Jean-Philippe Therrien

Works (4)

Updated: April 5th, 2024 14:10

2023 journal article

Tension as a key factor in skin responses to pollution

SCIENTIFIC REPORTS, 13(1).

By: E. Pambianchi n, Z. Hagenberg n, A. Pecorelli n , A. Pasqui*, J. Therrien n & G. Valacchi n 

TL;DR: The present work demonstrates that cutaneous exposure to ozone induces AMPs gene and protein levels and that the presence of tension can further modulate their expression, confirming the ability of pollution to induce the cutaneous expression of AMPs via redox signaling and corroborates the principle that skin explants are a good and reliable model to study skin responses. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: January 22, 2024

2021 journal article

Alaskan Bog Blueberry (Vaccinium uliginosum) Extract as an Innovative Topical Approach to Prevent UV-Induced Skin Damage

COSMETICS, 8(4).

By: E. Pambianchi n, Z. Hagenberg n, A. Pecorelli n , M. Grace n , J. Therrien n, M. Lila n , G. Valacchi n 

author keywords: cosmeceuticals; environmental stressor; oxidation; inflammation; antioxidant; OxInflammation; phytochemicals
TL;DR: It is observed that the topical application of BB extract on human ex vivo skin explants averted the UV-induced cutaneous OxInflammatory phenomenon by quenching the increase in the oxidative and inflammatory marker levels. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: December 2, 2021

2021 journal article

Deferoxamine Treatment Improves Antioxidant Cosmeceutical Formulation Protection against Cutaneous Diesel Engine Exhaust Exposure

ANTIOXIDANTS, 10(12).

By: E. Pambianchi n, F. Ferrara*, A. Pecorelli n , M. Benedusi *, H. Choudhary*, J. Therrien*, G. Valacchi n 

author keywords: cosmeceuticals; pollution; iron-chelator
TL;DR: It is suggested that iron plays a key role in DEE-induced skin damage and its chelation could be an adjuvant strategy to reinforce antioxidant topical formulations. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: January 24, 2022

2021 journal article

Novel Spray Dried Algae-Rosemary Particles Attenuate Pollution-Induced Skin Damage

MOLECULES, 26(13).

By: R. Hoskin  n, E. Pambianchi n, A. Pecorelli n , M. Grace n , J. Therrien*, G. Valacchi n , M. Lila n 

author keywords: cosmeceuticals; pollution; phytochemicals; herbs
MeSH headings : Antioxidants / chemistry; Antioxidants / pharmacology; Cells, Cultured; Chlorella / chemistry; Cinnamates / chemistry; Depsides / chemistry; Environmental Exposure / adverse effects; Filaggrin Proteins; Humans; Rosmarinus / chemistry; Skin / injuries; Skin / metabolism; Skin / pathology; Skin Aging / drug effects
TL;DR: The ex-vivo data clearly demonstrated the ability of RSP gel to prevent an oxinflammatory phenomenon in cutaneous tissue by decreasing the levels of 4-hydroxynonenal protein adducts and active matrix metalloproteinase-9 (MMP-9) by limiting the loss of filaggrin induced by DEE exposure. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: June 23, 2021

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