Works (2)

Updated: July 5th, 2023 15:47

2012 journal article

Disrupted Organization of RFamide Pathways in the Hypothalamus Is Associated with Advanced Puberty in Female Rats Neonatally Exposed to Bisphenol A


By: S. Losa-Ward n, K. Todd n, K. McCaffrey n, K. Tsutsui* & H. Patisaul n

author keywords: endocrine disruptor; kisspeptin; puberty; RFRP
MeSH headings : Animals; Benzhydryl Compounds; Body Weight / drug effects; Estrogens, Non-Steroidal / toxicity; Female; Gonadotropin-Releasing Hormone / metabolism; Hypothalamus / drug effects; Kisspeptins / metabolism; Male; Neuropeptides / metabolism; Phenols / toxicity; Puberty, Precocious / blood; Puberty, Precocious / chemically induced; Rats; Rats, Transgenic; Rats, Wistar; Vagina / drug effects
TL;DR: Data suggest that BPA-induced premature puberty results from decreased inhibition of GnRH neurons, which are critical for initiating puberty and maintaining estrous cyclicity by stimulating gonadotropin-releasing hormone (GnRH) release. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2011 journal article

Neonatal exposure to genistein adversely impacts the ontogeny of hypothalamic kisspeptin signaling pathways and ovarian development in the peripubertal female rat


By: S. Losa n, K. Todd n, A. Sullivan n, J. Cao n, J. Mickens n & H. Patisaul n

author keywords: Soy; Estrogen; Phytoestrogens; Endocrine disruptors; Development; Reproductive; Fertility; Ovary
MeSH headings : Animals; Animals, Newborn; Arcuate Nucleus of Hypothalamus / drug effects; Arcuate Nucleus of Hypothalamus / metabolism; Arcuate Nucleus of Hypothalamus / pathology; Female; Gene Expression Regulation, Developmental / drug effects; Genistein / toxicity; Hypothalamus / drug effects; Hypothalamus / metabolism; Immunohistochemistry; In Situ Hybridization; Kisspeptins; Midline Thalamic Nuclei / drug effects; Midline Thalamic Nuclei / metabolism; Midline Thalamic Nuclei / pathology; Ovary / drug effects; Ovary / growth & development; Phytoestrogens / toxicity; Proteins / genetics; Proteins / metabolism; RNA, Messenger / analysis; Rats; Rats, Long-Evans; Rats, Wistar; Sex Factors; Sexual Maturation / drug effects; Sexual Maturation / physiology; Signal Transduction / drug effects
TL;DR: Female rats exposed to the phytoestrogen genistein, estradiol benzoate, or vehicle from post natal day (P) 0-3 via subcutaneous injection were exposed to estrogenic endocrine disrupting compounds to establish sex specific development of KISS gene expression, cell number and neural fiber density across peripuberty. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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