Dorothy You

College of Sciences

Works (9)

Updated: August 31st, 2023 05:00

2023 journal article

Role of the protease-activated receptor-2 (PAR2) in the exacerbation of house dust mite-induced murine allergic lung disease by multi-walled carbon nanotubes

PARTICLE AND FIBRE TOXICOLOGY, 20(1).

By: H. Lee n, D. You n, A. Taylor-Just n, L. Tisch n, R. Bartone n, H. Atkins n, L. Ralph*, S. Antoniak *, J. Bonner n 

author keywords: Carbon nanotubes; Allergens; Protease-activated receptor 2; Lung; Inflammation; Fibrosis
TL;DR: This study indicates that protease-activated receptor 2 (PAR2) mediates airway fibrosis but not eosinophilic lung inflammation induced by co-exposure to MWCNTs and HDM allergens. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 28, 2023

2022 article

Pulmonary exposure of mice to ammonium perfluoro(2-methyl-3-oxahexanoate) (GenX) suppresses the innate immune response to carbon black nanoparticles and stimulates lung cell proliferation

Lee, H. Y., You, D. J., Taylor-Just, A. J., Linder, K. E., Atkins, H. M., Ralph, L. M., … Bonner, J. C. (2022, June 14). INHALATION TOXICOLOGY, Vol. 6.

By: H. Lee n, D. You n, A. Taylor-Just n, K. Linder n, H. Atkins n, L. Ralph*, G. Cruz *, J. Bonner n 

author keywords: Carbon black; nanoparticles; PFAS; lung; immunity
MeSH headings : Ammonium Compounds / toxicity; Animals; Bronchoalveolar Lavage Fluid / chemistry; Cell Proliferation; Cytokines / metabolism; Fluorocarbons / toxicity; Immunity, Innate; Ki-67 Antigen / metabolism; Lung; Male; Mice; Mice, Inbred C57BL; NF-kappa B / metabolism; Nanoparticles / toxicity; Soot / toxicity
TL;DR: Pulmonary exposure to GenX suppressed CBNP-induced innate immune response in the lungs of mice yet promoted the proliferation of macrophages and lung epithelial cells. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: June 27, 2022

2022 journal article

Synergistic induction of IL-6 production in human bronchial epithelial cells in vitro by nickel nanoparticles and lipopolysaccharide is mediated by eSTAT3 and C/EBP beta

TOXICOLOGY IN VITRO, 83.

By: D. You n, H. Lee n, A. Taylor-Just n & J. Bonner n 

author keywords: Nanoparticles; Nickel; Lipopolysaccharide; Cytokines; Cell signaling; Epithelial cells
MeSH headings : Animals; CCAAT-Enhancer-Binding Protein-beta / metabolism; Cell Line; Epithelial Cells; Female; Humans; Interleukin-6 / genetics; Interleukin-6 / metabolism; Lipopolysaccharides / pharmacology; Male; Mice; Nanoparticles; Nickel; STAT3 Transcription Factor / metabolism
TL;DR: The data suggest that LPS and NiNPs induce IL-6 via STAT3 and C/EBPβ in BEAS-2B cells, and that these cells do not appear to be suitable for studying the effect of sex hormones. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 15, 2022

2021 journal article

STAT6-dependent exacerbation of house dust mite-induced allergic airway disease in mice by multi-walled carbon nanotubes

NANOIMPACT, 22.

By: M. Ihrie n, K. Duke n, K. Shipkowski n, D. You n, H. Lee n, A. Taylor-Just n, J. Bonner n 

author keywords: Carbon nanotubes; House dust mite; Allergens; STAT6; Asthma
MeSH headings : Animals; Antigens, Dermatophagoides / adverse effects; Asthma / chemically induced; Dermatophagoides pteronyssinus; Fibrosis; Hypersensitivity / metabolism; Immunoglobulin E; Lung; Male; Metaplasia / chemically induced; Mice; Mice, Knockout; Nanotubes, Carbon / adverse effects; Pulmonary Eosinophilia / chemically induced; Pulmonary Fibrosis / chemically induced; Respiration Disorders / chemically induced; STAT6 Transcription Factor / genetics
TL;DR: Findings provide new mechanistic insight by demonstrating a requirement for STAT6 in MWCNT-induced exacerbation of allergic respiratory disease by demonstrating that airway fibrosis was significantly increased by the combination of HDM and M WCNTs in WT mice but not in Stat6 KO mice. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: June 21, 2021

2021 journal article

Sex Differences in Pulmonary Eicosanoids and Specialized Pro-Resolving Mediators in Response to Ozone Exposure

TOXICOLOGICAL SCIENCES, 183(1), 170–183.

By: M. Yaeger *, S. Reece *, B. Kilburg-Basnyat *, M. Hodge*, A. Pal *, K. Dunigan-Russell, B. Luo *, D. You n ...

author keywords: air pollution; lipids; lung; inflammation; sex differences
MeSH headings : Animals; Eicosanoids; Female; Lung; Male; Mice; Mice, Inbred C57BL; Ozone / toxicity; Sex Characteristics
TL;DR: Data indicate that O3 drives an increased pulmonary inflammatory and bioactive lipid mediator response in females, and ovariectomy increases susceptibility to O3-induced pulmonary inflammation and injury, as well as decreases pulmonary DHA concentrations. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: September 27, 2021

2020 article

Macrophages: First Innate Immune Responders to Nanomaterials

INTERACTION OF NANOMATERIALS WITH THE IMMUNE SYSTEM, pp. 15–34.

By: D. You n, H. Lee n & J. Bonner n 

author keywords: Macrophage; Nanomaterial; Toll-like receptors; Scavenger receptors; Reactive oxygen species; Inflammasome; Polarization
TL;DR: The immune response of macrophages to ENMs, including inflammasome activation and alternative polarization, plays important roles in immune-mediated diseases such as fibrosis, asthma, and cancer. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 16, 2021

2020 journal article

Sex differences in the acute and subchronic lung inflammatory responses of mice to nickel nanoparticles

NANOTOXICOLOGY, 14(8), 1058–1081.

By: D. You n, H. Lee n, A. Taylor-Just n, K. Linder n & J. Bonner n 

author keywords: Nickel nanoparticles; inflammation; lung; sex; susceptibility
MeSH headings : Animals; Bronchoalveolar Lavage Fluid / cytology; Chemokine CXCL1 / metabolism; Female; Humans; Inhalation Exposure; Interleukin-6 / metabolism; Lung / drug effects; Lung / immunology; Lung / pathology; Male; Metal Nanoparticles / toxicity; Mice; Mice, Inbred C57BL; Neutrophils / cytology; Neutrophils / drug effects; Nickel / toxicity; Pneumonia / chemically induced; Pneumonia / pathology; STAT Transcription Factors / metabolism; Sex Characteristics; Signal Transduction; Toxicity Tests, Acute; Toxicity Tests, Subchronic
TL;DR: Sex differences in the lung inflammatory response of mice to NiNPs that has implications for human disease are demonstrated and indicate that susceptibility of males to acute lung inflammation involves enhanced neutrophilia with increased CXCL1 and IL-6/STAT3 signaling, whereas susceptibility to subchronic lunginflammation involves enhanced monocytic infiltration withIncreased CXcl1 and CCL2. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: September 7, 2020

2020 review

Susceptibility Factors in Chronic Lung Inflammatory Responses to Engineered Nanomaterials

[Review of ]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21(19).

By: D. You n & J. Bonner n 

author keywords: engineered nanomaterials; susceptibility; chronic inflammation; lung inflammation
MeSH headings : Animals; Humans; Inflammation / chemically induced; Inflammation / complications; Inflammation / pathology; Inhalation Exposure; Lung / drug effects; Lung / pathology; Nanostructures / adverse effects; Nanostructures / therapeutic use; Pneumonia / complications; Pneumonia / drug therapy; Pneumonia / pathology
TL;DR: This review will address evidence from experimental animal models that highlights some important issues of susceptibility to chronic lung inflammation and systemic immune dysfunction after pulmonary exposure to ENMs. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: November 24, 2020

2020 journal article

The pulmonary toxicity of carboxylated or aminated multi-walled carbon nanotubes in mice is determined by the prior purification method

PARTICLE AND FIBRE TOXICOLOGY, 17(1).

By: A. Taylor-Just n, M. Ihrie n, K. Duke n, H. Lee n, D. You n, S. Hussain *, V. Kodali *, C. Ziemann * ...

author keywords: Carbon nanotubes; Purification; Functionalization; Lung injury; Fibrosis
MeSH headings : Administration, Inhalation; Air Pollutants / toxicity; Animals; Bronchoalveolar Lavage Fluid / chemistry; Cytokines / metabolism; Inhalation Exposure; Lung / drug effects; Lung Injury; Mice; Mice, Inbred C57BL; Nanotubes, Carbon / toxicity; Transforming Growth Factor beta1 / metabolism
TL;DR: The purification method is an important determinant of lung toxicity induced by carboxyl- and amine-functionalized MWCNTs, as indicated by Raman spectroscopy. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: December 21, 2020

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