Works (67)
Updated: April 4th, 2024 10:31
2015 journal article
Comparative Genomic Analysis Identifies Divergent Genomic Features of Pathogenic Enterococcus cecorum Including a Type IC CRISPR-Cas System, a Capsule Locus, an epa-Like Locus, and Putative Host Tissue Binding Proteins
PLOS ONE, 10(4).
MeSH headings : Animals; Bacterial Proteins / chemistry; Bacterial Proteins / metabolism; CRISPR-Cas Systems / genetics; Chickens; Comparative Genomic Hybridization; Enterococcus / classification; Enterococcus / genetics; Enterococcus / isolation & purification; Evolution, Molecular; Genetic Loci; Genome, Bacterial; Genomics; Genotype; Phylogeny; Poultry Diseases / epidemiology; Poultry Diseases / microbiology; Virulence / genetics
TL;DR:
Specific genomic regions, coding sequences, and predicted proteins which may be related to the divergent evolution and increased virulence of emerging pathogenic strains of EC are identified and potential mediators of virulence identified.
(via Semantic Scholar)
journals.plos.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2015 journal article
Phylogenetic, taxonomic and functional diversity of fungal denitrifiers and associated N2O production efficacy
Soil Biology and Biochemistry, 83, 160–175.
author keywords: Fungal denitrification; Nitrous oxide; Fusarium; Aspergillus; Sordariomycetes; Eurotiomycetes
TL;DR:
Challenges with assessment of fungal N2O-producing activity across genera are described, prospects for future studies are suggested and species diversity is discussed in order to gain knowledge of important taxonomic and phylogenetic groups mediating N 2O production and provide insight on ecological cues associated with fungalN2O production.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science; OpenAlex)
13. Climate Action
(Web of Science)
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018
2013 chapter
Retroviridae
In D. McVey (Ed.), Veterinary Microbiology (Third). Blackwell-Wiley.
Ed(s): D. McVey
Source: NC State University Libraries
Added: September 11, 2019
2011 journal article
Detection of Chicken Proventricular Necrosis Virus (R11/3 Virus) in Experimental and Naturally Occurring Cases of Transmissible Viral Proventriculitis with the Use of a Reverse Transcriptase-PCR Procedure
AVIAN DISEASES, 55(1), 70–75.
author keywords: polymerase chain reaction; chicken; proventriculitis
MeSH headings : Adenoviridae Infections / veterinary; Animals; Aviadenovirus; Cells, Cultured; Chick Embryo; Chickens; Poultry Diseases / virology; Proventriculus / virology; Reverse Transcriptase Polymerase Chain Reaction / veterinary
TL;DR:
Findings indicate the utility of the RT-PCR procedure for detection of CPNV and provide additional evidence for an etiologic role for this virus in TVP.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2011 journal article
Physical and Genomic Characteristics Identify Chicken Proventricular Necrosis Virus (R11/3 Virus) as a Novel Birnavirus
AVIAN DISEASES, 55(1), 2–7.
author keywords: birnavirus; chicken; proventriculitis
MeSH headings : Amino Acid Sequence; Animals; Birnaviridae / classification; Birnaviridae / genetics; Birnaviridae Infections / veterinary; Birnaviridae Infections / virology; Capsid Proteins / genetics; Capsid Proteins / metabolism; Chickens; Cloning, Molecular; Genes, Viral; Genome, Viral; Molecular Sequence Data; Phylogeny; Poultry Diseases / virology; RNA, Viral / genetics
TL;DR:
Chicken proventricular necrosis virus, isolate R11/3, previously was isolated from transmissible viral proventriculitis–affected chickens and was determined to be the likely etiology of this disease, and phylogenetic analyses based on VP1 demonstrated that CPNV is deeply divergent from other birnaviruses.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2010 journal article
EIAV S2 enhances pro-inflammatory cytokine and chemokine response in infected macrophages
VIROLOGY, 397(1), 217–223.
author keywords: EIAV; Cytokines; Chemokines; Macrophage; Gene expression; Dysregulation; Real-time PCR
MeSH headings : Animals; Cells, Cultured; Cytokines / biosynthesis; Cytokines / immunology; Gene Deletion; Gene Expression Profiling; Horses; Infectious Anemia Virus, Equine / genetics; Infectious Anemia Virus, Equine / immunology; Macrophages / immunology; Macrophages / virology; Viral Proteins / genetics; Viral Proteins / immunology
TL;DR:
Results may help explain the effect of cytokine and chemokine dysregulation in EIAV pathogenesis and suggest a role of S2 in optimizing the host cell environment to promote viral dissemination and replication.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2010 journal article
Identification of cellular proteins interacting with equine infectious anemia virus S2 protein
VIRUS RESEARCH, 151(2), 235–239.
author keywords: Equine infectious anemia virus; EIAV; OS-9; PSMC3; TBP-1; Lentivirus
MeSH headings : Animals; Equidae; Host-Pathogen Interactions; Humans; Immunoprecipitation; Infectious Anemia Virus, Equine / pathogenicity; Molecular Sequence Data; Protein Interaction Mapping; Sequence Analysis, DNA; Two-Hybrid System Techniques; Viral Proteins / metabolism; Virulence Factors / metabolism
TL;DR:
A yeast-2-hybrid screen to identify cellular proteins that interact with EIAV S2 identified two human cellular proteins, amplified in osteosarcoma and proteasome 26S ATPase subunit 3 (PSMC3) that interactions with S2 that are likely to play a role as an adaptor protein.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2010 journal article
Virulence Determinants of Equine Infectious Anemia Virus
CURRENT HIV RESEARCH, 8(1), 66–72.
MeSH headings : Animals; Disease Models, Animal; Equine Infectious Anemia / virology; Horses; Host-Pathogen Interactions; Infectious Anemia Virus, Equine / genetics; Infectious Anemia Virus, Equine / pathogenicity; Macrophages; Terminal Repeat Sequences; Viral Tropism; Virulence Factors; Virus Replication
TL;DR:
Equine infectious anemia virus is a macrophage-tropic lentivirus that rapidly Induces disease in experimentally infected horses and the V6 region of the viral env protein is an example of one identified region that may interact with the ELR-1 receptor in an important way.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2007 journal article
Phylogenetic analysis of spring virema of carp virus reveals distinct subgroups with common origins for recent isolates in North America and the UK
DISEASES OF AQUATIC ORGANISMS, 76(3), 193–204.
author keywords: spring viremia of carp; SVCV; phosphoprotein gene; glycoprotein gene; phylogenetic analysis; molecular epidemiology
MeSH headings : Animals; Base Sequence; Carps; Fish Diseases / virology; Genetic Variation; Glycoproteins / chemistry; Glycoproteins / genetics; Molecular Sequence Data; North America; Phosphoproteins / chemistry; Phosphoproteins / genetics; Phylogeny; RNA, Viral / chemistry; RNA, Viral / genetics; Reverse Transcriptase Polymerase Chain Reaction / veterinary; Rhabdoviridae / classification; Rhabdoviridae / genetics; Rhabdoviridae / isolation & purification; Rhabdoviridae Infections / veterinary; Rhabdoviridae Infections / virology; Sequence Alignment; Sequence Analysis, DNA; United Kingdom
TL;DR:
Combined P- and G-sequence data support the emergence of SVCV in Illinois,USA, and in Lake Ontario, Canada, from the initial outbreak in Wisconsin, USA, and demonstrate a close genetic link to viruses isolated during routine import checks on fish brought into the UK from Asia.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2006 journal article
The S2 accessory gene of equine infectious anemia virus is essential for expression of disease in ponies
VIROLOGY, 349(1), 22–30.
author keywords: equine infectious anemia virus; viral pathogenesis; S2 accessory gene; accessory gene deletion; pathogenesis mutant
MeSH headings : Amino Acid Sequence; Animals; Blood / virology; Body Temperature; Cell Line; Dogs; Equine Infectious Anemia / physiopathology; Equine Infectious Anemia / virology; Gene Deletion; Genes, Essential; Genes, Viral; Horses; Infectious Anemia Virus, Equine / genetics; Infectious Anemia Virus, Equine / pathogenicity; Macrophages / virology; Mutagenesis, Site-Directed; RNA-Directed DNA Polymerase / analysis; Sequence Homology; Viral Load; Viral Proteins / genetics; Viral Proteins / physiology; Virus Replication
TL;DR:
It is demonstrated that S2 gene expression is essential for disease expression of EIAV.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2005 journal article
Partial characterization of an adenovirus-like virus isolated from broiler chickens with transmissible viral proventriculitis
AVIAN DISEASES, 49(3), 344–351.
author keywords: adenovirus; chicken; proventriculitis
MeSH headings : Adenoviridae Infections / complications; Adenoviridae Infections / transmission; Adenoviridae Infections / veterinary; Adenoviridae Infections / virology; Animals; Aviadenovirus / isolation & purification; Cells, Cultured; Chickens / virology; Inflammation / complications; Inflammation / virology; Poultry Diseases / transmission; Poultry Diseases / virology; Proventriculus / pathology; Proventriculus / virology; Specific Pathogen-Free Organisms; Stomach Diseases / pathology; Stomach Diseases / veterinary
TL;DR:
The findings suggest an etiologic role for AdLV (R11/3) in TVP and indicate that this virus is distinct from known avian adenoviruses.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2004 journal article
Antigenic and genomic characterization of turkey enterovirus-like virus (North Carolina, 1988 isolate): Identification of the virus as turkey astrovirus 2
AVIAN DISEASES, 48(1), 206–211.
author keywords: turkey enterovirus; turkey astrovirus
MeSH headings : Amino Acid Sequence; Animals; Antibodies, Monoclonal; Antigens, Viral; Capsid Proteins / genetics; Genome, Viral; Mamastrovirus / classification; Mamastrovirus / genetics; Mamastrovirus / immunology; Mamastrovirus / isolation & purification; Molecular Sequence Data; North Carolina; Reverse Transcriptase Polymerase Chain Reaction; Sequence Homology, Amino Acid; Turkeys / virology; Viral Proteins / genetics
TL;DR:
These studies definitively identify TELV (North Carolina, 1988 isolate), a small round virus isolated in 1988 from droppings of enteritis-affected turkeys in North Carolina, as turkey astrovirus 2 (TAstV2), a recently characterized SRV of turkeys.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2004 journal article
Influence of long terminal repeat and Env on the virulence phenotype of equine infectious anemia virus
JOURNAL OF VIROLOGY, 78(5), 2478–2485.
MeSH headings : Amino Acid Sequence; Animals; Base Sequence; Genome, Viral; Genotype; Horses / virology; Infectious Anemia Virus, Equine / genetics; Infectious Anemia Virus, Equine / pathogenicity; Infectious Anemia Virus, Equine / physiology; Molecular Sequence Data; Phenotype; Terminal Repeat Sequences / genetics; Viral Envelope Proteins / genetics; Viral Envelope Proteins / metabolism; Virulence / genetics
TL;DR:
Results from in vivo infections with chimeric clones indicate that both LTR and env of EIAV17 are required for the development of severe acute disease.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2004 journal article
Mechanism of feline immunodeficiency virus envelope glycoprotein-mediated fusion
VIROLOGY, 321(2), 274–286.
author keywords: feline immunodeficiency virus; glycoprotein-mediated fusion; lentiviruses
MeSH headings : Amino Acid Sequence; Animals; Benzylamines; CD4-Positive T-Lymphocytes / metabolism; CD4-Positive T-Lymphocytes / virology; Cats; Cell Line; Cyclams; Giant Cells; Heterocyclic Compounds / pharmacology; Immunodeficiency Virus, Feline / isolation & purification; Immunodeficiency Virus, Feline / physiology; Molecular Sequence Data; Peptides / chemical synthesis; Peptides / pharmacology; Protein Conformation; Protein Structure, Tertiary; Receptors, CXCR4 / antagonists & inhibitors; Receptors, CXCR4 / physiology; Sequence Alignment; Tryptophan; Viral Fusion Proteins / genetics; Viral Fusion Proteins / metabolism; Viral Fusion Proteins / physiology
TL;DR:
It is shown that a conserved tryptophan-rich region in the membrane proximal ectodomain of gp41 is critical for fusion, possibly at steps post hairpin structure formation, and that the mechanism and kinetics are similar to HIV env.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2004 chapter
Retroviridae
In D. Hirsch, N. J. Maclachlan, & R. L. Walker (Eds.), Veterinary Microbiology (2nd ed., pp. 409–426). Ames, Iowa: Blackwell Publishing.
Ed(s): D. Hirsch, N. Maclachlan & R. Walker
Source: NC State University Libraries
Added: February 12, 2021
2000 journal article
Cloning and sequencing hybrid striped bass (Morone saxatilis x M. chrysops) transforming growth factor-β (TGF-β), and development of a reverse transcription quantitative competitive polymerase chain reaction (RT-qcPCR) assay to measure TGF-β mRNA of teleost fish
Fish & Shellfish Immunology, 10(1), 61–85.
author keywords: transforming growth factor-beta; TGF-beta; sequence; hybrid striped bass; Morone saxatilis X M-chrysops; quantitative PCR
MeSH headings : Amino Acid Sequence; Animals; Base Sequence; Bass / metabolism; Blotting, Northern / veterinary; Blotting, Southern / veterinary; Chimera / genetics; Cloning, Molecular; Consensus Sequence; Humans; Kidney / chemistry; Molecular Sequence Data; Oncorhynchus mykiss; RNA, Messenger / analysis; Rats; Reverse Transcriptase Polymerase Chain Reaction / methods; Transforming Growth Factor beta / genetics; Xenopus
TL;DR:
Higher levels of TGF-beta mRNA expression were detected in mononuclear cells of peripheral blood than from spleen or anterior kidney, and a reverse transcription quantitative competitive polymerase chain reaction (RT-qcPCR) assay was devised to measure T GF- beta mRNA expression in teleost fish.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018
2000 journal article
Nucleotide sequence and vaccinia expression of the nucleoprotein of a highly virulent, neurotropic strain of Newcastle disease virus
AVIAN DISEASES, 44(1), 34–44.
author keywords: Newcastle disease virus; nucleoprotein; NP sequence; recombinant vaccinia virus expression of NDV NP
TL;DR:
Although inoculation of chickens with the recombinant vaccinia virus expressing the NDV NP gene elicited anti-NDV antibodies in higher titers than in birds inoculated with live LaSota NDV, this strong anti- NDV response did not protect against lethal challenge with NDV-TGB.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
1999 journal article
Long terminal repeat sequences of equine infectious anaemia virus are a major determinant of cell tropism.
Journal of General Virology, 80(3), 755–759.
MeSH headings : Animals; Base Sequence; Cell Line; Consensus Sequence / genetics; Fibroblasts / virology; Gene Expression Regulation, Viral; Gene Products, tat / genetics; Gene Products, tat / metabolism; Genes, Reporter; Genetic Variation; Horses / virology; Infectious Anemia Virus, Equine / classification; Infectious Anemia Virus, Equine / genetics; Infectious Anemia Virus, Equine / growth & development; Infectious Anemia Virus, Equine / pathogenicity; Macrophages / virology; Molecular Sequence Data; Mutagenesis, Site-Directed; Promoter Regions, Genetic / genetics; Terminal Repeat Sequences / genetics; Transcriptional Activation; Transfection; Wyoming
TL;DR:
This work has compared the promoter activities of the Wyoming LTR with those of LTRs derived from fibroblast-adapted viruses by examining their abilities to drive a luciferase reporter gene as well as by construction of infectious molecular clones differing only in LTR sequence.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, ORCID
Added: July 20, 2019
1999 journal article
Platelets from thrombocytopenic ponies acutely infected with equine infectious anemia virus are activated in vivo and hypofunctional
VIROLOGY, 259(1), 7–19.
MeSH headings : Animals; Blood Platelets / pathology; Blood Platelets / virology; Equine Infectious Anemia / blood; Equine Infectious Anemia / complications; Equine Infectious Anemia / pathology; Humans; Infectious Anemia Virus, Equine / isolation & purification; Platelet Activation; Thrombocytopenia / blood; Thrombocytopenia / pathology; Thrombocytopenia / virology
TL;DR:
It is concluded that thrombocytopenia in ponies acutely infected with EIAV is regenerative and suggest that bone marrow platelet production is not severely compromised in these ponies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
1999 journal article
Sequence analysis of the matrix nucleocapsid gene region of turkey coronavirus
INTERVIROLOGY, 42(1), 22–29.
author keywords: coronavirus; infectious bronchitis virus; turkey coronavirus; polymerase chain reaction
MeSH headings : Amino Acid Sequence; Animals; Base Sequence; Coronavirus / chemistry; Coronavirus / genetics; Coronavirus, Turkey / chemistry; Coronavirus, Turkey / genetics; Genotype; Infectious bronchitis virus / chemistry; Infectious bronchitis virus / genetics; Molecular Sequence Data; Phylogeny; RNA, Viral / chemistry; RNA, Viral / genetics; Reverse Transcriptase Polymerase Chain Reaction; Sequence Alignment; Sequence Homology; Viral Matrix Proteins / genetics
TL;DR:
A reverse transcriptase, polymerase chain reaction procedure was used to amplify a segment of the genome of turkey coronavirus spanning portions of the matrix and nucleocapsid protein genes, demonstrating a close genetic relationship between the avian coronaviruses, IBV and TCV.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
1999 journal article
Sequence analysis of the turkey coronavirus nucleocapsid protein gene and 3 ' untranslated region identifies the virus as a close relative of infectious bronchitis virus
VIRUS RESEARCH, 65(2), 187–193.
author keywords: turkey coronavirus; infectious bronchitis virus; nucleocapsid gene
MeSH headings : 3' Untranslated Regions; Amino Acid Sequence; Animals; Base Sequence; Cattle; Coronavirus Nucleocapsid Proteins; Coronavirus, Turkey / genetics; DNA, Viral / analysis; Infectious bronchitis virus / classification; Infectious bronchitis virus / genetics; Molecular Sequence Data; Nucleocapsid / classification; Nucleocapsid / genetics; Nucleocapsid Proteins; Sequence Alignment; Turkeys
TL;DR:
Similarities in both size and sequence of TCV and IBV N proteins and 3′ UTRs provide additional evidence that these avian coronaviruses are closely related.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
1998 journal article
Disease induction by virus derived from molecular clones of equine infectious anemia virus
Journal of Virology, 72(1), 483–487.
Source: NC State University Libraries
Added: August 6, 2018
1997 journal article
Characterization and mutational studies of equine infectious anemia virus dUTPase
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY, 1339(2), 181–191.
author keywords: equine infectious anemia virus; dUTPase; phosphate-binding loop; P-loop; retrovirus
MeSH headings : Amino Acid Sequence; Escherichia coli / enzymology; Histidine / chemistry; Infectious Anemia Virus, Equine / enzymology; Infectious Anemia Virus, Equine / genetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Point Mutation; Pyrophosphatases / genetics; Pyrophosphatases / isolation & purification; Pyrophosphatases / metabolism; Recombinant Proteins / genetics; Substrate Specificity
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
1997 journal article
Genes controlling retroviral virulence
Advances in Veterinary Medicine, 40(1997), 135–155.
MeSH headings : Animals; Cats; Feline Acquired Immunodeficiency Syndrome / virology; Genes, Viral; Humans; Immunodeficiency Virus, Feline / genetics; Immunodeficiency Virus, Feline / pathogenicity; Lentivirus / genetics; Lentivirus / pathogenicity; Mice; Murine Acquired Immunodeficiency Syndrome / virology; Retroviridae / genetics; Retroviridae / pathogenicity; Retroviridae / physiology; Simian Acquired Immunodeficiency Syndrome / virology; Simian Immunodeficiency Virus / genetics; Simian Immunodeficiency Virus / pathogenicity; Virulence; Virus Replication
TL;DR:
A wide range of biologic effects are discerned from a variety of retrovirus infections from malignancy, benign proliferative states that can lead to malignancies, degenerative diseases, viremias, and insertional activation or the inactivations of cellular genes and transactivations at very low levels.
(via Semantic Scholar)
Sources: NC State University Libraries, ORCID
Added: August 6, 2018
1996 journal article
Equine infectious anemia virus replication is upregulated during differentiation of blood monocytes from acutely infected horses
Journal of Virology, 70(1), 590–594.
Source: NC State University Libraries
Added: March 5, 2021
1996 journal article
Phorbol ester stimulation of equine macrophage cultures alters expression of equine infectious anemia virus
Veterinary Microbiology, 52(3-4), 209–221.
author keywords: equine infectious anemia virus; horse; macrophage
MeSH headings : Animals; Base Sequence; Cell Survival; Cells, Cultured; Equine Infectious Anemia / virology; Gene Expression Regulation, Viral; Horses; Infectious Anemia Virus, Equine / genetics; Infectious Anemia Virus, Equine / physiology; Macrophage Activation / drug effects; Macrophages / drug effects; Macrophages / physiology; Macrophages / virology; Molecular Sequence Data; Repetitive Sequences, Nucleic Acid; Tetradecanoylphorbol Acetate / pharmacology
TL;DR:
A significant downregulation of viral expression occurred independent of the virulence of the virus strain used or the nucleic acid sequence of the viral LTR, which may represent an adaptive response of EIAV to evade the host immune response and establish a persistent infection.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, ORCID, Web Of Science
Added: August 6, 2018
1995 journal article
Detection of pseudorabies viral DNA in tonsillar epithelial cells of latently infected pigs
American Journal of Veterinary Research, 56(5), 587–594.
Source: NC State University Libraries
Added: March 5, 2021
1995 journal article
Incorporation of Uracil into Viral DNA Correlates with Reduced Replication of EIAV in Macrophages
Virology, 210(2), 302–313.
MeSH headings : Animals; Base Sequence; Binding Sites / genetics; Cells, Cultured; Cytopathogenic Effect, Viral; DNA Glycosylases; DNA Replication / physiology; DNA, Viral / biosynthesis; DNA, Viral / chemistry; Horses; Infectious Anemia Virus, Equine / enzymology; Infectious Anemia Virus, Equine / physiology; Macrophages / virology; Molecular Sequence Data; N-Glycosyl Hydrolases; Point Mutation; Pyrophosphatases / genetics; Pyrophosphatases / metabolism; Pyrophosphatases / physiology; RNA-Directed DNA Polymerase; Transcription, Genetic / genetics; Uracil / analysis; Uracil / metabolism; Uracil-DNA Glycosidase; Virus Integration; Virus Replication / physiology
TL;DR:
In vitro assays showed that while WT virions do not utilize dUTP, dUTpase-deficient virus and recombinant RT synthesize uracil-containing DNA, in macrophages, a virally encoded dutPase may be necessary to prevent the incorporation of Uracil into viral DNA.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, ORCID, Web Of Science
Added: September 11, 2019
1994 journal article
Characterization of infectious molecular clones of equine infectious anaemia virus
Journal of General Virology, 75(2), 425–429.
MeSH headings : Amino Acid Sequence; Animals; Base Sequence; Cells, Cultured; Horses; Infectious Anemia Virus, Equine / genetics; Molecular Sequence Data; Polymerase Chain Reaction; Repetitive Sequences, Nucleic Acid
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, ORCID
Added: July 20, 2019
1994 journal article
The immunopathogenesis of equine infectious anemia virus
Virus Research, 32(2), 111–138.
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, ORCID
Added: September 11, 2019
1993 journal article
Characterization of equine infectious anemia virus dUTPase: Growth properties of a dUTPase-deficient mutant
Journal of Virology, 67, 2592–2600.
Source: NC State University Libraries
Added: March 12, 2021
1993 journal article
Production and characterization of a monoclonal antibody recognizing a cytoplasmic antigen of equine mononuclear phagocytes
Veterinary Immunology and Immunopathology, 36(4), 303–318.
MeSH headings : Animals; Antibodies, Monoclonal / biosynthesis; Antibodies, Monoclonal / immunology; Antibodies, Viral / biosynthesis; Antibody Specificity; Antigens, Viral / immunology; Blotting, Western / veterinary; Equine Infectious Anemia / etiology; Equine Infectious Anemia / immunology; Fluorescent Antibody Technique / veterinary; Horses / immunology; Hybridomas; Immunoglobulin G / biosynthesis; Immunoglobulin G / immunology; Leukocytes, Mononuclear / immunology; Liver / immunology; Lung / immunology; Lymph Nodes / immunology; Macrophages / immunology; Mice; Phagocytes / immunology; Spleen / immunology
TL;DR:
An IgG1 mouse monoclonal antibody, designated 1.646, is described which recognizes a cytoplasmic antigen of equine mononuclear phagocytes, which is closely associated with lysosomal membranes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, ORCID, Web Of Science
Added: August 6, 2018
1992 journal article
Nucleotide Sequence of the Tick-borne Orthomyxo-like Dhori/India/1313/61 Virus Membrane Protein Gene
Journal of General Virology, 73(10), 2609–2616.
MeSH headings : Amino Acid Sequence; Amino Acids / analysis; Animals; Base Sequence; Chromosome Mapping; Genes, Viral / genetics; Influenza A virus / genetics; Influenza B virus / genetics; Influenzavirus C / genetics; Insect Vectors; Molecular Sequence Data; Open Reading Frames; Orthomyxoviridae / genetics; Protein Structure, Secondary; RNA, Messenger / genetics; RNA, Viral / genetics; Ticks; Viral Matrix Proteins / genetics
TL;DR:
The complete nucleotide sequence of the sixth largest segment of ssRNA (RNA-6) of the tick-borne orthomyxo-like Dhori/India/1313/61 virus was determined by using cloned cDNA derived from infected cell mRNA and dideoxynucleotide sequencing of viral RNA.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, ORCID, Web Of Science
Added: August 6, 2018
1992 journal article
The surface envelope protein gene region of equine infectious anemia virus is not an important determinant of tropism in vitro
Journal of Virology, 66(7), 4085–4097.
Source: NC State University Libraries
Added: March 12, 2021
1992 journal article
Wild-type equine infectious anemia virus replicates in vivo predominantly in tissue macrophages, not in peripheral blood monocytes
Journal of Virology, 66(10), 5906–5913.
Source: NC State University Libraries
Added: March 12, 2021
1991 journal article
Evolutionary relatedness of the predicted gene product of RNA segment 2 of the Tick-Borne Dhori virus and the PB1 polymerase gene of influenza viruses
Virology, 182(1), 1–7.
MeSH headings : Amino Acid Sequence; Base Sequence; Biological Evolution; Cloning, Molecular; DNA-Directed RNA Polymerases / genetics; Genes, Viral; Molecular Sequence Data; Oligonucleotides / chemistry; Orthomyxoviridae / genetics; Polymerase Chain Reaction; RNA Viruses / genetics; RNA, Viral; Viral Structural Proteins / genetics
TL;DR:
It is suggested that the Dhori PB1-like protein be designated the Pα protein of this virus, which indicates an acidic charge feature at pH 7.0 in contrast to the basic nature of the PB1 proteins of the influenza viruses.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, ORCID
Added: July 20, 2019
1991 journal article
Immune-mediated thrombocytopenia in horses infected with equine infectious anemia virus
Journal of Virology, 65(11), 6242–6251.
Source: NC State University Libraries
Added: March 15, 2021
1990 journal article
Equine infectious anemia virus derived from a molecular clone persistently infects horses
Journal of Virology, 64(12), 5750–5756.
Source: NC State University Libraries
Added: March 15, 2021
1990 journal article
Nucleotide sequence of the tick-borne, orthomyxo-like Dhori/Indian/1313/61 virus envelope gene
Virology, 175(1), 10–18.
MeSH headings : Amino Acid Sequence; Animals; Arboviruses / genetics; Base Sequence; Cell Line; Genes, Viral; Molecular Sequence Data; Orthomyxoviridae / genetics; Protein Conformation; Restriction Mapping; Sequence Homology, Nucleic Acid; Ticks; Viral Envelope Proteins / genetics
TL;DR:
The envelope protein of Dhori virus does not display significant amino acid sequence homology with any of the envelope proteins (hemagglutinin or neuraminidase) of the influenza virus family members (or any other virus group) suggesting that the Dhori envelope protein is unique and may at least in part account for its divergent biological properties with other orthomyxoviruses.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, ORCID
Added: July 20, 2019
1988 journal article
Bluetongue Virus Genome Remains Stable throughout Prolonged Infection of Cattle
Journal of General Virology, 69(10), 2629–2636.
MeSH headings : Animals; Antibodies, Monoclonal; Bluetongue / microbiology; Bluetongue virus / genetics; Cattle; Cattle Diseases / microbiology; Cells, Cultured; Electrophoresis, Gel, Two-Dimensional; Epitopes; Gene Frequency; Hybridomas; Neutralization Tests; Oligonucleotide Probes; RNA, Double-Stranded / analysis; RNA, Viral / analysis; Reoviridae / genetics; Time Factors
TL;DR:
The results suggest that antigenic drift is not the mechanism by which BTV is able to persist in cattle in spite of a strong humoral immune response.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, ORCID
Added: July 20, 2019
1988 journal article
Comparison of virologic and serologic responses of lambs and calves infected with bluetongue virus Serotype 10
Veterinary Microbiology, 18(3-4), 233–242.
MeSH headings : Animals; Antibodies, Viral / analysis; Antibodies, Viral / biosynthesis; Bluetongue / immunology; Bluetongue / microbiology; Bluetongue virus / immunology; Bluetongue virus / isolation & purification; Cattle; Cattle Diseases / immunology; Cattle Diseases / microbiology; Electrophoresis, Polyacrylamide Gel; Precipitin Tests; Reoviridae / immunology; Sheep; Sulfur Radioisotopes; Viremia
TL;DR:
The clearance of virus from the peripheral blood of BTV-infected lambs and calves is not caused simply by the production of virus-specific neutralizing antibody, however the intensity of humoral immune responses to individual BTV proteins might influence the duration of viremia in different animals.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, ORCID
Added: July 20, 2019
1988 journal article
Nucleotide sequence of the envelope protein genes of a highly virulent, neurotropic strain of newcastle disease virus
Virology, 165(1), 291–295.
MeSH headings : Amino Acid Sequence; Animals; Base Sequence; Chickens; DNA / genetics; Genes; Genes, Viral; HN Protein; Molecular Sequence Data; Newcastle disease virus / genetics; Newcastle disease virus / pathogenicity; Sequence Homology, Nucleic Acid; Viral Envelope Proteins / genetics; Viral Fusion Proteins / genetics; Virulence
TL;DR:
It is suggested that the neurovirulence phenotype could be due to the molecular properties of the HN protein; however, it cannot exclude the possibility that the two conservative amino acid differences between the two F proteins could also play a role in determining the phenotypic differences between these two virus strains.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, ORCID
Added: July 20, 2019
1988 journal article
Nucleotide sequence of the major structural protein genes of the tick-borne, orthomyxo-like Dhori/Indian/1313/61 virus
Virus Research, 11, 49.
Sources: Crossref, ORCID
Added: January 21, 2021
1987 journal article
Complete nucleotide sequence of the tick-borne, orthomyxo-like Dhori/Indian/1313/61 virus nucleoprotein gene
Virology, 160(1), 81–87.
MeSH headings : Base Sequence; Genes, Viral; Orthomyxoviridae / genetics; Phylogeny; RNA / genetics; RNA Viruses / genetics; RNA, Viral / genetics
TL;DR:
The complete nucleotide sequence of the fifth largest segment of single-stranded RNA of the tick-borne, orthomyxo-like Dhori/Ind/1313/61 virus was determined using cloned cDNA derived from infected cell mRNA and dideoxynucleotide sequencing of viral RNA to suggest that RNA 5 of Dhori viruses codes for the nucleoprotein.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, ORCID
Added: July 20, 2019
1987 journal article
Humoral immune response of calves to bluetongue virus infection
American Journal of Veterinary Research, 48(7), 1031–1035.
Source: NC State University Libraries
Added: March 22, 2021
1987 conference paper
Nucleic acid sequence analysis of Sindbis pathogenesis and penetration mutants
In M. A. Brinton & R. Rueckert (Eds.), Positive strand RNA viruses : proceedings of a UCLA symposium held in Keystone, Colorado, April 20-26, 1986. New York: Alan R. Liss, Inc.
Ed(s): M. Brinton & R. Rueckert
Source: NC State University Libraries
Added: March 22, 2021
1986 journal article
A single nucleotide change in the E2 glycoprotein gene of Sindbis virus affects penetration rate in cell culture and virulence in neonatal mice.
Proceedings of the National Academy of Sciences, 83(18), 6771–6775.
MeSH headings : Amino Acid Sequence; Animals; Animals, Newborn; Base Sequence; Cells, Cultured; Genes, Viral; Glycoproteins / analysis; Glycoproteins / genetics; Mice; Mutation; Sindbis Virus / genetics; Sindbis Virus / pathogenicity; Virulence
TL;DR:
These findings identify a single locus in a Sindbis virus surface glycoprotein gene that determines both efficiency of interaction with cultured baby hamster kidney cells and degree of virulence in neonatal mice.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, ORCID
Added: July 20, 2019
1986 journal article
Genetic stability in calves of a single strain of bluetongue virus
American Journal of Veterinary Research, 47(4), 762–764.
Source: NC State University Libraries
Added: March 22, 2021
1986 journal article
Turkey Coryza: Lack of Correlation between Plasmids and Pathogenicity of Bordetella avium
Avian Diseases, 30(3), 593.
TL;DR:
Plasmids were removed from pathogenic Bordetella avium using a variety of treatments and the plasmid-cure rates depended on the treatment and isolate.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, ORCID
Added: July 20, 2019
1984 chapter
Coding Analyses of Bunyavirus RNA Species
In Segmented Negative Strand Viruses (pp. 3–11).
TL;DR:
The direct RNA sequencing of SSH and LAC RNA species has demonstrated that the 3' ends of the three viral RNA species are conserved, at least for 10–15 nucleotides.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: December 16, 2019
1984 chapter
The Use of Reassortant Bunyaviruses to Deduce their Coding and Pathogenic Potentials
In Mechanisms of Viral Pathogenesis (pp. 49–60).
TL;DR:
The Bunyaviridae is a large family of arthropod-borne RNA viruses that has members that are pathogenic for man, or domestic animals, and which poses interesting, as yet poorly understood, morphogenetic questions.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: September 11, 2019
1983 chapter
Bunyavirus Gene Structure‐Function Relationships and Potential for RNA Segment Reassortment In The Vector: La Crosse and Snowshoe Hare Reassortant Viruses In Mosquitoes
In C. H. Calisher & W. H. Thompson (Eds.), California serogroup viruses : proceedings of an International Symposium, held in Cleveland, Ohio, November 12 and 13, 1982 (pp. 119–128). New York: A.R. Liss.
Ed(s): C. Calisher & W. Thompson
Event: International Symposium on California Serogroup Viruses at Cleveland, Ohio on November 12-13, 1982
Source: NC State University Libraries
Added: April 2, 2021
1983 journal article
Bunyavirus Nucleoprotein, N, and a Non-structural Protein, NSS, Are Coded by Overlapping Reading Frames in the S RNA
Journal of General Virology, 64(8), 1705–1714.
MeSH headings : Bunyaviridae / genetics; Capsid / analysis; Capsid / genetics; Encephalitis Virus, California / genetics; Genes, Viral; Peptides / analysis; Protein Biosynthesis; RNA, Messenger / genetics; RNA, Viral / genetics; Viral Nonstructural Proteins; Viral Proteins / analysis; Viral Proteins / genetics
TL;DR:
In vitro translation analyses of the S mRNA species recovered from virus-infected cells indicate that a single size class of mRNA directs the synthesis of N and NSS.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
4. Quality Education
(OpenAlex)
Sources: Crossref, ORCID
Added: July 20, 2019
1983 journal article
Bunyavirus gene structure-function relationships and potential for RNA segment reassortment in the vector: La Crosse and snowshoe hare reassortant viruses in mosquitoes
Progress in Clinical Biological Research, 123, 119–128.
Source: NC State University Libraries
Added: April 4, 2021
1983 chapter
Coding Assignments of the RNA Genome Segments of California Serogroup Viruses
In C. H. Calisher & W. H. Thompson (Eds.), California serogroup viruses : proceedings of an International Symposium, held in Cleveland, Ohio, November 12 and 13, 1982 (pp. 107–117). New York: A.R. Liss.
Ed(s): C. Calisher & W. Thompson
Event: California serogroup viruses International Symposium at Cleveland, Ohio on November 12-13, 1982
Source: NC State University Libraries
Added: April 2, 2021
1983 journal article
Coding assignments of the RNA genome segments of California serogroup viruses
Progress in Clinical Biological Research, 123, 107–117.
Source: NC State University Libraries
Added: April 4, 2021
1983 journal article
Interference between bunyaviruses in Aedes triseriatus mosquitoes
Virology, 127(1), 83–90.
MeSH headings : Aedes / microbiology; Bunyamwera virus / growth & development; Bunyaviridae / growth & development; Encephalitis Virus, California / genetics; Encephalitis Virus, California / growth & development; Mutation; Temperature; Vesicular stomatitis Indiana virus / growth & development; Viral Interference; Virus Replication; West Nile virus / growth & development
TL;DR:
Prior infection of mosquitoes with LAC virus did not interfere significantly with the subsequent infection and replication of Guaroa bunyavirus (Bunyamwera serogroup), or heterologous viruses such as West Nile flavivirus, or vesicular stomatitis rhabdovirus.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: July 20, 2019
1983 journal article
Tick-borne viruses structurally similar to orthomyxoviruses
Virology, 127(1), 205–219.
MeSH headings : Amanitins / pharmacology; Base Sequence; Bunyaviridae / classification; Bunyaviridae / drug effects; Bunyaviridae / growth & development; Dactinomycin / pharmacology; Microscopy, Electron; Orthomyxoviridae / classification; Orthomyxoviridae / drug effects; Orthomyxoviridae / growth & development; RNA, Viral / analysis; Ticks / microbiology; Tunicamycin / pharmacology; Viral Proteins / analysis
TL;DR:
Analyses of the virion RNA species and polypeptides of the tick-borne Thogoto and Dhori viruses indicate that they have structural characteristics similar to accepted members of the Orthomyxoviridae.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: July 20, 2019
1982 journal article
Coding assignments of the RNA genome segments of California serogroup viruses
Progress in Clinical Biological Research, 123, 107–117.
Source: NC State University Libraries
Added: April 2, 2021
1982 journal article
Identification of viral coded non‐structural polypeptides in Bunyavirus infected cells
Journal of Virology, 41(2), 643–648.
Source: NC State University Libraries
Added: April 4, 2021
1982 journal article
Synthesis and processing of sindbis virus nonstructural proteins in vitro
Virology, 118(2), 363–379.
MeSH headings : Cell-Free System; Kinetics; Peptides / analysis; Protein Biosynthesis; Protein Precursors / metabolism; RNA, Messenger / metabolism; RNA, Transfer, Amino Acyl / metabolism; RNA, Transfer, Met; RNA, Viral / metabolism; Sindbis Virus / metabolism; Viral Proteins / metabolism
TL;DR:
Polyadenylated 42 S genome RNA of Sindbis virus was extracted from purified virions, selected by binding to oligo(dT)-cellulose, and used to direct cell-free protein synthesis in nuclease-treated reticulocyte lysates, indicating that the 3′-terminal third of the 42 S RNA genome was essentially unavailable for independent translation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(OpenAlex)
Sources: Crossref, ORCID
Added: July 20, 2019
1982 journal article
The 3' Terminal RNA Sequences of Bunyaviruses and Nairoviruses (Bunyaviridae): Evidence of End Sequence Generic Differences within the Virus Family
Journal of General Virology, 61(2), 289–292.
MeSH headings : Base Sequence; Bunyaviridae / analysis; Bunyaviridae / classification; Encephalitis Virus, California / analysis; RNA, Viral; Serotyping; Species Specificity
TL;DR:
The 3' terminal nucleotide sequences of the three virus RNA species of viruses representing eight serog groups of bunyaviruses and six serogroups of nairoviruses have been characterized.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: July 20, 2019
1980 journal article
Interferon Induction by Viruses. IV. Sindbis Virus: Early Passage Defective-Interfering Particles Induce Interferon
Journal of General Virology, 48(1), 63–73.
MeSH headings : Animals; Chemical Phenomena; Chemistry; Chick Embryo; Defective Viruses / drug effects; Defective Viruses / physiology; Defective Viruses / radiation effects; Interferons / biosynthesis; Interferons / pharmacology; RNA, Double-Stranded; RNA, Viral; Sindbis Virus / drug effects; Sindbis Virus / physiology; Sindbis Virus / radiation effects; Ultraviolet Rays
TL;DR:
It is shown that a single defective-interfering (DI) particle of early (5th) passage Sindbis virus induces maximal amounts of interferon in an 'aged' primary chick embryo cell, and it is postulate that the genomic RNA which codes for genes G and A must be translated into products whose concerted action produces a dsRNA molecule upon synthesis of a segment of RNA complementary to the genome.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: July 20, 2019
1980 journal article
Interferon Induction by Viruses. Sindbis Virus: Defective-interfering Particles Temperature-sensitive for Interferon Induction
Journal of General Virology, 48(2), 391–394.
MeSH headings : Defective Viruses / genetics; Defective Viruses / physiology; Genes, Viral; Interferons / biosynthesis; Mutation; Protein Biosynthesis; RNA, Viral / genetics; Sindbis Virus / genetics; Sindbis Virus / physiology; Temperature; Viral Interference
TL;DR:
A defective-interfering particle of Sindbis virus was generated from a ts mutant of RNA-complementation group A by serially undiluted passages at 30 degrees C, demonstrating for the first time in a DI particle a ts function, namely, the ability to induce interferon.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: July 20, 2019
1980 journal article
Sindbis virus I. Gene order of translation in Vivo
Virology, 107(2), 441–451.
MeSH headings : Animals; Chick Embryo; Dose-Response Relationship, Radiation; Gene Expression Regulation; Genes, Viral / radiation effects; Genetic Complementation Test; Mutation; Protein Biosynthesis / radiation effects; RNA, Messenger / metabolism; RNA, Viral / metabolism; Sindbis Virus / genetics; Sindbis Virus / radiation effects; Ultraviolet Rays; Viral Proteins / biosynthesis
TL;DR:
Ultraviolet radiation was used to map the order of translation in vivo of Sindbis virus genes and assign nonstructural proteins to specific RNA − complementation groups and target sizes for each protein (gene), consistent with a model in which each molecule of 42 S and 26 S polycistronic mRNA initiates protein synthesis at a single site.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: July 20, 2019
1979 journal article
Cell surface-associated ribonuclease activities
Journal of Cellular Physiology, 98(1), 1–10.
MeSH headings : Adsorption; Cell Line; Cell Membrane / enzymology; Culture Media; Poly I-C; RNA, Viral; Ribonucleases / analysis; Ribonucleases / antagonists & inhibitors; Ribonucleases / metabolism
TL;DR:
The ribonuclease (RNase) activity associated with the surface of cells (primarily the Vero line of Green monkey kidney) was assayed under conditions where all cells remained viable as members of colonies or monolayers.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: July 20, 2019
1979 journal article
Interferon Induction by Viruses. II. Sindbis Virus: Interferon Induction Requires One-Quarter of the Genome -- Genes G and A
Journal of General Virology, 44(1), 169–177.
MeSH headings : Animals; Chick Embryo; Culture Techniques; Genes, Viral; Interferon Inducers; Interferons / biosynthesis; Mutation; RNA, Double-Stranded / pharmacology; RNA, Viral / pharmacology; Sindbis Virus / genetics; Sindbis Virus / growth & development; Sindbis Virus / radiation effects; Temperature; Ultraviolet Rays
TL;DR:
It appears that genes G and A represent a special one-quarter of the genome which must be functional in order to synthesize an interferon-inducing moiety, and it is suggested that this moiety is a double-stranded RNA molecule formed after synthesis of a segment of RNA complementary to the genome.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: July 20, 2019
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