Likun Duan

Biochemistry

Works (7)

Updated: June 4th, 2024 05:00

2024 journal article

Data-dependent and -independent acquisition lipidomics analysis reveals the tissue-dependent effect of metformin on lipid metabolism

METABOLOMICS, 20(3).

By: G. Scheidemantle n, L. Duan n, M. Lodge n, M. Cummings  n, D. Hilovsky n, E. Pham n, X. Wang n , A. Kennedy n , X. Liu

author keywords: Metformin; Intestinal metabolism; Lipidomics; DIA
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: May 20, 2024

2024 journal article

Targeting glutamine metabolism improves sarcoma response to radiation therapy in vivo

COMMUNICATIONS BIOLOGY, 7(1).

By: R. Patel *, D. Cooper *, K. Kadakia *, A. Allen *, L. Duan n, L. Luo *, N. Williams *, X. Liu n, J. Locasale  n, D. Kirsch *

UN Sustainable Development Goal Categories
Source: Web Of Science
Added: June 3, 2024

2023 journal article

Immunoediting instructs tumor metabolic reprogramming to support immune evasion

CELL METABOLISM, 35(1), 118-+.

By: C. Tsai *, Y. Chuang *, X. Li *, Y. Yu *, S. Tzeng *, S. Teoh *, K. Lindblad *, M. Di Matteo * ...

MeSH headings : Humans; Immune Evasion; Neoplasms / pathology; Interferon-gamma / metabolism; T-Lymphocytes / metabolism; Carcinogenesis; Cell Transformation, Neoplastic; Tumor Microenvironment
TL;DR: The findings uncover that immunoediting instructs deregulated bioenergetic programs in tumor cells to empower them to disarm the T cell-mediated immunosurveillance by imposing metabolic tug-of-war between tumor and infiltrating T cells and forming the suppressive tumor microenvironment. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: February 20, 2023

2023 article

Metabolomic Analysis of Uterine Luminal Fluid During the Peri-Implantation Period of Pregnancy in Pigs

Liu, B., Duan, L., Liu, X., & Wang, X. (2023, May). JOURNAL OF ANIMAL SCIENCE, Vol. 101.

By: B. Liu n , L. Duan n, X. Liu n & X. Wang n 

author keywords: metabolomics; pig; pregnancy
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: March 4, 2024

2022 journal article

C-13 tracer analysis suggests extensive recycling of endogenous CO2 in vivo

CANCER & METABOLISM, 10(1).

By: L. Duan n, D. Cooper *, G. Scheidemantle n, J. Locasale *, D. Kirsch * & X. Liu n

author keywords: C-13 tracing; High-resolution mass spectrometry; Anaplerotic metabolism; CO2 recycling
TL;DR: The results show that recycling of endogenous CO2 is substantial in vivo and incorporation of endogenous 13CO2 into M’+ 1 metabolites is substantial and should be considered, and provide a new paradigm to understand carbon atom transformations in vivo. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: July 18, 2022

2022 journal article

Prioritize biologically relevant ions for data-independent acquisition (BRI-DIA) in LC-MS/MS-based lipidomics analysis

METABOLOMICS, 18(8).

By: L. Duan n, G. Scheidemantle n, M. Lodge n, M. Cummings  n, E. Pham n, X. Wang n , A. Kennedy n , X. Liu

MeSH headings : Animals; Cardiolipins; Chromatography, Liquid / methods; Ions; Lipidomics; Metabolomics; Mice; Reproducibility of Results; Tandem Mass Spectrometry / methods
TL;DR: A novel workflow using biologically relevant lipids to construct inclusion list for data-independent acquisition (DIA), named as BRI-DIA workflow, which is as efficient as traditional DDA method in profiling lipids, but offers better consistency of lipid identification, compared to D DA method. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: July 26, 2022

2021 journal article

Reinforcing one-carbon metabolism via folic acid/Folr1 promotes beta-cell differentiation

NATURE COMMUNICATIONS, 12(1).

By: C. Karampelias *, H. Rezanejad*, M. Rosko*, L. Duan n, J. Lu *, L. Pazzagli *, P. Bertolino *, C. Cesta * ...

MeSH headings : Animals; Animals, Genetically Modified; Animals, Newborn; Carbon / metabolism; Carnitine / metabolism; Cell Differentiation / drug effects; Cell Differentiation / genetics; Cells, Cultured; Folate Receptor 1 / genetics; Folate Receptor 1 / metabolism; Gene Expression Regulation / drug effects; Humans; Insulin-Secreting Cells / cytology; Insulin-Secreting Cells / metabolism; Larva / genetics; Larva / metabolism; Leucovorin / pharmacology; Metabolic Networks and Pathways / drug effects; Mice; Pyrimidines / metabolism; Swine; Zebrafish / genetics; Zebrafish / metabolism
TL;DR: It is found that both folate receptor 1 (folr1) overexpression and treatment with folinic acid, stimulated β-cell differentiation in zebrafish, suggesting evolutionarily conserved and previously unknown roles for folic acid and one-carbon metabolism in the generation of β-cells. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: July 19, 2021

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