Elizabeth S. B. Cook

Works (2)

Updated: July 5th, 2023 15:40

2015 journal article

Expression of WNT5A in Idiopathic Pulmonary Fibrosis and Its Control by TGF-β and WNT7B in Human Lung Fibroblasts

Journal of Histochemistry & Cytochemistry, 64(2), 99–111.

By: D. Newman n, W. Sills n, K. Hanrahan n, A. Ziegler n , K. Tidd n, E. Cook n, P. Sannes n

MeSH headings : Cells, Cultured; Fibroblasts / metabolism; Fibroblasts / pathology; Gene Expression Regulation; Gene Silencing; Humans; Idiopathic Pulmonary Fibrosis / genetics; Idiopathic Pulmonary Fibrosis / metabolism; Idiopathic Pulmonary Fibrosis / pathology; Lung / metabolism; Lung / pathology; Myocytes, Smooth Muscle / metabolism; Myofibroblasts / metabolism; Myofibroblasts / pathology; Proto-Oncogene Proteins / analysis; Proto-Oncogene Proteins / genetics; Proto-Oncogene Proteins / metabolism; Transforming Growth Factor beta / analysis; Transforming Growth Factor beta / genetics; Transforming Growth Factor beta / metabolism; Up-Regulation; Wnt Proteins / analysis; Wnt Proteins / genetics; Wnt Proteins / metabolism; Wnt-5a Protein
topics (OpenAlex): Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis; Neonatal Respiratory Health Research
TL;DR: A wide distribution of Wnt5A expression in cells of the IPF lung is demonstrated and it is revealed that it is significantly increased by Wnt7B and TGF-β1, which, in combination, could represent key signaling pathways that modulate the pathogenesis of IPF. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: NC State University Libraries, NC State University Libraries, Crossref
Added: August 6, 2018

2015 article

Topically Administered Janus-Kinase Inhibitors Tofacitinib and Oclacitinib Display Impressive Antipruritic and Anti-Inflammatory Responses in a Model of Allergic Dermatitis

Fukuyama, T., Ehling, S., Cook, E., & Bäumer, W. (2015, July 10). Journal of Pharmacology and Experimental Therapeutics.

By: T. Fukuyama n, S. Ehling n, E. Cook n & W. Bäumer n

MeSH headings : Administration, Oral; Administration, Topical; Animals; Anti-Inflammatory Agents / administration & dosage; Antipruritics / administration & dosage; Cytokines / metabolism; Dermatitis, Allergic Contact / drug therapy; Dermatitis, Allergic Contact / metabolism; Disease Models, Animal; Female; Inflammation / drug therapy; Inflammation / metabolism; Janus Kinases / antagonists & inhibitors; Lymph Nodes / drug effects; Lymph Nodes / metabolism; Mice; Mice, Inbred BALB C; Piperidines / administration & dosage; Pruritus / drug therapy; Pruritus / metabolism; Pyrimidines / administration & dosage; Pyrroles / administration & dosage; Skin / drug effects; Skin / metabolism; Sulfonamides / administration & dosage
topics (OpenAlex): Dermatology and Skin Diseases; Urticaria and Related Conditions; Allergic Rhinitis and Sensitization
TL;DR: Oral treatment with JAK inhibitors reduced itch behavior dramatically but had only little effect on the inflammatory response, whereas topical treatment improved both itch and inflammatory response. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

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