Works (2)

Updated: July 5th, 2023 15:40

2015 journal article

Expression of WNT5A in Idiopathic Pulmonary Fibrosis and Its Control by TGF-β and WNT7B in Human Lung Fibroblasts

Journal of Histochemistry & Cytochemistry, 64(2), 99–111.

By: D. Newman n, W. Sills n, K. Hanrahan n, A. Ziegler n, K. Tidd n, E. Cook n, P. Sannes n

MeSH headings : Cells, Cultured; Fibroblasts / metabolism; Fibroblasts / pathology; Gene Expression Regulation; Gene Silencing; Humans; Idiopathic Pulmonary Fibrosis / genetics; Idiopathic Pulmonary Fibrosis / metabolism; Idiopathic Pulmonary Fibrosis / pathology; Lung / metabolism; Lung / pathology; Myocytes, Smooth Muscle / metabolism; Myofibroblasts / metabolism; Myofibroblasts / pathology; Proto-Oncogene Proteins / analysis; Proto-Oncogene Proteins / genetics; Proto-Oncogene Proteins / metabolism; Transforming Growth Factor beta / analysis; Transforming Growth Factor beta / genetics; Transforming Growth Factor beta / metabolism; Up-Regulation; Wnt Proteins / analysis; Wnt Proteins / genetics; Wnt Proteins / metabolism; Wnt-5a Protein
TL;DR: A wide distribution of Wnt5A expression in cells of the IPF lung is demonstrated and it is revealed that it is significantly increased by Wnt7B and TGF-β1, which, in combination, could represent key signaling pathways that modulate the pathogenesis of IPF. (via Semantic Scholar)
Sources: NC State University Libraries, ORCID, Crossref
Added: August 6, 2018

2015 journal article

Topically Administered Janus-Kinase Inhibitors Tofacitinib and Oclacitinib Display Impressive Antipruritic and Anti-Inflammatory Responses in a Model of Allergic Dermatitis


By: T. Fukuyama n, S. Ehling n, E. Cook n & W. Baeumer

MeSH headings : Administration, Oral; Administration, Topical; Animals; Anti-Inflammatory Agents / administration & dosage; Antipruritics / administration & dosage; Cytokines / metabolism; Dermatitis, Allergic Contact / drug therapy; Dermatitis, Allergic Contact / metabolism; Disease Models, Animal; Female; Inflammation / drug therapy; Inflammation / metabolism; Janus Kinases / antagonists & inhibitors; Lymph Nodes / drug effects; Lymph Nodes / metabolism; Mice; Mice, Inbred BALB C; Piperidines / administration & dosage; Pruritus / drug therapy; Pruritus / metabolism; Pyrimidines / administration & dosage; Pyrroles / administration & dosage; Skin / drug effects; Skin / metabolism; Sulfonamides / administration & dosage
TL;DR: Oral treatment with JAK inhibitors reduced itch behavior dramatically but had only little effect on the inflammatory response, whereas topical treatment improved both itch and inflammatory response. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

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