2023 journal article

Enteric glial cell network function is required for epithelial barrier restitution following intestinal ischemic injury in the early postnatal period

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 326(3), G228–G246.

By: A. Ziegler n , M. Caldwell n, S. Craig, E. Hellstrom n, A. Sheridan n, M. Touvron n, T. Pridgen n, S. Magness* ...

author keywords: enteric glia; epithelial restitution; intestinal barrier; intestinal ischemia; restitution
TL;DR: A neonatal phenotype characterized by a complete lack of coordinated reparative signaling in the mucosal microenvironment is confirmed and important evidence is reported that the subepithelial EGC network changes significantly over the early postnatal period and that proximity of a specific functional population of EGC to wounded intestinal epithelium contributes to intestinal barrier restitution following ischemic injury. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Web Of Science
Added: November 18, 2024

This study refines a powerful translational pig model, defining an age-dependent relationship between enteric glia and the intestinal epithelium during intestinal ischemic injury and confirming an important role for enteric glial cell (EGC) activity in driving mucosal barrier restitution. This study suggests that targeting the enteric glial network could lead to novel interventions to improve recovery from intestinal injury in neonatal patients.