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Works (10)
Updated: April 3rd, 2024 19:04
2023 journal article
Pharmacogenomic Analyses Implicate B Cell Developmental Status and MKL1 as Determinants of Sensitivity toward Anti-CD20 Monoclonal Antibody Therapy
CELLS, 12(12).
author keywords: rituximab (Rituxan (R)); ofatumumab (Arzerra (R),& nbsp;Kesimpta (R)); obinutuzumab (Gazyva (R)); CD20 (MS4A1); MKL1 (MRTFA); TGFB1
TL;DR:
Results suggest that the efficacy of anti-CD20 mAb therapy may be influenced by B cell developmental status as well as polymorphism in the MKL1 gene.
(via Semantic Scholar)
open access via www.mdpi.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: June 8, 2023
2022 journal article
Hands-on immunology: Engaging learners of all ages through tactile teaching tools
FRONTIERS IN MICROBIOLOGY, 13.
Contributors: M. Ramirez n
author keywords: tactile teaching tool-guided inquiry learning; antibody; epitope; MHC; haplotype; universal design for learning; inclusive teaching; active learning
TL;DR:
Two TTT-GIL activities are reported here designed to engage diverse learners from middle schoolers to masters students in exploring molecular interactions within the immune system and can be adapted for use with learners of different levels and educational backgrounds.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
4. Quality Education
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: October 25, 2022
2011 review
The intestinal microbiota, gastrointestinal environment and colorectal cancer: a putative role for probiotics in prevention of colorectal cancer?
[Review of ]. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 301(3), G401–G424.
Contributors: M. Azcárate-Peril *, n & J. Bruno-Bárcena n
author keywords: lactic acid bacteria
MeSH headings : Antimutagenic Agents / pharmacology; Bile / physiology; Carcinogens; Cell Adhesion; Colorectal Neoplasms / genetics; Colorectal Neoplasms / microbiology; Colorectal Neoplasms / physiopathology; Colorectal Neoplasms / prevention & control; Diet; Gastrointestinal Tract / microbiology; Gastrointestinal Tract / physiology; Humans; Intestinal Mucosa / physiology; Intestines / microbiology; Metagenome; Oxidative Stress; Probiotics / therapeutic use
TL;DR:
Examination of probiotic metabolic activities that may have an effect on the prevention of CRC by scavenging toxic compounds or preventing their generation in situ are examined.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2010 journal article
Fur Negatively Regulates hns and Is Required for the Expression of HilA and Virulence in Salmonella enterica Serovar Typhimurium
JOURNAL OF BACTERIOLOGY, 193(2), 497–505.
MeSH headings : Animals; Bacterial Proteins / biosynthesis; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Chromatin Immunoprecipitation; DNA, Bacterial / metabolism; DNA-Binding Proteins / biosynthesis; DNA-Binding Proteins / metabolism; Disease Models, Animal; Gene Expression Regulation, Bacterial; Gene Knockout Techniques; Genes, Bacterial; Genomic Islands; Mice; Mice, Inbred C3H; Operon; Protein Binding; Repressor Proteins / genetics; Repressor Proteins / metabolism; Salmonella Infections, Animal / microbiology; Salmonella typhimurium / pathogenicity; Salmonella typhimurium / physiology; Survival Analysis; Trans-Activators / biosynthesis; Transcription Factors / biosynthesis; Virulence; Virulence Factors / biosynthesis
TL;DR:
Fur is required for virulence in Salmonella enterica serovar Typhimurium and that Fur is necessary for the activation of hilA, as well as of other HilA-dependent genes, invF and sipC, and chromatin immunoprecipitation was used to show that Fur bound to the upstream region of hns in a metal-dependent fashion.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2010 journal article
Tetra-O-methyl nordihydroguaiaretic acid (Terameprocol) inhibits the NF-kappa B-dependent transcription of TNF-alpha and MCP-1/CCL2 genes by preventing RelA from binding its cognate sites on DNA
JOURNAL OF INFLAMMATION-LONDON, 7.
TL;DR:
TMP acts indirectly as an inhibitor of NF-κB-dependent transcription by preventing RelA from binding the promoters of certain key cytokine and chemokine genes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2010 review
The Center of Accessibility: D beta Control of V(D)J Recombination
[Review of ]. ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS, 58(6), 427–433.
author keywords: T cell receptor; Tcrb; Transcription; V(D)J recombination; Thymocytes; Double negative
MeSH headings : Acetylation; Animals; Chromatin Assembly and Disassembly; Epigenesis, Genetic; Gene Rearrangement, T-Lymphocyte; Genes, T-Cell Receptor beta; Histones / metabolism; Humans; Protein Processing, Post-Translational; Thymus Gland / enzymology; Thymus Gland / immunology; Transcription, Genetic; VDJ Recombinases / metabolism
TL;DR:
Examining Tcrb assembly in developing thymocytes, the central roles of RSS elements and germline promoters as foci for epigenetic reorganization of recombinationally accessible gene segments are reviewed in light of recent findings and persistent questions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
A streamlined method for rapid and sensitive chromatin immunoprecipitation
JOURNAL OF IMMUNOLOGICAL METHODS, 344(1), 58–63.
author keywords: Chromatin immunoprecipitation; Histone; Epigenetics; cad; TEA; Thymocyte; Rag
MeSH headings : Animals; Aspartate Carbamoyltransferase / genetics; Aspartate Carbamoyltransferase / metabolism; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing) / genetics; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing) / metabolism; Cell Line; Chromatin / genetics; Chromatin / isolation & purification; Chromatin / metabolism; Chromatin Immunoprecipitation / methods; DNA-Binding Proteins / genetics; DNA-Binding Proteins / metabolism; Dihydroorotase / genetics; Dihydroorotase / metabolism; Gene Knockdown Techniques; Histones / genetics; Histones / metabolism; Mice; Mice, Knockout; RNA Polymerase II / genetics; RNA Polymerase II / metabolism; T-Lymphocytes / metabolism
TL;DR:
A streamlined ChIP is reported to efficiently carry samples from chromatin to qPCR-compatible DNA in as little as 4 h and it is shown that the protocol readily quantified histone modifications in chromatin from 10(4) Rag-deficient DN thymocytes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Molybdenum and tungsten in Campylobacter jejuni: their physiological role and identification of separate transporters regulated by a single ModE-like protein
MOLECULAR MICROBIOLOGY, 74(3), 758–771.
MeSH headings : ATP-Binding Cassette Transporters / genetics; ATP-Binding Cassette Transporters / metabolism; Amino Acid Sequence; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Campylobacter jejuni / genetics; Campylobacter jejuni / metabolism; Electron Transport / genetics; Escherichia coli / genetics; Escherichia coli / metabolism; Formate Dehydrogenases / genetics; Formate Dehydrogenases / metabolism; Humans; Membrane Transport Proteins / genetics; Membrane Transport Proteins / metabolism; Molecular Sequence Data; Molybdenum / chemistry; Molybdenum / metabolism; Nitrate Reductase / genetics; Nitrate Reductase / metabolism; Nitrate Reductase (NAD(P)H) / metabolism; Nitrate Reductases / chemistry; Nitrate Reductases / genetics; Nitrate Reductases / metabolism; Phylogeny; Protein Engineering; Pterins / metabolism; Sequence Alignment; Sequence Homology, Amino Acid; Transcription Factors / metabolism; Tungsten / chemistry; Tungsten / metabolism
TL;DR:
Results indicate that mod is primarily a molybdenum transporter that can also transport tungsten, while tup is a tungsen‐specific transporter.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Promoter activity 5 ' of D beta 2 is coordinated by E47, Runx1, and GATA-3
MOLECULAR IMMUNOLOGY, 46(15), 3009–3017.
author keywords: T cell receptor; Transcription; V(D)J recombination; Thymocytes; Double negative; E47; GATA-3; Runx1
MeSH headings : Animals; Base Sequence; Cell Differentiation / immunology; Cell Line; Chromatin / immunology; Chromatin / metabolism; Core Binding Factor Alpha 2 Subunit / immunology; Core Binding Factor Alpha 2 Subunit / metabolism; GATA3 Transcription Factor / immunology; GATA3 Transcription Factor / metabolism; Gene Rearrangement, beta-Chain T-Cell Antigen Receptor; Homeodomain Proteins / genetics; Homeodomain Proteins / immunology; Homeodomain Proteins / metabolism; Mice; Mice, Knockout; Molecular Sequence Data; Promoter Regions, Genetic; Receptors, Antigen, T-Cell, alpha-beta / genetics; T-Lymphocytes / immunology; T-Lymphocytes / metabolism; TCF Transcription Factors / immunology; TCF Transcription Factors / metabolism; Thymus Gland / immunology; Thymus Gland / metabolism; Transcription Factor 7-Like 1 Protein; Tumor Suppressor Protein p53 / genetics; Tumor Suppressor Protein p53 / immunology; Tumor Suppressor Protein p53 / metabolism; Upstream Stimulatory Factors / immunology; Upstream Stimulatory Factors / metabolism
TL;DR:
The dependence of 5'PDbeta2 on E47 is consistent with the reported role of E proteins in post-DN1 thymocyte development and V-to-DJbeta recombination and a complex interplay among Runx1, GATA-3, and E47 transcription factors.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Differential activation of dual promoters alters D beta 2 germline transcription during thymocyte development
JOURNAL OF IMMUNOLOGY, 180(5), 3218–3228.
MeSH headings : Animals; Base Sequence; Cell Differentiation / genetics; Cell Differentiation / immunology; Cell Line; Cell Line, Tumor; Gene Rearrangement, beta-Chain T-Cell Antigen Receptor / genetics; Germ-Line Mutation / immunology; Mice; Mice, Inbred C57BL; Mice, Knockout; Molecular Sequence Data; Promoter Regions, Genetic / immunology; Receptors, Antigen, T-Cell, alpha-beta / genetics; Receptors, Antigen, T-Cell, alpha-beta / metabolism; Thymus Gland / cytology; Thymus Gland / enzymology; Thymus Gland / immunology; Thymus Gland / metabolism; Transcription, Genetic / immunology; Transcriptional Activation / immunology; VDJ Recombinases / genetics
TL;DR:
The unique organization and timing of Dβ2 promoter activity are consistent with a model in which promoter placement selectively regulates the rearrangement potential of D β2 during TCR β locus assembly.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
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