Lauren Brenna Gilvey

Works (5)

Updated: July 11th, 2023 20:10

2009 journal article

Characterization of Dehaloperoxidase Compound ES and Its Reactivity with Trihalophenols†

Biochemistry, 48(5), 995–1005.

By: J. Feducia n , R. Dumarieh n, L. Gilvey n, T. Smirnova n , S. Franzen n  & R. Ghiladi n 

Contributors: J. Feducia n , R. Dumarieh n, L. Gilvey n, T. Smirnova n , S. Franzen n  & R. Ghiladi n 

MeSH headings : Animals; Binding Sites; Chlorophenols / chemistry; Chlorophenols / metabolism; Crystallography, X-Ray; Cytochrome-c Peroxidase / chemistry; Cytochrome-c Peroxidase / metabolism; Electron Transport Complex IV / chemistry; Electron Transport Complex IV / metabolism; Hemoglobins / chemistry; Hemoglobins / metabolism; Peroxidases / chemistry; Peroxidases / metabolism; Polychaeta / enzymology
TL;DR: It is demonstrated that the first detectable intermediate following the addition of hydrogen peroxide to ferric DHP contains both a ferryl heme and a tyrosyl radical, analogous to Compound ES of cytochrome c peroxidase. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: August 6, 2018

2006 journal article

Proximal cavity, distal histidine, and substrate hydrogen-bonding mutations modulate the activity of Amphitrite ornata dehaloperoxidase

BIOCHEMISTRY, 45(30), 9085–9094.

By: S. Franzen n , J. Belyea n, L. Gilvey n, M. Davis n, C. Chaudhary n, T. Sit n , S. Lommel n

Contributors: S. Franzen n , J. Belyea n, L. Gilvey n, M. Davis n, C. Chaudhary n, T. Sit n , S. Lommel n

MeSH headings : Animals; Binding Sites / genetics; Hemoglobins; Histidine / chemistry; Histidine / genetics; Hydrogen Bonding; Mutagenesis, Site-Directed; Peroxidases / chemistry; Peroxidases / genetics; Peroxidases / metabolism; Phenylalanine / genetics; Polychaeta / enzymology; Polychaeta / genetics; Substrate Specificity / genetics; Tyrosine / genetics; Valine / genetics
TL;DR: The role of tyrosine 38 (Y38), which hydrogen bonds to the hydroxyl group of the substrate, was probed and it was suggested that abolishing this hydrogen bond may open a pathway for the escape of the one-electron product, the phenoxy radical leading to polymeric products. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2006 journal article

The pH dependence of the activity of dehaloperoxidase from Amphitrite ornata

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 1774(1), 121–130.

By: S. Franzen n , L. Gilvey n & J. Belyea n

author keywords: peroxidase; Fourier-transform infrared spectroscopy; X-ray crystallography; enzyme kinetics
MeSH headings : Animals; Crystallography, X-Ray; Hemoglobins / metabolism; Hydrogen-Ion Concentration; Kinetics; Peroxidases / metabolism; Phenols / metabolism; Polychaeta / enzymology; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared
TL;DR: A study of the pH dependence of the activity of DHP reveals a substantial difference in mechanism, and other known peroxidases, which oxidize substrates at the heme edge are discussed by comparison. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2005 journal article

Enzyme function of the globin dehaloperoxidase from Amphitrite ornata is activated by substrate binding

BIOCHEMISTRY, 44(48), 15637–15644.

By: J. Belyea n, L. Gilvey n, M. Davis n, M. Godek n, T. Sit n , S. Lommel n, S. Franzen n 

Contributors: J. Belyea n, L. Gilvey n, M. Davis n, M. Godek n, T. Sit n , S. Lommel n, S. Franzen n 

MeSH headings : Animals; Cloning, Molecular; Enzyme Activation; Escherichia coli / enzymology; Escherichia coli / genetics; Globins / metabolism; Hemoglobins; Hydrogen Peroxide / metabolism; Peroxidases / antagonists & inhibitors; Peroxidases / genetics; Peroxidases / metabolism; Phenols / metabolism; Polychaeta / enzymology; Protein Binding; Recombinant Proteins / isolation & purification; Recombinant Proteins / metabolism
TL;DR: The present study shows that, unlike other known peroxidases, DHP activity requires the addition of substrate, TBP, prior to the cosubstrate, peroxide. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2004 journal article

Characterization of single- and double-stranded DNA on gold surfaces

LANGMUIR, 20(25), 11134–11140.

By: S. Moses n, S. Brewer n, L. Lowe n, S. Lappi n, L. Gilvey n, M. Sauthier n, R. Tenent n, D. Feldheim n, S. Franzen n 

MeSH headings : DNA / chemistry; Gold / chemistry; Surface Properties; Temperature; Time Factors
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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