Lingling Peng

Works (6)

Updated: July 23rd, 2023 19:25

2015 article

Membrane-Permeabilizing Activity of Reverse-Amide 2-Aminoimidazole Antibiofilm Agents Against Acinetobacter baumannii

Stowe, S., Thompson, R., Peng, L., Su, Z., Blackledge, M., Draughn, G., … Cavanagh, J. (2015, April 23). Current Drug Delivery.

By: S. Stowe*, R. Thompson*, L. Peng*, Z. Su*, M. Blackledge*, G. Draughn*, W. Coe, E. Johannes* ...

author keywords: 2-aminoimidazole; Acinetobacter baumannii; biofilm; membrane permeabilization; reverse amide; SEM
MeSH headings : Acinetobacter baumannii / drug effects; Amides / chemistry; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Biofilms / drug effects; Cell Membrane Permeability / drug effects; Cells, Cultured; Cross Infection; Imidazoles / chemistry; Imidazoles / pharmacology; Microbial Sensitivity Tests
topics (OpenAlex): Antibiotic Resistance in Bacteria; Bacterial biofilms and quorum sensing; Antimicrobial agents and applications
TL;DR: A model is proposed that describes how the structure of RA-2AI allows it to insert itself into and disrupt the fluidity of the membrane, creating an opportunity for increased molecular permeability. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2012 article

Identification of BfmR, a Response Regulator Involved in Biofilm Development, as a Target for a 2-Aminoimidazole-Based Antibiofilm Agent

Thompson, R. J., Bobay, B. G., Stowe, S. D., Olson, A. L., Peng, L., Su, Z., … Cavanagh, J. (2012, November 27). Biochemistry.

By: R. Thompson n, B. Bobay n, S. Stowe n, A. Olson n, L. Peng n, Z. Su n, L. Actis *, C. Melander n, J. Cavanagh n

MeSH headings : Acinetobacter baumannii / drug effects; Acinetobacter baumannii / growth & development; Bacterial Proteins / chemistry; Bacterial Proteins / physiology; Biofilms / drug effects; Imidazoles / pharmacology; Microscopy, Confocal; Models, Molecular
topics (OpenAlex): Bacterial biofilms and quorum sensing; Antimicrobial Peptides and Activities; Bacterial Genetics and Biotechnology
TL;DR: The 2AI compound studied here represents a unique small molecule scaffold that targets bacterial response regulators and is cell permeable, while pull-down assays identified BfmR, a response regulator that is the master controller of biofilm formation, as a target for this compound. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2012 article

Synthesis of Guanidinium Functionalized Polycarbodiimides and Their Antibacterial Activities

Budhathoki-Uprety, J., Peng, L. L., Melander, C., & Novak, B. M. (2012, February 21). ACS Macro Letters, Vol. 1, pp. 370–374.

By: J. Budhathoki-Uprety n , L. Peng n, C. Melander n & B. Novak *

topics (OpenAlex): Click Chemistry and Applications; Antimicrobial agents and applications; Antimicrobial Peptides and Activities
TL;DR: These polycarbodiimide-guanidinium-triazole conjugates offered moderate to significant antibacterial activity and rapid interaction with red blood cells causing blood precipitation without significant hemolysis in case of Poly-2(b-e). (via Semantic Scholar)
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6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2011 article

A modular approach to the synthesis of 1,4,5-substituted-2-aminoimidazoles

Su, Z., Peng, L., & Melander, C. (2011, December 31). Tetrahedron Letters.

By: Z. Su n, L. Peng n & C. Melander n

author keywords: N-H insertion; 2-Aminoimidazole; Antibiotic; Polysubstitution; Heterocycle
topics (OpenAlex): Cyclopropane Reaction Mechanisms; Synthesis and Catalytic Reactions; Chemical Synthesis and Reactions
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Source: Web Of Science
Added: August 6, 2018

2011 article

Evaluation of 4,5‐Disubstituted‐2‐Aminoimidazole–Triazole Conjugates for Antibiofilm/Antibiotic Resensitization Activity Against MRSA and Acinetobacter baumannii

Su, Z., Peng, L., Worthington, R. J., & Melander, C. (2011, September 16). ChemMedChem.

By: Z. Su n, L. Peng n, R. Worthington n & C. Melander n

author keywords: aminoimidazoles; antibiotic resensitization; biofilms; MRSA; synergism
MeSH headings : Acinetobacter baumannii / drug effects; Acinetobacter baumannii / physiology; Anti-Bacterial Agents / chemical synthesis; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Biofilms / drug effects; Imidazoles / chemistry; Methicillin-Resistant Staphylococcus aureus / drug effects; Methicillin-Resistant Staphylococcus aureus / physiology; Oxacillin / chemistry; Oxacillin / pharmacology; Structure-Activity Relationship; Triazoles / chemistry
topics (OpenAlex): Bacterial biofilms and quorum sensing; Antimicrobial Resistance in Staphylococcus; Antimicrobial agents and applications
TL;DR: This class of small molecules was found to inhibit biofilm formation by methicillin‐resistant Staphylococcus aureus (MRSA) at low‐micromolar concentrations and the ability of selected compounds to resensitize MRSA to traditional antibiotics (resensitization activity) was determined. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2011 journal article

Inhibition of Acinetobacter baumannii biofilm formation on a methacrylate polymer containing a 2-aminoimidazole subunit

Chemical Communications (Cambridge, England), 47(17), 4896–4898.

By: L. Peng, J. DeSousa, Z. Su, B. Novak, A. Nevzorov, E. Garland, C. Melander

Source: NC State University Libraries
Added: August 6, 2018

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