Likun Duan
Biochemistry
Works (5)
Updated: March 5th, 2024 05:02
2023 journal article
Immunoediting instructs tumor metabolic reprogramming to support immune evasion
CELL METABOLISM, 35(1), 118-+.
MeSH headings : Humans; Immune Evasion; Neoplasms / pathology; Interferon-gamma / metabolism; T-Lymphocytes / metabolism; Carcinogenesis; Cell Transformation, Neoplastic; Tumor Microenvironment
TL;DR:
The findings uncover that immunoediting instructs deregulated bioenergetic programs in tumor cells to empower them to disarm the T cell-mediated immunosurveillance by imposing metabolic tug-of-war between tumor and infiltrating T cells and forming the suppressive tumor microenvironment.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: February 20, 2023
2023 article
Metabolomic Analysis of Uterine Luminal Fluid During the Peri-Implantation Period of Pregnancy in Pigs
Liu, B., Duan, L., Liu, X., & Wang, X. (2023, May). JOURNAL OF ANIMAL SCIENCE, Vol. 101.
author keywords: metabolomics; pig; pregnancy
academic.oup.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Web Of Science, ORCID
Added: March 4, 2024
2022 journal article
C-13 tracer analysis suggests extensive recycling of endogenous CO2 in vivo
CANCER & METABOLISM, 10(1).
author keywords: C-13 tracing; High-resolution mass spectrometry; Anaplerotic metabolism; CO2 recycling
TL;DR:
The results show that recycling of endogenous CO2 is substantial in vivo and incorporation of endogenous 13CO2 into M’+ 1 metabolites is substantial and should be considered, and provide a new paradigm to understand carbon atom transformations in vivo.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: July 18, 2022
2022 journal article
Prioritize biologically relevant ions for data-independent acquisition (BRI-DIA) in LC-MS/MS-based lipidomics analysis
METABOLOMICS, 18(8).
MeSH headings : Animals; Cardiolipins; Chromatography, Liquid / methods; Ions; Lipidomics; Metabolomics; Mice; Reproducibility of Results; Tandem Mass Spectrometry / methods
TL;DR:
A novel workflow using biologically relevant lipids to construct inclusion list for data-independent acquisition (DIA), named as BRI-DIA workflow, which is as efficient as traditional DDA method in profiling lipids, but offers better consistency of lipid identification, compared to D DA method.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: July 26, 2022
2021 journal article
Reinforcing one-carbon metabolism via folic acid/Folr1 promotes beta-cell differentiation
NATURE COMMUNICATIONS, 12(1).
MeSH headings : Animals; Animals, Genetically Modified; Animals, Newborn; Carbon / metabolism; Carnitine / metabolism; Cell Differentiation / drug effects; Cell Differentiation / genetics; Cells, Cultured; Folate Receptor 1 / genetics; Folate Receptor 1 / metabolism; Gene Expression Regulation / drug effects; Humans; Insulin-Secreting Cells / cytology; Insulin-Secreting Cells / metabolism; Larva / genetics; Larva / metabolism; Leucovorin / pharmacology; Metabolic Networks and Pathways / drug effects; Mice; Pyrimidines / metabolism; Swine; Zebrafish / genetics; Zebrafish / metabolism
TL;DR:
It is found that both folate receptor 1 (folr1) overexpression and treatment with folinic acid, stimulated β-cell differentiation in zebrafish, suggesting evolutionarily conserved and previously unknown roles for folic acid and one-carbon metabolism in the generation of β-cells.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: July 19, 2021
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