities; Gastrointestinal Tract / embryology; Gastrula / embryology; Gastrula / metabolism; Models, Biological; Morphogenesis / genetics; Nonmuscle Myosin Type IIB / genetics; Nonmuscle Myosin Type IIB / metabolism; Nonmuscle Myosin Type IIB / physiology; Signal Transduction / genetics; Xenopus / embryology; Xenopus / genetics; Xenopus / metabolism; rho-Associated Kinases / genetics; rho-Associated Kinases / metabolism; rho-Associated Kinases / physiology; rhoA GTP-Binding Protein / genetics; rhoA GTP-Binding Protein / metabolism; rhoA GTP-Binding Protein / physiology
topics (OpenAlex): Pancreatic function and diabetes; Congenital heart defects research; Ion Transport and Channel Regulation
TL;DR: The results suggest that the cellular and molecular events driving tissue elongation in the PGT are mechanistically analogous to those that function during gastrulation, but occur within a novel cylindrical geometry to generate an epithelial‐lined tube. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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