Leela Goel

College of Engineering

Works (8)

Updated: July 5th, 2023 14:45

2021 journal article

An Analysis of Sonothrombolysis and Cavitation for Retracted and Unretracted Clots Using Microbubbles Versus Low-Boiling-Point Nanodroplets

IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, 69(2), 711–719.

By: J. Kim*, K. Bautista*, R. Deruiter*, L. Goel*, X. Jiang n , Z. Xu *, P. Dayton*

author keywords: Ultrasonic imaging; Acoustics; Medical treatment; Frequency control; Coagulation; Transducers; Surface treatment; Cavitation; microbubble (MB); nanodroplet (ND); retracted clot; sonothrombolysis; thrombosis
MeSH headings : Aged; Blood Coagulation; Humans; Microbubbles; Thrombosis / diagnostic imaging; Thrombosis / therapy; Ultrasonic Therapy / methods
TL;DR: It is concluded that ND-mediated sonothrombolysis outperforms MB-mediated therapy regardless of clot retraction, and this advantage of ND- mediated cavitation is emphasized for retracted clots. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: February 14, 2022

2021 journal article

Dual-Frequency Intravascular Sonothrombolysis: An <i>In Vitro</i> Study

IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, 68(12), 3599–3607.

By: H. Wu n, L. Goel n, H. Kim n , B. Zhang n , J. Kim*, P. Dayton*, Z. Xu *, X. Jiang n 

Contributors: H. Wu n, L. Goel n, H. Kim n , B. Zhang n , J. Kim*, P. Dayton*, Z. Xu *, X. Jiang n 

author keywords: Transducers; Acoustics; Ultrasonic imaging; Frequency measurement; Frequency control; Impedance; Broadband communication; Dual-frequency thrombolysis; intravascular ultrasound transducer; passive cavitation; sonothrombolysis
MeSH headings : Acoustics; Contrast Media; Microbubbles; Transducers; Ultrasonic Therapy
TL;DR: A new broadband intravascular transducer is developed and tests indicated that the MB-mediated, dual-frequency (750+500 kHz) sonothrombolysis yields an 85% higher lysis rate compared with the single-frequency treatment, and the lysis Rate increases with the difference between the two frequency components. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: November 24, 2021

2021 journal article

Magneto-sonothrombolysis with combination of magnetic microbubbles and nanodroplets

Ultrasonics, 116, 106487.

By: B. Zhang n , H. Wu n, L. Goel n, H. Kim n , C. Peng n, J. Kim n, P. Dayton n, Y. Gao *, X. Jiang n 

Contributors: B. Zhang n , H. Wu n, L. Goel n, H. Kim n , C. Peng n, J. Kim n, P. Dayton n, Y. Gao *, X. Jiang n 

author keywords: Magnetic microbubbles; Magnetic nanoparticles; Nanodroplets; Sonothrombolysis; Cavitation
TL;DR: It is demonstrated that tPA-mediated magneto-sonothrombolysis in combining NDs with MMBs could significantly enhance in vitro lysis of both unretracted clots and retracted clots in a flow model with 30 min treatment. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: August 23, 2021

2021 journal article

Nanodroplet-mediated catheter-directed sonothrombolysis of retracted blood clots

Microsystems & Nanoengineering, 7(1).

By: L. Goel n, H. Wu n, B. Zhang n , J. Kim n, P. Dayton n, Z. Xu *, X. Jiang n 

Contributors: L. Goel n, H. Wu n, B. Zhang n , J. Kim n, P. Dayton n, Z. Xu *, X. Jiang n 

TL;DR: For the first time, it is demonstrated that a sub-megahertz, forward-viewing intravascular (FVI) transducer can be used for ND-mediated sonothrombolysis, in vitro and combined nanodroplet with tPA-mediatedSonothromBolysis was able to significantly enhance retracted clot lysis in retracted blood clots. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: February 15, 2021

2021 journal article

Safety Evaluation of a Forward-Viewing Intravascular Transducer for Sonothrombolysis: An in Vitro and ex Vivo Study

Ultrasound in Medicine & Biology, 47(11), 3231–3239.

By: L. Goel n, H. Wu n, B. Zhang n , J. Kim n, P. Dayton n, Z. Xu *, X. Jiang n 

Contributors: L. Goel n, H. Wu n, B. Zhang n , J. Kim n, P. Dayton n, Z. Xu *, X. Jiang n 

author keywords: Intravascular sonothrombolysis; Safety; Retracted clots; Nanodroplets; Microbubbles; Ultrasound-assisted thrombolysis; Tissue plasminogen activator
MeSH headings : Animals; Microbubbles; Particle Size; Thrombolytic Therapy; Thrombosis / therapy; Tissue Plasminogen Activator; Transducers; Ultrasonic Therapy
TL;DR: In vitro and ex vivo tests using FVI transducers revealed a temperature rise of less than 1°C, no vessel damage as assessed by histology and no downstream clot particles >500 µm, which indicates that the F VI transducer poses minimal risk for sonothrombolysis applications and should be further evaluated in animal models. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: October 26, 2021

2020 journal article

A COMPARISON OF SONOTHROMBOLYSIS IN AGED CLOTS BETWEEN LOWBOILING-POINT PHASE-CHANGE NANODROPLETS AND MICROBUBBLES OF THE SAME COMPOSITION

ULTRASOUND IN MEDICINE AND BIOLOGY, 46(11), 3059–3068.

By: J. Kim n, R. DeRuiter n, L. Goel n, Z. Xu *, X. Jiang n  & P. Dayton n

author keywords: Sonothrombolysis; Nanodroplets; Microbubbles; Cavitation; Clot
MeSH headings : Animals; Cattle; Mechanical Thrombolysis / methods; Microbubbles; Nanostructures; Thrombosis / therapy; Time Factors; Transition Temperature; Ultrasonic Therapy
TL;DR: Enhanced cavitation erosion of blood clots exposed to low-boiling-point (-2°C) perfluorocarbon phase-change nanodroplets and pulsed ultrasound, as well as microbubbles with the same formulation under the same conditions are presented. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: October 12, 2020

2020 review

Advances in Sonothrombolysis Techniques Using Piezoelectric Transducers

[Review of ]. SENSORS, 20(5).

By: L. Goel n & X. Jiang n 

author keywords: sonothrombolysis; ultrasound enhanced thrombolysis; microbubbles; ultrasound contrast agents; high intensity focused ultrasound; histotripsy; intravascular ultrasound
MeSH headings : Animals; Contrast Media / metabolism; High-Intensity Focused Ultrasound Ablation / methods; Humans; Microbubbles; Thrombosis / metabolism; Thrombosis / pathology; Transducers; Ultrasonography / methods; Ultrasonography, Doppler, Transcranial / methods
TL;DR: Recent advances in sonothrombolysis techniques, including targeted and drug loaded microbubbles, phase change nanodroplets, high intensity focused ultrasound, histotripsy, and improved intravascular transducers, address some of the limitations of conventional sonothroma bolysis treatments. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: April 27, 2020

2020 journal article

EXAMINING THE INFLUENCE OF LOW-DOSE TISSUE PLASMINOGEN ACTIVATOR ON MICROBUBBLE-MEDIATED FORWARD-VIEWING INTRAVASCULAR SONOTHROMBOLYSIS

ULTRASOUND IN MEDICINE AND BIOLOGY, 46(7), 1698–1706.

By: L. Goel n, H. Wu n, H. Kim n , B. Zhang n , J. Kim n, P. Dayton n, Z. Xu *, X. Jiang n 

Contributors: L. Goel n, H. Wu n, H. Kim n , B. Zhang n , J. Kim n, P. Dayton n, Z. Xu *, X. Jiang n 

author keywords: Sonothrombolysis; Intravascular sonothrombolysis; Microbubble-mediated sonothrombolysis; Clot lysis; Tissue plasminogen activator
MeSH headings : Animals; Cattle; Combined Modality Therapy; Mechanical Thrombolysis / methods; Microbubbles / therapeutic use; Thrombolytic Therapy / methods; Thrombosis / drug therapy; Thrombosis / therapy; Tissue Plasminogen Activator / administration & dosage; Tissue Plasminogen Activator / therapeutic use; Ultrasonic Therapy / methods
TL;DR: Changes in stable and inertial cavitation doses were observed, corresponding to changes in clot lysis in MB-mediated FVI sonothrombolysis with and without tPA. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: July 20, 2020

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