Works (22)

Updated: August 18th, 2023 21:22

2023 journal article

Evaluation of Anti-Oxinflammatory and ACE-Inhibitory Properties of Protein Hydrolysates Obtained from Edible Non-Mulberry Silkworm Pupae (Antheraea assama and Philosomia ricinii)

NUTRIENTS, 15(4).

author keywords: non-mulberry silkworm pupae; angiotensin converting enzyme-inhibitory peptides; antioxidative peptides; ultrafiltration; anti-inflammatory peptides
MeSH headings : Animals; Angiotensin-Converting Enzyme Inhibitors / pharmacology; Antioxidants / pharmacology; Protein Hydrolysates / pharmacology; Bombyx; Pupa; Endothelial Cells; Lipopolysaccharides; Peptides / pharmacology; Hypertension; Hydrolysis
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: March 20, 2023

2021 journal article

Inflammasome Activation in Pollution-Induced Skin Conditions

PLASTIC AND RECONSTRUCTIVE SURGERY, 147(1S-2), 15S–24S.

By: F. Ferrara*, R. Prieux*, B. Woodby* & G. Valacchi*

MeSH headings : Air Pollutants / adverse effects; Air Pollution / adverse effects; Animals; Dermatitis / immunology; Dermatitis / pathology; Dermatitis / prevention & control; Disease Models, Animal; Environmental Exposure / adverse effects; Furans; Heterocyclic Compounds, 4 or More Rings / pharmacology; Heterocyclic Compounds, 4 or More Rings / therapeutic use; Humans; Indenes; Inflammasomes / antagonists & inhibitors; Inflammasomes / immunology; Inflammasomes / metabolism; Interleukin-18 / metabolism; Interleukin-1beta / metabolism; Mice; NLR Family, Pyrin Domain-Containing 3 Protein / antagonists & inhibitors; NLR Family, Pyrin Domain-Containing 3 Protein / metabolism; Nitriles / pharmacology; Nitriles / therapeutic use; Skin / drug effects; Skin / immunology; Skin / pathology; Skin Aging / immunology; Sulfonamides; Sulfones / pharmacology; Sulfones / therapeutic use
TL;DR: The cutaneous inflammasome is proposed as a novel target of pollutant exposure and the eventual usage of inflamMASome inhibitor as new technologies to counteract pollution-induced skin damage. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: July 6, 2021

2021 review

SARS-CoV-2 infection, COVID-19 pathogenesis, and exposure to air pollution: What is the connection?

[Review of ]. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1486(1), 15–38.

By: B. Woodby n, M. Arnold* & G. Valacchi n

author keywords: air pollution; coronavirus; particulate matter; ozone; nitrogen dioxide; viral infection
MeSH headings : Adaptive Immunity; Air Pollutants / adverse effects; Air Pollution / adverse effects; COVID-19 / etiology; COVID-19 / immunology; COVID-19 / virology; Host Microbial Interactions; Humans; Immunity, Innate; Models, Biological; Pandemics; Particulate Matter / adverse effects; Receptors, Virus / physiology; Respiratory System / physiopathology; SARS-CoV-2 / immunology; SARS-CoV-2 / pathogenicity; SARS-CoV-2 / physiology; Toll-Like Receptors / physiology; Virus Internalization; Virus Replication
TL;DR: Air pollution exposure may affect different stages of the viral life cycle, including inhibition of mucociliary clearance, alteration of viral receptors and proteases required for entry, changes to antiviral interferon production and viral replication, changes in viral assembly mediated by autophagy, prevention of uptake by macrophages, and promotion of viral spread by increasing epithelial permeability. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: October 19, 2020

2020 journal article

Alterations of mitochondrial bioenergetics, dynamics, and morphology support the theory of oxidative damage involvement in autism spectrum disorder

FASEB JOURNAL, 34(5), 6521–6538.

author keywords: 4-hydroxynonenal; fission; fusion; mitophagy; nuclear factor erythroid 2-related factor 2
MeSH headings : Adolescent; Adult; Autism Spectrum Disorder / metabolism; Autism Spectrum Disorder / pathology; Case-Control Studies; Child; Energy Metabolism; Female; Fibroblasts / metabolism; Fibroblasts / pathology; Humans; Male; Mitochondria / metabolism; Mitochondria / pathology; Mitochondrial Dynamics; Mitochondrial Proteins / metabolism; Oxidative Stress; Young Adult
TL;DR: It is suggested that many of the changes observed in mitochondria could represent compensatory mechanisms by which ASD cells try to adapt to altered energy demand, possibly resulting from a chronic oxinflammatory status. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: April 20, 2020

2020 journal article

Human Papillomavirus 16 E5 Inhibits Interferon Signaling and Supports Episomal Viral Maintenance

JOURNAL OF VIROLOGY, 94(2).

By: M. Scott*, B. Woodby*, J. Ulicny*, G. Raikhy*, A. Orr*, W. Songock*, J. Bodily*

author keywords: E5; EGFR; STAT signaling; TGFBR2; innate immunity; interferon kappa; papillomavirus
MeSH headings : Cell Line; Genome, Viral; Genomic Instability; Human papillomavirus 16 / genetics; Human papillomavirus 16 / metabolism; Humans; Interferon Type I / genetics; Interferon Type I / metabolism; Keratinocytes / metabolism; Keratinocytes / pathology; Keratinocytes / virology; Oncogene Proteins, Viral / genetics; Oncogene Proteins, Viral / metabolism; Papillomavirus Infections / genetics; Papillomavirus Infections / metabolism; Papillomavirus Infections / pathology; Plasmids / genetics; Plasmids / metabolism; Signal Transduction
TL;DR: A previously unknown function of the HPV16 E5 oncoprotein in the suppression of interferon (IFN) responses is discovered and it is found that the E5 protein is important for helping the virus avoid integration into the host genome, which is a frequent step along the pathway to cancer development. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
5. Gender Equality (Web of Science)
Source: Web Of Science
Added: January 21, 2020

2020 journal article

KRIT1 as a possible new player in melanoma aggressiveness

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 691.

By: J. Ercoli*, F. Finetti*, B. Woodby*, G. Belmonte*, C. Miracco*, G. Valacchi*, L. Trabalzini*

author keywords: KRIT1; Melanoma; Tumor suppressor; N-cadherin; Inflammation; beta-catenin
MeSH headings : Adult; Aged; Aged, 80 and over; Cell Line, Tumor; Cell Movement / physiology; Cell Nucleus / metabolism; Cell Proliferation / genetics; Down-Regulation; Female; Gene Knockdown Techniques / methods; Humans; KRIT1 Protein / genetics; KRIT1 Protein / metabolism; Male; Melanocytes / metabolism; Melanoma / metabolism; Melanoma / pathology; Middle Aged; beta Catenin / metabolism
TL;DR: KRIT1 has been studied as a regulator of endothelial cell functions and represents a determinant in the pathogenesis of Cerebral Cavernous Malformation, a cerebrovascular disease characterized by the formation of clusters of abnormally dilated and leaky blood capillaries, which predispose to seizures, neurological deficits and intracerebral hemorrhage. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: October 5, 2020

2020 journal article

Mechanisms involved in the unbalanced redox homeostasis in osteoblastic cellular model of Alkaptonuria

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 690.

author keywords: Alkaptonuria; Osteoblast; Oxidative stress; Nrf2; Mitochondria; NADPH oxidase
MeSH headings : Alkaptonuria / metabolism; Cell Line; DNA-Binding Proteins / metabolism; Homeostasis / physiology; Homogentisic Acid / metabolism; Humans; Hydrogen Peroxide / metabolism; Mitochondria / metabolism; Mitochondria / ultrastructure; NADPH Oxidases / metabolism; NF-E2-Related Factor 2 / metabolism; Osteoblasts / cytology; Oxidation-Reduction; Oxidative Stress / physiology; Signal Transduction; Superoxide Dismutase / metabolism; Thioredoxins / metabolism
TL;DR: HGA is able to alter the cellular redox homeostasis by modulating the endogenous ROS production via NOX activation and mitochondrial dysfunctions and impair the cellular response mechanism, which can be useful for understanding the pathophysiology of AKU. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: January 19, 2021

2020 journal article

Mixed Flavonoid Supplementation Attenuates Postexercise Plasma Levels of 4-Hydroxynonenal and Protein Carbonyls in Endurance Athletes

INTERNATIONAL JOURNAL OF SPORT NUTRITION AND EXERCISE METABOLISM, 30(2), 112–119.

By: D. Nieman*, G. Valacchi*, L. Wentz*, F. Ferrara*, A. Pecorelli*, B. Woodby*, C. Sakaguchi*, A. Simonson*

author keywords: inflammation exercise; oxidative stress; peripheral blood mononuclear cells
TL;DR: Flavonoid supplementation prior to intensive exercise decreased plasma peroxidation and oxidative damage, as determined by 4-hydroxynonenal. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: July 6, 2020

2020 journal article

Particulate Matter Induces Tissue OxInflammation: From Mechanism to Damage

ANTIOXIDANTS & REDOX SIGNALING, 33(4), 308–326.

By: G. Valacchi n, N. Magnani*, B. Woodby n, S. Maria Ferreira & P. Evelson*

author keywords: oxidative stress; inflammation; particulate matter; air pollution
MeSH headings : Air Pollution / adverse effects; Animals; Cytokines / metabolism; Disease Susceptibility; Humans; Inflammation / etiology; Inflammation / metabolism; Inflammation / pathology; Inflammation Mediators / metabolism; Oxidation-Reduction; Oxidative Stress; Particulate Matter / adverse effects; Reactive Oxygen Species / metabolism
TL;DR: Research is required to elucidate the exact mechanisms by which PM exposure results in adverse health effects, in terms of the relationship between the redox responses triggered by the presence of the particles and the inflammation observed in the different organs, so the development/exacerbation of PM-associated health problems can be prevented. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: July 13, 2020

2020 journal article

Postexercise Inflammasome Activation and IL-1 beta Production Mitigated by Flavonoid Supplementation in Cyclists

INTERNATIONAL JOURNAL OF SPORT NUTRITION AND EXERCISE METABOLISM, 30(6), 396–404.

By: D. Nieman*, F. Ferrara*, A. Pecorelli*, B. Woodby*, A. Hoyle*, A. Simonson*, G. Valacchi*

author keywords: cytokines; gasdermin D; IL-18; inflammation
TL;DR: The data indicate that 2-week FLAV ingestion mitigated inflammasome activation, with a corresponding decrease in IL-1β release in cyclists after a 75-km cycling time trial, and support the strategy of ingesting high amounts of FLAV to mitigate postexercise inflammation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: November 9, 2020

2020 journal article

Redox regulation of cutaneous inflammasome by ozone exposure

FREE RADICAL BIOLOGY AND MEDICINE, 152, 561–570.

By: F. Ferrara*, E. Pambianchi*, A. Pecorelli*, B. Woodby*, N. Messano*, J. Therrien, M. Lila*, G. Valacchi*

MeSH headings : Caspase 1 / metabolism; Humans; Hydrogen Peroxide; Inflammasomes / metabolism; Interleukin-1beta / genetics; Interleukin-1beta / metabolism; NLR Family, Pyrin Domain-Containing 3 Protein / genetics; NLR Family, Pyrin Domain-Containing 3 Protein / metabolism; Oxidation-Reduction; Ozone / toxicity; Reactive Oxygen Species
TL;DR: It is demonstrated that O3 can activate cutaneous inflammasome in a redox dependent manner suggesting a possible role of this new pathway in pollution induced inflammatory skin conditions. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: July 13, 2020

2020 article

Skin Health from the Inside Out

ANNUAL REVIEW OF FOOD SCIENCE AND TECHNOLOGY, VOL 11, Vol. 11, pp. 235–254.

By: B. Woodby n, K. Penta n, A. Pecorelli n, M. Lila n & G. Valacchi n

author keywords: pollution; skin; diet; GI tract; inflammation; antioxidant; vitamins
MeSH headings : Antioxidants / metabolism; Humans; Reactive Oxygen Species / metabolism; Skin Physiological Phenomena
TL;DR: This review discusses how topical application of antioxidants, including vitamins C and E, carotenoids, resveratrol, and pycnogenol, can be combined with dietary supplementation of these antioxidant compounds in addition to probiotics and essential minerals to protect against outdoor stressor-induced skin damage, including the damage associated with aging. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: April 27, 2020

2020 journal article

The PDE4 inhibitor CHF6001 affects keratinocyte proliferation via cellular redox pathways

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 685.

By: B. Woodby n, C. Sticozzi*, E. Pambianchi n, G. Villetti, M. Civelli, G. Valacchi n, F. Facchinetti

author keywords: NOX; NF-kappa B; Cyclin D1; Skin; p21
MeSH headings : Aldehydes / metabolism; Cell Line; Cell Proliferation / drug effects; Cell Survival / drug effects; Cyclin D1 / metabolism; Humans; Keratinocytes / drug effects; Lipid Peroxidation / drug effects; NADPH Oxidases / metabolism; Oxidative Stress / drug effects; Phosphodiesterase 4 Inhibitors / pharmacology; Phosphodiesterase 4 Inhibitors / toxicity; Psoriasis / drug therapy; Sulfonamides / pharmacology; Sulfonamides / toxicity; Transcription Factor RelA / metabolism; para-Aminobenzoates / pharmacology; para-Aminobenzoates / toxicity
TL;DR: CHF6001 has the potential to treat skin disorders associated with hyperproliferative keratinocytes, such as psoriasis by targeting oxidative stress, abnormal re-epithelization, and inflammation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: May 8, 2020

2019 article

Blueberries Topical Application Prevents Ozone Induced Cutaneous Inflammasome Activation

Pambianchi, E., Francesca, F., Pecorelli, A., Woodby, B., Lila, M., & Valacchi, G. (2019, December). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 145, pp. S148–S148.

By: E. Pambianchi, F. Francesca, A. Pecorelli, B. Woodby, M. Lila & G. Valacchi

Sources: Web Of Science, NC State University Libraries
Added: December 2, 2019

2019 article

HGA Induces Oxidative Damage in an Ostcoblastic Cellular Model of Alkaptonuria: Sources and Mechanisms HGA Induces Oxidative Damage in an Osteoblastic Cellular Model of Alkaptonuria: Sources and Mechanisms

Schiavone, M. L., Pecorelli, A., Woodby, B., Ferrara, F., Santucci, A., & Valacchi, G. (2019, December). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 145, pp. S37–S38.

By: M. Schiavone, A. Pecorelli, B. Woodby, F. Ferrara, A. Santucci & G. Valacchi

UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: December 2, 2019

2019 review

Involvement of 4-hydroxy-2-nonenal in pollution-induced skin damage

[Review of ]. BIOFACTORS, 45(4), 536–547.

By: A. Pecorelli n, B. Woodby n, R. Prieux* & G. Valacchi n

author keywords: ozone; particulate matter; cigarette smoke; peroxidation
MeSH headings : Air Pollutants / metabolism; Air Pollutants / toxicity; Aldehydes / metabolism; Aldehydes / toxicity; Dermatitis, Atopic / chemically induced; Dermatitis, Atopic / genetics; Dermatitis, Atopic / metabolism; Dermatitis, Atopic / pathology; Gene Expression Regulation / drug effects; Humans; Mitogen-Activated Protein Kinases / genetics; Mitogen-Activated Protein Kinases / metabolism; Oxidation-Reduction; Oxidative Stress; Ozone / metabolism; Ozone / toxicity; Particulate Matter / toxicity; Psoriasis / chemically induced; Psoriasis / genetics; Psoriasis / metabolism; Psoriasis / pathology; Reactive Oxygen Species / agonists; Reactive Oxygen Species / metabolism; Signal Transduction; Skin / drug effects; Skin / metabolism; Skin / pathology; Skin Aging / drug effects; Skin Aging / genetics; Skin Aging / pathology; Tobacco Smoke Pollution / adverse effects; Transcription Factors / genetics; Transcription Factors / metabolism
TL;DR: Increased levels of HNE in the skin, in response to pollutants, likely accelerates skin aging and exacerbates existing skin inflammatory conditions; thus, targeting HNE formation could be an innovative cosmeceutical approach for topical applications. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: April 20, 2020

2019 journal article

Involvement of cutaneous SR-B1 in skin lipid homeostasis

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 666, 1–7.

By: X. Muresan*, M. Narzt*, B. Woodby n, F. Ferrara n, F. Gruber & G. Valacchi n

author keywords: Scavenger receptor; Skin; Keratinocytes; Lipids; Ceramides; Cholesterol; Differentiation
MeSH headings : Cell Differentiation / physiology; Cells, Cultured; Filaggrin Proteins; Gene Expression Regulation; Homeostasis; Humans; Keratinocytes / cytology; Lipid Metabolism / genetics; Scavenger Receptors, Class B / genetics; Scavenger Receptors, Class B / physiology; Skin / cytology; Skin / metabolism
TL;DR: One of the main functions of SR-B1 in the skin is to regulate ceramide levels and thereby maintain the barrier function of the skin, resulting in the protection of cutaneous tissues from outdoor insults. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: June 17, 2019

2019 review

Ozonated Oils and Cutaneous Wound Healing

[Review of ]. CURRENT PHARMACEUTICAL DESIGN, 25(20), 2264–2278.

By: Y. Lim*, H. Lee*, B. Woodby n & G. Valacchi*

author keywords: Cutaneous wound healing; ROS; peroxidation; topical application; ozonated oil; inflammation
MeSH headings : Humans; Ozone; Phytotherapy; Plant Oils / therapeutic use; Skin; Wound Healing
TL;DR: The present review intends to summarize the actual state of the art of the topical usage of ozonated oil in cutaneous wounds with special emphasis to the importance of theozonated degree of the oil. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: October 7, 2019

2019 article

Redox Regulation of Cutaneous Inflammasome Pathway by Ozone Exposure

Ferrara, F., Pecorelli, A., Woodby, B., Pambianchi, E., Messano, N., Therrien, J. P., & Valacchi, G. (2019, December). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 145, pp. S22–S23.

By: F. Ferrara, A. Pecorelli, B. Woodby, E. Pambianchi, N. Messano, J. Therrien, G. Valacchi

Sources: Web Of Science, NC State University Libraries
Added: December 2, 2019

2019 article

Redox-Regulation of Antimicrobial Peptides

Woodby, B., Pambianchi, E., Francesca, F., Messano, N., Pecorelli, A., Therrien, J. P., & Valacchii, G. (2019, December). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 145, pp. S54–S55.

By: B. Woodby, E. Pambianchi, F. Francesca, N. Messano, A. Pecorelli, J. Therrien, G. Valacchii

UN Sustainable Development Goal Categories
4. Quality Education (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: December 2, 2019

2019 journal article

Skin damage by tropospheric ozone

HAUTARZT, 70(3), 163–168.

By: K. Fuks*, B. Woodby n & G. Valacchi n

author keywords: Air pollution; Skin aging; Skin wrinkling; Oxidative stress; Peroxidation
MeSH headings : Air Pollutants / adverse effects; Air Pollution; Humans; Lipid Peroxidation / drug effects; Nitrogen Dioxide / analysis; Oxidative Stress; Ozone / adverse effects; Ozone / analysis; Particulate Matter / analysis; Public Health; Skin Aging / drug effects; Skin Aging / radiation effects; Ultraviolet Rays / adverse effects
TL;DR: The experimental evidence suggests a positive correlation of O3 exposure with oxidative damage, impaired antioxidant defence and proinflammatory response in the skin, and skin might be a potentially overlooked target organ of ambient O3. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: March 25, 2019

2019 journal article

Suppression of Stromal Interferon Signaling by Human Papillomavirus 16

JOURNAL OF VIROLOGY, 93(19).

author keywords: E5; fibroblast; immunity; interferon; keratinocyte differentiation; organotypic culture; papillomavirus; stroma
MeSH headings : Cells, Cultured; Fibroblasts / immunology; Fibroblasts / virology; Gene Expression Profiling; Host-Pathogen Interactions; Human papillomavirus 16 / growth & development; Human papillomavirus 16 / immunology; Humans; Immune Evasion; Immunity, Innate; Immunologic Factors / antagonists & inhibitors; Interferons / antagonists & inhibitors; Keratinocytes / immunology; Keratinocytes / virology; Models, Biological; Papillomavirus Infections / immunology; Papillomavirus Infections / virology; Signal Transduction
TL;DR: HPVs infect squamous epithelia and cause several important cancers, and the role of epithelial-stromal interactions in the HPV16 life cycle is examined, showing that HPV can suppress the expression of immune-related genes in neighboring fibroblasts in a three-dimensional (3D) model of human epithelium and revealing a new role for E5 as a stromal innate immune suppressor. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
5. Gender Equality (Web of Science)
Source: Web Of Science
Added: October 7, 2019

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