Works (25)

Updated: April 5th, 2024 05:12

2023 journal article

Global gene expression analysis of the turkey hen hypothalamo-pituitary-gonadal axis during the preovulatory hormonal surge

POULTRY SCIENCE, 102(4).

By: K. Brady*, H. Liu n, J. Hicks n, J. Long* & T. Porter*

author keywords: hypothalamo-pituitary-gonadal axis; preovulatory surge; turkey; RNA sequencing; pathway analysis
MeSH headings : Female; Animals; Progesterone / metabolism; Chickens / metabolism; Ovarian Follicle / physiology; Luteinizing Hormone / metabolism; Ovulation; Gene Expression Profiling / veterinary; Granulosa Cells / metabolism
TL;DR: Gene Ontology (GO) analysis revealed key roles for metabolic processes, steroid hormone feedback, and hypoxia induced gene expression changes in the hypothalamus, pituitary, F1G, and F5G respectively, and upstream analysis identified potential regulators of downstream gene expression. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (Web of Science)
Source: Web Of Science
Added: April 11, 2023

2023 journal article

Intestinal Carnitine Status and Fatty Acid Oxidation in Response to Clofibrate and Medium-Chain Triglyceride Supplementation in Newborn Pigs

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24(7).

By: B. Pike n, J. Zhao n, J. Hicks n, F. Wang n, R. Hagen n, H. Liu n, J. Odle n, . Lin n

author keywords: carnitine; fatty acid oxidation; intestine; medium-chain fatty acid; newborn pigs
MeSH headings : Animals; Swine; Clofibrate / pharmacology; Animals, Newborn; Carnitine / pharmacology; Carnitine / metabolism; Liver / metabolism; Palmitic Acid / pharmacology; Triglycerides / metabolism; Intestines; Dietary Supplements; Fatty Acids / metabolism; Oxidation-Reduction
TL;DR: It is suggested that dietary clofibrate improved carnitine status and increased fatty acid oxidation in neonates, and Propionyl-CoA, generated from TC5 and TMPA, could stimulate the increased fatty acids oxidation rate induced by cl ofibrate as anaplerotic carbon sources. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: March 25, 2023

2022 journal article

Alterations in hepatic mitotic and cell cycle transcriptional networks during the metabolic switch in broiler chicks

FRONTIERS IN PHYSIOLOGY, 13.

By: J. Hicks n, B. Pike n & H. Liu n

author keywords: broiler; metabolic switch; liver; RNA-seq; mitosis
TL;DR: Estimation patterns suggest that hepatocytes of delayed-fed birds have abnormal mitosis and increased polyploidization, which suggests that post-hatch feed consumption maintains the rate and integrity of liver growth immediately, which in turn, likely helps facilitate the appropriate programming of hepatic metabolic networks. (via Semantic Scholar)
Source: Web Of Science
Added: November 21, 2022

2022 article

Transcriptome Analysis of Chicken Reveals the Impact of Herpesvirus of Turkeys on Bursa RNA Expression in Marek's Disease Virus Infections

Wang, J., Hicks, J., Jiang, J., & Liu, H.-C. (2022, October). JOURNAL OF ANIMAL SCIENCE, Vol. 100, pp. 215–215.

By: J. Wang n, J. Hicks n, J. Jiang n & H. Liu n

author keywords: chicken RNA-seq MDV
TL;DR: The result of differential gene expression showed that 14 days post infection might be the point in time when HVT worked and better understand host-pathogen interaction in the bursa and elucidate the mechanism how HVT contribute to resist MDV. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, ORCID
Added: June 26, 2023

2021 review

Centennial Review: Metabolic microRNA- shifting gears in the regulation of metabolic pathways in poultry

[Review of ]. POULTRY SCIENCE, 100(3).

By: J. Hicks n & H. Liu n

author keywords: metabolism; microRNA; growth; next-generation sequencing
MeSH headings : Animals; Chickens / genetics; Metabolic Networks and Pathways / genetics; MicroRNAs / genetics
TL;DR: The current knowledge of miRNA-mediated regulation of metabolic development and function in chickens is reviewed. (via Semantic Scholar)
Source: Web Of Science
Added: April 5, 2021

2021 journal article

Expression Signatures of microRNAs and Their Targeted Pathways in the Adipose Tissue of Chickens during the Transition from Embryonic to Post-Hatch Development

GENES, 12(2).

By: J. Hicks n & H. Liu n

author keywords: chicken; development; adipose tissue; microRNA
MeSH headings : Adipose Tissue / growth & development; Adipose Tissue / metabolism; Animals; Chick Embryo; Chickens / genetics; Chickens / growth & development; Embryonic Development / genetics; Gene Expression Regulation, Developmental / genetics; High-Throughput Nucleotide Sequencing; Lipogenesis / genetics; Liver / growth & development; Liver / metabolism; MicroRNAs / classification; MicroRNAs / genetics; Signal Transduction / genetics; Transcriptome / genetics
TL;DR: Next generation sequencing (NGS) and real-time quantitative PCR (RT-qPCR) are used to generate miRNome and transcriptome signatures of the adipose tissue during the transition from late embryonic to early post-hatch development and identify a group of miRNAs which work concordantly to regulate a diverse but interconnected group of developmental, immune and metabolic processes in the adipOSE tissue duringThe metabolic switch. (via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Source: Web Of Science
Added: March 15, 2021

2021 journal article

Transcriptome Analysis During Follicle Development in Turkey Hens With Low and High Egg Production

FRONTIERS IN GENETICS, 12.

By: K. Brady*, H. Liu n, J. Hicks n, J. Long* & T. Porter*

author keywords: turkey; RNA-seq; thyroid hormone; estradiol; HPT axis; HPG axis; steroidogenesis; egg production
Source: Web Of Science
Added: April 12, 2021

2020 journal article

Transcriptional Immune Signatures of Alveolar Macrophages and the Impact of the NLRP3 Inflammasome on Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Replication

VIRUSES-BASEL, 12(11).

By: J. Hicks n, D. Yoo* & H. Liu n

author keywords: PRRSV; RNA-seq; macrophage; NLRP3 inflammasome
MeSH headings : Animals; Gene Expression Profiling; Inflammasomes / metabolism; Macrophages, Alveolar / immunology; Macrophages, Alveolar / metabolism; Macrophages, Alveolar / virology; NLR Family, Pyrin Domain-Containing 3 Protein / metabolism; Porcine Reproductive and Respiratory Syndrome / etiology; Porcine Reproductive and Respiratory Syndrome / metabolism; Porcine Reproductive and Respiratory Syndrome / pathology; Porcine respiratory and reproductive syndrome virus / physiology; Signal Transduction; Swine; Transcriptome
TL;DR: Transcriptome and immunoregulatory data highlight the complex changes PRRSV infection induces in the molecular immune networks of its cellular host and suggests that PR RSV is sensitive to the effects of NLRP3 inflammasome activity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: December 21, 2020

2020 journal article

Transcriptome analysis of the hypothalamus and pituitary of turkey hens with low and high egg production

BMC GENOMICS, 21(1).

By: K. Brady*, H. Liu n, J. Hicks n, J. Long* & T. Porter*

author keywords: Turkey; HPT axis; HPG axis; Gonadotropin production; Egg production
MeSH headings : Animals; Avian Proteins / genetics; Avian Proteins / metabolism; Eggs / standards; Estradiol / metabolism; Female; Fertility; Gonadotropin-Releasing Hormone / metabolism; Hypothalamus / metabolism; Pituitary Gland / metabolism; Transcriptome; Turkeys / genetics; Turkeys / physiology
TL;DR: High egg producing hens (HEPH) show increased hypothalamic and pituitary gene expression related to hypothalamo-pituitary-gonadal (HPG) axis stimulation as well as increased in vitro responsiveness to gonadotropin releasing hormone (GnRH) stimulation in the pituitsary when compared to low egg producinghens (LEPH). (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (Web of Science)
Source: Web Of Science
Added: October 19, 2020

2019 journal article

Alterations in cellular and viral microRNA and cellular gene expression in Marek's disease virus-transformed T-cell lines treated with sodium butyrate

POULTRY SCIENCE, 98(2), 642–652.

By: J. Hicks n, N. Trakooljul n & H. Liu n

author keywords: Marek's disease virus; latency; transformation; microRNA; microarray
MeSH headings : Animals; Butyric Acid / pharmacology; Cell Line; Chickens; Herpesvirus 2, Gallid / genetics; Marek Disease / immunology; Marek Disease / virology; MicroRNAs / genetics; MicroRNAs / metabolism; RNA, Viral / genetics; RNA, Viral / metabolism; T-Lymphocytes / immunology; T-Lymphocytes / virology; Transcriptome / genetics; Virus Activation / drug effects
TL;DR: The present study was undertaken to determine transcriptome and miRNome changes induced by sodium butyrate in 2 MDV‐transformed cell lines, RP2 and CU115 and identified 17 cellular miRNAs that were differentially expressed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: April 22, 2019

2019 journal article

Delayed Feeding Alters Transcriptional and Post-Transcriptional Regulation of Hepatic Metabolic Pathways in Peri-Hatch Broiler Chicks

GENES, 10(4).

By: J. Hicks n, T. Porter*, N. Sunny* & H. Liu n

author keywords: chicken; metabolic switch; microRNA
MeSH headings : Animals; Body Weight; Chickens; Food Deprivation / physiology; Gene Expression Profiling / veterinary; Gene Expression Regulation; Lipid Peroxidation; Lipogenesis; Liver / chemistry; Male; Metabolic Networks and Pathways; MicroRNAs / genetics; Oxidative Stress
TL;DR: It is demonstrated that many transcriptional and post-transcriptional mechanisms, including miRNA, form a complex interconnected regulatory network that is involved in controlling lipid and glucose molecular pathways during the metabolic transition in peri-hatch chicks. (via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Source: Web Of Science
Added: May 28, 2019

2019 journal article

Impact of HVT Vaccination on Splenic miRNA Expression in Marek's Disease Virus Infections

GENES, 10(2).

By: J. Hicks n & H. Liu n

author keywords: Marek's disease virus; microRNA; transcriptional regulation
MeSH headings : Animals; Chick Embryo; Herpesvirus 1, Meleagrid / immunology; Herpesvirus 1, Meleagrid / pathogenicity; Marek Disease / genetics; Marek Disease / immunology; Marek Disease / prevention & control; Marek Disease / virology; MicroRNAs / genetics; MicroRNAs / metabolism; Spleen / metabolism; Vaccination / veterinary
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: March 25, 2019

2017 journal article

Identification of microRNAs controlling hepatic mRNA levels for metabolic genes during the metabolic transition from embryonic to posthatch development in the chicken

BMC GENOMICS, 18.

By: J. Hicks n, T. Porter* & H. Liu n

author keywords: Chicken; Genomics; miRNA; Metabolism; Liver
MeSH headings : Animals; Chick Embryo; Chickens / genetics; Chickens / growth & development; Chickens / metabolism; Gene Expression Profiling; High-Throughput Nucleotide Sequencing; Liver / embryology; Liver / growth & development; Liver / metabolism; MicroRNAs / genetics; RNA, Messenger / genetics; Sequence Analysis, RNA
TL;DR: A key role for miRNAs is found in controlling the metabolic switch that occurs between embryonic and posthatch development in the chicken and several proteins are identified that likely regulate expression of one of these important mi RNAs. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Characterization of the microRNAome in Porcine Reproductive and Respiratory Syndrome Virus Infected Macrophages

PLOS ONE, 8(12).

By: J. Hicks n, D. Yoo* & H. Liu n

MeSH headings : Animals; Cells, Cultured; Cytokines / biosynthesis; Cytokines / immunology; Macrophages, Alveolar / immunology; Macrophages, Alveolar / metabolism; Macrophages, Alveolar / pathology; Macrophages, Alveolar / virology; MicroRNAs / biosynthesis; MicroRNAs / immunology; Porcine Reproductive and Respiratory Syndrome / immunology; Porcine Reproductive and Respiratory Syndrome / metabolism; Porcine Reproductive and Respiratory Syndrome / pathology; Porcine respiratory and reproductive syndrome virus; Signal Transduction; Swine; Time Factors
TL;DR: Overall, the present study has revealed that a large and diverse group of miRNAs are expressed in swine alveolar macrophages and that the expression of a subset of these mi RNAs is altered in PRRSV infected macrophage. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2013 article

Current State of Marek's Disease Virus MicroRNA Research

Hicks, J. A., & Liu, H.-C. (2013, June). AVIAN DISEASES, Vol. 57, pp. 332–339.

By: J. Hicks* & H. Liu*

author keywords: herpesvirus; MDV; microRNA; gene regulation
MeSH headings : Animals; Conserved Sequence; Gene Expression Regulation, Viral; Herpesviridae / genetics; Herpesviridae / metabolism; Herpesviridae / pathogenicity; Host-Pathogen Interactions; Mardivirus / genetics; Mardivirus / metabolism; Mardivirus / pathogenicity; Marek Disease / virology; MicroRNAs / genetics; MicroRNAs / metabolism; Poultry; Poultry Diseases / virology; RNA, Viral / genetics; RNA, Viral / metabolism
TL;DR: Current research suggests that viral miRNAs are a key component of MDV pathogenesis, and particularmente virus ADN grandes como the virus of Marek codifican su propio conjunto of micro ARN. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2013 review

Involvement of Eukaryotic Small RNA Pathways in Host Defense and Viral Pathogenesis

[Review of ]. VIRUSES-BASEL, 5(11), 2659–2678.

By: J. Hicks n & H. Liu n

author keywords: small RNA; immunity; pathogens
MeSH headings : Animals; Eukaryota / genetics; Eukaryota / immunology; Eukaryota / virology; Host-Pathogen Interactions; Humans; MicroRNAs / genetics; MicroRNAs / immunology; Plant Diseases / immunology; Plant Diseases / virology; Plants / genetics; Plants / immunology; Plants / virology; RNA, Small Interfering / genetics; RNA, Small Interfering / immunology; Virus Diseases / immunology; Virus Diseases / virology; Viruses / genetics; Viruses / immunology; Viruses / pathogenicity
TL;DR: The goal of this review is to summarize the current knowledge of the involvement of eukaryotic small RNA pathways in host defense and viral pathogenesis. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2013 article

The Interplay Between MDV and HVT Affects Viral miRNA Expression

Goher, M., Hicks, J. A., & Liu, H.-C. (2013, June). AVIAN DISEASES, Vol. 57, pp. 372–379.

By: M. Goher, J. Hicks* & H. Liu*

author keywords: MDV1; HVT; microRNA; MD5; immune response
MeSH headings : Animals; Chickens; Coinfection / virology; Herpesvirus 1, Meleagrid / genetics; Herpesvirus 1, Meleagrid / metabolism; Herpesvirus 2, Gallid / genetics; Herpesvirus 2, Gallid / metabolism; High-Throughput Nucleotide Sequencing / veterinary; Marek Disease / virology; Marek Disease Vaccines / administration & dosage; MicroRNAs / genetics; MicroRNAs / metabolism; Poultry Diseases / virology; RNA, Viral / genetics; RNA, Viral / metabolism; Real-Time Polymerase Chain Reaction / veterinary; Sequence Analysis, RNA / veterinary; Specific Pathogen-Free Organisms; Spleen / virology
TL;DR: Target prediction analysis suggests that these differentially expressed viral miRNAs are involved in regulating several cellular processes, including cell proliferation and the adaptive immune response. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Characterization of miR-10a mediated gene regulation in avian splenocytes

GENE, 500(1), 107–114.

By: N. Trakooljul n, J. Hicks n & H. Liu n

author keywords: microRNA; miR-10a; Chicken
MeSH headings : Animals; Avian Proteins / genetics; Chickens; Gene Expression Regulation; Hematopoiesis; Homeodomain Proteins / genetics; MicroRNAs / metabolism; Spleen / cytology; Transcription Factors / genetics
TL;DR: Functional analysis suggests that miR-10a is involved in regulating gene expression in pathways associated with Ras signaling, intracellular trafficking, and development of immune functions in avian spleen, lung, kidneys, and fat tissues. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2012 article

Characterization of miR-10a mediated gene regulation in avian splenocytes (vol 500, pg 107, 2012)

Trakooljul, N., Hicks, J. A., & Liu, H.-C. (2012, August 10). GENE, Vol. 504, pp. 315–316.

By: N. Trakooljul n, J. Hicks n & H. Liu n

UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Discovery of chicken microRNAs associated with lipogenesis and cell proliferation

PHYSIOLOGICAL GENOMICS, 41(2), 185–193.

By: J. Hicks n, N. Trakooljul n & H. Liu n

author keywords: liver; targets
MeSH headings : Animals; Cell Proliferation; Chick Embryo; Gene Expression Regulation, Developmental; Gene Library; Gene Regulatory Networks; Lipogenesis / genetics; Liver / embryology; Liver / metabolism; MicroRNAs / metabolism; Sequence Analysis, RNA; Time Factors
TL;DR: It is demonstrated that a diverse group of miRNAs are expressed in developing avian livers, some of which have been suggested to play a key role(s) in regulating metabolic pathways. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Identification of target genes and pathways associated with chicken microRNA miR-143

ANIMAL GENETICS, 41(4), 357–364.

By: N. Trakooljul n, J. Hicks n & H. Liu n

author keywords: chicken; microRNA; miR-143
MeSH headings : Algorithms; Animals; Chick Embryo; Chickens / genetics; Gene Expression Regulation; Genes, Reporter; MicroRNAs / genetics; Oligonucleotide Array Sequence Analysis
TL;DR: Overall, the current study suggests that miR-143 is ubiquitously expressed among tissues and is likely to be involved in the regulation of cell proliferation and apoptosis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Proteins involved in iron metabolism in beef cattle are affected by copper deficiency in combination with high dietary manganese, but not by copper deficiency alone

JOURNAL OF ANIMAL SCIENCE, 88(1), 275–283.

By: S. Hansen n, N. Trakooljul n, H. Liu n, J. Hicks n, M. Ashwell n & J. Spears n

author keywords: cattle; copper; iron; metal transporter
MeSH headings : Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Cation Transport Proteins / genetics; Cation Transport Proteins / metabolism; Cattle; Copper / blood; Copper / deficiency; Diet / veterinary; Dose-Response Relationship, Drug; Female; Gene Expression Regulation / drug effects; Iron / metabolism; Male; Manganese / administration & dosage; Manganese / pharmacology
TL;DR: It is confirmed that Cu deficiency alone did affect hepatic gene expression of hepcidin and ferroportin, but did not affect duodenal expression of proteins important in Fe metabolism, however, the addition of 500 mg of Mn/kg of DM to a diet low in Cu reduced duodentally expression of the Fe import protein DMT1. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 6, 2018

2009 journal article

Identification of microRNA in the developing chick immune organs

IMMUNOGENETICS, 61(3), 231–240.

By: J. Hicks n, P. Tembhurne n & H. Liu n

author keywords: MicroRNA; Molecular biology; Spleen; Bursa; Chicken embryos
MeSH headings : Animals; Base Sequence; Bursa of Fabricius / immunology; Bursa of Fabricius / metabolism; Chick Embryo / immunology; Gene Expression Regulation; Gene Library; MicroRNAs / chemistry; MicroRNAs / genetics; MicroRNAs / metabolism; Molecular Sequence Data; Specific Pathogen-Free Organisms; Spleen / immunology; Spleen / metabolism
TL;DR: Overall, the results show that many of the identified miRNAs display dynamic expression patterns, suggesting that these mi RNAs play diverse roles in the immune system. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2008 journal article

MicroRNA Expression in Chicken Embryos

POULTRY SCIENCE, 87(11), 2335–2343.

By: J. Hicks n, P. Tembhurne n & H. Liu n

author keywords: microRNA; chicken embryo; expression
MeSH headings : Animals; Chick Embryo; Chickens / genetics; Chromosome Mapping; Conserved Sequence; DNA Primers; Gene Expression Regulation, Developmental; Liver; MicroRNAs / genetics; Polymerase Chain Reaction; Sequence Alignment; Sequence Homology, Nucleic Acid; Species Specificity; Spleen
TL;DR: This study demonstrates that a very diverse and dynamic set of miRNA is expressed in the embryonic chick at 11 d of incubation and identifies the expression of 110 known chicken miRNA, 36 homologous chicken mi RNA, and 14 novel chicken-specific miRNA not identified in any other species. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2007 article

Using proteomics to understand avian systems biology and infectious disease

Liu, H.-C. S., & Hicks, J. A. (2007, July). POULTRY SCIENCE, Vol. 86, pp. 1523–1529.

By: H. Liu n & J. Hicks n

author keywords: proteomics; systems biology; infectious disease
MeSH headings : Animals; Bird Diseases / immunology; Bird Diseases / metabolism; Bird Diseases / parasitology; Bird Diseases / virology; Communicable Diseases / metabolism; Communicable Diseases / parasitology; Communicable Diseases / veterinary; Communicable Diseases / virology; Eye / metabolism; Muscles / metabolism; Proteomics; Systems Biology
TL;DR: Several techniques are frequently used in proteomics; these include 2-hybrid systems, 2-dimensional gel electrophoresis, and mass spectrometry, which can simultaneously probe the properties of numerous proteins and are a great aid to the emerging field of systems biology. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

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