Works (3)

Updated: July 7th, 2023 21:13

2019 journal article

Genome-wide DNA copy number analysis and targeted transcriptional analysis of canine histiocytic malignancies identifies diagnostic signatures and highlights disruption of spindle assembly complex

CHROMOSOME RESEARCH, 27(3), 179–202.

By: K. Kennedy n, R. Thomas n, J. Durrant n, T. Jiang n, A. Motsinger-Reif n & M. Breen n

author keywords: Histiocytic sarcoma; Chromothripsis; MMP9; Aurora kinase; Dendritic cell sarcoma
MeSH headings : Animals; Chromosome Disorders; DNA Copy Number Variations / genetics; Dog Diseases / diagnosis; Dog Diseases / genetics; Dogs; Gene Expression Profiling; Genome / genetics; Histiocytic Disorders, Malignant / diagnosis; Histiocytic Disorders, Malignant / genetics; Histiocytic Disorders, Malignant / veterinary; Humans; Immunohistochemistry / methods; Matrix Metalloproteinase 9 / metabolism; Spindle Apparatus / pathology
TL;DR: Droplet digital PCR evaluation of these regions in numerous cancer specimens effectively discriminated HM from other common round cell tumors, including lymphoma and hemangiosarcoma, resulting in a novel, rapid diagnostic aid for veterinary medicine. (via Semantic Scholar)
UN Sustainable Development Goal Categories
10. Reduced Inequalities (OpenAlex)
Source: Web Of Science
Added: September 30, 2019

2017 journal article

Integrated immunohistochemical and DNA copy number profiling analysis provides insight into the molecular pathogenesis of canine follicular lymphoma


By: R. Thomas n, Z. Demeter*, K. Kennedy n, L. Borst n, K. Singh*, V. Valli, K. Le Boedec*, M. Breen n

author keywords: BCL2; canine; comparative genomic hybridization; fluorescence in situ hybridization; follicular lymphoma; immunohistochemistry
MeSH headings : Animals; DNA Copy Number Variations / genetics; DNA Fingerprinting / veterinary; Dog Diseases / etiology; Dog Diseases / genetics; Dog Diseases / pathology; Dogs; Female; Genome-Wide Association Study / veterinary; Lymphoma, Follicular / etiology; Lymphoma, Follicular / genetics; Lymphoma, Follicular / pathology; Lymphoma, Follicular / veterinary; Male; Risk Factors
TL;DR: Parallel exploration of canine and human cases may reveal alternative tumour-initiating mechanisms other than BCL2 disruption, yielding a more complete definition of the molecular pathogenesis of FL. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 journal article

BRAF Mutations in Canine Cancers

PLOS ONE, 10(6).

By: H. Mochizuki n, K. Kennedy n, S. Shapiro n & M. Breen n

Contributors: H. Mochizuki n, K. Kennedy n, S. Shapiro n & M. Breen n

MeSH headings : Amino Acid Sequence; Amino Acid Substitution; Animals; Base Sequence; Dogs; Exons / genetics; Female; Genetic Predisposition to Disease; Humans; Male; Molecular Sequence Data; Mutation / genetics; Neoplasms / genetics; Neoplasms / veterinary; Proto-Oncogene Proteins B-raf / chemistry; Proto-Oncogene Proteins B-raf / genetics; Sequence Analysis, DNA
TL;DR: The evolutional conservation of the BRAF V600E mutation highlights the importance of MAPK pathway activation in neoplasia and may offer opportunity for molecular diagnostics and targeted therapeutics for dogs bearing BRAF-mutated cancers. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

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