Leigh Ann Samsa

Works (4)

Updated: July 5th, 2023 15:32

2022 article

Media portrayal of ethical and social issues in brain organoid research

Presley, A., Samsa, L. A., & Dubljević, V. (2022, April 13). Philosophy Ethics and Humanities in Medicine, Vol. 4.

By: A. Presley n, L. Samsa* & V. Dubljević n 

author keywords: Brain organoid; Cerebroid; Bioethics; Neuroethics; Media
MeSH headings : Animals; Brain / physiology; Chimera; Consciousness / physiology; Ethics, Research; Humans; Organoids / physiology
topics (OpenAlex): Neuroethics, Human Enhancement, Biomedical Innovations; Psychology of Moral and Emotional Judgment; Pluripotent Stem Cells Research
TL;DR: A systematic review of media literature indexed in the Nexis Uni database from 2013–2019 suggests increasing polarization, coupled with misplaced and unfounded ethical concern in brain organoid research. (via Semantic Scholar)
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10. Reduced Inequalities (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: April 14, 2022

2021 journal article

Divide and Conquer: A Simple Modern Technique for Collaborative Small Group Learning with Reciprocal Peer Teaching

Journal of Microbiology and Biology Education, 22(1), ev22i1-2153.

By: L. Samsa* & C. Goller n 

Contributors: L. Samsa* & C. Goller n 

topics (OpenAlex): Innovative Teaching and Learning Methods; Innovative Teaching Methods; Problem and Project Based Learning
TL;DR: Divide and Conquer is a simple, easy-to-use, and modern technique that faculty and instructors can use to rapidly transform traditional lecture content into collaborative small group learning and peer-teaching experiences. (via Semantic Scholar)
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4. Quality Education (Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 21, 2021

2018 article

A Guide to Reproducibility in Preclinical Research

Samsa, G., & Samsa, L. (2018, July 11). Academic Medicine.

By: G. Samsa * & L. Samsa n

MeSH headings : Biomedical Research / standards; Clinical Trials as Topic / standards; Guidelines as Topic; Humans; Reproducibility of Results; Research Design / standards; United States
topics (OpenAlex): Meta-analysis and systematic reviews; Cell Image Analysis Techniques; Ethics in Clinical Research
TL;DR: This Perspective, the authors address this “reproducibility crisis” by distilling discussions around reproducibility into a simple guide to facilitate understanding of the topic. (via Semantic Scholar)
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Source: Web Of Science
Added: January 14, 2019

2018 journal article

IL22 Inhibits Epithelial Stem Cell Expansion in an Ileal Organoid Model

Cellular and Molecular Gastroenterology and Hepatology, 7(1), 1–17.

By: B. Zwarycz*, A. Gracz *, K. Rivera n, I. Williamson n , L. Samsa*, J. Starmer*, M. Daniele n , L. Salter-Cid *, Q. Zhao*, S. Magness n

Contributors: B. Zwarycz*, A. Gracz *, K. Rivera n, I. Williamson n , L. Samsa*, J. Starmer*, M. Daniele n , . al.

author keywords: Intestinal Stem Cells; Interleukin-22; Inflammatory Bowel Disease
MeSH headings : Animals; Biomarkers / metabolism; Cell Lineage / drug effects; Cell Proliferation / drug effects; Cell Self Renewal / drug effects; Cellular Microenvironment / drug effects; Computer Simulation; Epithelial Cells / cytology; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Ileum / cytology; Inflammatory Bowel Diseases / pathology; Interleukins / pharmacology; Mice, Inbred C57BL; Models, Biological; Organoids / cytology; Organoids / drug effects; Organoids / metabolism; Receptors, Interleukin / metabolism; Serum / metabolism; Stem Cells / cytology; Stem Cells / drug effects; Stem Cells / metabolism
topics (OpenAlex): Cancer Cells and Metastasis; IL-33, ST2, and ILC Pathways; Single-cell and spatial transcriptomics
TL;DR: Increased IL22 limits ISC expansion in favor of increased TA progenitor cell expansion, and chronically increased IL22 levels, similar to predicted microenvironment levels, showed increases in proliferative cells in the TA zone with no increase in ISCs. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: January 14, 2019

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