Lauren Brenna Gilvey

Works (5)

Updated: July 11th, 2023 20:10

2009 journal article

Characterization of Dehaloperoxidase Compound ES and Its Reactivity with Trihalophenols†

Biochemistry, 48(5), 995–1005.

By: J. Feducia n , R. Dumarieh n, L. Gilvey n, T. Smirnova n , S. Franzen n  & R. Ghiladi n 

Contributors: J. Feducia n , R. Dumarieh n, L. Gilvey n, T. Smirnova n , S. Franzen n  & R. Ghiladi n 

MeSH headings : Animals; Binding Sites; Chlorophenols / chemistry; Chlorophenols / metabolism; Crystallography, X-Ray; Cytochrome-c Peroxidase / chemistry; Cytochrome-c Peroxidase / metabolism; Electron Transport Complex IV / chemistry; Electron Transport Complex IV / metabolism; Hemoglobins / chemistry; Hemoglobins / metabolism; Peroxidases / chemistry; Peroxidases / metabolism; Polychaeta / enzymology
topics (OpenAlex): Redox biology and oxidative stress; Heme Oxygenase-1 and Carbon Monoxide; Free Radicals and Antioxidants
TL;DR: It is demonstrated that the first detectable intermediate following the addition of hydrogen peroxide to ferric DHP contains both a ferryl heme and a tyrosyl radical, analogous to Compound ES of cytochrome c peroxidase. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: August 6, 2018

2006 article

Proximal Cavity, Distal Histidine, and Substrate Hydrogen-Bonding Mutations Modulate the Activity of Amphitrite ornata Dehaloperoxidase

Franzen, S., Belyea, J., Gilvey, L. B., Davis, M. F., Chaudhary, C. E., Sit, T. L., & Lommel, S. A. (2006, July 7). Biochemistry, Vol. 45, pp. 9085–9094.

By: S. Franzen n , J. Belyea n, L. Gilvey n, M. Davis n, C. Chaudhary n, T. Sit n , S. Lommel n

Contributors: S. Franzen n , J. Belyea n, L. Gilvey n, M. Davis n, C. Chaudhary n, T. Sit n , S. Lommel n

MeSH headings : Animals; Binding Sites / genetics; Hemoglobins; Histidine / chemistry; Histidine / genetics; Hydrogen Bonding; Mutagenesis, Site-Directed; Peroxidases / chemistry; Peroxidases / genetics; Peroxidases / metabolism; Phenylalanine / genetics; Polychaeta / enzymology; Polychaeta / genetics; Substrate Specificity / genetics; Tyrosine / genetics; Valine / genetics
topics (OpenAlex): Hemoglobin structure and function; Heme Oxygenase-1 and Carbon Monoxide; Erythrocyte Function and Pathophysiology
TL;DR: The role of tyrosine 38 (Y38), which hydrogen bonds to the hydroxyl group of the substrate, was probed and it was suggested that abolishing this hydrogen bond may open a pathway for the escape of the one-electron product, the phenoxy radical leading to polymeric products. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2006 article

The pH dependence of the activity of dehaloperoxidase from Amphitrite ornata

Franzen, S., Gilvey, L. B., & Belyea, J. L. (2006, November 2). Biochimica Et Biophysica Acta (BBA) - Proteins and Proteomics, Vol. 1774, pp. 121–130.

By: S. Franzen n , L. Gilvey n & J. Belyea n

author keywords: peroxidase; Fourier-transform infrared spectroscopy; X-ray crystallography; enzyme kinetics
MeSH headings : Animals; Crystallography, X-Ray; Hemoglobins / metabolism; Hydrogen-Ion Concentration; Kinetics; Peroxidases / metabolism; Phenols / metabolism; Polychaeta / enzymology; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared
topics (OpenAlex): Hemoglobin structure and function; Heme Oxygenase-1 and Carbon Monoxide; Erythrocyte Function and Pathophysiology
TL;DR: A study of the pH dependence of the activity of DHP reveals a substantial difference in mechanism, and other known peroxidases, which oxidize substrates at the heme edge are discussed by comparison. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2005 article

Enzyme Function of the Globin Dehaloperoxidase from Amphitrite ornata Is Activated by Substrate Binding

Belyea, J., Gilvey, L. B., Davis, M. F., Godek, M., Sit, T. L., Lommel, S. A., & Franzen, S. (2005, November 9). Biochemistry, Vol. 44, pp. 15637–15644.

By: J. Belyea n, L. Gilvey n, M. Davis n, M. Godek n, T. Sit n , S. Lommel n, S. Franzen n 

Contributors: J. Belyea n, L. Gilvey n, M. Davis n, M. Godek n, T. Sit n , S. Lommel n, S. Franzen n 

MeSH headings : Animals; Cloning, Molecular; Enzyme Activation; Escherichia coli / enzymology; Escherichia coli / genetics; Globins / metabolism; Hemoglobins; Hydrogen Peroxide / metabolism; Peroxidases / antagonists & inhibitors; Peroxidases / genetics; Peroxidases / metabolism; Phenols / metabolism; Polychaeta / enzymology; Protein Binding; Recombinant Proteins / isolation & purification; Recombinant Proteins / metabolism
topics (OpenAlex): Hemoglobin structure and function; Porphyrin Metabolism and Disorders; Heme Oxygenase-1 and Carbon Monoxide
TL;DR: The present study shows that, unlike other known peroxidases, DHP activity requires the addition of substrate, TBP, prior to the cosubstrate, peroxide. (via Semantic Scholar)
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6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2004 article

Characterization of Single- and Double-Stranded DNA on Gold Surfaces

Moses, S., Brewer, S. H., Lowe, L. B., Lappi, S. E., Gilvey, L. B. G., Sauthier, M., … Franzen, S. (2004, November 9). Langmuir, Vol. 20, pp. 11134–11140.

By: S. Moses n, S. Brewer n, L. Lowe n, S. Lappi n, L. Gilvey n, M. Sauthier n, R. Tenent n, D. Feldheim n, S. Franzen n 

MeSH headings : DNA / chemistry; Gold / chemistry; Surface Properties; Temperature; Time Factors
topics (OpenAlex): Advanced biosensing and bioanalysis techniques; Gold and Silver Nanoparticles Synthesis and Applications; Molecular Junctions and Nanostructures
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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