Kelly Anne Shipkowski

Works (7)

Updated: August 6th, 2023 21:15

2021 journal article

STAT6-dependent exacerbation of house dust mite-induced allergic airway disease in mice by multi-walled carbon nanotubes

NANOIMPACT, 22.

By: M. Ihrie n, K. Duke n, K. Shipkowski n, D. You n, H. Lee n, A. Taylor-Just n, J. Bonner n 

author keywords: Carbon nanotubes; House dust mite; Allergens; STAT6; Asthma
MeSH headings : Animals; Antigens, Dermatophagoides / adverse effects; Asthma / chemically induced; Dermatophagoides pteronyssinus; Fibrosis; Hypersensitivity / metabolism; Immunoglobulin E; Lung; Male; Metaplasia / chemically induced; Mice; Mice, Knockout; Nanotubes, Carbon / adverse effects; Pulmonary Eosinophilia / chemically induced; Pulmonary Fibrosis / chemically induced; Respiration Disorders / chemically induced; STAT6 Transcription Factor / genetics
TL;DR: Findings provide new mechanistic insight by demonstrating a requirement for STAT6 in MWCNT-induced exacerbation of allergic respiratory disease by demonstrating that airway fibrosis was significantly increased by the combination of HDM and M WCNTs in WT mice but not in Stat6 KO mice. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: June 21, 2021

2018 journal article

Role of p53 in the chronic pulmonary immune response to tangled or rod-like multi-walled carbon nanotubes

NANOTOXICOLOGY, 12(9), 975–991.

By: K. Duke n, E. Thompson n, M. Ihrie n, A. Taylor-Just n, E. Ash n, K. Shipkowski n, J. Hall n , D. Tokarz n ...

author keywords: Caron nanotubes; immunotoxicology; cancer; granuloma; p53
MeSH headings : Animals; Dose-Response Relationship, Drug; Granuloma, Respiratory Tract / chemically induced; Granuloma, Respiratory Tract / genetics; Granuloma, Respiratory Tract / immunology; Inhalation Exposure; Lung / drug effects; Lung / immunology; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nanotubes, Carbon / chemistry; Nanotubes, Carbon / toxicity; Surface Properties; Tertiary Lymphoid Structures / chemically induced; Tertiary Lymphoid Structures / genetics; Tertiary Lymphoid Structures / immunology; Tumor Suppressor Protein p53 / genetics; Tumor Suppressor Protein p53 / physiology
TL;DR: Findings indicate that a combination of p53 deficiency and physicochemical characteristics including nanotube geometry are factors in susceptibility to MWCNT-induced lymphoid infiltration and granuloma formation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: March 4, 2019

2017 journal article

STAT1-dependent and -independent pulmonary allergic and fibrogenic responses in mice after exposure to tangled versus rod-like multi-walled carbon nanotubes

PARTICLE AND FIBRE TOXICOLOGY, 14.

By: K. Duke n, A. Taylor-Just n, M. Ihrie n, K. Shipkowski n, E. Thompson n, E. Dandley n, G. Parsons n , J. Bonner n 

author keywords: Carbon nanotubes; Lung; Fibrosis; Growth factors; Transcription factors
MeSH headings : Animals; Bronchoalveolar Lavage Fluid / chemistry; Cell Proliferation / drug effects; Cytokines / metabolism; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Epithelial Cells / pathology; Genetic Predisposition to Disease; Granuloma, Respiratory Tract / chemically induced; Granuloma, Respiratory Tract / metabolism; Granuloma, Respiratory Tract / pathology; Immunoglobulin E / blood; Lung / drug effects; Lung / metabolism; Lung / pathology; Male; Mice, Knockout; Nanotubes, Carbon / chemistry; Nanotubes, Carbon / toxicity; Phenotype; Phosphorylation; Pneumonia / chemically induced; Pneumonia / metabolism; Pneumonia / pathology; Pulmonary Fibrosis / chemically induced; Pulmonary Fibrosis / genetics; Pulmonary Fibrosis / metabolism; Pulmonary Fibrosis / pathology; Respiratory Hypersensitivity / chemically induced; Respiratory Hypersensitivity / genetics; Respiratory Hypersensitivity / metabolism; Respiratory Hypersensitivity / pathology; Risk Assessment; STAT1 Transcription Factor / deficiency; STAT1 Transcription Factor / genetics; STAT1 Transcription Factor / metabolism; Signal Transduction / drug effects; Smad2 Protein / metabolism; Smad3 Protein / metabolism; Time Factors; Transforming Growth Factor beta1 / metabolism
TL;DR: Rigidity plays a key role in the toxicity of MWCNTs and results in increased inflammatory, immunologic, and fibrogenic effects in the lung, and both rigidity and genetic susceptibility should be major considerations for risk assessment of MMWNTs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 journal article

An allergic lung microenvironment suppresses carbon nanotube-induced inflammasome activation via STAT6-dependent inhibition of caspase-1

PLoS One, 10(6).

By: K. Shipkowski, A. Taylor, E. Thompson, E. Glista-Baker, B. Sayers, Z. Messenger, R. Bauer, I. Jaspers, J. Bonner 

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Atomic layer deposition coating of carbon nanotubes with zinc oxide causes acute phase immune responses in human monocytes in vitro and in mice after pulmonary exposure

PARTICLE AND FIBRE TOXICOLOGY, 13.

By: E. Dandley n, A. Taylor n, K. Duke n, M. Ihrie n, K. Shipkowski n, G. Parsons n , J. Bonner n 

Contributors: E. Dandley n, A. Taylor n, K. Duke n, M. Ihrie n, K. Shipkowski n, G. Parsons n , J. Bonner n 

author keywords: Atomic layer deposition; Carbon nanotubes; Pulmonary fibrosis; Inflammation
MeSH headings : Acute-Phase Reaction / chemically induced; Acute-Phase Reaction / immunology; Acute-Phase Reaction / metabolism; Acute-Phase Reaction / pathology; Air Pollutants / chemistry; Air Pollutants / toxicity; Animals; Cell Line; Cytokines / agonists; Cytokines / genetics; Cytokines / metabolism; Disease Progression; Gene Expression Regulation / drug effects; Humans; Inhalation Exposure / adverse effects; Lung / drug effects; Lung / immunology; Lung / metabolism; Lung / pathology; Male; Mice, Inbred C57BL; Microscopy, Electron, Scanning Transmission; Monocytes / drug effects; Monocytes / immunology; Monocytes / metabolism; Monocytes / pathology; Nanotubes, Carbon / chemistry; Nanotubes, Carbon / toxicity; Nanotubes, Carbon / ultrastructure; Pulmonary Fibrosis / etiology; RNA, Messenger / metabolism; Respiratory Mucosa / drug effects; Respiratory Mucosa / immunology; Respiratory Mucosa / pathology; Surface Properties; Zinc Oxide / chemistry; Zinc Oxide / toxicity
TL;DR: It is hypothesized that surface functionalization of multi-walled carbon nanotubes with polycrystalline ZnO by ALD would alter pro-inflammatory cytokine expression by human monocytes in vitro and modulate the lung and systemic immune response following oropharyngeal aspiration in mice. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2015 journal article

Role of Signal Transducer and Activator of Transcription 1 in Murine Allergen-Induced Airway Remodeling and Exacerbation by Carbon Nanotubes

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 53(5), 625–636.

By: E. Thompson n, B. Sayers n, E. Glista-Baker n, K. Shipkowski n, M. Ihrie n, K. Duke n, A. Taylor n, J. Bonner n 

author keywords: asthma; allergen; nanomaterials; carbon nanotubes; airway remodeling
MeSH headings : Allergens / pharmacology; Animals; Bronchoalveolar Lavage Fluid / chemistry; Eosinophils / drug effects; Eosinophils / immunology; Eosinophils / pathology; Epithelial Cells / drug effects; Epithelial Cells / immunology; Epithelial Cells / pathology; Gene Expression Regulation; Goblet Cells / drug effects; Goblet Cells / immunology; Goblet Cells / pathology; Interleukin-10 / genetics; Interleukin-10 / immunology; Interleukin-13 / genetics; Interleukin-13 / immunology; Male; Mice; Mice, Knockout; Nanotubes / adverse effects; Neutrophils / drug effects; Neutrophils / immunology; Neutrophils / pathology; Osteopontin / genetics; Osteopontin / immunology; Ovalbumin / immunology; Respiratory Hypersensitivity / etiology; Respiratory Hypersensitivity / genetics; Respiratory Hypersensitivity / immunology; Respiratory Hypersensitivity / pathology; STAT1 Transcription Factor / deficiency; STAT1 Transcription Factor / genetics; STAT1 Transcription Factor / immunology; Signal Transduction; T-Lymphocytes, Helper-Inducer / drug effects; T-Lymphocytes, Helper-Inducer / immunology; T-Lymphocytes, Helper-Inducer / pathology; Transforming Growth Factor beta1 / genetics; Transforming Growth Factor beta1 / immunology; Transforming Growth Factor beta1 / pharmacology; Tumor Necrosis Factor-alpha / genetics; Tumor Necrosis Factor-alpha / immunology
TL;DR: A protective role for STAT1 is supported in chronic AAI and exacerbation of remodeling caused by MWCNTs and fibroblasts isolated from the lungs of Stat1(-/-) mice produced significantly more collagen mRNA and protein in response to transforming growth factor-β1 compared with WT lung fibro Blasts. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 journal article

Atomic Layer Deposition Coating of Carbon Nanotubes with Aluminum Oxide Alters Pro-Fibrogenic Cytokine Expression by Human Mononuclear Phagocytes In Vitro and Reduces Lung Fibrosis in Mice In Vivo

PLOS ONE, 9(9).

By: A. Taylor n, C. McClure n, K. Shipkowski n, E. Thompson n, S. Hussain *, S. Garantziotis *, G. Parsons n , J. Bonner n 

Contributors: A. Taylor n, C. McClure n, K. Shipkowski n, E. Thompson n, S. Hussain *, S. Garantziotis *, G. Parsons n , J. Bonner n 

MeSH headings : Aluminum Oxide / pharmacology; Animals; Cell Death / drug effects; Cell Line; Cytokines / metabolism; Humans; Inflammation / pathology; Interleukin-1beta / biosynthesis; Interleukin-6 / metabolism; Leukocytes, Mononuclear / drug effects; Leukocytes, Mononuclear / metabolism; Lung / drug effects; Lung / metabolism; Lung / pathology; Macrophages / drug effects; Macrophages / metabolism; Macrophages / ultrastructure; Mice, Inbred C57BL; Nanotechnology / methods; Nanotubes, Carbon / chemistry; Nanotubes, Carbon / ultrastructure; Osteopontin / metabolism; Phagocytes / drug effects; Phagocytes / metabolism; Pulmonary Fibrosis; Soot / pharmacology; Surface Properties; Tumor Necrosis Factor-alpha / metabolism
TL;DR: Findings indicate that ALD thin film coating of MWCNTs with Al2O3 reduces fibrosis in mice and that in vitro phagocyte expression of IL-6, TNF-α, and OPN, but not IL-1β, predict M WCNT-induced fibrosisIn the lungs of mice in vivo. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

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