Dorothy You

College of Sciences

Works (9)

Updated: August 31st, 2023 05:00

2023 journal article

Role of the protease-activated receptor-2 (PAR2) in the exacerbation of house dust mite-induced murine allergic lung disease by multi-walled carbon nanotubes

PARTICLE AND FIBRE TOXICOLOGY, 20(1).

By: H. Lee n, D. You n, A. Taylor-Just n, L. Tisch n, R. Bartone n, H. Atkins n, L. Ralph*, S. Antoniak*, J. Bonner n

co-author countries: United States of America 🇺🇸
author keywords: Carbon nanotubes; Allergens; Protease-activated receptor 2; Lung; Inflammation; Fibrosis
Source: Web Of Science
Added: August 28, 2023

2022 article

Pulmonary exposure of mice to ammonium perfluoro(2-methyl-3-oxahexanoate) (GenX) suppresses the innate immune response to carbon black nanoparticles and stimulates lung cell proliferation

Lee, H. Y., You, D. J., Taylor-Just, A. J., Linder, K. E., Atkins, H. M., Ralph, L. M., … Bonner, J. C. (2022, June 14). INHALATION TOXICOLOGY.

By: H. Lee n, D. You n, A. Taylor-Just n, K. Linder n, H. Atkins n, L. Ralph*, G. Cruz*, J. Bonner n

co-author countries: United States of America 🇺🇸
author keywords: Carbon black; nanoparticles; PFAS; lung; immunity
MeSH headings : Ammonium Compounds / toxicity; Animals; Bronchoalveolar Lavage Fluid / chemistry; Cell Proliferation; Cytokines / metabolism; Fluorocarbons / toxicity; Immunity, Innate; Ki-67 Antigen / metabolism; Lung; Male; Mice; Mice, Inbred C57BL; NF-kappa B / metabolism; Nanoparticles / toxicity; Soot / toxicity
Source: Web Of Science
Added: June 27, 2022

2022 journal article

Synergistic induction of IL-6 production in human bronchial epithelial cells in vitro by nickel nanoparticles and lipopolysaccharide is mediated by eSTAT3 and C/EBP beta

TOXICOLOGY IN VITRO, 83.

By: D. You n, H. Lee n, A. Taylor-Just n & J. Bonner n

co-author countries: United States of America 🇺🇸
author keywords: Nanoparticles; Nickel; Lipopolysaccharide; Cytokines; Cell signaling; Epithelial cells
MeSH headings : Animals; CCAAT-Enhancer-Binding Protein-beta / metabolism; Cell Line; Epithelial Cells; Female; Humans; Interleukin-6 / genetics; Interleukin-6 / metabolism; Lipopolysaccharides / pharmacology; Male; Mice; Nanoparticles; Nickel; STAT3 Transcription Factor / metabolism
Source: Web Of Science
Added: August 15, 2022

2021 journal article

STAT6-dependent exacerbation of house dust mite-induced allergic airway disease in mice by multi-walled carbon nanotubes

NANOIMPACT, 22.

By: M. Ihrie n, K. Duke n, K. Shipkowski n, D. You n, H. Lee n, A. Taylor-Just n, J. Bonner n

co-author countries: United States of America 🇺🇸
author keywords: Carbon nanotubes; House dust mite; Allergens; STAT6; Asthma
MeSH headings : Animals; Antigens, Dermatophagoides / adverse effects; Asthma / chemically induced; Dermatophagoides pteronyssinus; Fibrosis; Hypersensitivity / metabolism; Immunoglobulin E; Lung; Male; Metaplasia / chemically induced; Mice; Mice, Knockout; Nanotubes, Carbon / adverse effects; Pulmonary Eosinophilia / chemically induced; Pulmonary Fibrosis / chemically induced; Respiration Disorders / chemically induced; STAT6 Transcription Factor / genetics
Source: Web Of Science
Added: June 21, 2021

2021 journal article

Sex Differences in Pulmonary Eicosanoids and Specialized Pro-Resolving Mediators in Response to Ozone Exposure

TOXICOLOGICAL SCIENCES, 183(1), 170–183.

By: M. Yaeger*, S. Reece*, B. Kilburg-Basnyat*, M. Hodge*, A. Pal*, K. Dunigan-Russell*, B. Luo*, D. You n ...

co-author countries: United States of America 🇺🇸
author keywords: air pollution; lipids; lung; inflammation; sex differences
MeSH headings : Animals; Eicosanoids; Female; Lung; Male; Mice; Mice, Inbred C57BL; Ozone / toxicity; Sex Characteristics
Source: Web Of Science
Added: September 27, 2021

2020 article

Macrophages: First Innate Immune Responders to Nanomaterials

INTERACTION OF NANOMATERIALS WITH THE IMMUNE SYSTEM, pp. 15–34.

By: D. You n, H. Lee n & J. Bonner n

co-author countries: United States of America 🇺🇸
author keywords: Macrophage; Nanomaterial; Toll-like receptors; Scavenger receptors; Reactive oxygen species; Inflammasome; Polarization
Source: Web Of Science
Added: August 16, 2021

2020 journal article

Sex differences in the acute and subchronic lung inflammatory responses of mice to nickel nanoparticles

NANOTOXICOLOGY, 14(8), 1058–1081.

By: D. You n, H. Lee n, A. Taylor-Just n, K. Linder n & J. Bonner n

co-author countries: United States of America 🇺🇸
author keywords: Nickel nanoparticles; inflammation; lung; sex; susceptibility
MeSH headings : Animals; Bronchoalveolar Lavage Fluid / cytology; Chemokine CXCL1 / metabolism; Female; Humans; Inhalation Exposure; Interleukin-6 / metabolism; Lung / drug effects; Lung / immunology; Lung / pathology; Male; Metal Nanoparticles / toxicity; Mice; Mice, Inbred C57BL; Neutrophils / cytology; Neutrophils / drug effects; Nickel / toxicity; Pneumonia / chemically induced; Pneumonia / pathology; STAT Transcription Factors / metabolism; Sex Characteristics; Signal Transduction; Toxicity Tests, Acute; Toxicity Tests, Subchronic
Source: Web Of Science
Added: September 7, 2020

2020 review

Susceptibility Factors in Chronic Lung Inflammatory Responses to Engineered Nanomaterials

[Review of ]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21(19).

By: D. You n & J. Bonner n

co-author countries: United States of America 🇺🇸
author keywords: engineered nanomaterials; susceptibility; chronic inflammation; lung inflammation
MeSH headings : Animals; Humans; Inflammation / chemically induced; Inflammation / complications; Inflammation / pathology; Inhalation Exposure; Lung / drug effects; Lung / pathology; Nanostructures / adverse effects; Nanostructures / therapeutic use; Pneumonia / complications; Pneumonia / drug therapy; Pneumonia / pathology
Source: Web Of Science
Added: November 24, 2020

2020 journal article

The pulmonary toxicity of carboxylated or aminated multi-walled carbon nanotubes in mice is determined by the prior purification method

PARTICLE AND FIBRE TOXICOLOGY, 17(1).

By: A. Taylor-Just n, M. Ihrie n, K. Duke n, H. Lee n, D. You n, S. Hussain*, V. Kodali*, C. Ziemann* ...

co-author countries: Belgium 🇧🇪 Germany 🇩🇪 Romania 🇷🇴 United States of America 🇺🇸
author keywords: Carbon nanotubes; Purification; Functionalization; Lung injury; Fibrosis
MeSH headings : Administration, Inhalation; Air Pollutants / toxicity; Animals; Bronchoalveolar Lavage Fluid / chemistry; Cytokines / metabolism; Inhalation Exposure; Lung / drug effects; Lung Injury; Mice; Mice, Inbred C57BL; Nanotubes, Carbon / toxicity; Transforming Growth Factor beta1 / metabolism
Source: Web Of Science
Added: December 21, 2020

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