Likun Duan

Biochemistry

Works (8)

Updated: April 25th, 2025 18:01

2024 article

Data-dependent and -independent acquisition lipidomics analysis reveals the tissue-dependent effect of metformin on lipid metabolism

Scheidemantle, G., Duan, L., Lodge, M., Cummings, M. J., Hilovsky, D., Pham, E., … Liu, X. (2024, May 9). Metabolomics, Vol. 20.

By: G. Scheidemantle n, L. Duan n, M. Lodge n, M. Cummings n, D. Hilovsky n, E. Pham n, X. Wang n , A. Kennedy n , X. Liu n

author keywords: Metformin; Intestinal metabolism; Lipidomics; DIA
MeSH headings : Metformin / pharmacology; Metformin / metabolism; Animals; Mice; Male; Lipidomics / methods; Lipid Metabolism / drug effects; Lipids / blood; Hypoglycemic Agents / pharmacology; Hypoglycemic Agents / metabolism; Mice, Inbred C57BL; Tandem Mass Spectrometry / methods
topics (OpenAlex): Metabolomics and Mass Spectrometry Studies; Advanced Proteomics Techniques and Applications; Metabolism, Diabetes, and Cancer
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Sources: Web Of Science, NC State University Libraries
Added: May 20, 2024

2024 article

Metabolic regulation of the glioblastoma stem cell epitranscriptome by malate dehydrogenase 2

Lv, D., Dixit, D., Cruz, A. F., Kim, L. J. Y., Duan, L., Xu, X., … Rich, J. N. (2024, October 24). Cell Metabolism.

By: D. Lv *, D. Dixit *, A. Cruz *, L. Kim, L. Duan*, X. Xu *, Q. Wu *, C. Zhong* ...

MeSH headings : Glioblastoma / metabolism; Glioblastoma / pathology; Glioblastoma / genetics; Neoplastic Stem Cells / metabolism; Neoplastic Stem Cells / pathology; Humans; Malate Dehydrogenase / metabolism; Malate Dehydrogenase / genetics; Animals; Mice; Transcriptome; Cell Line, Tumor; Brain Neoplasms / metabolism; Brain Neoplasms / pathology; Brain Neoplasms / genetics; Gene Expression Regulation, Neoplastic; Cell Proliferation / drug effects
topics (OpenAlex): RNA modifications and cancer; Cancer, Hypoxia, and Metabolism; Epigenetics and DNA Methylation
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2. Zero Hunger (OpenAlex)
Source: Web Of Science
Added: November 18, 2024

2024 article

Targeting glutamine metabolism improves sarcoma response to radiation therapy in vivo

Patel, R., Cooper, D. E., Kadakia, K. T., Allen, A., Duan, L., Luo, L., … Kirsch, D. G. (2024, May 20). Communications Biology.

By: R. Patel *, D. Cooper *, K. Kadakia *, A. Allen *, L. Duan n, L. Luo *, N. Williams *, X. Liu n, J. Locasale  n, D. Kirsch

MeSH headings : Animals; Glutamine / metabolism; Mice; Glutaminase / metabolism; Glutaminase / genetics; Glutaminase / antagonists & inhibitors; Sarcoma / metabolism; Sarcoma / radiotherapy; Sarcoma / genetics; Glucose / metabolism; Disease Models, Animal; Radiation Tolerance
topics (OpenAlex): Cancer, Hypoxia, and Metabolism; Cancer Research and Treatments; Glioma Diagnosis and Treatment
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Source: Web Of Science
Added: June 3, 2024

2023 article

43 Metabolomic Analysis of Uterine Luminal Fluid During the Peri-Implantation Period of Pregnancy in Pigs

Liu, B., Duan, L., Liu, X., & Wang, X. (2023, May 1). Journal of Animal Science, Vol. 101.

By: B. Liu n , L. Duan n, X. Liu n & X. Wang n 

author keywords: metabolomics; pig; pregnancy
topics (OpenAlex): Reproductive Physiology in Livestock; Effects of Environmental Stressors on Livestock; Animal Behavior and Welfare Studies
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3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: March 4, 2024

2023 article

Immunoediting instructs tumor metabolic reprogramming to support immune evasion

Tsai, C.-H., Chuang, Y.-M., Li, X., Yu, Y.-R., Tzeng, S.-F., Teoh, S. T., … Ho, P.-C. (2023, January 1). Cell Metabolism.

By: C. Tsai *, Y. Chuang*, X. Li *, Y. Yu *, S. Tzeng *, S. Teoh *, K. Lindblad *, M. Matteo * ...

MeSH headings : Humans; Immune Evasion; Neoplasms / pathology; Interferon-gamma / metabolism; T-Lymphocytes / metabolism; Carcinogenesis; Cell Transformation, Neoplastic; Tumor Microenvironment
topics (OpenAlex): Cancer, Hypoxia, and Metabolism; Immune cells in cancer; Autophagy in Disease and Therapy
TL;DR: The findings uncover that immunoediting instructs deregulated bioenergetic programs in tumor cells to empower them to disarm the T cell-mediated immunosurveillance by imposing metabolic tug-of-war between tumor and infiltrating T cells and forming the suppressive tumor microenvironment. (via Semantic Scholar)
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Source: Web Of Science
Added: February 20, 2023

2022 article

13C tracer analysis suggests extensive recycling of endogenous CO2 in vivo

Duan, L., Cooper, D. E., Scheidemantle, G., Locasale, J. W., Kirsch, D. G., & Liu, X. (2022, July 7). Cancer & Metabolism.

By: L. Duan n, D. Cooper *, G. Scheidemantle n, J. Locasale *, D. Kirsch * & X. Liu n

author keywords: C-13 tracing; High-resolution mass spectrometry; Anaplerotic metabolism; CO2 recycling
topics (OpenAlex): Cancer, Hypoxia, and Metabolism; Metabolomics and Mass Spectrometry Studies; Mitochondrial Function and Pathology; Diet and metabolism studies
TL;DR: The results show that recycling of endogenous CO2 is substantial in vivo and incorporation of endogenous 13CO2 into M’+ 1 metabolites is substantial and should be considered, and provide a new paradigm to understand carbon atom transformations in vivo. (via Semantic Scholar)
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Source: Web Of Science
Added: July 18, 2022

2022 article

Prioritize biologically relevant ions for data-independent acquisition (BRI-DIA) in LC–MS/MS-based lipidomics analysis

Duan, L., Scheidemantle, G., Lodge, M., Cummings, M. J., Pham, E., Wang, X., … Liu, X. (2022, July 16). Metabolomics, Vol. 7.

By: L. Duan n, G. Scheidemantle n, M. Lodge n, M. Cummings n, E. Pham n, X. Wang n , A. Kennedy n , X. Liu n

MeSH headings : Animals; Cardiolipins; Chromatography, Liquid / methods; Ions; Lipidomics; Metabolomics; Mice; Reproducibility of Results; Tandem Mass Spectrometry / methods
topics (OpenAlex): Metabolomics and Mass Spectrometry Studies; Mitochondrial Function and Pathology; Advanced Proteomics Techniques and Applications
TL;DR: A novel workflow using biologically relevant lipids to construct inclusion list for data-independent acquisition (DIA), named as BRI-DIA workflow, which is as efficient as traditional DDA method in profiling lipids, but offers better consistency of lipid identification, compared to D DA method. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: July 26, 2022

2021 article

Reinforcing one-carbon metabolism via folic acid/Folr1 promotes β-cell differentiation

Karampelias, C., Rezanejad, H., Rosko, M., Duan, L., Lu, J., Pazzagli, L., … Andersson, O. (2021, June 7). Nature Communications.

By: C. Karampelias *, H. Rezanejad*, M. Rosko*, L. Duan n, J. Lu *, L. Pazzagli *, P. Bertolino *, C. Cesta * ...

MeSH headings : Animals; Animals, Genetically Modified; Animals, Newborn; Carbon / metabolism; Carnitine / metabolism; Cell Differentiation / drug effects; Cell Differentiation / genetics; Cells, Cultured; Folate Receptor 1 / genetics; Folate Receptor 1 / metabolism; Gene Expression Regulation / drug effects; Humans; Insulin-Secreting Cells / cytology; Insulin-Secreting Cells / metabolism; Larva / genetics; Larva / metabolism; Leucovorin / pharmacology; Metabolic Networks and Pathways / drug effects; Mice; Pyrimidines / metabolism; Swine; Zebrafish / genetics; Zebrafish / metabolism
topics (OpenAlex): Pancreatic function and diabetes; Diabetes and associated disorders; Genetics and Neurodevelopmental Disorders
TL;DR: It is found that both folate receptor 1 (folr1) overexpression and treatment with folinic acid, stimulated β-cell differentiation in zebrafish, suggesting evolutionarily conserved and previously unknown roles for folic acid and one-carbon metabolism in the generation of β-cells. (via Semantic Scholar)
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Source: Web Of Science
Added: July 19, 2021

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