Bernard Andrew Brown, II

Works (5)

Updated: July 5th, 2023 16:03

2009 article

A Dimeric Structure for Archaeal Box C/D Small Ribonucleoproteins

Bleichert, F., Gagnon, K. T., Brown, B. A., Maxwell, E. S., Leschziner, A. E., Unger, V. M., & Baserga, S. J. (2009, September 10). Science.

By: F. Bleichert *, K. Gagnon n, B. Brown n, E. Maxwell n, A. Leschziner *, V. Unger*, S. Baserga *

MeSH headings : Archaeal Proteins / chemistry; Archaeal Proteins / metabolism; Archaeal Proteins / ultrastructure; Base Sequence; Chromosomal Proteins, Non-Histone / chemistry; Methanococcales / chemistry; Microscopy, Electron; Models, Molecular; Molecular Weight; Nucleic Acid Conformation; Protein Multimerization; Protein Structure, Quaternary; Protein Structure, Tertiary; RNA, Archaeal / chemistry; RNA, Archaeal / ultrastructure; Ribonucleoproteins / chemistry; Ribonucleoproteins / metabolism; Ribonucleoproteins / ultrastructure
topics (OpenAlex): RNA modifications and cancer; RNA and protein synthesis mechanisms; RNA Research and Splicing
TL;DR: The structure of a reconstituted and catalytically active box C/D sRNP from the archaeon Methanocaldococcus jannaschii was determined by single-particle electron microscopy and Mutational analysis demonstrated that this di-sRNP structure was relevant for the enzymatic function of archaeal box C /D sRNPs. (via Semantic Scholar)
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Added: August 6, 2018

2009 article

Signature amino acids enable the archaeal L7Ae box C/D RNP core protein to recognize and bind the K-loop RNA motif

Gagnon, K. T., Zhang, X., Qu, G., Biswas, S., Suryadi, J., Brown, B. A., & Maxwell, E. S. (2009, November 19). RNA.

By: K. Gagnon n, X. Zhang n, G. Qu n, S. Biswas n, J. Suryadi *, B. Brown n, E. Maxwell n

author keywords: box C/D snoRNA; snoRNP; kink-turn; L7Ae/L30 proteins; RNA-protein interaction
MeSH headings : Amino Acid Motifs / physiology; Amino Acid Sequence; Archaea / genetics; Archaea / metabolism; Archaeal Proteins / chemistry; Archaeal Proteins / genetics; Archaeal Proteins / metabolism; Base Sequence; Binding Sites / genetics; Conserved Sequence; Models, Biological; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Nucleic Acid Conformation; Protein Binding / genetics; RNA, Archaeal / chemistry; RNA, Archaeal / metabolism; Ribonucleoproteins / chemistry; Ribonucleoproteins / genetics; Ribonucleoproteins / metabolism; Sequence Homology, Amino Acid
topics (OpenAlex): RNA and protein synthesis mechanisms; RNA modifications and cancer; RNA Research and Splicing
TL;DR: These five signature amino acids are distinct for each of the L7Ae/L30 family members, suggesting an evolutionary continuum of these RNA-binding proteins for recognition of the various K-turn motifs contained in their cognate RNAs. (via Semantic Scholar)
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1999 patent

Antibodies that selectively bind quadruplex nucleic acids

Washington, DC: U.S. Patent and Trademark Office.

By: C. Hardin, B. Brown, J. Roberts & S. Pelsue

Source: NC State University Libraries
Added: August 6, 2018

1999 article

Folding of pyrimidine-enriched RNA fragments from the vicinity of the internal ribosomal entry site of Hepatitis A virus

Hardin, C. C., Sneeden, J. L., Lemon, S. M., Brown, B. A., Guenther, R. H., & Sierzputowska-Gracz, H. (1999, January 1). Nucleic Acids Research.

By: C. Hardin n, J. Sneeden n, S. Lemon*, B. Brown n, R. Guenther n & H. Sierzputowska-Gracz n

MeSH headings : Base Pairing; Base Sequence; Circular Dichroism; Hepatovirus / genetics; Hydrogen-Ion Concentration; Models, Molecular; Molecular Sequence Data; Nuclear Magnetic Resonance, Biomolecular; Nucleic Acid Conformation; Nucleic Acid Denaturation; Potentiometry; Protein Biosynthesis; Pyrimidine Nucleotides / chemistry; RNA, Viral / chemistry; Ribosomes / metabolism
topics (OpenAlex): RNA and protein synthesis mechanisms; Viral Infections and Immunology Research; Viral gastroenteritis research and epidemiology
TL;DR: A series of possible models in which chain folding draws the strand termini closer together, possibly serving to pull the attached WC hairpin domains together and providing a functional advantage by nucleating reversible formation of a more viable RNA substrate are presented. (via Semantic Scholar)
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1997 article

Allosteric Interactions between DNA Strands and Monovalent Cations in DNA Quadruplex Assembly:  Thermodynamic Evidence for Three Linked Association Pathways

Hardin, C. C., Corregan, M. J., Lieberman, D. V., & Brown, B. A. (1997, December 1). Biochemistry.

By: C. Hardin n, M. Corregan n, D. Lieberman n & B. Brown n

MeSH headings : Allosteric Regulation; Cations, Monovalent; Circular Dichroism; DNA / chemistry; Kinetics; Magnetic Resonance Spectroscopy; Nucleic Acid Conformation; Nucleic Acid Denaturation; Thermodynamics
topics (OpenAlex): DNA and Nucleic Acid Chemistry; Advanced biosensing and bioanalysis techniques; RNA Interference and Gene Delivery
TL;DR: It is proposed that, in addition to the more conventional assembly mechanisms involving duplex dimerization and stepwise strand addition, quadruplex formation can also proceed by triplex-triplex disproportionation. (via Semantic Scholar)
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