Rocco M. DiSanto

author keywords: diabetes; drug delivery; glucose-responsive; hypoxia-sensitive; microneedle

MeSH headings : Animals; Blood Glucose / analysis; Diabetes Mellitus, Experimental / blood; Diabetes Mellitus, Experimental / drug therapy; Diabetes Mellitus, Type 1 / blood; Diabetes Mellitus, Type 1 / drug therapy; Drug Delivery Systems / instrumentation; Drug Delivery Systems / methods; Glucose / metabolism; Glucose Oxidase / metabolism; Humans; Hyaluronic Acid / chemistry; Hyaluronic Acid / metabolism; Hypoglycemic Agents / administration & dosage; Hypoglycemic Agents / chemistry; Hypoxia / metabolism; Insulin / administration & dosage; Insulin / chemistry; Insulin / metabolism; Male; Mice, Inbred C57BL; Microscopy, Electron, Transmission; Molecular Structure; Oxidation-Reduction; Reproducibility of Results

topics (OpenAlex): Advancements in Transdermal Drug Delivery; Advanced Drug Delivery Systems; Lipid Membrane Structure and Behavior

TL;DR: The “smart insulin patch” with a new enzyme-based glucose-responsive mechanism can regulate the blood glucose of type 1 diabetic mice to achieve normal levels, with faster responsiveness compared with the commonly used pH-sensitive formulations, and can avoid the risk of hypoglycemia. (via Semantic Scholar)

MeSH headings : Diabetes Mellitus / therapy; Electrochemical Techniques; Glucose / analysis; Humans; Insulin / administration & dosage; Insulin Infusion Systems; Nanotechnology / trends

topics (OpenAlex): Electrochemical sensors and biosensors; Graphene and Nanomaterials Applications; Advanced biosensing and bioanalysis techniques

TL;DR: Recent progress in the field of diabetes research at its interface with nanotechnology is examined, including glucose sensors with nanoscale components including metal nanoparticles and carbon nanostructures and 'Closing the loop' between BGL measurements and insulin administration by removing the requirement of patient action is discussed. (via Semantic Scholar)

MeSH headings : Adenosine Triphosphate / chemistry; Animals; Antineoplastic Agents / administration & dosage; Antineoplastic Agents / pharmacokinetics; Apoptosis; Cell Line; Cell Line, Tumor; Doxorubicin / administration & dosage; Doxorubicin / pharmacokinetics; Drug Carriers / chemistry; Female; Humans; MCF-7 Cells; Mice; Mice, Nude; Nanoparticles / chemistry; Polymers / chemistry; Xenograft Model Antitumor Assays

topics (OpenAlex): RNA Interference and Gene Delivery; Nanoparticle-Based Drug Delivery; Nanoplatforms for cancer theranostics

TL;DR: Nanocarriers are developed that take advantage of high ATP levels in tumour cells and show that these nanoparticles encapsulating the chemotherapeutic doxorubicin can inhibit tumour growth in mice. (via Semantic Scholar)