John Clay Overall

Works (5)

Updated: July 5th, 2023 15:37

2019 article

Alaskan Berry Extracts Promote Dermal Wound Repair Through Modulation of Bioenergetics and Integrin Signaling

Esposito, D., Overall, J., Grace, M. H., Komarnytsky, S., & Lila, M. A. (2019, September 27). Frontiers in Pharmacology, Vol. 10.

By: D. Esposito n , J. Overall n , M. Grace n , S. Komarnytsky n  & M. Lila n 

Contributors: D. Esposito n , J. Overall n , M. Grace n , S. Komarnytsky n  & M. Lila n 

author keywords: skin regeneration; wound healing; Alaskan berries; integrins; proanthocyanidins; epicatechins
topics (OpenAlex): Wound Healing and Treatments; Phytochemicals and Antioxidant Activities; Bee Products Chemical Analysis; Skin Protection and Aging
TL;DR: Targeting cellular bioenergetics and integrin-mediated cell–ECM signaling with bioactives from Alaskan wild berries shows considerable therapeutic promise to treat chronic skin wounds and inflammatory skin disorders, as well as more generally to support regenerative healing responses and restore function in a variety of tissue and organ settings after injury or aging. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: October 14, 2019

2019 article

Changes in the bioactive properties of strawberries caused by the storage in oxygen‐ and carbon dioxide‐enriched atmospheres

Velde, F. V., Esposito, D., Overall, J., Méndez‐Galarraga, M. P., Grace, M., Pirovani, M. É., & Lila, M. A. (2019, July 15). Food Science & Nutrition, Vol. 7, pp. 2527–2536.

By: F. Velde *, D. Esposito n , J. Overall n , M. Méndez‐Galarraga*, M. Grace n , M. Pirovani *, M. Lila n 

Contributors: F. Velde *, D. Esposito n , J. Overall n , M. Méndez-Galarraga*, M. Grace n , M. Pirovani *, M. Lila n 

author keywords: 2; 2-diphenyl-1-picrylhydrazil; cyclooxygenase-2; ferric reducing antioxidant power; human dermal fibroblast migration; interleukin-6; modified atmosphere storage
topics (OpenAlex): Phytochemicals and Antioxidant Activities; Bee Products Chemical Analysis; Wound Healing and Treatments
TL;DR: Evidence suggests that strawberry storage in 90% O2 + 10% CO2 can be a promissory alternative to offer fruits with enhanced bioactivity. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 5, 2019

2017 journal article

Anthocyanins in metabolic health and disease

Nutrigenomics and Proteomics in Health and Disease: towards a Systems-Level Understanding of Gene-Diet Interactions, 2nd Edition, 92–124.

By: J. Overall , M. Lila  & S. Komarnytsky 

Source: NC State University Libraries
Added: August 6, 2018

2017 article

Berries containing anthocyanins with enhanced methylation profiles are more effective at ameliorating high fat diet-induced metabolic damage

Skates, E., Overall, J., DeZego, K., Wilson, M., Esposito, D., Lila, M. A., & Komarnytsky, S. (2017, November 28). Food and Chemical Toxicology, Vol. 111, pp. 445–453.

By: E. Skates n, J. Overall n , K. DeZego n, M. Wilson n, D. Esposito n , M. Lila n , S. Komarnytsky n 

author keywords: Bioactive food components; Polyphenols; Obesity; Diabetes; Bioenergetics; Functional food
MeSH headings : Animal Feed; Animals; Anthocyanins / chemistry; Diet; Diet, High-Fat / adverse effects; Energy Metabolism; Fruit / chemistry; Lipid Metabolism; Male; Metabolic Diseases; Methylation; Mice; Mice, Inbred C57BL; Rubus / chemistry
topics (OpenAlex): Phytochemicals and Antioxidant Activities; Adipose Tissue and Metabolism; Sirtuins and Resveratrol in Medicine
TL;DR: It is shown that consumption of berries containing anthocyanins with enhanced methylation profiles (malvidin and petunidin) is more effective at reducing high fat diet-induced metabolic damage in the C57BL/6 mouse model of polygenic obesity. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2017 article

Metabolic Effects of Berries with Structurally Diverse Anthocyanins

Overall, J., Bonney, S., Wilson, M., Beermann, A., Grace, M., Esposito, D., … Komarnytsky, S. (2017, February 15). International Journal of Molecular Sciences, Vol. 18.

By: J. Overall n , S. Bonney n, M. Wilson n, A. Beermann n, M. Grace n , D. Esposito n , M. Lila n , S. Komarnytsky n 

Contributors: J. Overall n , S. Bonney n, M. Wilson n, A. Beermann n, M. Grace n , D. Esposito n , M. Lila n , S. Komarnytsky n 

author keywords: berry; gut microbiome; obesity; inflammation; functional food
MeSH headings : Animal Feed; Animals; Anthocyanins / chemistry; Anthocyanins / metabolism; Body Composition; Body Weight; Chromatography, High Pressure Liquid; Dietary Supplements; Feces / chemistry; Fruit / metabolism; Gastrointestinal Microbiome; Glucose / metabolism; Humans; Insulin Resistance; Mice; Molecular Structure; Oxygen Consumption
topics (OpenAlex): Phytochemicals and Antioxidant Activities; Diet and metabolism studies; Metabolomics and Mass Spectrometry Studies
TL;DR: Examination of effects of six berries with structurally diverse anthocyanin profiles on development of metabolic risk factors in the C57BL/6 mouse model of polygenic obesity showed a prominent discrepancy between biological activities of delphinidin/malvidin-versus cyanidin-type anthocianins that could be explained by differences in their structure and metabolism in the gut. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

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