Swapnil Ramesh Chhabra

Works (8)

Updated: July 5th, 2023 16:00

2005 journal article

An expression-driven approach to the prediction of carbohydrate transport and utilization regulons in the hyperthermophilic bacterium Thermotoga maritima

JOURNAL OF BACTERIOLOGY, 187(21), 7267–7282.

By: S. Conners n, C. Montero n, D. Comfort n, K. Shockley n, M. Johnson n, . Chhabra n, R. Kelly n 

MeSH headings : 5' Flanking Region / genetics; ATP-Binding Cassette Transporters / chemistry; ATP-Binding Cassette Transporters / genetics; Biological Evolution; Biological Transport / genetics; Carbohydrate Metabolism; Computational Biology; Gene Duplication; Gene Expression Profiling; Genes, Bacterial; Genes, Regulator; Genomics; Monosaccharide Transport Proteins / genetics; Nucleic Acid Conformation; Oligosaccharides / metabolism; Pentose Phosphate Pathway / genetics; Regulon / physiology; Rhamnose / metabolism; Thermotoga maritima / genetics; Thermotoga maritima / metabolism; Xylose / metabolism
TL;DR: The results indicate that T. maritima relies extensively on ABC transporters for carbohydrate uptake, many of which are likely controlled by local regulators responsive to either the transport substrate or a key metabolic degradation product. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2003 journal article

Carbohydrate-induced differential gene expression patterns in the hyperthermophilic bacterium Thermotoga maritima

JOURNAL OF BIOLOGICAL CHEMISTRY, 278(9), 7540–7552.

By: . Chhabra, K. Shockley*, S. Conners*, K. Scott*, R. Wolfinger* & R. Kelly* 

MeSH headings : Carbohydrate Metabolism; Carbohydrate Sequence; Carbohydrates / chemistry; Carbon / metabolism; DNA, Complementary / metabolism; Down-Regulation; Gene Expression Regulation, Bacterial; Hydrolases / chemistry; Hydrolases / metabolism; Molecular Sequence Data; Oligonucleotide Array Sequence Analysis; Open Reading Frames; Thermotoga maritima / metabolism; Up-Regulation
TL;DR: The transcriptional response of T. maritima to specific carbohydrate growth substrates indicated that sugar backbone- and linkage-specific regulatory networks are operational in this organism during the uptake and utilization of carbohydrate substrates, and suggests that this organism is capable of adapting to a variety of growth environments containing carbohydrate growth substrate. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2003 journal article

Heat shock response by the hyperthermophilic archaeon Pyrococcus furiosus

APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 69(4), 2365–2371.

By: K. Shockley n, D. Ward n, . Chhabra n, S. Conners n, C. Montero n & R. Kelly n 

MeSH headings : Archaeal Proteins / genetics; Archaeal Proteins / metabolism; Blotting, Northern; Gene Expression Profiling; Gene Expression Regulation, Archaeal; Heat-Shock Response; Oligonucleotide Array Sequence Analysis; Protein Folding; Pyrococcus furiosus / genetics; Pyrococcus furiosus / metabolism; Transcription, Genetic
TL;DR: Collective transcriptional analysis of heat shock response in the hyperthermophilic archaeon Pyrococcus furiosus was examined by using a targeted cDNA microarray in conjunction with Northern analyses and differential gene expression suggests that P.furiosus relies on a cooperative strategy of rescue, proteolysis, and stabilization to cope with polypeptide processing during thermal stress. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2002 journal article

Biochemical characterization of Thermotoga maritima endoglucanase Ce174 with and without a carbohydrate binding module (CBM)

FEBS LETTERS, 531(2), 375–380.

By: . Chhabra n & R. Kelly n 

MeSH headings : Amino Acid Sequence; Binding Sites; Carbohydrate Metabolism; Cellulase / chemistry; Cellulase / genetics; Cellulase / metabolism; Cellulose / metabolism; Chitinases / genetics; Molecular Sequence Data; Protein Structure, Tertiary; Pyrococcus furiosus / enzymology; Recombinant Fusion Proteins / metabolism; Sequence Alignment; Substrate Specificity; Thermotoga maritima / enzymology
TL;DR: Based on the cleavage pattern determined for Tm Cel74 on glucan‐based substrates, this enzyme likely initiates recruitment of carbohydrate carbon and energy sources by creating oligosaccharides that are transported into the cell for further processing. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2002 journal article

Regulation of endo-acting glycosyl hydrolases in the hyperthermophilic bacterium Thermotoga maritima grown on glucan- and mannan-based polysaccharides

APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 68(2), 545–554.

By: . Chhabra n, K. Shockley n, D. Ward n & R. Kelly n 

MeSH headings : Amino Acid Sequence; Culture Media; Gene Expression Regulation, Bacterial; Glucans / chemistry; Glucans / metabolism; Glycoside Hydrolases / chemistry; Glycoside Hydrolases / genetics; Glycoside Hydrolases / metabolism; Hot Temperature; Mannans / chemistry; Mannans / metabolism; Molecular Sequence Data; Polysaccharides / chemistry; Polysaccharides / metabolism; Recombinant Proteins / genetics; Recombinant Proteins / metabolism; Sequence Analysis, DNA; Thermotoga maritima / enzymology; Thermotoga maritima / genetics; Thermotoga maritima / growth & development
TL;DR: The genome sequence of the hyperthermophilic bacterium Thermotoga maritima encodes a number of glycosyl hydrolases, and the intracellular localization of Cel5A suggest that the physiological role of this enzyme includes hydrolysis of glucomannan oligosaccharides that are transported following initial hydrolyzing by extracellular glycosidases, such as Man5. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2001 journal article

Galactomannanases man2 and man5 from Thermotoga species: Growth physiology on galactomannans, gene sequence analysis, and biochemical properties of recombinant enzymes

BIOTECHNOLOGY AND BIOENGINEERING, 75(3), 322–333.

By: K. Parker n, . Chhabra n, D. Lam*, W. Callen*, G. Duffaud n, M. Snead*, J. Short*, E. Mathur*, R. Kelly n 

author keywords: Thermotoga; hyperthermophile; hemicellulase; glycosyl hydrolase; galactomannan; beta-mannanase; beta-mannosidase
MeSH headings : Amino Acid Sequence; Bacteria / enzymology; Bacteria / genetics; Bacteria / growth & development; Bacterial Proteins; Galactose / analogs & derivatives; Mannans / metabolism; Mannosidases / chemistry; Mannosidases / genetics; Mannosidases / metabolism; Microscopy, Electron; Molecular Sequence Data; Sequence Homology, Amino Acid; beta-Mannosidase
TL;DR: The identification of the galactomannan-degrading enzymes in these Thermotoga species adds to the list of biotechnologically important hemicellulases produced by members of this hyperthermophilic genera. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2001 journal article

beta-Mannanases from Thermotoga species

Hyperthermophilic Enzymes. Part A, 330, 224–238.

By: S. Chhabra, K. Parker, D. Lam, W. Callen, M. Snead, E. Mathur, J. Short, R. Kelly 

Source: NC State University Libraries
Added: August 6, 2018

2001 journal article

beta-Mannosidase from Thermotoga species

Hyperthermophilic Enzymes. Part A, 330, 238–246.

By: K. Parker, S. Chhabra, D. Lam, M. Snead, E. Mathur & R. Kelly 

Source: NC State University Libraries
Added: August 6, 2018

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