Mahsa Mohiti Asli

Works (7)

Updated: July 5th, 2023 15:42

2017 journal article

Creation and Evaluation of New Porcine Model for Investigation of Treatments of Surgical Site Infection

TISSUE ENGINEERING PART C-METHODS, 23(11), 795–803.

By: M. Mohiti-Asli n, M. Risselada n, M. Jacob n, B. Pourdeyhimi n  & E. Loboa n

author keywords: surgical site infection; porcine model; antimicrobial scaffold; silver; electrospinning; MRSA
MeSH headings : Animals; Anti-Infective Agents / pharmacology; Anti-Infective Agents / therapeutic use; Disease Models, Animal; Female; Methicillin-Resistant Staphylococcus aureus / drug effects; Nanofibers / chemistry; Nanofibers / ultrastructure; Polyesters / chemistry; Porosity; Surgical Wound Infection / drug therapy; Surgical Wound Infection / microbiology; Surgical Wound Infection / pathology; Sus scrofa; Tissue Scaffolds / chemistry
TL;DR: A porcine full-thickness incision model to investigate SSI caused by methicillin-resistant Staphylococcus aureus is developed, and the potential of silver releasing nanofibrous scaffolds for treatment/prevention of SSI is confirmed, and a new porcines model is introduced for in vivo evaluation of additional SSI treatment approaches are introduced. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 journal article

Fabrication and Evaluation of Electrospun, 3D-Bioplotted, and Combination of Electrospun/3D-Bioplotted Scaffolds for Tissue Engineering Applications

BIOMED RESEARCH INTERNATIONAL, 2017.

By: L. Mellor n, P. Huebner  n, S. Cai n, M. Mohiti-Asli n, M. Taylor n, J. Spang*, R. Shirwaiker n , E. Loboa*

Contributors: L. Mellor n, P. Huebner  n, S. Cai n, M. Mohiti-Asli n, M. Taylor n, J. Spang*, R. Shirwaiker n , E. Loboa*

MeSH headings : Animals; Cells, Cultured; Extracellular Matrix / chemistry; Humans; Nanofibers / chemistry; Nanofibers / therapeutic use; Polyesters / chemistry; Polyesters / therapeutic use; Porosity; Printing, Three-Dimensional; Swine; Tissue Engineering / methods; Tissue Scaffolds / chemistry
TL;DR: The approach combining these two commonly used scaffold fabrication technologies allows for the creation of a scaffold with more close resemblance to heterogeneous tissue architecture, holding great potential for tissue engineering and regenerative medicine applications of osteochondral tissue and other heterogeneous tissues. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2017 journal article

Ibuprofen loaded PLA nanofibrous scaffolds increase proliferation of human skin cells in vitro and promote healing of full thickness incision wounds in vivo

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, 105(2), 327–339.

By: M. Mohiti-Asli n, S. Saha n, S. Murphy *, H. Gracz n, B. Pourdeyhimi n , A. Atala*, E. Loboa n

author keywords: controlled release; drug delivery/release; inflammation; PLLA; wound healing
MeSH headings : Animals; Dermis / injuries; Dermis / metabolism; Dermis / pathology; Drug Carriers / chemistry; Drug Carriers / pharmacokinetics; Drug Carriers / pharmacology; Fibroblasts / metabolism; Fibroblasts / pathology; Humans; Ibuprofen / chemistry; Ibuprofen / pharmacokinetics; Ibuprofen / pharmacology; Keratinocytes / metabolism; Keratinocytes / pathology; Mice, Nude; Nanofibers / chemistry; Nanofibers / therapeutic use; Polyesters / chemistry; Polyesters / pharmacokinetics; Polyesters / pharmacology; Wound Healing / drug effects
TL;DR: It is found that degradable anti-inflammatory scaffolds containing 20 wt % ibuprofen promote human skin cell viability and proliferation in vitro, reduce wound contraction in vivo, and when seeded with skin cells, also enhance new blood vessel formation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2016 journal article

Electrospun nanofibrous scaffolds increase the efficacy of stem cell-mediated therapy of surgically resected glioblastoma

BIOMATERIALS, 90, 116–125.

By: J. Bago *, G. Pegna*, O. Okolie*, M. Mohiti-Asli n, E. Loboa n & S. Hingtgen *

author keywords: Cytotoxic stem cell; Electrospun nanofibrous scaffolds; Surgical resection; Cancer; Molecular imaging
MeSH headings : Animals; Antineoplastic Agents / administration & dosage; Antineoplastic Agents / therapeutic use; Brain / pathology; Brain / surgery; Brain Neoplasms / pathology; Brain Neoplasms / surgery; Brain Neoplasms / therapy; Cell Line; Cell Line, Tumor; Drug Delivery Systems / methods; Glioblastoma / pathology; Glioblastoma / surgery; Glioblastoma / therapy; Humans; Mice, Nude; Nanofibers / chemistry; Nanofibers / ultrastructure; Polyesters / chemistry; Stem Cell Transplantation / methods; Stem Cells / cytology; Tissue Scaffolds / chemistry
TL;DR: A biocompatible electrospun nanofibrous scaffold (bENS) implant capable of delivering and retaining tumor-homing cytotoxic stem cells that suppress recurrence of post-surgical GBM is described. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Evaluation of Silver Ion-Releasing Scaffolds in a 3D Coculture System of MRSA and Human Adipose-Derived Stem Cells for Their Potential Use in Treatment or Prevention of Osteomyelitis

TISSUE ENGINEERING PART A, 22(21-22), 1258–1263.

By: M. Mohiti-Asli n, C. Molina n, T. Diteepeng *, B. Pourdeyhimi n  & E. Loboa n

author keywords: nanofiber; antimicrobial; coculture; osteomyelitis
MeSH headings : Adipose Tissue / metabolism; Cell Differentiation / drug effects; Coculture Techniques; Humans; Methicillin-Resistant Staphylococcus aureus / growth & development; Osteogenesis / drug effects; Osteomyelitis / prevention & control; Silver / chemistry; Silver / pharmacokinetics; Silver / pharmacology; Stem Cells / metabolism; Tissue Scaffolds / chemistry
TL;DR: It is suggested that these biocompatible, degradable, silver ion-releasing scaffolds can be used at an infection site to treat osteomyelitis and/or to coat bone implants as a preventative measure against infection postsurgery. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 journal article

Extracellular Calcium Modulates Chondrogenic and Osteogenic Differentiation of Human Adipose-Derived Stem Cells: A Novel Approach for Osteochondral Tissue Engineering Using a Single Stem Cell Source

TISSUE ENGINEERING PART A, 21(17-18), 2323–2333.

By: L. Mellor n, M. Mohiti-Asli n, J. Williams n, A. Kannan n, M. Dent n, F. Guilak *, E. Loboa n

MeSH headings : Adipose Tissue / cytology; Adult; Calcification, Physiologic / drug effects; Calcium / pharmacology; Calcium Phosphates / pharmacology; Cell Differentiation / drug effects; Cells, Cultured; Chondrogenesis / drug effects; Extracellular Space / chemistry; Gene Expression Regulation / drug effects; Glycosaminoglycans / metabolism; Humans; Immunohistochemistry; Lactic Acid / pharmacology; Osteogenesis / drug effects; Polyesters; Polymers / pharmacology; Stem Cells / cytology; Stem Cells / drug effects; Stem Cells / ultrastructure; Tissue Engineering / methods; Tissue Scaffolds; Young Adult
TL;DR: This is the first study to report the effects of elevated calcium on chondrogenic differentiation of hASC, and to develop osteochondral nanofibrous scaffolds using a single cell source and controlled calcium release to induce site-specific differentiation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Skin Tissue Engineering for the Infected Wound Site: Biodegradable PLA Nanofibers and a Novel Approach for Silver Ion Release Evaluated in a 3D Coculture System of Keratinocytes and Staphylococcus aureus

TISSUE ENGINEERING PART C-METHODS, 20(10), 790–797.

By: M. Mohiti-Asli n, B. Pourdeyhimi n  & E. Loboa n

MeSH headings : Biocompatible Materials / chemistry; Cell Proliferation / drug effects; Cell Survival / drug effects; Coculture Techniques; DNA / metabolism; Epidermal Cells; Humans; Ions; Keratinocytes / cytology; Keratinocytes / drug effects; Keratinocytes / ultrastructure; Lactic Acid / chemistry; Nanofibers / chemistry; Nanofibers / ultrastructure; Polyesters; Polymers / chemistry; Porosity; Silver / analysis; Skin / pathology; Staphylococcus aureus / cytology; Staphylococcus aureus / drug effects; Staphylococcus aureus / growth & development; Tissue Engineering / methods; Tissue Scaffolds / chemistry; Wound Infection / microbiology; Wound Infection / pathology
TL;DR: It is found that highly porous AgMPs could be successfully incorporated in nanofibrous wound dressings, and exhibited comparable antimicrobial efficacy and cytotoxicity to AgNPs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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