Works Published in 2016
Displaying works 101 - 120 of 254 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2016 journal article
The fungal cultivar of leaf-cutter ants produces specific enzymes in response to different plant substrates
Molecular Ecology, 25(22), 5795–5805.
Contributors: L. Khadempour *, K. Burnum-Johnson *, E. Baker* , C. Nicora *, B. Webb-Robertson*, R. White *, M. Monroe *, E. Huang*, R. Smith *, C. Currie *
author keywords: fungi; leaf-cutter ants; metaproteomics; microbial ecology; symbiosis
MeSH headings : Agaricales / enzymology; Animals; Ants / microbiology; Flowers / metabolism; Fungal Proteins / metabolism; Plant Leaves / metabolism; Plants / metabolism; Proteomics; Symbiosis
TL;DR:
Flexible, substrate‐specific enzymatic response of the fungal cultivar allows leaf‐cutter ants to derive energy from a wide range of substrates, which likely contributes to their ability to be dominant generalist herbivores.
(via Semantic Scholar)
europepmc.org (repository)
Source: ORCID
Added: December 5, 2019
2016 journal article
Surprising impact of remote groups on the folding-unfolding and dimer-chain equilibria of bifunctional H-bonding unimers (vol 52, pg 3773, 2016)
Chemical Communications, 52(29), 5205.
Contributors: R. Liu, S. Chen *, E. Baker* , R. Smith *, X. Zeng* & B. Gong *
Source: ORCID
Added: December 5, 2019
2016 journal article
SPE-IMS-MS: An automated platform for sub-sixty second surveillance of endogenous metabolites and xenobiotics in biofluids
Clinical Mass Spectrometry, 2, 1–10.
Contributors: X. Zhang *, M. Romm*, X. Zheng *, E. Zink *, Y. Kim *, K. Burnum-Johnson *, D. Orton *, A. Apffel*
author keywords: Ion mobility spectrometry; Mass spectrometry; Metabolomics; Exposomics
TL;DR:
This SPE-IMS-MS platform overcomes many of the current challenges of large-scale metabolomic and exposomic analyses and offers a viable option for population and patient cohort screening in an effort to gain insights into disease processes and human environmental chemical exposure.
(via Semantic Scholar)
Source: ORCID
Added: December 5, 2019
2016 journal article
Surprising impact of remote groups on the folding-unfolding and dimer-chain equilibria of bifunctional H-bonding unimers
Chemical Communications, 52(19), 3773–3776.
Contributors: R. Liu, S. Cheng *, E. Baker* , R. Smith *, X. Zeng * & B. Gong *
MeSH headings : Amides / chemistry; Dimerization; Hydrogen Bonding; Proton Magnetic Resonance Spectroscopy
TL;DR:
Replacing the side chains and end groups ofligoamide 1 with derivatives that show the surprising impact of end groups on the folding and dimer-chain equilibria of the resultant molecules.
(via Semantic Scholar)
Source: ORCID
Added: December 5, 2019
2016 journal article
Squeezing of Ion Populations and Peaks in Traveling Wave Ion Mobility Separations and Structures for Lossless Ion Manipulations Using Compression Ratio Ion Mobility Programming
Analytical Chemistry, 88(23), 11877–11885.
Contributors: S. Garimella *, A. Hamid *, L. Deng *, Y. Ibrahim *, I. Webb *, E. Baker* , S. Prost*, R. Norheim*, G. Anderson*, R. Smith *
MeSH headings : Electrodes; Ions / chemistry; Ions / isolation & purification; Mass Spectrometry / instrumentation; Mass Spectrometry / methods; Molecular Structure
TL;DR:
This work collapses ion distributions in ion mobility (IM) separations into tighter packets providing higher sensitivity measurements in conjunction with mass spectrometry (MS), providing greatly enhanced IM resolution by reducing the detrimental effects of diffusional peak broadening and increasing peak widths.
(via Semantic Scholar)
Source: ORCID
Added: December 5, 2019
2016 journal article
Spatial Ion Peak Compression and its Utility in Ion Mobility Spectrometry
Journal of the American Society For Mass Spectrometry, 27(6), 1128–1135.
Contributors: S. Garimella *, Y. Ibrahim *, K. Tang *, I. Webb *, E. Baker* , A. Tolmachev *, T. Chen*, G. Anderson*, R. Smith *
author keywords: Ion mobility spectrometry; Diffusion; Peak compression; High resolution IMS
MeSH headings : Ion Mobility Spectrometry; Ions; Pressure
TL;DR:
A novel concept for ion spatial peak compression is described, and discussed primarily in the context of ion mobility spectrometry (IMS), which can be particularly useful for mitigating diffusion-driven peak broadening over very long path length separations and for achieving higher S/N and IMS resolution over a selected mobility range.
(via Semantic Scholar)
Source: ORCID
Added: December 5, 2019
2016 journal article
Simultaneous Proteomic Discovery and Targeted Monitoring using Liquid Chromatography, Ion Mobility Spectrometry, and Mass Spectrometry
Molecular &Amp; Cellular Proteomics, 15(12), 3694–3705.
Contributors: K. Burnum-Johnson *, S. Nie*, C. Casey *, M. Monroe *, D. Orton *, Y. Ibrahim *, M. Gritsenko *, T. Clauss*
MeSH headings : Animals; Breast Neoplasms / metabolism; Chromatography, Liquid / methods; Female; Humans; Mass Spectrometry / methods; Mice; Neoplasm Transplantation; Peptides / analysis; Proteome / isolation & purification; Proteomics / methods
TL;DR:
A new approach is described that performs both discovery and targeted monitoring (DTM) in a single analysis by combining liquid chromatography, ion mobility spectrometry and mass Spectrometry (LC-IMS-MS).
(via Semantic Scholar)
Source: ORCID
Added: December 5, 2019
2016 journal article
Mobility-Selected Ion Trapping and Enrichment Using Structures for Lossless Ion Manipulations
Analytical Chemistry, 88(3), 1728–1733.
Contributors: T. Chen *, Y. Ibrahim *, I. Webb *, S. Garimella *, X. Zhang *, A. Hamid *, L. Deng *, W. Karnesky*
MeSH headings : Humans; Ions / chemistry; Mass Spectrometry / methods; Peptides / analysis; Protein Conformation
TL;DR:
An ion separation and trapping module and a method based upon SLIM that consists of a linear mobility ion drift region, a switch/tee and a trapping region that allows the isolation and accumulation of mobility-separated species are demonstrated.
(via Semantic Scholar)
Source: ORCID
Added: December 5, 2019
2016 journal article
Mass spectrometry-based monitoring of millisecond protein-ligand binding dynamics using an automated microfluidic platform
Lab on a Chip, 16(9), 1544–1548.
Contributors: Y. Cong *, S. Katipamula*, C. Trader*, D. Orton *, T. Geng *, E. Baker* , R. Kelly *
MeSH headings : Algorithms; Automation, Laboratory; Carbonic Anhydrase I / antagonists & inhibitors; Carbonic Anhydrase I / chemistry; Carbonic Anhydrase I / metabolism; Carbonic Anhydrase Inhibitors / chemistry; Carbonic Anhydrase Inhibitors / metabolism; Carbonic Anhydrase Inhibitors / pharmacology; Diffusion; Diuretics / chemistry; Diuretics / metabolism; Diuretics / pharmacology; Equipment Design; Furosemide / chemistry; Furosemide / metabolism; Humans; Kinetics; Lab-On-A-Chip Devices; Ligands; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization
TL;DR:
A novel microfluidic platform that features rapid mixing of protein and ligand solutions, variable incubation times, and an integrated electrospray ionization source for mass spectrometry-based monitoring of protein-ligand binding dynamics is presented.
(via Semantic Scholar)
Source: ORCID
Added: December 5, 2019
2016 journal article
Ion Mobility Separations of Isomers based upon Long Path Length Structures for Lossless Ion Manipulations Combined with Mass Spectrometry
Chemistryselect, 1(10), 2396–2399.
Contributors: L. Deng *, Y. Ibrahim *, E. Baker* , N. Aly*, A. Hamid *, X. Zhang *, X. Zheng *, S. Garimella *
author keywords: Structures for Lossless Ion Manipulations (SLIM); Ion Mobility Spectrometry; Mass Spectrometry; Isomers
TL;DR:
A new approach using Structures for Lossless Ion Manipulations (SLIM) to enable long serpentine path ion mobility spectrometry (IMS) separations followed by MS analyses, which provides previously unachieved resolution for biomolecular species, in conjunction with more effective ion utilization.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(OpenAlex)
Source: ORCID
Added: December 5, 2019
2016 journal article
Greatly Increasing Trapped Ion Populations for Mobility Separations Using Traveling Waves in Structures for Lossless Ion Manipulations
Analytical Chemistry, 88(20), 10143–10150.
Contributors: L. Deng *, Y. Ibrahim *, S. Garimella *, I. Webb *, A. Hamid *, R. Norheim*, S. Prost*, J. Sandoval*, E. Baker* , R. Smith *
TL;DR:
Wide m/z range ion transmission is demonstrated, along with significant increases in the signal-to-noise ratios (S/N) due to the larger ion populations injected and a reduction in the chemical background, which was attributed to more efficient desolvation of solvent related clusters over the extended ion accumulation periods.
(via Semantic Scholar)
Source: ORCID
Added: December 5, 2019
2016 journal article
Development of an Ion Mobility Spectrometry-Orbitrap Mass Spectrometer Platform
Analytical Chemistry, 88(24), 12152–12160.
Contributors: Y. Ibrahim *, S. Garimella *, S. Prost*, R. Wojcik *, R. Norheim*, E. Baker* , I. Rusyn *, R. Smith *
MeSH headings : Algorithms; Animals; Artifacts; Cattle; Equipment Design; Ion Mobility Spectrometry / instrumentation; Ions / analysis; Mass Spectrometry / instrumentation; Petroleum / analysis; Phosphopyruvate Hydratase / chemistry; Proteomics / instrumentation; Serum Albumin, Bovine / chemistry
TL;DR:
The new IMS-Orbitrap MS platform was demonstrated by the analysis of proteomic and petroleum samples, where the integration of IMS and high mass resolution proved essential for accurate assignment of molecular formulas.
(via Semantic Scholar)
Source: ORCID
Added: December 5, 2019
2016 journal article
Achieving High Resolution Ion Mobility Separations Using Traveling Waves in Compact Multiturn Structures for Lossless Ion Manipulations
Analytical Chemistry, 88(18), 8949–8956.
Contributors: A. Hamid *, S. Garimella *, Y. Ibrahim *, L. Deng *, X. Zheng *, I. Webb *, G. Anderson*, S. Prost*
MeSH headings : Algorithms; Amino Acid Sequence; Bradykinin / analysis; Equipment Design; Ions / chemistry; Mass Spectrometry / methods; Peptides / analysis
TL;DR:
The combined attributes of flexible design, low voltage requirements and lossless ion transmission through multiple turns for the present TW-SLIM module provides a basis for SLIM devices capable of achieving much greater IM resolution via greatly extended ion path lengths and using compact serpentine designs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy
(OpenAlex)
Source: ORCID
Added: December 5, 2019
2016 journal article
A Structures for Lossless Ion Manipulations (SLIM) Module for Collision Induced Dissociation
Journal of the American Society For Mass Spectrometry, 27(7), 1285–1288.
Contributors: I. Webb *, S. Garimella *, R. Norheim*, E. Baker* , Y. Ibrahim * & R. Smith *
author keywords: Collision induced dissociation; Ion mobility spectrometry; rf Confinement; Ion optics; Peptide fragmentation; Manipulation; Conveyor
TL;DR:
The SLIM CID module was mounted after an ion mobility (IM) drift tube to enable IM/CID/MS studies, and the efficiency of CID was studied by using the model peptide leucine enkephalin.
(via Semantic Scholar)
Source: ORCID
Added: December 5, 2019
2016 journal article
A multi-omic future for microbiome studies
Nature Microbiology, 1(5).
Contributors: J. Jansson * & E. Baker*
MeSH headings : Gene Expression Profiling; Humans; Metabolomics; Metagenomics; Microbiota; Proteomics
TL;DR:
Integration of multiple ‘omics’ technologies will allow researchers to gain a more complete picture of the constituents and functions of microbial communities and provide far richer information for predictive modelling of community phenotypes.
(via Semantic Scholar)
Source: ORCID
Added: December 5, 2019
2016 journal article
ChemInform Abstract: Synthesis of 7-Norbornenols via Diels-Alder Cycloadditions of Cyclopentadienol Generated by Decomposition of Ferrocenium Cation.
ChemInform, 47(9), no-no.
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Source: ORCID
Added: November 12, 2019
2016 journal article
1,2,4-Triazolidine-3-thiones as Narrow Spectrum Antibiotics against Multidrug-Resistant Acinetobacter baumannii
ACS Medicinal Chemistry Letters, 8(1), 27–31.
author keywords: antibiotic resistance; antibiotics; Acinetobacter baumannii
TL;DR:
A small molecule with potent antibiotic activity against multiple strains of multidrug-resistant and extensively drug-resistant Acinetobacter baumannii is identified and represents a promising start in the development of a class of drugs that can target this bacterial pathogen.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: November 12, 2019
2016 article
Bringing PLOS Genetics Editors to Preprint Servers
Barsh, G. S., Bergman, C. M., Brown, C. D., Singh, N. D., & Copenhaver, G. P. (2016, December). PLOS GENETICS, Vol. 12.
MeSH headings : Database Management Systems; Humans; Periodicals as Topic; Publications; Publishing
TL;DR:
This paper presents a meta-analyses of the H2O2na “spatially aggregating event” and its role in disease and suggests a “cell reprograming” mechanism that is similar to that of “ ” “clinically checkpoints” found in the TSPs.
(via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018
2016 journal article
Synthesis of C-4 Substituted Amido Nicotine Derivatives via Copper(I)- and (II)-Catalyzed Cross-Coupling Reactions
JOURNAL OF ORGANIC CHEMISTRY, 81(22), 11529–11534.
MeSH headings : Amides / chemistry; Carbon-13 Magnetic Resonance Spectroscopy; Catalysis; Copper / chemistry; Mass Spectrometry; Nicotine / chemical synthesis; Nicotine / chemistry; Proton Magnetic Resonance Spectroscopy
TL;DR:
The syntheses of seven novel amido nicotine derivatives 12-18 from (S)-nicotine are presented, providing a useful method for preparing C-4 amide-containing nicotine analogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2016 journal article
Northern-Southern Route to Synthetic Bacteriochlorins
JOURNAL OF ORGANIC CHEMISTRY, 81(23), 11882–11897.
MeSH headings : Carbon-13 Magnetic Resonance Spectroscopy; Catalysis; Crystallography, X-Ray; Molecular Structure; Porphyrins / chemical synthesis; Porphyrins / chemistry; Proton Magnetic Resonance Spectroscopy; Spectrometry, Mass, Electrospray Ionization
TL;DR:
Ten new bacteriochlorins bearing 0-6 total aryl, alkyl, and carboethoxy substituents at the β-pyrrole and/or meso-positions have been prepared, with yields of macrocycle formation of up to 39%.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
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