Stephen J. Libby

Works (13)

Updated: July 5th, 2023 16:03

2010 journal article

Vaccination with attenuated Salmonella enterica Dublin expressing E coli O157:H7 outer membrane protein Intimin induces transient reduction of fecal shedding of E coli O157:H7 in cattle

BMC Veterinary Research, 6.

By: S. Khare, W. Alali, S. Zhang, D. Hunter, R. Pugh, F. Fang, S. Libby, L. Adams

Source: NC State University Libraries
Added: August 6, 2018

2005 journal article

Co-regulation of Salmonella enterica genes required for virulence and resistance to antimicrobial peptides by SlyA and PhoP/PhoQ

MOLECULAR MICROBIOLOGY, 56(2), 492–508.

By: W. Navarre *, T. Halsey n, D. Walthers*, J. Frye *, M. McClelland*, J. Potter n, L. Kenney *, J. Gunn *, F. Fang *, S. Libby n

MeSH headings : Antimicrobial Cationic Peptides / pharmacology; Bacterial Proteins / pharmacology; Drug Resistance, Bacterial; Gene Expression Regulation, Bacterial; Salmonella enterica / drug effects; Salmonella enterica / genetics; Salmonella enterica / pathogenicity; Virulence / genetics
TL;DR: The absence of almost all SlyA‐activated genes from the Escherichia coli K12 genome suggests that the functional linkage between the SlyA and PhoP/PhoQ regulatory systems arose as Salmonella evolved its distinctive pathogenic lifestyle. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2004 journal article

Expression of a heterologous manganese superoxide dismutase gene in intestinal lactobacilli provides protection against hydrogen peroxide toxicity

APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 70(8), 4702–4710.

By: J. Bruno-Barcena* , J. Andrus*, S. Libby*, T. Klaenhammer n & H. Hassan n 

Contributors: J. Bruno-Bárcena* , J. Andrus*, S. Libby*, T. Klaenhammer n & H. Hassan n 

MeSH headings : Cloning, Molecular; Humans; Hydrogen Peroxide / pharmacology; Intestines / microbiology; Lactobacillus / classification; Lactobacillus / drug effects; Lactobacillus / enzymology; Lactobacillus / genetics; Oxidative Stress / drug effects; Protein Biosynthesis; Streptococcus / enzymology; Streptococcus / genetics; Superoxide Dismutase / genetics; Superoxide Dismutase / metabolism; Transcription, Genetic
TL;DR: The data show that MnSOD protects cells against hydrogen peroxide by removing O2·− and preventing the redox cycling of iron and is the first report of a sodA from S. thermophilus being expressed in other lactic acid bacteria. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2004 journal article

The ferritin-like Dps protein is required for Salmonella enterica serovar typhimurium oxidative stress resistance and virulence

INFECTION AND IMMUNITY, 72(2), 1155–1158.

By: T. Halsey*, A. Vazquez-Torres *, D. Gravdahl*, F. Fang  n & S. Libby*

MeSH headings : Animals; Bacterial Proteins / physiology; DNA-Binding Proteins / physiology; Female; Ferritins / physiology; Mice; Mice, Inbred C3H; Oxidative Stress; Salmonella typhimurium / metabolism; Salmonella typhimurium / pathogenicity; Virulence
TL;DR: Evidence is provided that Dps protectsSalmonella from iron-dependent killing by hydrogen peroxide, promotes Salmonella survival in murine macrophages, and enhances Salmoneella virulence. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2003 journal article

Inhibition of bacterial DNA replication by zinc mobilization during nitrosative stress

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 100(14), 8496–8501.

By: J. Schapiro n, S. Libby n & F. Fang  n

MeSH headings : Animals; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Chromosome Breakage; Chromosomes, Bacterial / genetics; DNA Damage; DNA Helicases / deficiency; DNA Helicases / genetics; DNA Helicases / metabolism; DNA Repair; DNA Replication; DNA, Bacterial / biosynthesis; Endodeoxyribonucleases / deficiency; Endodeoxyribonucleases / genetics; Endodeoxyribonucleases / metabolism; Escherichia coli Proteins; Exodeoxyribonuclease V; Exodeoxyribonucleases / deficiency; Exodeoxyribonucleases / genetics; Exodeoxyribonucleases / metabolism; Membrane Glycoproteins / deficiency; Membrane Glycoproteins / genetics; Membrane Glycoproteins / metabolism; Mice; Mice, Inbred C57BL; NADPH Oxidase 2; NADPH Oxidases; Nitric Oxide / physiology; Nitric Oxide Synthase / deficiency; Nitric Oxide Synthase / genetics; Nitric Oxide Synthase / metabolism; Nitric Oxide Synthase Type II; Phagocytosis / physiology; S-Nitrosothiols / metabolism; Salmonella enterica / genetics; Salmonella enterica / metabolism; Zinc / metabolism
TL;DR: Introduction of a recG mutation restores both resistance to NO and the ability of an attenuated recBC mutant Salmonella strain to cause lethal infection in mice, demonstrating that bacterial DNA replication is inhibited during host–pathogen interactions. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2002 journal article

Characterization of the spv locus in Salmonella enterica serovar Arizona

Infection and Immunity, 70(6), 3290–3294.

By: S. Libby, M. Lesnick, P. Hasegawa, M. Kurth, C. Belcher, J. Fierer, D. Guiney

MeSH headings : ADP Ribose Transferases / genetics; Amino Acid Sequence; Animals; Antigens, Bacterial; Bacterial Proteins / genetics; Carrier Proteins / genetics; Conserved Sequence; Frameshift Mutation; Gene Deletion; Humans; Molecular Sequence Data; Promoter Regions, Genetic; Reptiles / microbiology; Salmonella Infections / microbiology; Salmonella arizonae / genetics; Salmonella arizonae / isolation & purification; Sequence Homology, Amino Acid; Virulence Factors
Source: NC State University Libraries
Added: August 6, 2018

2002 journal article

The alternative sigma factor sigma(E) controls antioxidant defences required for Salmonella virulence and stationary-phase survival

MOLECULAR MICROBIOLOGY, 43(3), 771–782.

By: T. Testerman *, A. Vazquez-Torres *, Y. Xu *, J. Jones-Carson*, S. Libby n & F. Fang *

MeSH headings : Aerobiosis; Animals; Antioxidants / metabolism; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Cell Division; Cell Survival; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mutation; Oxidative Stress; Regulon; Respiratory Burst; Salmonella Infections, Animal / microbiology; Salmonella typhimurium / pathogenicity; Salmonella typhimurium / physiology; Sigma Factor / genetics; Sigma Factor / metabolism
TL;DR: It is shown here that the alternative sigma factor σE (σ24, RpoE) also facilitates the survival of Salmonella typhimurium under conditions of nutrient deprivation, suggesting that oxidative injury is one of the major mechanisms of reduced microbial viability during periods of nutrients deprivation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2001 journal article

Fis, a DNA nucleoid-associated protein, is involved in Salmonella typhimurium SPI-1 invasion gene expression

Molecular Microbiology, 39(1), 79–88.

By: R. Wilson, S. Libby, A. Freet, J. Boddicker, T. Fahlen & B. Jones

Source: NC State University Libraries
Added: August 6, 2018

2001 journal article

In Vitro and In Vivo Assessment of Salmonella enterica Serovar Typhimurium DT104 Virulence

Infection and Immunity, 69(7), 4673–4677.

By: C. Allen n, P. Fedorka-Cray*, A. Vazquez-Torres *, M. Suyemoto n, C. Altier n, L. Ryder n, F. Fang *, S. Libby n

MeSH headings : Animals; Disease Models, Animal; Humans; Hydrogen Peroxide / pharmacology; Macrophages, Peritoneal / microbiology; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Nitrates / pharmacology; Salmonella Infections / microbiology; Salmonella typhimurium / drug effects; Salmonella typhimurium / growth & development; Salmonella typhimurium / isolation & purification; Salmonella typhimurium / pathogenicity; Tumor Cells, Cultured; Virulence
TL;DR: In vitro and in vivo virulence-associated phenotypes of several clinical isolates of S. enterica serovar Typhimurium DT104 isolates failed to demonstrate that these strains are more virulent than S. entersicaserovar Typhoon ATCC 14028s. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref
Added: August 6, 2018

2000 journal article

The Salmonella virulence plasmid spv genes are required for cytopathology in human monocyte-derived macrophages

CELLULAR MICROBIOLOGY, 2(1), 49–58.

By: S. Libby n, M. Lesnick*, P. Hasegawa*, E. Weidenhammer* & D. Guiney*

MeSH headings : Apoptosis; Cell Adhesion; Colony Count, Microbial; Gene Expression; Genetic Complementation Test; Humans; Macrophages / microbiology; Macrophages / physiology; Macrophages / ultrastructure; Monocytes / microbiology; Mutation; Operon; Phenotype; Plasmids; Salmonella / genetics; Salmonella / growth & development; Salmonella / pathogenicity; Salmonella typhimurium / genetics; Salmonella typhimurium / growth & development; Salmonella typhimurium / pathogenicity; Virulence
TL;DR: The current findings suggest that the mechanism of the spv effect is through induction of increased cytopathology in host macrophages, with characteristics of apoptosis, with release of nucleosomes into the cytoplasm, nuclear condensation and DNA fragmentation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1999 journal article

Differential regulation of enteric and systemic salmonellosis by slyA

Infection and Immunity, 67(9), 4950–4954.

By: P. Watson, S. Paulin, A. Bland, S. Libby, P. Jones & T. Wallis

Source: NC State University Libraries
Added: August 6, 2018

1998 journal article

Regulation of the Escherichia coli sheA gene and characterization of its encoded hemolytic activity

FEMS MICROBIOLOGY LETTERS, 168(1), 85–90.

By: S. Fernandez *, J. Xing*, V. Kapur *, S. Libby n, R. Barletta * & R. Moxley*

author keywords: SheA; SlyA; hemolysin
MeSH headings : Animals; Base Sequence; Blotting, Northern; Calcium / metabolism; Cloning, Molecular; Escherichia coli / genetics; Escherichia coli / metabolism; Escherichia coli Infections / veterinary; Escherichia coli Proteins; Gene Expression Regulation, Bacterial; Genes, Bacterial; Hemolysin Proteins / genetics; Hemolysin Proteins / metabolism; Hemolysis; Molecular Sequence Data; Promoter Regions, Genetic; RNA, Bacterial / analysis; Sequence Analysis, DNA; Swine; Transcription, Genetic
TL;DR: Northern blot analysis demonstrated that the transcriptional regulator SlyA activates the E. coli K-12 sheA gene and the SheA hemolytic activity was cell associated and Ca2+ independent. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

1997 journal article

SlyA, a transcriptional regulator of Salmonella typhimurium, is required for resistance to oxidative stress and is expressed in the intracellular environment of macrophages

Infection and Immunity, 65(9), 3725–3730.

By: N. Buchmeier, S. Bossie, C. Chen, F. Fang, D. Guiney & S. Libby

Source: NC State University Libraries
Added: August 6, 2018

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