Works (7)

Updated: August 7th, 2023 21:15

2021 article

The evaluation of a multiphasic 3D-bioplotted scaffold seeded with adipose derived stem cells to repair osteochondral defects in a porcine model

Nordberg, R. C., Huebner, P., Schuchard, K. G., Mellor, L. F., Shirwaiker, R. A., Loboa, E. G., & Spang, J. T. (2021, June 10). JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, Vol. 6.

By: R. Nordberg n, P. Huebner n, K. Schuchard n, L. Mellor n, R. Shirwaiker n, E. Loboa*, J. Spang*

author keywords: in vivo; osteochondral; stem cells; tissue engineering; 3D-printing
MeSH headings : Animals; Cartilage, Articular / injuries; Stem Cells; Swine; Swine, Miniature; Tissue Engineering / methods; Tissue Scaffolds / chemistry
TL;DR: Overall, scaffold groups repaired the defect more successfully than an open lesion but achieved limited repair in the cartilage region, indicating that this approach holds potential to treat focal cartilage lesions in a highly personalized manner using a human patient's own ASC cells. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, ORCID
Added: June 21, 2021

2020 journal article

Investigation of multiphasic 3D-bioplotted scaffolds for site-specific chondrogenic and osteogenic differentiation of human adipose-derived stem cells for osteochondral tissue engineering applications

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, 108(5), 2017–2030.

By: L. Mellor n, R. Nordberg n, P. Huebner n, M. Mohiti-Asli n, M. Taylor n, W. Efird*, J. Oxford*, J. Spang*, R. Shirwaiker n, E. Loboa*

author keywords: 3D-printing; chondrogenic differentiation; human adipose derived stem cells; osteochondral; osteogenic differentiation
MeSH headings : Adipose Tissue / metabolism; Biocompatible Materials / chemistry; Bone and Bones; Calcium Phosphates / chemistry; Calcium Phosphates / metabolism; Cartilage, Articular / metabolism; Cell Differentiation; Cells, Cultured; Chondrogenesis / physiology; Collagen Type I / genetics; Collagen Type I / metabolism; Extracellular Matrix / chemistry; Extracellular Matrix / metabolism; Humans; Mesenchymal Stem Cells / cytology; Mesenchymal Stem Cells / metabolism; Osteogenesis / physiology; Polyesters / chemistry; Polyesters / metabolism; Printing, Three-Dimensional; Tissue Engineering; Tissue Scaffolds / chemistry
TL;DR: A scaffold that would induce site‐specific osteogenic and chondrogenic differentiation of human adipose‐derived stem cells (hASC) to generate a full osteochondral implant is created and holds great promise as cartilage morbidity is minimized since autologous cartilage harvest is not required. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: January 6, 2020

2019 journal article

Evidence for Aryl hydrocarbon Receptor-Mediated Inhibition of Osteoblast Differentiation in Human Mesenchymal Stem Cells

TOXICOLOGICAL SCIENCES, 167(1), 145–156.

By: A. Watson n, R. Nordberg n, E. Loboa n & S. Kullman n

author keywords: aryl hydrocarbon receptor; 2,3,7,8-tetrachlorodibenzo-p-dioxin; TCDD; mesenchymal stem cell; osteoblast differentiation; skeletal toxicity; bone toxicity
MeSH headings : Basic Helix-Loop-Helix Transcription Factors / agonists; Cell Differentiation / drug effects; Fibroblast Growth Factor 9 / genetics; Fibroblast Growth Factors / genetics; Humans; Ligands; Mesenchymal Stem Cells / cytology; Mesenchymal Stem Cells / drug effects; Mesenchymal Stem Cells / metabolism; Osteoblasts / cytology; Osteoblasts / drug effects; Osteoblasts / metabolism; Osteogenesis / drug effects; Osteogenesis / genetics; Polychlorinated Dibenzodioxins / toxicity; Receptors, Aryl Hydrocarbon / agonists; Up-Regulation
TL;DR: Experimental evidence from this study suggests that AhR transactivation likely attenuates osteoblast differentiation in multipotent hBMSCs, and underscores the use of primary human MSCs to evaluate osteoinductive or osteotoxic potential of chemical and pharmacologic agents in vitro. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: April 15, 2019

2017 journal article

Comparison of simulated microgravity and hydrostatic pressure for chondrogenesis of hASC

Aerospace Medicine and Human Performance, 88(4), 377–384.

By: L. Mellor, A. Steward, R. Nordberg, M. Taylor & E. Loboa

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

Electrical Cell-Substrate Impedance Spectroscopy Can Monitor Age-Grouped Human Adipose Stem Cell Variability During Osteogenic Differentiation

STEM CELLS TRANSLATIONAL MEDICINE, 6(2), 502–511.

By: R. Nordberg n, J. Zhang n, E. Griffith n, M. Frank n, B. Starly n & E. Loboa n

author keywords: Electrical cell-substrate impedance spectroscopy; Adipose stem cells; Osteogenesis; Bioimpedance
MeSH headings : Adipose Tissue / cytology; Adult; Age Factors; Aged; Aged, 80 and over; Bone and Bones / cytology; Cell Differentiation; Cell Proliferation; Cells, Cultured; Dielectric Spectroscopy / methods; Electric Impedance; Humans; Middle Aged; Osteogenesis; Phenotype; Stem Cells / metabolism; Stem Cells / physiology; Time Factors; Young Adult
TL;DR: This is the first study to use ECIS to predict osteogenic potential of multiple hASC populations and to show that donor age may temporally control onset of osteogenesis, which could be critical for development of patient‐specific bone tissue engineering and regenerative medicine therapies. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2016 journal article

Enhanced cellular infiltration of human adipose-derived stem cells in allograft menisci using a needle-punch method

Journal of Orthopaedic Surgery and Research, 11.

By: R. Nordberg, A. Charoenpanich, C. Vaughn, E. Griffith, M. Fisher, J. Cole, J. Spang, E. Loboa

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Our Fat Future: Translating Adipose Stem Cell Therapy

STEM CELLS TRANSLATIONAL MEDICINE, 4(9), 974–979.

By: R. Nordberg n & E. Loboa n

MeSH headings : Adipocytes / cytology; Adipocytes / physiology; Adipose Tissue / cytology; Adipose Tissue / physiology; Automation, Laboratory / instrumentation; Biomimetic Materials / chemistry; Biosensing Techniques / instrumentation; Cell Differentiation; Cell- and Tissue-Based Therapy / methods; Clinical Trials as Topic; Humans; Stem Cell Transplantation / methods; Stem Cells / cytology; Stem Cells / physiology; Translational Research, Biomedical / legislation & jurisprudence; Translational Research, Biomedical / trends; United States; United States Food and Drug Administration / legislation & jurisprudence; Workforce
TL;DR: The progress and challenges of bringing adipose stem cell therapy into mainstream clinical use are discussed. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

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