Works Published in 2014
Displaying works 301 - 320 of 706 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2014 journal article
Comparing metabolomic and pathologic biomarkers alone and in combination for discriminating Alzheimer's disease from normal cognitive aging
Acta Neuropathologica Communications, 2(1).
Contributors: A. Motsinger-Reif n, H. Zhu *, M. Kling*, W. Matson*, S. Sharma *, O. Fiehn *, D. Reif n , D. Appleby *
author keywords: Alzheimer's disease; Dementias; Metabolomics; Cerebrospinal fluid biomarkers; Stepwise logistic regression
MeSH headings : Aged; Aging / cerebrospinal fluid; Aging / drug effects; Aging / pathology; Alzheimer Disease / cerebrospinal fluid; Alzheimer Disease / diagnosis; Alzheimer Disease / drug therapy; Alzheimer Disease / pathology; Amyloid beta-Peptides / cerebrospinal fluid; Area Under Curve; Biomarkers / cerebrospinal fluid; Chromatography, Liquid; Cognition; Diagnosis, Differential; Female; Gas Chromatography-Mass Spectrometry; Humans; Logistic Models; Male; Metabolomics / methods; Neuropsychological Tests; tau Proteins / cerebrospinal fluid
TL;DR:
Several CSF small-molecule metabolites that discriminated especially well between clinically diagnosed AD and control groups appear to be suitable for further confirmatory and validation studies, and show the potential to provide predictive performance for AD.
(via Semantic Scholar)
actaneurocomms.biomedcentral.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
10. Reduced Inequalities
(OpenAlex)
Source: ORCID
Added: May 14, 2019
2014 journal article
Test driving ToxCast: Endocrine profiling for 1858 chemicals included in phase II
Current Opinion in Pharmacology, 19, 145–152.
Contributors: D. Filer*, H. Patisaul n, T. Schug*, D. Reif n & K. Thayer *
MeSH headings : Animals; Databases, Factual; Endocrine Disruptors / toxicity; High-Throughput Screening Assays; Humans; Models, Theoretical; Risk Assessment; United States; United States Environmental Protection Agency
TL;DR:
Results from this exercise suggest the spectrum of environmental chemicals with potential endocrine activity is much broader than indicated, and that some aspects of endocrine disruption are not fully covered in ToxCast.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Source: ORCID
Added: May 14, 2019
2014 journal article
Profiling of the Tox21 10K compound library for agonists and antagonists of the estrogen receptor alpha signaling pathway
Scientific Reports, 4.
Contributors: R. Huang *, S. Sakamuru *, M. Martin*, D. Reif* , R. Judson *, K. Houck *, W. Casey *, J. Hsieh *
MeSH headings : Cell Line; Estrogen Receptor alpha / agonists; Estrogen Receptor alpha / antagonists & inhibitors; Genes, Reporter / drug effects; HEK293 Cells; High-Throughput Screening Assays / methods; Humans; Ligands; Protein Binding / drug effects; Signal Transduction / drug effects; Small Molecule Libraries / pharmacology; Structure-Activity Relationship
TL;DR:
The results demonstrate the feasibility of qHTS to identify environmental chemicals with the potential to interact with the ERα signaling pathway and the two different assay formats improve the confidence in correctly identifying these chemicals.
(via Semantic Scholar)
Source: ORCID
Added: May 14, 2019
2014 journal article
Predictive endocrine testing in the 21st century using in vitro assays of estrogen receptor signaling responses
Environmental Science and Technology, 48(15), 8706–8716.
Contributors: D. Rotroff *, M. Martin*, D. Dix*, D. Filer*, K. Houck *, T. Knudsen *, N. Sipes *, D. Reif*
MeSH headings : Algorithms; Animals; Biological Assay; Endocrine Disruptors / analysis; Estrogen Antagonists / analysis; Estrogen Receptor alpha / agonists; Estrogen Receptor alpha / antagonists & inhibitors; Estrogen Receptor beta / agonists; Estrogen Receptor beta / antagonists & inhibitors; Estrogens / analysis; High-Throughput Screening Assays; Humans; MCF-7 Cells; Models, Chemical; Pesticides; Signal Transduction
TL;DR:
A novel method for combining in vitro concentration response data from multiple assays and, when applied to a large set of ER data, accurately predicted estrogenic responses and demonstrated its utility for chemical prioritization is provided.
(via Semantic Scholar)
Source: ORCID
Added: May 14, 2019
2014 journal article
Phenotypic screening of the ToxCast chemical library to classify toxic and therapeutic mechanisms
Nature Biotechnology, 32(6), 583–591.
Contributors: N. Kleinstreuer *, J. Yang *, E. Berg*, T. Knudsen *, A. Richard *, M. Martin*, D. Reif* , R. Judson *
MeSH headings : Animal Testing Alternatives / methods; Animals; Computer Simulation; High-Throughput Screening Assays / methods; Humans; Mice; Models, Biological; Phenotype; Rats; Small Molecule Libraries; Toxicity Tests / methods; United States; United States Environmental Protection Agency
TL;DR:
The results demonstrate that assaying complex biological pathways in primary human cells can identify potential chemical targets, toxicological liabilities and mechanisms useful for elucidating adverse outcome pathways.
(via Semantic Scholar)
Source: ORCID
Added: May 14, 2019
2014 journal article
Multidimensional in vivo hazard assessment using zebrafish.
Toxicological Sciences, 137(1), 212–233.
Contributors: L. Truong *, D. Reif n , L. Mary *, M. Geier*, H. Truong* & R. Tanguay *
MeSH headings : Animals; Cluster Analysis; Computational Biology; Dose-Response Relationship, Drug; Embryo, Nonmammalian / drug effects; Embryo, Nonmammalian / metabolism; Embryo, Nonmammalian / pathology; Embryonic Development / drug effects; Environmental Pollutants / toxicity; High-Throughput Screening Assays; Humans; Motor Activity / drug effects; Notochord / drug effects; Notochord / pathology; Reproducibility of Results; Risk Assessment; Toxicity Tests / methods; Zebrafish / embryology
TL;DR:
An experimental design for high-throughput characterization of multidimensional in vivo effects with the power to evaluate trends relating to commonly cited chemical predictors is described and it is demonstrated that the developmental zebrafish detects adverse responses that would be missed by less comprehensive testing strategies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: May 14, 2019
2014 journal article
Hierarchical dose-response modeling for high-throughput toxicity screening of environmental chemicals
Biom, 70(1), 237â246.
Contributors: A. Wilson n, D. Reif n & B. Reich n
author keywords: Bayesian; Computational toxicology; Dose-response; MCMC; Monotonicity; Semiparametric; ToxCast
MeSH headings : Algorithms; Bayes Theorem; Computer Simulation; Dose-Response Relationship, Drug; Environmental Pollutants / toxicity; Estrogen Receptor alpha / metabolism; Humans; Markov Chains; Models, Statistical; Monte Carlo Method; PPAR gamma / metabolism; Toxicity Tests / methods; United States; United States Environmental Protection Agency
TL;DR:
This work proposes a semiparametric Bayesian model that borrows strength across chemicals and assays and demonstrates that the hierarchical method provides more accurate estimates of the probability of response, efficacy, and potency than separate curve estimation in a simulation study.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Source: ORCID
Added: May 14, 2019
2014 journal article
Erratum to Incorporating human dosimetry and exposure into High-throughput in Vitro Toxicity Screening [Toxicological sciences 137, 2, (2014), 499]
Toxicological Sciences, 137(2).
Contributors: D. Rotroff, B. Wetmore, D. Dix, S. Ferguson, H. Clewell, K. Houck, E. LeCluyse, M. Andersen
Source: ORCID
Added: May 14, 2019
2014 journal article
The performance of pathogenic bacterial phytosensing transgenic tobacco in the field
Plant Biotechnology Journal, 12(6), 755–764.
Contributors: M. Fethe*, W. Liu* , J. Burris*, R. Millwood *, M. Mazarei*, M. Rudis*, D. Yeaman*, M. Dubosquielle*, C. Stewart *
author keywords: transgenic plants; phytosensor; synthetic promoters; phytopathogen sensing; phytobacterial pathogens; field tested
MeSH headings : Cyclopentanes / pharmacology; Ethylenes / pharmacology; Luminescent Proteins / metabolism; Oxylipins / pharmacology; Plant Diseases / microbiology; Plants, Genetically Modified; Promoter Regions, Genetic; Pseudomonas syringae / drug effects; Pseudomonas syringae / growth & development; Pseudomonas syringae / physiology; Salicylic Acid / pharmacology; Time Factors; Tobacco / drug effects; Tobacco / genetics; Tobacco / microbiology; Transcription, Genetic / drug effects; Transgenes
TL;DR:
Transgenic tobacco harbouring a synthetic inducible promoter-driven OFP could be used to facilitate monitoring and early-warning reporting of phytopathogen infections in agricultural fields.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: May 13, 2019
2014 journal article
Synthetic TAL effectors for targeted enhancement of transgene expression in plants
Plant Biotechnology Journal, 12(4), 436–446.
Contributors: W. Liu* , M. Rudis*, Y. Peng *, M. Mazarei*, R. Millwood *, J. Yang *, W. Xu *, J. Chesnut*, C. Stewart *
author keywords: targeted transgene activation; synthetic TALEs; additive effects; pporRFP; AtPAP1; transgenic plants
MeSH headings : Arabidopsis Proteins / metabolism; Base Sequence; Binding Sites; DNA, Plant / metabolism; Gene Expression Regulation, Plant; Genes, Reporter; Genetic Engineering / methods; Pigmentation; Plant Leaves / physiology; Plants, Genetically Modified; Promoter Regions, Genetic / genetics; Protein Binding; Protein Structure, Tertiary; Tobacco / genetics; Trans-Activators / chemistry; Trans-Activators / metabolism; Transcription Factors / metabolism; Transcriptional Activation; Transgenes / genetics
TL;DR:
It is demonstrated that transient expression of de novo-engineered TALEs using agroinfiltration could significantly increase reporter gene expression in stable transgenic tobacco expressing the orange fluorescent protein reporter gene pporRFP under the control of synthetic inducible, minimal or full-length 35S promoters.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: May 13, 2019
2014 journal article
Computational discovery of soybean promoter cis-regulatory elements for the construction of soybean cyst nematode-inducible synthetic promoters
Plant Biotechnology Journal, 12(8), 1015–1026.
Contributors: W. Liu* , M. Mazarei*, Y. Peng *, M. Fethe*, M. Rudis*, J. Lin*, R. Millwood *, P. Arelli, C. Stewart *
author keywords: de novo motif discovery; plant synthetic biology; pporRFP; transgenic soybean hairy system; soybean cyst nematode; soybean
MeSH headings : Amino Acid Motifs; Animals; Biotechnology; Computational Biology; Crops, Agricultural; Gene Expression Regulation, Plant; Plant Proteins / genetics; Plant Roots / genetics; Plant Roots / parasitology; Plants, Genetically Modified; Promoter Regions, Genetic / genetics; Regulatory Sequences, Nucleic Acid / genetics; Soybeans / genetics; Soybeans / parasitology; Synthetic Biology; Tylenchida / genetics; Tylenchida / physiology
TL;DR:
An ensemble strategy for de novo soybean cyst nematode (SCN)-inducible motif discovery among promoters of 18 co-expressed soybean genes that were selected from six reported microarray studies involving a compatible soybean-SCN interaction offers great potential for novel motif discovery and synthetic promoter engineering for any plant and trait in crop biotechnology.
(via Semantic Scholar)
Source: ORCID
Added: May 13, 2019
2014 journal article
Genotype X Environment Interaction for Storage Root Yield in Sweetpotato Under Managed Drought Stress Conditions
Journal of Agricultural Science, 6(10).
TL;DR:
Genotypes G5, G22 and G2 may be used across environments, while genotypes G7 and G14 could be used in specific locations to boost production under unpredictable rainfall conditions and incorporated into drought screening breeding programmes to develop a new generation of drought tolerant sweetpotato varieties to meet changing climatic conditions.
(via Semantic Scholar)
Source: ORCID
Added: May 13, 2019
2014 journal article
Combining ability and heterosis for yield and drought tolerance traits under managed drought stress in sweetpotato
Euphytica, 201(3), 423–440.
author keywords: Combining ability; Homozygous recessive; Drought tolerance; Gene effects; Heterosis
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science; OpenAlex)
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science)
Sources: ORCID, NC State University Libraries, Crossref
Added: May 13, 2019
2014 article
Large-scale patterns of insect and disease activity in the conterminous United States and Alaska from the national insect and disease survey, 2011
Unpublished.
Contributors: K. Potter & J. Paschke
Source: ORCID
Added: March 22, 2019
2014 article
Large-scale patterns of forest fire occurrence in the conterminous United States and Alaska, 2011
Unpublished.
Contributors: K. Potter
Source: ORCID
Added: March 22, 2019
2014 article
Genetic Assessment of Ponderosa Pine (Pinus ponderosa) within Glacier National Park, Montana
US Forest Service, National Genetics Laboratory.
Contributors: K. Potter , V. Hipkins & R. Means
Source: ORCID
Added: March 22, 2019
2014 article
Genetic Assessment of Ponderosa Pine (Pinus ponderosa) at Yosemite National Park, California
US Forest Service, National Genetics Laboratory.
Contributors: K. Potter , V. Hipkins & R. Means
Source: ORCID
Added: March 22, 2019
2014 article
Genetic Assessment of Ponderosa Pine (Pinus ponderosa) at Sagauro National Park, Arizona
US Forest Service, National Genetics Laboratory.
Contributors: K. Potter , V. Hipkins & R. Means
Source: ORCID
Added: March 22, 2019
2014 article
Genetic Assessment of Ponderosa Pine (Pinus ponderosa) at Rocky Mountain National Park, Colorado
US Forest Service, National Genetics Laboratory.
Contributors: K. Potter , V. Hipkins & R. Means
Source: ORCID
Added: March 22, 2019
2014 article
Genetic Assessment of Ponderosa Pine (Pinus ponderosa) at Lava Beds National Monument, California
US Forest Service, National Genetics Laboratory.
Contributors: K. Potter , V. Hipkins & R. Means
Source: ORCID
Added: March 22, 2019
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