Alana W. Sullivan

Works (6)

Updated: July 5th, 2023 15:47

2016 article

Interaction of bisphenol A (BPA) and soy phytoestrogens on sexually dimorphic sociosexual behaviors in male and female rats

Hicks, K. D., Sullivan, A. W., Cao, J., Sluzas, E., Rebuli, M., & Patisaul, H. B. (2016, July 2). Hormones and Behavior, Vol. 84, pp. 121–126.

By: K. Hicks n, A. Sullivan n, J. Cao n, E. Sluzas n, M. Rebuli n & H. Patisaul n 

author keywords: Endocrine disruption; Neuroendocrine disruption; Neuropeptides; Social; Diet; Open field; Affiliation; Activity; Environment
MeSH headings : Animals; Benzhydryl Compounds / pharmacology; Endocrine Disruptors / pharmacology; Exploratory Behavior / drug effects; Female; Isoflavones / pharmacology; Male; Phenols / pharmacology; Phytoestrogens / pharmacology; Rats; Sexual Behavior, Animal / drug effects; Social Behavior
topics (OpenAlex): Effects and risks of endocrine disrupting chemicals; Early Childhood Education and Development; Estrogen and related hormone effects
TL;DR: Testing the individual and combined effects of low dose oral BPA and soy diet or the individual isoflavone genistein on rat sociosexual behaviors with the hypothesis that soy would obfuscate any BPA-related effects reinforces that environmental factors can shape complex behaviors and even reverse expected sex differences. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 article

A Novel Model for Neuroendocrine Toxicology: Neurobehavioral Effects of BPA Exposure in a Prosocial Species, the Prairie Vole (Microtus ochrogaster)

Sullivan, A. W., Beach, E. C., Stetzik, L. A., Perry, A., D'Addezio, A. S., Cushing, B. S., & Patisaul, H. B. (2014, July 22). Endocrinology, Vol. 155, pp. 3867–3881.

By: A. Sullivan n, E. Beach*, L. Stetzik*, A. Perry*, A. D'Addezio n, B. Cushing *, H. Patisaul n 

MeSH headings : Affect / drug effects; Animals; Arvicolinae / physiology; Arvicolinae / psychology; Behavior, Animal / drug effects; Benzhydryl Compounds / toxicity; Defense Mechanisms; Endocrine Disruptors / toxicity; Environmental Exposure; Environmental Pollutants / toxicity; Female; Male; Models, Animal; Motor Activity / drug effects; Neurosecretory Systems / drug effects; Phenols / toxicity; Social Behavior; Toxicity Tests
topics (OpenAlex): Neuroendocrine regulation and behavior; Effects and risks of endocrine disrupting chemicals
TL;DR: The hypothesis that BPA alters affective behaviors, potentially via disruption of OT/AVP pathways, is supported in the prairie vole, which is more prosocial than lab rats or mice. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 article

Soy but not bisphenol A (BPA) induces hallmarks of polycystic ovary syndrome (PCOS) and related metabolic co-morbidities in rats

Patisaul, H. B., Mabrey, N., Adewale, H. B., & Sullivan, A. W. (2014, September 19). Reproductive Toxicology, Vol. 49, pp. 209–218.

By: H. Patisaul n , N. Mabrey n, H. Adewale n & A. Sullivan n

author keywords: Phytoestrogens; Genistein; Endocrine disruptors; Ovary; Development
MeSH headings : Animals; Benzhydryl Compounds / adverse effects; Diet / adverse effects; Endocrine Disruptors / adverse effects; Female; Ovary / drug effects; Ovary / pathology; Phenols / adverse effects; Polycystic Ovary Syndrome / chemically induced; Polycystic Ovary Syndrome / pathology; Pregnancy; Rats; Rats, Wistar; Soy Foods / adverse effects; Testosterone / blood
topics (OpenAlex): Effects and risks of endocrine disrupting chemicals; Phytoestrogen effects and research; Reproductive Biology and Fertility
TL;DR: Lifetime exposure to a soy diet, containing endocrine active phytoestrogens, but not developmental exposure to the endocrine disrupting monomer bisphenol A (BPA), can induce key features of PCOS in the rat, results which support the hypothesis that hormonally active diets may contribute to risk when consumed throughout gestation and post-natal life. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2012 article

Anxiogenic Effects of Developmental Bisphenol A Exposure Are Associated with Gene Expression Changes in the Juvenile Rat Amygdala and Mitigated by Soy

Patisaul, H. B., Sullivan, A. W., Radford, M. E., Walker, D. M., Adewale, H. B., Winnik, B., … Gore, A. C. (2012, September 5). PLoS ONE, Vol. 7.

By: H. Patisaul n , A. Sullivan n, M. Radford n, D. Walker *, H. Adewale n, B. Winnik*, J. Coughlin*, B. Buckley *, A. Gore *

MeSH headings : Amygdala / drug effects; Animals; Anxiety / chemically induced; Anxiety / etiology; Benzhydryl Compounds / adverse effects; Estrogen Receptor beta / metabolism; Female; Gene Expression Profiling; Genistein / pharmacology; Maternal Exposure; Phenols / adverse effects; Pregnancy; Pregnancy, Animal; Rats; Rats, Wistar; Receptors, Melanocortin / metabolism; Sex Characteristics; Soybeans / drug effects; Water / chemistry
topics (OpenAlex): Effects and risks of endocrine disrupting chemicals; Early Childhood Education and Development; Nutrition, Genetics, and Disease
TL;DR: Results show that behavioral impacts of BPA can manifest during adolescence, but wane in adulthood, and may be mitigated by diet, and reveal that, because ERβ and melanocortin receptors are crucial to their function, oxytocin/vasopressin signaling pathways, which have been linked to human affective disorders, may underlie these behavioral outcomes. (via Semantic Scholar)
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6. Clean Water and Sanitation (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2011 journal article

Neonatal agonism of ERβ impairs male reproductive behavior and attractiveness

Hormones and Behavior, 60(2), 185–194.

By: A. Sullivan n, P. Hamilton  n & H. Patisaul n 

author keywords: Sex behavior; Endocrine disruptor; Genistein; Estrogen receptor; Partner preference; DPN; Estrogen; Masculinization; Virility; Soy
MeSH headings : Animals; Dose-Response Relationship, Drug; Estradiol / analogs & derivatives; Estradiol / pharmacology; Estrogen Receptor alpha / agonists; Estrogen Receptor alpha / metabolism; Estrogen Receptor beta / agonists; Estrogen Receptor beta / metabolism; Estrogens / pharmacology; Genistein / pharmacology; Male; Mating Preference, Animal / drug effects; Nitriles / pharmacology; Phenols / pharmacology; Phytoestrogens / pharmacology; Propionates / pharmacology; Pyrazoles / pharmacology; Rats; Rats, Long-Evans; Sexual Behavior, Animal / drug effects
topics (OpenAlex): Estrogen and related hormone effects; Hypothalamic control of reproductive hormones; Effects and risks of endocrine disrupting chemicals
TL;DR: DPN had a greater adverse impact than PPT on reproductive behavior, suggesting a functional role for ERβ in the organization of these male-specific behaviors and EB exposure significantly lowered the testis to body weight ratio, and circulating testosterone levels. (via Semantic Scholar)
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5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2010 article

Neonatal exposure to genistein adversely impacts the ontogeny of hypothalamic kisspeptin signaling pathways and ovarian development in the peripubertal female rat

Losa, S. M., Todd, K. L., Sullivan, A. W., Cao, J., Mickens, J. A., & Patisaul, H. B. (2010, October 18). Reproductive Toxicology, Vol. 31, pp. 280–289.

By: S. Losa n, K. Todd n, A. Sullivan n, J. Cao n, J. Mickens n & H. Patisaul n 

author keywords: Soy; Estrogen; Phytoestrogens; Endocrine disruptors; Development; Reproductive; Fertility; Ovary
MeSH headings : Animals; Animals, Newborn; Arcuate Nucleus of Hypothalamus / drug effects; Arcuate Nucleus of Hypothalamus / metabolism; Arcuate Nucleus of Hypothalamus / pathology; Female; Gene Expression Regulation, Developmental / drug effects; Genistein / toxicity; Hypothalamus / drug effects; Hypothalamus / metabolism; Immunohistochemistry; In Situ Hybridization; Kisspeptins; Midline Thalamic Nuclei / drug effects; Midline Thalamic Nuclei / metabolism; Midline Thalamic Nuclei / pathology; Ovary / drug effects; Ovary / growth & development; Phytoestrogens / toxicity; Proteins / genetics; Proteins / metabolism; RNA, Messenger / analysis; Rats; Rats, Long-Evans; Rats, Wistar; Sex Factors; Sexual Maturation / drug effects; Sexual Maturation / physiology; Signal Transduction / drug effects
topics (OpenAlex): Hypothalamic control of reproductive hormones; Ovarian function and disorders; Neuroendocrine regulation and behavior
TL;DR: Female rats exposed to the phytoestrogen genistein, estradiol benzoate, or vehicle from post natal day (P) 0-3 via subcutaneous injection were exposed to estrogenic endocrine disrupting compounds to establish sex specific development of KISS gene expression, cell number and neural fiber density across peripuberty. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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