Clay Morrison

Works (4)

Updated: July 5th, 2023 15:51

2014 article

Abrogation of TLR3 inhibition by discrete amino acid changes in the C-terminal half of the West Nile virus NS1 protein

Morrison, C. R., & Scholle, F. (2014, April 2). Virology, Vol. 456, pp. 96–107.

By: C. Morrison n & F. Scholle n 

author keywords: Flavivirus; West Nile virus; TLR3; NS1; Innate immunity
MeSH headings : Amino Acid Substitution; DNA Mutational Analysis; HeLa Cells; Host-Pathogen Interactions; Humans; Immune Evasion; Mutant Proteins / genetics; Mutant Proteins / immunology; Toll-Like Receptor 3 / antagonists & inhibitors; Toll-Like Receptor 3 / immunology; Viral Nonstructural Proteins / genetics; Viral Nonstructural Proteins / immunology; Virus Replication; West Nile virus / genetics; West Nile virus / immunology; West Nile virus / physiology
topics (OpenAlex): Mosquito-borne diseases and control; Malaria Research and Control; Viral Infections and Vectors
TL;DR: A novel FACS-based screen to attempt to separate the functions of the WNV non-structural protein 1 and virus replication was developed, suggesting that the two functions are not easily separated and may be contained within overlapping domains. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 article

Modulation of innate immune signaling by the secreted form of the West Nile virus NS1 glycoprotein

Crook, K. R., Miller-Kittrell, M., Morrison, C. R., & Scholle, F. (2014, May 13). Virology, Vol. 458, pp. 172–182.

By: K. Crook n, M. Miller-Kittrell n, C. Morrison n & F. Scholle n 

author keywords: West Nile virus; Flaviviridae; Nonstructural protein; Toll like receptor; Innate immunity
MeSH headings : Animals; HeLa Cells; Humans; Immunity, Innate; Luciferases / metabolism; Macrophages / immunology; Macrophages / metabolism; Mice; Mice, Inbred C57BL; Myeloid Cells / immunology; Myeloid Cells / metabolism; Poly I-C / pharmacology; Signal Transduction / immunology; Specific Pathogen-Free Organisms; Toll-Like Receptor 3 / antagonists & inhibitors; Viral Nonstructural Proteins / immunology; Viral Nonstructural Proteins / physiology; West Nile virus / immunology; West Nile virus / metabolism
topics (OpenAlex): Mosquito-borne diseases and control; Viral Infections and Vectors; Malaria Research and Control
TL;DR: Investigating whether the secreted form of NS1 inhibits innate immune signaling pathways in uninfected cells reduces TLR3 signaling and WNV replicon particle-mediated cytokine transcription in popliteal lymph nodes found the protein associated predominantly with macrophages and dendritic cells in the draining lymph node. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2009 article

A streamlined method for rapid and sensitive chromatin immunoprecipitation

Sikes, M. L., Bradshaw, J. M., Ivory, W. T., Lunsford, J. L., McMillan, R. E., & Morrison, C. R. (2009, March 27). Journal of Immunological Methods, Vol. 344, pp. 58–63.

By: M. Sikes n , J. Bradshaw n, W. Ivory n, J. Lunsford n, R. McMillan n & C. Morrison n

author keywords: Chromatin immunoprecipitation; Histone; Epigenetics; cad; TEA; Thymocyte; Rag
MeSH headings : Animals; Aspartate Carbamoyltransferase / genetics; Aspartate Carbamoyltransferase / metabolism; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing) / genetics; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing) / metabolism; Cell Line; Chromatin / genetics; Chromatin / isolation & purification; Chromatin / metabolism; Chromatin Immunoprecipitation / methods; DNA-Binding Proteins / genetics; DNA-Binding Proteins / metabolism; Dihydroorotase / genetics; Dihydroorotase / metabolism; Gene Knockdown Techniques; Histones / genetics; Histones / metabolism; Mice; Mice, Knockout; RNA Polymerase II / genetics; RNA Polymerase II / metabolism; T-Lymphocytes / metabolism
topics (OpenAlex): Genomics and Chromatin Dynamics; Epigenetics and DNA Methylation; RNA Interference and Gene Delivery
TL;DR: A streamlined ChIP is reported to efficiently carry samples from chromatin to qPCR-compatible DNA in as little as 4 h and it is shown that the protocol readily quantified histone modifications in chromatin from 10(4) Rag-deficient DN thymocytes. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2008 article

Convergent Evolution in the Genetic Basis of Mullerian Mimicry in Heliconius Butterflies

Baxter, S. W., Papa, R., Chamberlain, N., Humphray, S. J., Joron, M., Morrison, C., … Jiggins, C. D. (2008, September 15). Genetics.

By: S. Baxter *, R. Papa *, N. Chamberlain*, S. Humphray*, M. Joron*, C. Morrison n, R. ffrench-Constant *, W. McMillan n, C. Jiggins *

MeSH headings : Adaptation, Biological / genetics; Amplified Fragment Length Polymorphism Analysis; Animals; Biomimetics; Body Patterning; Butterflies / physiology; Chromosome Mapping; Chromosomes, Artificial, Bacterial; Crosses, Genetic; Evolution, Molecular; Genes, Insect; Genetic Drift; Genetic Linkage; Genetic Markers; Genetic Variation; Phenotype; Predatory Behavior; Selection, Genetic; Wings, Animal / anatomy & histology; Wings, Animal / physiology
topics (OpenAlex): Lepidoptera: Biology and Taxonomy; Chromosomal and Genetic Variations; Insect and Arachnid Ecology and Behavior
TL;DR: Comparative genetic mapping shows red wing color loci are in homologous regions of the genome of H. erato and H. melpomene and implies they evolved independently using somewhat different developmental routes, but are nonetheless regulated by the same switch locus. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

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