2020 journal article
Associations between maternal obesity, gestational cytokine levels and child obesity in the NEST cohort
PEDIATRIC OBESITY, 16(7).
author keywords: cytokines; maternal obesity; childhood obesity
MeSH headings : Black or African American; Body Mass Index; Child; Child, Preschool; Cohort Studies; Cytokines / blood; Female; Humans; Obesity, Maternal / epidemiology; Pediatric Obesity / epidemiology; Pregnancy; White People
TL;DR:
Although maternal systemic inflammation is hypothesized to link maternal pre‐pregnancy obesity to offspring metabolic dysfunction, patient empirical data are limited.
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UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
5. Gender Equality
(Web of Science)
Source: Web Of Science
Added: January 19, 2021
SummaryBackgroundAlthough maternal systemic inflammation is hypothesized to link maternal pre‐pregnancy obesity to offspring metabolic dysfunction, patient empirical data are limited.ObjectivesIn this study, we hypothesized that pre‐pregnancy obesity alters systemic chemo/cytokines concentrations in pregnancy, and this alteration contributes to obesity in children.MethodsIn a multi‐ethnic cohort of 361 mother‐child pairs, we measured prenatal concentrations of plasma TNF‐α, IL‐6, IL‐8, IL‐1β, IL‐4, IFN‐γ, IL‐12 p70 subunit, and IL‐17A using a multiplex ELISA and examined associations of pre‐pregnancy obesity on maternal chemo/cytokine levels, and associations of these cytokine levels with offspring body mass index z score (BMI‐z) at age 2–6 years using linear regression.ResultsAfter adjusting for maternal smoking, ethnicity, age, and education, pre‐pregnancy obesity was associated with increased concentrations of TNF‐α (P = .026) and IFN‐γ (P = .06). While we found no evidence for associations between TNF‐α concentrations and offspring BMI‐z, increased IFN‐γ concentrations were associated with decreased BMI‐z (P = .0002), primarily in Whites (P = .0011). In addition, increased maternal IL‐17A concentrations were associated with increased BMI‐z in offspring (P = .0005) with stronger associations in African Americans (P = .0042) than Whites (P = .24).ConclusionsData from this study are consistent with maternal obesity‐related inflammation during pregnancy, increasing the risk of childhood obesity in an ethnic‐specific manner.