Center for Environmental and Health Effects of PFAS

Works Published in 2023

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Displaying works 1 - 20 of 74 in total

Sorted by most recent date added to the index first, which may not be the same as publication date order.

2023 journal article

CTD tetramers: a new online tool that computationally links curated chemicals, genes, phenotypes, and diseases to inform molecular mechanisms for environmental health

TOXICOLOGICAL SCIENCES, 195(2), 155–168.

author keywords: database tool; chemical-disease pathway; molecular mechanisms; environmental health; knowledge gaps; adverse outcome pathway
Sources: Web Of Science, NC State University Libraries
Added: April 1, 2024

2023 article

Human DOCK11 Deficiency Causes Defective Erythropoiesis and Systemic Inflammation

Block, J., Rashkova, C., Castanon, I., Platon, J., Zoghi, S., Fujiwara, M., … Boztug, K. (2023, November 2). BLOOD, Vol. 142.

By: J. Block*, C. Rashkova*, I. Castanon*, J. Platon*, S. Zoghi*, M. Fujiwara*, B. Chaves*, R. Schoppmeyer* ...

TL;DR: It is found that human DOCK11 regulates T-cell morphology and migration, suggesting that defects in Docks11 might impact the T cells' capability to fight infections and the immune dysregulation observed in the patients was uncovered. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: March 4, 2024

2023 article

Quasi-Mechanistic 3D Finite Element Model Predicts Temperatures in a U.S. Landfill

Hao, Z., Barlaz, M. A., & Ducoste, J. J. (2023, November 28). ACS ES&T ENGINEERING, Vol. 11.

By: Z. Hao n, M. Barlaz n & J. Ducoste n

author keywords: heat generation; ash hydration; ash carbonation; elevated temperature; solidwaste
Sources: Web Of Science, NC State University Libraries
Added: February 19, 2024

2023 article

Investigating the impact of whole genome duplication on transposable element evolution in ray-finned fishes

Mallik, R., Wcisel, D. J., Near, T. J., Yoder, J. A., & Dornburg, A. (2023, December 23).

By: R. Mallik*, D. Wcisel, T. Near, J. Yoder* & A. Dornburg*

TL;DR: The degree to which the teleost genome duplication (TGD) shaped the diversification trajectory of the ray-finned fish mobilome is investigated and the results suggest that historic ploidy events may not necessarily catalyze bursts of TE diversification and innovation. (via Semantic Scholar)
Source: ORCID
Added: February 1, 2024

2023 article

Quantitative Cross-Species Comparison of Serum Albumin Binding of Per- and Polyfluoroalkyl Substances from Five Structural Classes

Starnes, H. M., Jackson, T. W., Rock, K. D., & Belcher, S. M. (2023, November 14).

UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Source: ORCID
Added: January 29, 2024

2023 journal article

Automated, high-throughput quantification of EGFP-expressing neutrophils in zebrafish by machine learning and a highly-parallelized microscope

PLOS ONE, 18(12).

By: J. Efromson, G. Ferrero n, A. Begue, T. Doman, C. Dugo, A. Barker n, V. Saliu, P. Reamey ...

TL;DR: This open-source software package is presented which allows the user to train and evaluate a custom machine learning segmentation model and use it to localize zebrafish and analyze cell counts within the segmented region of interest. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: January 22, 2024

2023 journal article

Achieving Cross-Ring Fragmentation of <i>N</i>-Linked Glycans by IR-MALDESI

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 35(1), 166–171.

By: T. Palomino n & D. Muddiman n

author keywords: N-linked glycans; lithium doping; fragmentation; IR-MALDESI; cross-ring fragment
Sources: Web Of Science, NC State University Libraries
Added: January 16, 2024

2023 journal article

Degradation of imidacloprid by Phanerodontia chrysosporium on wood chips for stormwater treatment

ENVIRONMENTAL SCIENCE-WATER RESEARCH & TECHNOLOGY, 9(12), 3333–3343.

By: L. Weaver n, N. Alexander n, M. Cubeta n, D. Knappe n & T. Aziz n

Sources: Web Of Science, NC State University Libraries, ORCID
Added: December 18, 2023

2023 journal article

Characterizing Adeno-Associated Virus Capsids with Both Denaturing and Intact Analysis Methods

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 34(12), 2811–2821.

By: J. Ryan*, M. Kostelic*, C. Hsieh*, J. Powers n, C. Aspinwall*, J. Dodds*, J. Schiel, M. Marty*, E. Baker*

Source: Web Of Science
Added: December 18, 2023

2023 journal article

Uncovering the common factors of chemical exposure and behavior: Evaluating behavioral effects across a testing battery using factor analysis

NEUROTOXICOLOGY, 99, 264–273.

By: W. Marinello n, S. Gillera n, L. Huang n, J. Rollman n, D. Reif n & H. Patisaul n

author keywords: EDCs; Endocrine disruptors; Neurodevelopment; Neurotoxicology; Organophosphate; Flame retardants; Vole; Behavior
Sources: Web Of Science, NC State University Libraries
Added: December 18, 2023

2023 journal article

Interlaboratory Comparison of Extractable Organofluorine Measurements in Groundwater and Eel (<i>Anguilla rostrata</i>): Recommendations for Methods Standardization

ENVIRONMENTAL SCIENCE & TECHNOLOGY, 57(48), 20159–20168.

By: B. Ruyle*, H. Pickard*, L. Schultes*, F. Fredriksson*, A. Heffernan, D. Knappe n, H. Lord, P. Meng n ...

author keywords: Extractable organofluorine; combustion ion chromatography; per- and polyfluoroalkyl substances; analytical methods; interlaboratory comparison; aquatic contamination
Sources: Web Of Science, NC State University Libraries, ORCID
Added: December 18, 2023

2023 journal article

Respirometry reveals major lineage-based differences in the energetics of osmoregulation in aquatic invertebrates

JOURNAL OF EXPERIMENTAL BIOLOGY, 226(20).

author keywords: Aquatic invertebrates; Salinity; Metabolic rate; Aquatic insects; Calcium; Ion transport
TL;DR: It is shown here for the first time that metabolic rate was unchanged by salinity in the aquatic insects, whereas ion transport rates were positively correlated with higher salinities, which potentially implicates the cost of calcium uptake as a driver of increased metabolic rate under dilute conditions in organisms with calcified exoskeletons. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Source: Web Of Science
Added: December 4, 2023

2023 article

From big data to big insights: statistical and bioinformatic approaches for exploring the lipidome

Chappel, J. R., Kirkwood-Donelson, K. I., Reif, D. M., & Baker, E. S. (2023, October 25). ANALYTICAL AND BIOANALYTICAL CHEMISTRY, Vol. 10.

By: J. Chappel n, K. Kirkwood-Donelson*, D. Reif* & E. Baker*

author keywords: Lipidomics; Univariate; Multivariate; Pathway; Enrichment
TL;DR: A framework for guiding lipidomic data analysis to promote a greater assessment of lipidomic results, while understanding potential advantages and weaknesses along the way is provided. (via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: November 20, 2023

2023 journal article

Using Multidimensional Separations to Distinguish Isomeric Amino Acid-Bile Acid Conjugates and Assess Their Presence and Perturbations in Model Systems

ANALYTICAL CHEMISTRY, 95(41), 15357–15366.

By: A. Stewart n, M. Foley n, M. Dougherty*, S. Mcgill*, A. Gulati*, E. Gentry*, L. Hagey*, P. Dorrestein* ...

TL;DR: This work analyzed 8 core bile acids synthetically conjugated with 22 proteinogenic and nonproteogenic amino acids totaling 176 MCBAs and created an in-house extended bile acid library that was applied to healthy mice dosed with antibiotics and humans having fecal microbiota transplantation (FMT) to assess the MCBA presence and changes in the gut before and after each perturbation. (via Semantic Scholar)
Source: Web Of Science
Added: October 30, 2023

2023 journal article

Evaluating the optimal tissue thickness for mass spectrometry imaging using infrared matrix-assisted laser desorption electrospray ionization

RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 37(22).

TL;DR: This work defines an optimal sample thickness for IR-MALDESI-MSI and demonstrates the utility of optimizing tissue thickness for MSI platforms of comparable Z resolution. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: October 30, 2023

2023 journal article

Estimation of the Half-Lives of Recently Detected Per- and Polyfluorinated Alkyl Ethers in an Exposed Community

ENVIRONMENTAL SCIENCE & TECHNOLOGY, 57(41), 15348–15355.

author keywords: exposure; PFAS; water; humans; environment; toxicokinetic modeling
TL;DR: These fluoroethers had biological half-Lives longer than published half-lives for PFHxA and PFHpA but shorter than those for PFOA andPFOS (800-1200 days). (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: October 7, 2023

2023 journal article

A vision for safer food contact materials: Public health concerns as drivers for improved testing

ENVIRONMENT INTERNATIONAL, 180.

author keywords: Food packaging; Hazard assessment; Chronic disease; Chemical safety
TL;DR: The safety of FCMs may be improved by testing the overall migrate, including non-intentionally added substances (NIAS), of finished food contact articles, and expanding toxicological testing beyond genotoxicity to multiple endpoints associated with non-communicable diseases relevant to human health. (via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: September 26, 2023

2023 article

Comparative analysis of sucrose-embedding for whole-body zebrafish MSI by IR-MALDESI

Wang, M. F., Ritter, M. M., Kullman, S. W., & Muddiman, D. C. (2023, August 29). ANALYTICAL AND BIOANALYTICAL CHEMISTRY, Vol. 8.

author keywords: IR-MALDESI; Mass spectrometry imaging; Sucrose; PFA; Zebrafish
TL;DR: Danio rerio, or zebrafish, are model organisms for various disease states and can be imaged as a multi-organ sample to analyze morphological and metabolomic preservation as a result of sample preparation to compare sucrose-embedding with paraformaldehyde fixation against conventional fresh-frozen sample preparation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: September 25, 2023

2023 article

Deep autoencoder-based behavioral pattern recognition outperforms standard statistical methods in high-dimensional zebrafish studies

Green, A. J., Truong, L., Thunga, P., Leong, C., Hancock, M., Tanguay, R. L., & Reif, D. M. (2023, September 17).

By: A. Green n, L. Truong, P. Thunga n, C. Leong, M. Hancock n, R. Tanguay, D. Reif n

TL;DR: It is demonstrated that a deep autoencoder using raw behavioral tracking data from zebrafish toxicity screens outperforms conventional statistical methods, resulting in a comprehensive evaluation of behavioral data. (via Semantic Scholar)
Source: ORCID
Added: September 18, 2023

2023 article

Target and Suspect Screening Integrated with Machine Learning to Discover Per- and Polyfluoroalkyl Substance Source Fingerprints

Joseph, N. T., Schwichtenberg, T., Cao, D., Jones, G. D., Rodowa, A. E., Barlaz, M. A., … Helbling, D. E. (2023, September 11). ENVIRONMENTAL SCIENCE & TECHNOLOGY, Vol. 9.

author keywords: PFAS forensics; source allocation; principalcomponent analysis; hierarchical clustering; supportvector classification; logistic regression; randomforest; multivariate analyses
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: September 12, 2023

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