Richard T. Miller

Works (13)

Updated: August 16th, 2024 13:38

2006 review

The role of pathology in the identification of drug-induced hepatic toxicity

[Review of ]. EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY, 2(2), 241–247.

By: J. Cullen n & R. Miller*

author keywords: drug-induced toxicity; liver; pathology; safety assessment; toxicology
MeSH headings : Animals; Chemical and Drug Induced Liver Injury / diagnosis; Chemical and Drug Induced Liver Injury / etiology; Drug Evaluation, Preclinical / methods; Drug Industry / methods; Humans; Liver / pathology; Pathology, Clinical / education; Pathology, Clinical / methods
TL;DR: Technological advances require pathologists to integrate molecular-based mechanistic data effectively with traditional morphological evaluation to develop a more detailed grasp of the pathogenesis of drug-induced injury. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2003 journal article

The herbicide metolachlor induces liver cytochrome P450s 2B1/2 and 3A1/2, but not thyroxine-uridine dinucleotide phosphate glucuronosyltransferase and associated thyroid gland activity

International Journal of Toxicology, 22(4), 287–295.

By: S. Dalton, R. Miller & S. Meyer

Source: NC State University Libraries
Added: August 6, 2018

2001 journal article

Role of thyroid hormones in hepatic effects of peroxisome proliferators

TOXICOLOGIC PATHOLOGY, 29(1), 149–155.

By: R. Miller n, L. Scappino n, S. Ling & J. Corton *

author keywords: liver; cell replication; hepatocarcinogenesis; thyroid receptor; acyl-CoA oxidase; hepatomegaly
MeSH headings : Animals; Cell Division / drug effects; Hepatomegaly / chemically induced; Hepatomegaly / pathology; Immunohistochemistry; Liver / drug effects; Liver / metabolism; Liver / pathology; Liver Neoplasms, Experimental / chemically induced; Liver Neoplasms, Experimental / pathology; Male; Peroxisome Proliferators / pharmacology; Proliferating Cell Nuclear Antigen / biosynthesis; RNA, Messenger / biosynthesis; RNA, Messenger / genetics; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear / biosynthesis; Receptors, Thyroid Hormone / biosynthesis; Thyroid Hormones / pharmacology; Thyroxine / blood; Transcription Factors / biosynthesis; Triiodothyronine / blood
TL;DR: Significant differences between humans and rodents with respect to thyroid hormone physiology and metabolism, in conjunction with the results of these studies, may be indicative of yet another mechanism to explain differential sensitivity to hepatic effects of peroxisome proliferators. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2000 journal article

Apoptosis, mitosis and cyclophilin-40 expression in regressing peroxisome proliferator-induced adenomas

CARCINOGENESIS, 21(4), 647–652.

By: R. Miller*, S. Anderson n, J. Corton n & R. Cattley n

MeSH headings : Adenoma / chemically induced; Adenoma / metabolism; Adenoma / pathology; Animals; Apoptosis / drug effects; Carrier Proteins / analysis; Carrier Proteins / physiology; Cyclophilin D; Cyclophilins; Liver / drug effects; Liver Neoplasms, Experimental / chemically induced; Liver Neoplasms, Experimental / metabolism; Liver Neoplasms, Experimental / pathology; Male; Mitosis / drug effects; Peptidylprolyl Isomerase / analysis; Peptidylprolyl Isomerase / physiology; Peroxisome Proliferators / toxicity; Pyrimidines / metabolism; Rats; Rats, Inbred F344; Receptors, Cytoplasmic and Nuclear / physiology; Transcription Factors / physiology
TL;DR: Results indicate that WY, 643-induced adenomas regress rapidly following withdrawal of the PP in association with declining liver WY-14,643 levels, suggesting that peroxisome proliferator-activated receptor alpha may mediate PP-induced alterations in mitogenic and/or apoptotic regulation in growing tumors, in conjunction with alterations in Cyp-40 signal transduction. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2000 journal article

Neurotoxicity of manganese chloride in neonatal and adult CD rats following subchronic (21-day) high-dose oral exposure

Journal of Applied Toxicology, 20(3), 179–187.

By: D. Dorman *, M. Struve*, D. Vitarella*, F. Byerly*, J. Goetz * & R. Miller n

TL;DR: The results of this experiment suggest that neonates may be at greater risk for Mn‐induced neurotoxicity when compared to adults receiving similar high oral levels of Mn. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: NC State University Libraries
Added: August 6, 2018

1999 journal article

Alteration of protein kinase C isoform-specific expression during rat hepatocarcinogenesis after exposure to the peroxisome proliferator WY-14,643

CANCER LETTERS, 137(1), 9–15.

By: J. Corton *, C. Swanson*, R. Miller n & R. Cattley*

author keywords: protein kinase C; peroxisome proliferators; hepatocarcinogenesis; rat
MeSH headings : Adenoma / chemically induced; Adenoma / enzymology; Animals; Carcinogens; Chloroform / toxicity; Liver Neoplasms, Experimental / chemically induced; Liver Neoplasms, Experimental / enzymology; Male; Neoplasm Proteins / metabolism; Protein Isoforms / metabolism; Protein Kinase C / metabolism; Pyrimidines; Rats; Rats, Inbred F344; Rats, Sprague-Dawley
TL;DR: Results indicate that alterations in PKCalpha, beta and delta isoforms, which regulate mitogenesis, could play important roles in perpetuating the high cell proliferative rate in PPC-induced hepatocellular adenomas. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1999 journal article

Platelets from thrombocytopenic ponies acutely infected with equine infectious anemia virus are activated in vivo and hypofunctional

VIROLOGY, 259(1), 7–19.

By: K. Russell n, P. Perkins*, M. Hoffman *, R. Miller n, K. Walker n, F. Fuller n , D. Sellon n

MeSH headings : Animals; Blood Platelets / pathology; Blood Platelets / virology; Equine Infectious Anemia / blood; Equine Infectious Anemia / complications; Equine Infectious Anemia / pathology; Humans; Infectious Anemia Virus, Equine / isolation & purification; Platelet Activation; Thrombocytopenia / blood; Thrombocytopenia / pathology; Thrombocytopenia / virology
TL;DR: It is concluded that thrombocytopenia in ponies acutely infected with EIAV is regenerative and suggest that bone marrow platelet production is not severely compromised in these ponies. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

1998 journal article

Axillary cystadenocarcinoma in a Moluccan cockatoo (Cacatua moluccensis)

AVIAN DISEASES, 42(2), 408–412.

By: L. Powers*, C. Merrill*, L. Degernes*, R. Miller*, K. Latimer & H. Barnes*

author keywords: Cacatua moluccensis; cystadenocarcinoma; humerus; Moluccan cockatoo; neoplasia; respiratory
TL;DR: Findings suggest a respiratory neoplasm in the right axillary region of the Moluccan cockatoo, although the tissue of origin remained undetermined. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1998 journal article

Cutaneous lymphoma with extensive periarticular involvement in a horse

Journal of the American Veterinary Medical Association, 213(3), 391–393.

By: M. Gerard, L. Healy, K. Bowman & R. Miller

Source: NC State University Libraries
Added: August 6, 2018

1998 journal article

Hyperglobulinemia and lymphocyte subset changes in naturally infected, in apparent carriers of equine infectious anemia virus

American Journal of Veterinary Research, 59(8), 1009–1015.

By: K. Russell, K. Walker, R. Miller & D. Sellon

Source: NC State University Libraries
Added: August 6, 2018

1998 journal article

Impact of Helicobacter hepaticus infection in B6C3F(1) mice from twelve national toxicology program two-year carcinogenesis studies

TOXICOLOGIC PATHOLOGY, 26(5), 602–611.

By: . Hailey*, J. Haseman*, . Bucher *, A. Radovsky*, D. Malarkey n, R. Miller n, A. Nyska *, R. Maronpot*

author keywords: liver neoplasia; mice; hemangiosarcoma; cell proliferation; H-ras; hepatitis
MeSH headings : Animals; Carcinogenicity Tests; Cell Cycle / physiology; Female; Genes, ras; Helicobacter; Helicobacter Infections / complications; Hepatitis / microbiology; Liver Neoplasms, Experimental / genetics; Liver Neoplasms, Experimental / microbiology; Male; Mice; Mice, Inbred Strains; Mutation; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Rats; Rats, Inbred F344
TL;DR: Data support the hypothesis that the increased incidence of liver neoplasms is associated with H. hepaticus and that hepatitis may be important in the pathogenesis and interpretation of carcinogenic effects in the liver of B6C3F1 mice may be confounded if there is H. liveraticus-associaled hepatitis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1998 article

Single-stage revision using an uncemented, porous-coated, anatomic endoprosthesis in two dogs: Case report

VETERINARY SURGERY, Vol. 27, pp. 268–277.

By: B. Massat n, R. Miller n, B. DeYoung n, R. Schiller n, H. Aberman n & D. DeYoung n

MeSH headings : Animals; Arthroplasty, Replacement, Hip / veterinary; Dogs / surgery; Hip Joint / diagnostic imaging; Hip Joint / pathology; Hip Prosthesis / veterinary; Male; Radiography
TL;DR: Revision with an uncemented implant in a single-stage procedure was successful in the two dogs described in this report and is a potential treatment for either condition as demonstrated by the successful outcome. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1997 journal article

Fatal perforating intestinal ulceration attributable to flunixin meglumine overdose in rats

Laboratory Animal Science, 47(2), 205–208.

By: C. King & R. Miller

Source: NC State University Libraries
Added: August 6, 2018

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