Andrew L. Olson

Works (8)

Updated: July 23rd, 2023 19:25

2019 article

The Solution Structures and Interaction of SinR and SinI: Elucidating the Mechanism of Action of the Master Regulator Switch for Biofilm Formation in Bacillus subtilis

Milton, M. E., Draughn, G. L., Bobay, B. G., Stowe, S. D., Olson, A. L., Feldmann, E. A., … Cavanagh, J. (2019, September 5). Journal of Molecular Biology.

By: M. Milton *, G. Draughn n, B. Bobay n, S. Stowe n, A. Olson n, E. Feldmann n, R. Thompson*, K. Myers n ...

author keywords: Biofilms; Bacillus subtilis; Transcriptional regulation; NMR solution structure
MeSH headings : Amino Acid Sequence / genetics; Bacillus subtilis / genetics; Bacillus subtilis / ultrastructure; Bacterial Proteins / chemistry; Bacterial Proteins / genetics; Bacterial Proteins / ultrastructure; Biofilms / growth & development; DNA-Binding Proteins / chemistry; DNA-Binding Proteins / genetics; DNA-Binding Proteins / ultrastructure; Gene Expression Regulation, Bacterial / genetics; Molecular Docking Simulation; Mutation / genetics; Protein Binding / genetics; Protein Conformation
topics (OpenAlex): Bacterial Genetics and Biotechnology; Bacterial biofilms and quorum sensing; Bacteriophages and microbial interactions
TL;DR: This work presents the first full-length structural model of tetrameric SinR using a hybrid approach combining high-resolution solution NMR, chemical crosslinking, mass spectrometry, and molecular docking, and provides an evidence-based mechanism that confirms how disruption of the SinR tetramer by SinI regulates gene expression. (via Semantic Scholar)
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Source: Web Of Science
Added: February 27, 2020

2014 article

A DNA Mimic: The Structure and Mechanism of Action for the Anti-Repressor Protein AbbA

Tucker, A. T., Bobay, B. G., Banse, A. V., Olson, A. L., Soderblom, E. J., Moseley, M. A., … Cavanagh, J. (2014, February 15). Journal of Molecular Biology.

By: A. Tucker n, B. Bobay n, A. Banse*, A. Olson n, E. Soderblom *, M. Moseley *, R. Thompson n, K. Varney *, R. Losick *, J. Cavanagh n

author keywords: transition state regulator; AbbA; DNA mimic; molecular docking; NMR
MeSH headings : Bacillus subtilis / chemistry; Bacillus subtilis / metabolism; Bacterial Proteins / chemistry; Bacterial Proteins / metabolism; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Docking Simulation; Protein Conformation; Protein Multimerization
topics (OpenAlex): Bacterial Genetics and Biotechnology; RNA and protein synthesis mechanisms; Bacteriophages and microbial interactions
TL;DR: Interestingly, it is shown that AbbA has structural and surface characteristics that closely mimic the DNA phosphate backbone, enabling it to readily carry out its physiological function. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2014 article

Structure and DNA-Binding Traits of the Transition State Regulator AbrB

Olson, A. L., Tucker, A. T., Bobay, B. G., Soderblom, E. J., Moseley, M. A., Thompson, R. J., & Cavanagh, J. (2014, October 9). Structure.

By: A. Olson n, A. Tucker n, B. Bobay n, E. Soderblom *, M. Moseley *, R. Thompson n, J. Cavanagh n

MeSH headings : Bacillus subtilis / metabolism; Bacterial Proteins / chemistry; Bacterial Proteins / metabolism; Binding Sites; DNA, Bacterial / metabolism; DNA-Binding Proteins / chemistry; DNA-Binding Proteins / metabolism; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Docking Simulation; Protein Multimerization; Protein Structure, Secondary; Transcription Factors / chemistry; Transcription Factors / metabolism
topics (OpenAlex): Bacterial Genetics and Biotechnology; Antibiotic Resistance in Bacteria; Bacteriophages and microbial interactions
TL;DR: It is noted that AbrB possesses a strip of positive electrostatic potential encompassing its DNA-binding region and that its C-terminal domain aids in DNA binding. (via Semantic Scholar)
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Added: August 6, 2018

2013 article

Chemical crosslinking and LC/MS analysis to determine protein domain orientation: Application to AbrB

Olson, A. L., Liu, F., Tucker, A. T., Goshe, M. B., & Cavanagh, J. (2013, January 9). Biochemical and Biophysical Research Communications.

By: A. Olson n, F. Liu n, A. Tucker n, M. Goshe n & J. Cavanagh n

author keywords: NMR; Solution structure; Chemical crosslinking; Domain orientation; AbrB; Gas-phase cleavable
MeSH headings : Amino Acid Sequence; Bacterial Proteins / chemistry; Chromatography, Liquid; Cross-Linking Reagents / chemistry; DNA-Binding Proteins / chemistry; Molecular Sequence Data; Protein Structure, Tertiary; Tandem Mass Spectrometry; Transcription Factors / chemistry
topics (OpenAlex): Mass Spectrometry Techniques and Applications; Electron Spin Resonance Studies; Photosynthetic Processes and Mechanisms
TL;DR: This work solved the NMR structures of both domains independently and utilized gas-phase cleavable chemical crosslinking and LC/MS(n) analysis to correctly position the domains within the full tetrameric AbrB protein structure. (via Semantic Scholar)
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Added: August 6, 2018

2013 article

Chemical shift assignments and secondary structure prediction of the master biofilm regulator, SinR, from Bacillus subtilis

Stowe, S. D., Olson, A. L., Losick, R., & Cavanagh, J. (2013, March 9). Biomolecular NMR Assignments.

By: S. Stowe n, A. Olson n, R. Losick * & J. Cavanagh n

author keywords: NMR; SinR; Bacillus subtilis; Biofilm regulation
MeSH headings : Bacillus subtilis / metabolism; Bacterial Proteins / chemistry; Biofilms; Nuclear Magnetic Resonance, Biomolecular; Protein Structure, Secondary
topics (OpenAlex): Bacterial biofilms and quorum sensing; Bacterial Genetics and Biotechnology; Antibiotic Resistance in Bacteria
TL;DR: The full-length backbone and side chain chemical shift values in addition to the experimentally derived secondary structure predictions are reported as the first step towards directly studying the complex interaction dynamics between SinR and SinI. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2012 article

Chemical shift assignments and secondary structure prediction of the C-terminal domain of the response regulator BfmR from Acinetobacter baumannii

Olson, A. L., Thompson, R. J., Melander, C., & Cavanagh, J. (2012, December 20). Biomolecular NMR Assignments.

By: A. Olson n, R. Thompson n, C. Melander  n & J. Cavanagh n

author keywords: NMR; BfmR; Acinetobacter baumannii; Assignment
MeSH headings : Acinetobacter baumannii / metabolism; Bacterial Proteins / chemistry; Nuclear Magnetic Resonance, Biomolecular; Protein Structure, Secondary; Protein Structure, Tertiary
topics (OpenAlex): Antibiotic Resistance in Bacteria; Bacterial Genetics and Biotechnology; Bacterial biofilms and quorum sensing
TL;DR: Backbone and sidechain resonance assignments and secondary structure prediction for the C-terminal domain of BfmR (residues 130–238) from A. baumannii are reported. (via Semantic Scholar)
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Added: August 6, 2018

2012 article

Identification of BfmR, a Response Regulator Involved in Biofilm Development, as a Target for a 2-Aminoimidazole-Based Antibiofilm Agent

Thompson, R. J., Bobay, B. G., Stowe, S. D., Olson, A. L., Peng, L., Su, Z., … Cavanagh, J. (2012, November 27). Biochemistry.

By: R. Thompson n, B. Bobay n, S. Stowe n, A. Olson n, L. Peng n, Z. Su n, L. Actis *, C. Melander n, J. Cavanagh n

MeSH headings : Acinetobacter baumannii / drug effects; Acinetobacter baumannii / growth & development; Bacterial Proteins / chemistry; Bacterial Proteins / physiology; Biofilms / drug effects; Imidazoles / pharmacology; Microscopy, Confocal; Models, Molecular
topics (OpenAlex): Bacterial biofilms and quorum sensing; Antimicrobial Peptides and Activities; Bacterial Genetics and Biotechnology
TL;DR: The 2AI compound studied here represents a unique small molecule scaffold that targets bacterial response regulators and is cell permeable, while pull-down assays identified BfmR, a response regulator that is the master controller of biofilm formation, as a target for this compound. (via Semantic Scholar)
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Added: August 6, 2018

2011 article

1H, 13C, and 15N resonance assignments and secondary structure prediction of the full-length transition state regulator AbrB from Bacillus anthracis

Olson, A. L., Bobay, B. G., Melander, C., & Cavanagh, J. (2011, August 3). Biomolecular NMR Assignments.

By: A. Olson n, B. Bobay n, C. Melander n & J. Cavanagh n

author keywords: AbrB; NMR; Bacillus anthracis; Transition state regulator
MeSH headings : Bacillus anthracis; Bacterial Proteins / chemistry; DNA-Binding Proteins / chemistry; Nuclear Magnetic Resonance, Biomolecular; Protein Structure, Secondary; Transcription Factors / chemistry
topics (OpenAlex): Bacterial Genetics and Biotechnology; Enzyme Structure and Function; Protein Structure and Dynamics
TL;DR: Backbone and sidechain resonance assignments and secondary structure prediction for the full-length AbrB protein from B. anthracis are reported. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

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