Nathalie Plundrich

Works (11)

Updated: July 5th, 2023 15:44

2019 article

Binding of peanut allergen Ara h 2 with Vaccinium fruit polyphenols

Plundrich, N. J., Cook, B. T., Maleki, S. J., Fourches, D., & Lila, M. A. (2019, January 18). Food Chemistry, Vol. 284, pp. 287–295.

By: N. Plundrich n, B. Cook n, S. Maleki *, D. Fourches n & M. Lila n 

author keywords: Ara h 2; Molecular docking; Polyphenol; IgE binding; Circular dichroism (CD); Food allergy
MeSH headings : 2S Albumins, Plant / chemistry; 2S Albumins, Plant / immunology; 2S Albumins, Plant / metabolism; Antigens, Plant / chemistry; Antigens, Plant / immunology; Antigens, Plant / metabolism; Arachis / metabolism; Biflavonoids / chemistry; Biflavonoids / metabolism; Binding Sites; Catechin / chemistry; Catechin / metabolism; Chlorogenic Acid / chemistry; Chlorogenic Acid / metabolism; Circular Dichroism; Epitopes / chemistry; Epitopes / metabolism; Fruit / chemistry; Fruit / metabolism; Glycoproteins / chemistry; Glycoproteins / immunology; Glycoproteins / metabolism; Humans; Immunoglobulin E / chemistry; Immunoglobulin E / metabolism; Molecular Docking Simulation; Polyphenols / chemistry; Polyphenols / metabolism; Proanthocyanidins / chemistry; Proanthocyanidins / metabolism; Protein Binding; Protein Structure, Secondary; Spectrophotometry; Vaccinium / chemistry; Vaccinium / metabolism
topics (OpenAlex): Food Allergy and Anaphylaxis Research; Transgenic Plants and Applications; Allergic Rhinitis and Sensitization
TL;DR: Results suggest that certain polyphenols can inhibit IgE recognition of Ara h 2 by obstructing linear IgE epitopes. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: February 25, 2019

2019 article

Peanut protein-polyphenol aggregate complexation suppresses allergic sensitization to peanut by reducing peanut-specific IgE in C3H/HeJ mice

Bansode, R. R., Randolph, P. D., Plundrich, N. J., Lila, M. A., & Williams, L. L. (2019, June 17). Food Chemistry, Vol. 299.

By: R. Bansode*, P. Randolph*, N. Plundrich n, M. Lila n  & L. Williams*

author keywords: Peanut allergy; IgE; CD63; Polyphenol; Blueberry; Cranberry
MeSH headings : Animals; Arachis / chemistry; Arachis / immunology; Female; Immunoglobulin E / immunology; Mice; Mice, Inbred C3H; Peanut Hypersensitivity / prevention & control; Plant Proteins / chemistry; Plant Proteins / immunology; Polyphenols / chemistry; Species Specificity
topics (OpenAlex): Food Allergy and Anaphylaxis Research; Allergic Rhinitis and Sensitization; Contact Dermatitis and Allergies
TL;DR: It is demonstrated for the first time that complexation of polyphenols to peanut flour can potentially lower plasma IgE of peanut-sensitized C3H/HeJ mice. (via Semantic Scholar)
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2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 12, 2019

2017 article

In vitro Hypoallergenicity of Peanut Protein-Blueberry Polyphenol Aggregate Particles

Plundrich, N., Bansode, R., Williams, L., & Lila, M. A. (2017, February 1). Journal of Allergy and Clinical Immunology, Vol. 139, pp. AB139–139.

By: N. Plundrich n, R. Bansode*, L. Williams * & M. Lila n 

topics (OpenAlex): Food Allergy and Anaphylaxis Research
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2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 journal article

In vitro hypoallergenic potential of peanut protein-polyphenol aggregate particles

FASEB Journal, 31.

By: N. Plundrich, R. Bansode, L. Williams & M. Lila 

Source: NC State University Libraries
Added: August 6, 2018

2017 article

Protein-bound Vaccinium fruit polyphenols decrease IgE binding to peanut allergens and RBL-2H3 mast cell degranulation in vitro

Plundrich, N. J., Bansode, R. R., Foegeding, E. A., Williams, L. L., & Lila, M. A. (2017, January 1). Food & Function, Vol. 8, pp. 1611–1621.

By: N. Plundrich n, R. Bansode*, E. Foegeding n, L. Williams * & M. Lila n 

MeSH headings : Allergens / immunology; Arachis / immunology; Cell Degranulation / drug effects; Fruit / chemistry; Humans; Immunoglobulin E / immunology; Mast Cells / drug effects; Mast Cells / immunology; Mast Cells / physiology; Peanut Hypersensitivity / drug therapy; Peanut Hypersensitivity / immunology; Plant Extracts / pharmacology; Plant Proteins / immunology; Polyphenols / pharmacology; Vaccinium / chemistry
topics (OpenAlex): Food Allergy and Anaphylaxis Research; Transgenic Plants and Applications; Respiratory and Cough-Related Research; Allergic Rhinitis and Sensitization; Pediatric health and respiratory diseases
TL;DR: The modification of peanut proteins with cranberry or blueberry polyphenols led to the formation of peanut protein-polyphenol complexes with significantly reduced allergenic potential. (via Semantic Scholar)
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2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 article

Protein-polyphenol particles for delivering structural and health functionality

Foegeding, E. A., Plundrich, N., Schneider, M., Campbell, C., & Lila, M. A. (2017, June 6). Food Hydrocolloids, Vol. 72, pp. 163–173.

By: E. Foegeding n, N. Plundrich n, M. Schneider n, C. Campbell n & M. Lila n 

author keywords: Protein; Polyphenols; Colloidal aggregates; Health, and Structural Functionality
topics (OpenAlex): Proteins in Food Systems; Muscle metabolism and nutrition; Consumer Attitudes and Food Labeling
TL;DR: The overall goal should be a rational design of protein-polyphenol particles to ensure a positive contribution to food quality, protein nutrition, and delivery of a health-relevant dose of polyphenols to the gastrointestinal tract. (via Semantic Scholar)
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2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 article

Stability and immunogenicity of hypoallergenic peanut protein–polyphenol complexes during in vitro pepsin digestion

Plundrich, N. J., White, B. L., Dean, L. L., Davis, J. P., Foegeding, E. A., & Lila, M. A. (2015, January 1). Food & Function, Vol. 6, pp. 2145–2154.

By: N. Plundrich n, B. White*, L. Dean *, J. Davis*, E. Foegeding n & M. Lila n 

MeSH headings : Antigens, Plant / chemistry; Antigens, Plant / immunology; Arachis / chemistry; Arachis / immunology; Digestion; Pepsin A / chemistry; Plant Proteins / chemistry; Plant Proteins / immunology; Polyphenols / chemistry; Polyphenols / immunology
topics (OpenAlex): Food Allergy and Anaphylaxis Research; Allergic Rhinitis and Sensitization; Contact Dermatitis and Allergies
TL;DR: It is suggested that peanut protein-polyphenol complexes may be less immunoreactive passing through the digestive tract in vivo, contributing to their attenuated allergenicity. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 article

Compounds leached from quinoa seeds inhibit matrix metalloproteinase activity and intracellular reactive oxygen species

Graf, B. L., Cheng, D. M., Esposito, D., Shertel, T., Poulev, A., Plundrich, N., … Raskin, I. (2014, December 11). International Journal of Cosmetic Science, Vol. 37, pp. 212–221.

By: B. Graf *, D. Cheng*, D. Esposito n , T. Shertel*, A. Poulev *, N. Plundrich n, D. Itenberg*, N. Dayan, M. Lila n , I. Raskin *

author keywords: ageing; cell culture; chemical analysis; oxidative damage; phytochemistry; phytoecdysteroid
MeSH headings : Cells, Cultured; Chenopodium quinoa / embryology; Chromatography, Liquid; Humans; Mass Spectrometry; Matrix Metalloproteinase 1 / drug effects; Matrix Metalloproteinase 1 / genetics; Monophenol Monooxygenase / antagonists & inhibitors; Protease Inhibitors / pharmacology; Reactive Oxygen Species / metabolism; Seeds / chemistry
topics (OpenAlex): Antioxidant Activity and Oxidative Stress; Transgenic Plants and Applications
TL;DR: This work aimed to determine the effect of QL and its chemically distinct fractions on five biochemical endpoints relevant to skin care applications: cell viability, matrix metalloproteinase (MMP) mRNA expression, MMP enzymatic activity, tyrosinase enzymatics activity and intracellular reactive oxygen species (ROS) production. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 article

Novel Strategy To Create Hypoallergenic Peanut Protein–Polyphenol Edible Matrices for Oral Immunotherapy

Plundrich, N. J., Kulis, M., White, B. L., Grace, M. H., Guo, R., Burks, A. W., … Lila, M. A. (2014, April 24). Journal of Agricultural and Food Chemistry, Vol. 62, pp. 7010–7021.

By: N. Plundrich n, M. Kulis*, B. White*, M. Grace n , R. Guo *, A. Burks *, J. Davis*, M. Lila n 

Contributors: N. Plundrich n, M. Kulis*, B. White*, M. Grace n , R. Guo *, A. Burks *, J. Davis*, M. Lila n 

author keywords: basophil; cranberry; mouse model; peanut allergy; polyphenols
MeSH headings : Administration, Oral; Arachis / immunology; Arachis / metabolism; Chromatography, High Pressure Liquid; Electrophoresis, Polyacrylamide Gel; Humans; Immunotherapy; Peanut Hypersensitivity / prevention & control; Plant Proteins / administration & dosage; Plant Proteins / immunology; Polyphenols / administration & dosage; Polyphenols / immunology; Spectroscopy, Fourier Transform Infrared
topics (OpenAlex): Food Allergy and Anaphylaxis Research; Eosinophilic Esophagitis; Viral gastroenteritis research and epidemiology
TL;DR: Polyphenol fortification of peanut flour resulted in a hypoallergenic matrix with reduced IgE binding and degranulation capacity, likely due to changes in protein secondary structure or masking of epitopes, suggesting potential applications for oral immunotherapy. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2013 article

Bioactive polyphenols from muscadine grape and blackcurrant stably concentrated onto protein‐rich matrices for topical applications

Plundrich, N., Grace, M. H., Raskin, I., & Lila, M. A. (2013, April 24). International Journal of Cosmetic Science, Vol. 35, pp. 394–401.

By: N. Plundrich n, M. Grace n , I. Raskin * & M. Lila n 

Contributors: N. Plundrich n, M. Grace n , I. Raskin * & M. Ann Lila n 

author keywords: antimicrobial; blackcurrant; muscadine grape; polyphenols; topical applications; tyrosinase
MeSH headings : Polyphenols / administration & dosage; Polyphenols / pharmacology; Proteins / drug effects; Ribes / chemistry; Vitis / chemistry
topics (OpenAlex): Phytochemicals and Antioxidant Activities; melanin and skin pigmentation; Skin Protection and Aging
TL;DR: Natural botanical agents that are antimicrobial, or that modulate skin hyperpigmentation via tyrosinase inhibition, are increasingly sought in the cosmetic industry. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2011 article

Efficient sorption of polyphenols to soybean flour enables natural fortification of foods

Roopchand, D. E., Grace, M. H., Kuhn, P., Cheng, D. M., Plundrich, N., Poulev, A., … al. (2011, October 2). Food Chemistry, Vol. 131, pp. 1193–1200.

By: D. Roopchand *, M. Grace n , P. Kuhn *, D. Cheng*, N. Plundrich n, A. Poulev *, A. Howell *, B. Fridlender* ...

Contributors: D. Roopchand *, M. Grace n , P. Kuhn *, D. Cheng*, N. Plundrich n, A. Poulev *, A. Howell *, B. Fridlender*, M. Lila n , I. Raskin *

topics (OpenAlex): Phytochemicals and Antioxidant Activities; Food composition and properties; Microbial Metabolites in Food Biotechnology
TL;DR: It is demonstrated that defatted soybean flour (DSF) can sorb polyphenols from blueberry and cranberry juices while separating them from sugars, providing a means to create protein-rich food ingredients containing concentrated plant bioactives without excess sugars, fats and water that can be incorporated in a variety of scientifically validated functional foods and dietary supplements. (via Semantic Scholar)
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Sources: NC State University Libraries, ORCID, NC State University Libraries
Added: August 6, 2018

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