Xiaojun Li

Works (6)

Updated: October 14th, 2025 15:10

2025 article

Comparison of a Nonheme Iron Cyclopropanase with a Homologous Hydroxylase Reveals Mechanistic Features Associated with Distinct Reaction Outcomes

Zheng, Y.-C., Li, X., Cha, L., Paris, J. C., Michael, C., Ushimaru, R., … Chang, W.-chen. (2025, February 4). Journal of the American Chemical Society, Vol. 2.

By: Y. Zheng n , X. Li n, L. Cha n , J. Paris *, C. Michael n, R. Ushimaru *, Y. Ogasawara *, I. Abe *, Y. Guo *, W. Chang n 

MeSH headings : Mixed Function Oxygenases / chemistry; Mixed Function Oxygenases / metabolism; Cyclopropanes / chemistry; Cyclopropanes / metabolism; Models, Molecular; Iron / chemistry; Nonheme Iron Proteins / chemistry; Nonheme Iron Proteins / metabolism; Kinetics
topics (OpenAlex): Metal-Catalyzed Oxygenation Mechanisms; Metalloenzymes and iron-sulfur proteins; Porphyrin Metabolism and Disorders
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: February 17, 2025

2025 article

Multiple Catalytic Branch Points in the Mechanism of Pyrrolidine Formation During Kainoid Biosynthesis Leads to Diverse Reaction Outcomes

Chen, T.-Y., Ruszczycky, M. W., Yao, A., Li, X., Chien, T.-C., & Chang, W.-chen. (2025, August 5). Journal of the American Chemical Society, Vol. 8.

By: T. Chen n, M. Ruszczycky*, A. Yao n, X. Li n, T. Chien * & W. Chang n 

topics (OpenAlex): Metal-Catalyzed Oxygenation Mechanisms; Photosynthetic Processes and Mechanisms; Metalloenzymes and iron-sulfur proteins; Radical Photochemical Reactions
Sources: Web Of Science, NC State University Libraries
Added: August 18, 2025

2023 article

A Ferric-Superoxide Intermediate Initiates P450-Catalyzed Cyclic Dipeptide Dimerization

Gering, H. E., Li, X., Tang, H., Swartz, P. D., Chang, W.-C., & Makris, T. M. (2023, August 23). Journal of the American Chemical Society, Vol. 8.

By: H. Gering n, X. Li n, H. Tang n, P. Swartz n, W. Chang n  & T. Makris n 

MeSH headings : Superoxides; Dimerization; Iron; Cytochrome P-450 Enzyme System; Oxidants; Diketopiperazines; Dipeptides; Electrolytes; Catalysis
topics (OpenAlex): Alkaloids: synthesis and pharmacology; Pharmacogenetics and Drug Metabolism
Sources: Web Of Science, NC State University Libraries, ORCID
Added: September 11, 2023

2023 article

Mechanistic Analysis of Stereodivergent Nitroalkane Cyclopropanation Catalyzed by Nonheme Iron Enzymes

Ushimaru, R., Cha, L., Shimo, S., Li, X., Paris, J. C., Mori, T., … Abe, I. (2023, October 24). Journal of the American Chemical Society, Vol. 145, pp. 24210–24217.

By: R. Ushimaru *, L. Cha n , S. Shimo*, X. Li n, J. Paris *, T. Mori *, K. Miyamoto *, L. Coffer n ...

MeSH headings : Stereoisomerism; Aminocaproates; Oxidation-Reduction
topics (OpenAlex): Metal-Catalyzed Oxygenation Mechanisms; Asymmetric Hydrogenation and Catalysis; Cyclopropane Reaction Mechanisms
TL;DR: The results suggest that the nitroalkane moiety of the substrate is first deprotonated to produce the nitronate form, and Sequence and structure comparisons of these cyclopropanases enable us to determine the amino acid residues critical for controlling the stereoselectivity of cycloprostanation. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: December 11, 2023

2022 article

Mechanism of Methyldehydrofosmidomycin Maturation: Use Olefination to Enable Chain Elongation

Li, X., Xue, S., Guo, Y., & Chang, W.-chen. (2022, April 28). Journal of the American Chemical Society, Vol. 5.

By: X. Li n, S. Xue *, Y. Guo * & W. Chang n 

MeSH headings : Alkenes / chemistry; Catalysis; Hydroxylation; Iron / chemistry; Ketoglutaric Acids / metabolism
topics (OpenAlex): Metal-Catalyzed Oxygenation Mechanisms; Synthesis and Catalytic Reactions; Metalloenzymes and iron-sulfur proteins
TL;DR: This work characterized the reactive species, revealed the structure of the reaction intermediate, and used mechanistic probes to investigate the reaction pathway and mechanism, leading to the elucidation of a two-step process in which the first reaction employs a long-lived Fe(IV)-oxo species to trigger C═C bond installation. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: June 6, 2022

2021 article

Identification of Cyclopropane Formation in the Biosyntheses of Hormaomycins and Belactosins: Sequential Nitration and Cyclopropanation by Metalloenzymes

Li, X., Shimaya, R., Dairi, T., Chang, W., & Ogasawara, Y. (2021, December 14). Angewandte Chemie International Edition, Vol. 12.

By: X. Li n, R. Shimaya*, T. Dairi *, W. Chang n  & Y. Ogasawara *

author keywords: Biosynthesis; Cyclopropane; Metalloenzymes; Natural products; Peptides
MeSH headings : Catalysis; Cyclopropanes / chemistry; Cyclopropanes / metabolism; Depsipeptides / chemistry; Depsipeptides / metabolism; Intercellular Signaling Peptides and Proteins / chemistry; Intercellular Signaling Peptides and Proteins / metabolism; Metalloproteins / chemistry; Metalloproteins / metabolism; Molecular Structure
topics (OpenAlex): Metal-Catalyzed Oxygenation Mechanisms; Synthetic Organic Chemistry Methods; Microbial Natural Products and Biosynthesis
TL;DR: Observations disclose a novel pathway of cyclopropane ring construction and exemplify the new chemistry involving metalloenzymes in natural product biosynthesis. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: January 10, 2022

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