Rocco M. DiSanto

Works (3)

Updated: July 13th, 2023 21:18

2015 journal article

Microneedle-array patches loaded with hypoxia-sensitive vesicles provide fast glucose-responsive insulin delivery

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 112(27), 8260–8265.

By: J. Yu n, Y. Zhang*, Y. Ye*, R. DiSanto*, W. Sun*, D. Ranson n, F. Ligler*, J. Buse *, Z. Gu n

author keywords: diabetes; drug delivery; glucose-responsive; hypoxia-sensitive; microneedle
MeSH headings : Animals; Blood Glucose / analysis; Diabetes Mellitus, Experimental / blood; Diabetes Mellitus, Experimental / drug therapy; Diabetes Mellitus, Type 1 / blood; Diabetes Mellitus, Type 1 / drug therapy; Drug Delivery Systems / instrumentation; Drug Delivery Systems / methods; Glucose / metabolism; Glucose Oxidase / metabolism; Humans; Hyaluronic Acid / chemistry; Hyaluronic Acid / metabolism; Hypoglycemic Agents / administration & dosage; Hypoglycemic Agents / chemistry; Hypoxia / metabolism; Insulin / administration & dosage; Insulin / chemistry; Insulin / metabolism; Male; Mice, Inbred C57BL; Microscopy, Electron, Transmission; Molecular Structure; Oxidation-Reduction; Reproducibility of Results
TL;DR: The “smart insulin patch” with a new enzyme-based glucose-responsive mechanism can regulate the blood glucose of type 1 diabetic mice to achieve normal levels, with faster responsiveness compared with the commonly used pH-sensitive formulations, and can avoid the risk of hypoglycemia. (via Semantic Scholar)
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Added: August 6, 2018

2015 review

Recent advances in nanotechnology for diabetes treatment

[Review of ]. WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY, 7(4), 548–564.

By: R. DiSanto n, V. Subramanian n & Z. Gu n

MeSH headings : Diabetes Mellitus / therapy; Electrochemical Techniques; Glucose / analysis; Humans; Insulin / administration & dosage; Insulin Infusion Systems; Nanotechnology / trends
TL;DR: Recent progress in the field of diabetes research at its interface with nanotechnology is examined, including glucose sensors with nanoscale components including metal nanoparticles and carbon nanostructures and 'Closing the loop' between BGL measurements and insulin administration by removing the requirement of patient action is discussed. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2014 journal article

ATP-triggered anticancer drug delivery

NATURE COMMUNICATIONS, 5.

By: R. Mo n, T. Jiang n, R. DiSanto n, W. Tai  n & Z. Gu*

MeSH headings : Adenosine Triphosphate / chemistry; Animals; Antineoplastic Agents / administration & dosage; Antineoplastic Agents / pharmacokinetics; Apoptosis; Cell Line; Cell Line, Tumor; Doxorubicin / administration & dosage; Doxorubicin / pharmacokinetics; Drug Carriers / chemistry; Female; Humans; MCF-7 Cells; Mice; Mice, Nude; Nanoparticles / chemistry; Polymers / chemistry; Xenograft Model Antitumor Assays
TL;DR: Nanocarriers are developed that take advantage of high ATP levels in tumour cells and show that these nanoparticles encapsulating the chemotherapeutic doxorubicin can inhibit tumour growth in mice. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

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