Works Published in 2002
Displaying works 21 - 40 of 60 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2002 journal article
Time course and manner of Purkinje neuron death following a single ethanol exposure on postnatal day 4 in the developing rat
Neuroscience, 114(2), 327–337.
Contributors: K. Light*, S. Belcher* & D. Pierce*
author keywords: cerebellum; neuronal development; apoptosis; caspase-3; cytochrome c
MeSH headings : Alcohol-Induced Disorders, Nervous System / metabolism; Alcohol-Induced Disorders, Nervous System / pathology; Alcohol-Induced Disorders, Nervous System / physiopathology; Animals; Animals, Newborn; Apoptosis / drug effects; Apoptosis / physiology; Calbindin 1; Calbindins; Caspase 3; Caspases / drug effects; Caspases / metabolism; Cerebellar Cortex / drug effects; Cerebellar Cortex / growth & development; Cerebellar Cortex / pathology; Cytochrome c Group / drug effects; Cytochrome c Group / metabolism; Drug Administration Schedule; Ethanol / toxicity; Female; Fetal Alcohol Spectrum Disorders / metabolism; Fetal Alcohol Spectrum Disorders / pathology; Fetal Alcohol Spectrum Disorders / physiopathology; Immunohistochemistry; In Situ Nick-End Labeling; Male; Mitochondria / drug effects; Mitochondria / metabolism; Mitochondria / pathology; Nerve Degeneration / chemically induced; Nerve Degeneration / metabolism; Nerve Degeneration / physiopathology; Pregnancy; Prenatal Exposure Delayed Effects; Purkinje Cells / drug effects; Purkinje Cells / metabolism; Purkinje Cells / pathology; Rats; Rats, Sprague-Dawley; S100 Calcium Binding Protein G / metabolism; Time Factors
TL;DR:
The data demonstrate that a single dose of ethanol results in a significant and extensive, lobular dependent loss of Purkinje cells within 24 h after administration, and support the hypothesis that ethanol-induced loss ofPurkinje Cells involves apoptotic mechanisms.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: March 5, 2021
2002 journal article
Ethanol-induced alterations of neurotrophin receptor expression on Purkinje cells in the neonatal rat cerebellum
Brain Research, 924(1), 71–81.
Contributors: K. Light*, D. Brown*, B. Newton *, S. Belcher* & C. Kane*
author keywords: cerebellum; truncated TrkB; TrkC; ethanol exposure; immunohistochemical
MeSH headings : Alcohol-Induced Disorders, Nervous System / metabolism; Alcohol-Induced Disorders, Nervous System / physiopathology; Animals; Brain-Derived Neurotrophic Factor / metabolism; Cell Differentiation / drug effects; Cell Differentiation / physiology; Cerebellar Cortex / drug effects; Cerebellar Cortex / growth & development; Cerebellar Cortex / pathology; Ethanol / pharmacology; Female; Fetal Alcohol Spectrum Disorders / metabolism; Fetal Alcohol Spectrum Disorders / physiopathology; Immunohistochemistry; Male; Nerve Degeneration / chemically induced; Nerve Degeneration / metabolism; Nerve Degeneration / physiopathology; Nerve Growth Factors / metabolism; Neurotrophin 3 / metabolism; Pregnancy; Purkinje Cells / drug effects; Purkinje Cells / metabolism; Purkinje Cells / pathology; Rats; Rats, Sprague-Dawley; Receptor, trkB / metabolism; Receptor, trkC / metabolism; Receptors, Nerve Growth Factor / drug effects; Receptors, Nerve Growth Factor / metabolism
TL;DR:
Ethanol selectively decreased Purkinje cell expression of TrkB and TrkC receptors following exposures within the vulnerable period (PN4-6), suggesting that ethanol may induce loss ofPurkinje cells by alteration of neurotrophic regulation at this critical stage.
(via Semantic Scholar)
Source: ORCID
Added: March 5, 2021
2002 journal article
Estrogen regulates GFAP-expression in specific subnuclei of the female rat interpeduncular nucleus: A potential role for estrogen receptor β
Brain Research, 958(2), 488–496.
Contributors: A. Zsarnovszky*, T. Smith*, F. Hajos* & S. Belcher*
author keywords: astrocyte; estrogen; estrogen receptor betas; glia, glial fibrillary acidic protein immunohistochemistry; interpeduncular nucleus
MeSH headings : Animals; Estradiol / pharmacology; Estrogen Receptor beta; Estrogens / pharmacology; Female; Glial Fibrillary Acidic Protein / analysis; Glial Fibrillary Acidic Protein / biosynthesis; Mesencephalon / chemistry; Mesencephalon / drug effects; Mesencephalon / metabolism; Ovariectomy; Rats; Rats, Sprague-Dawley; Receptors, Estrogen / analysis; Receptors, Estrogen / physiology
TL;DR:
Results indicate that E(2), in the absence of other ovarian hormones, modulates GFAP-expression within select IPN subnuclei and that these affects are dependent on position along the AP axis and suggest that in the IPN, E( 2) may directly modulateGFAP- expression through ERbeta-mediated mechanisms.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: March 5, 2021
2002 chapter
Anaerobic Decomposition of Refuse in Landfills and Methane Oxidation in Landfill Cover Soils
In C. Hurst & R. Crawford (Eds.), Manual of Environmental Microbiology (2nd ed., pp. 696–718). Washington, D. C: American Society of Microbiology.
Ed(s): C. Hurst & R. Crawford
Source: NC State University Libraries
Added: March 5, 2021
2002 journal article
Tailoring the gas-phase dissociation and determining the relative energy of activation for dissociation of 7-deaza purine modified oligonucleotides containing a repeating motif
International Journal of Mass Spectrometry, 219(1), 139–150.
TL;DR:
7-Deaza purine modified oligonucleotides with a repeating motif have been sequenced by slow heating methods illustrating the ability to alter the preferred unimolecular decomposition pathway and limited the number of product ions per repeat unit resulting in an increased signal-to-noise ratio for the tandem mass spectrometry data.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: February 27, 2021
2002 journal article
Evaluation of sample preparation techniques for mass measurements of PCR products using ESI-FT-ICR mass spectrometry
Journal of the American Society for Mass Spectrometry, 13(4), 338–344.
MeSH headings : 2-Propanol / chemistry; 2-Propanol / isolation & purification; DNA / chemistry; Ethanol / chemistry; Ethanol / isolation & purification; Indicators and Reagents; Microdialysis; Polymerase Chain Reaction / methods; Solvents; Spectrometry, Mass, Electrospray Ionization / methods
TL;DR:
Alternative cleanup techniques that are compatible with automation are explored here with the intent of expanding the bottleneck that exists between the production of PCR products and analysis by electrospray ionization mass spectrometry (ESI-MS).
(via Semantic Scholar)
link.springer.com (publisher PDF)
Sources: Crossref, NC State University Libraries
Added: February 27, 2021
2002 journal article
In celebration of the 70th birthday of Dr David M. Hercules
Analytical and Bioanalytical Chemistry, 373(7), 517–518.
MeSH headings : Chemistry, Analytic / history; History, 20th Century; History, 21st Century; Spectrum Analysis; United States
Sources: Crossref, NC State University Libraries
Added: February 12, 2021
2002 journal article
Memoirs, Hercules lineage, students, visiting scientists and staff
Analytical and Bioanalytical Chemistry, 373(7), 669–675.
Sources: Crossref, NC State University Libraries
Added: February 12, 2021
2002 journal article
Dual-micro-ESI source for precise mass determination on a quadrupole time-of-flight mass spectrometer for genomic and proteomic applications
Analytical and Bioanalytical Chemistry, 373(7), 538–546.
author keywords: electrospray; time-of-flight; mass spectrometry; internal calibration; accurate mass
MeSH headings : Amino Acid Sequence; Calibration; Caseins / chemistry; Caseins / metabolism; Genomics / methods; Ions; Molecular Sequence Data; Phosphoproteins / chemistry; Phosphoproteins / metabolism; Polymerase Chain Reaction; Proteome; Sensitivity and Specificity; Sequence Analysis, Protein; Spectrometry, Mass, Electrospray Ionization / instrumentation; Spectrometry, Mass, Electrospray Ionization / methods; Trypsin / metabolism
TL;DR:
In this report, the dual-sprayer is demonstrated in the negative-ion mode for internal calibration of polymerase chain reaction (PCR) amplicons generated from synthetic and genomic templates as well as a proteolytic digest of a naturally phosphorylated protein.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: February 12, 2021
2002 journal article
Gas-Phase Ion Unimolecular Dissociation for Rapid Phosphopeptide Mapping by IRMPD in a Penning Ion Trap: An Energetically Favored Process
Journal of the American Chemical Society, 124(23), 6546–6547.
MeSH headings : Amino Acid Sequence; Lasers; Peptide Mapping / methods; Phosphopeptides / chemistry; Receptor, Insulin / chemistry; Spectrometry, Mass, Electrospray Ionization / methods; Spectroscopy, Fourier Transform Infrared / methods; Thermodynamics
TL;DR:
This research demonstrates that the energy of activation for dissociation of the phosphopeptides is lower than that of the unmodified analogues providing the basis for the success of this technique, and IRMPD of ions in a Penning ion trap is an ideal platform for rapid phosphopeptic mapping.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: February 12, 2021
2002 journal article
Solution composition and thermal denaturation for the production of single-stranded PCR amplicons: Piperidine-induced destabilization of the DNA duplex?
Journal of the American Society for Mass Spectrometry, 13(3), 232–240.
MeSH headings : Cyclotrons; DNA / chemistry; DNA / drug effects; DNA, Single-Stranded / chemistry; Fourier Analysis; Hot Temperature; Humans; Nucleic Acid Denaturation / drug effects; Oligonucleotides / chemistry; Piperidines / pharmacology; Reverse Transcriptase Polymerase Chain Reaction; Spectrometry, Mass, Electrospray Ionization
TL;DR:
The volatile base piperidine, present at 20 mM concentrations in the electrospray solution, was found to play a critical role in the formation of single-stranded species at the higher aqueous percentages and a duplex destabilization mechanism has been proposed.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: February 12, 2021
2002 journal article
CEPH family 1362 STR database: An online resource for characterization of PCR products using electrospray ionization mass spectrometry
Journal of the American Society for Mass Spectrometry, 13(1), 89–90.
MeSH headings : DNA, Complementary / chemistry; Databases, Genetic; Genetic Markers; Humans; Internet; Polymerase Chain Reaction / methods; Spectrometry, Mass, Electrospray Ionization / methods; Tandem Repeat Sequences / genetics
TL;DR:
An online database has been established in order to validate electrospray ionization mass spectrometry (ESI-MS) for genotyping and to publicize the procedures developed in the laboratory for the characterization of PCR products by ESI-MS.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: February 12, 2021
2002 journal article
In the (adsorption) competition between NOM and MIB, who is the winner, and why?
Water Science and Technology: Water Supply, 2(2), 59–67.
Contributors: G. Newcombe*, J. Morrison, C. Hepplewhite & D. Knappe n
author keywords: activated carbon; adsorption; MIB; tastes and odours
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Sources: Crossref, ORCID
Added: August 28, 2020
2002 journal article
Reproducibility of urinary phthalate metabolites in first morning urine samples.
Environmental Health Perspectives, 110(5), 515–518.
Contributors: J. Hoppin* , J. Brock*, B. Davis * & D. Baird*
author keywords: biologic markers; environmental exposure; phthalates; reliability; urine; women's health
MeSH headings : Adult; Biomarkers / analysis; Chromatography, High Pressure Liquid; Environmental Exposure; Female; Half-Life; Humans; Middle Aged; Phthalic Acids / urine; Reproducibility of Results; Sensitivity and Specificity; Specimen Handling; Urinalysis
TL;DR:
The results suggest that even with the short half-lives of phthalates, women's patterns of exposure may be sufficiently stable to assign an exposure level based on a single first morning void urine measurement.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: September 13, 2019
2002 journal article
Prevalence of exposure to solvents, metals, grain dust, and other hazards among farmers in the Agricultural Health Study
Journal of Exposure Science & Environmental Epidemiology, 12(6), 418–426.
Contributors: J. Coble*, J. Hoppin* , L. Engel *, O. Elci *, M. Dosemeci*, C. Lynch *, M. Alavanja*
author keywords: confounding; exposure; farmers; pesticides
MeSH headings : Agriculture; Confounding Factors, Epidemiologic; Dust; Epidemiologic Studies; Female; Humans; Iowa / epidemiology; Male; Metals, Heavy / adverse effects; Metals, Heavy / analysis; Middle Aged; North Carolina / epidemiology; Occupational Exposure; Occupational Health; Pesticides / adverse effects; Pesticides / analysis; Prevalence; Risk Assessment; Solvents / adverse effects; Solvents / analysis
TL;DR:
The associations between the use of pesticides and the frequency with which the farmers in the AHS reported performing various types of specific farming activities were assessed to evaluate potential confounding, suggesting the magnitude of bias due to confounding is likely to be minimal.
(via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 13, 2019
2002 journal article
Potential for selection bias with tumor tissue retrieval in molecular epidemiology studies
Annals of Epidemiology, 12(1), 1–6.
Contributors: J. Hoppin* , P. Tolbert, J. Taylor, J. Schroeder & E. Holly
author keywords: molecular epidemiology; selection bias; tumor tissue
MeSH headings : Aged; California / epidemiology; Female; Humans; Male; Middle Aged; Molecular Epidemiology; Pancreatic Neoplasms / diagnosis; Pancreatic Neoplasms / epidemiology; Pancreatic Neoplasms / pathology; SEER Program; Selection Bias
TL;DR:
The potential for bias associated with differential availability of tumor blocks is discussed including consideration of tumor, patient, and hospital characteristics and the determinants of selection are described in all studies using tumor tissue.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: September 13, 2019
2002 journal article
Chemical Predictors of Wheeze among Farmer Pesticide Applicators in the Agricultural Health Study
American Journal of Respiratory and Critical Care Medicine, 165(5), 683–689.
Contributors: J. Hoppin* , D. Umbach *, S. London *, M. Alavanja* & D. Sandler *
MeSH headings : Adolescent; Adult; Aged; Aged, 80 and over; Agricultural Workers' Diseases / chemically induced; Agricultural Workers' Diseases / epidemiology; Asthma / chemically induced; Asthma / epidemiology; Causality; Cohort Studies; Female; Humans; Iowa; Male; Middle Aged; North Carolina; Pesticides / adverse effects; Respiratory Sounds / etiology; Risk Factors
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, ORCID
Added: September 13, 2019
2002 journal article
Occupational exposure to crystalline silica and risk of systemic lupus erythematosus: A population-based, case-control study in the Southeastern United States
Arthritis & Rheumatism, 46(7), 1840–1850.
Contributors: C. Parks, G. Cooper, L. Nylander-French, W. Sanderson, J. Dement, P. Cohen, M. Dooley, E. Treadwell
MeSH headings : Adolescent; Adult; Aged; Aged, 80 and over; Case-Control Studies; Educational Status; Female; Humans; Logistic Models; Lupus Erythematosus, Systemic / chemically induced; Lupus Erythematosus, Systemic / epidemiology; Male; Middle Aged; Occupational Exposure; Prevalence; Racial Groups; Silicon Dioxide / adverse effects; Southeastern United States / epidemiology
TL;DR:
It is suggested that crystalline silica exposure may promote the development of SLE in some individuals and additional research is recommended in other populations.
(via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 13, 2019
2002 journal article
Accuracy of self-reported pesticide use duration information from licensed pesticide applicators in the Agricultural Health Study
Journal of Exposure Science & Environmental Epidemiology, 12(5), 313–318.
Contributors: J. Hoppin* , F. Yucel*, M. Dosemeci* & D. Sandler *
author keywords: accuracy; farmers; pesticides; pesticide registration; questionnaire
MeSH headings : Epidemiologic Studies; Humans; Mental Recall; Occupational Exposure; Pesticides / chemistry; Pesticides / classification; Quality Control; Reproducibility of Results; Retrospective Studies; Time Factors
TL;DR:
The quality of the self-reported pesticide product use history of 57,311 licensed pesticide applicators in the Agricultural Health Study is compared to the year the pesticide active ingredient was first registered for use to suggest participants provide plausible information regarding their pesticide use.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 13, 2019
2002 journal article
A Quantitative Approach for Estimating Exposure to Pesticides in the Agricultural Health Study
The Annals of Occupational Hygiene, 46(2), 245–260.
Contributors: M. Dosemeci*, M. Alavanja, A. Rowland, D. Mage, S. Hoar Zahm, N. Rothman, J. Lubin, J. Hoppin* , D. Sandler, A. Blair
author keywords: exposure assessment; pesticide exposure; agricultural exposures; farmers; pesticide applicators; occupational exposures
MeSH headings : Accidents, Occupational; Agriculture; Algorithms; Humans; Iowa; North Carolina; Occupational Exposure; Pesticides / poisoning; Prospective Studies; Protective Clothing; Risk Assessment / methods; Surveys and Questionnaires
TL;DR:
A quantitative method to estimate long-term chemical-specific pesticide exposures in a large prospective cohort study of more than 58000 pesticide applicators in North Carolina and Iowa found that the take-home questionnaire sub-cohort of applicators is representative of the entire cohort in terms of exposure.
(via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 13, 2019
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