Nagendran Muthusamy

Works (7)

Updated: July 13th, 2023 21:19

2017 article

Ependymal cell contribution to scar formation after spinal cord injury is minimal, local and dependent on direct ependymal injury

Ren, Y., Ao, Y., O’Shea, T. M., Burda, J. E., Bernstein, A. M., Brumm, A. J., … Sofroniew, M. V. (2017, January 24). Scientific Reports.

By: Y. Ren *, Y. Ao*, T. O’Shea *, J. Burda *, A. Bernstein*, A. Brumm*, N. Muthusamy n, H. Ghashghaei n ...

MeSH headings : Animals; Astrocytes / physiology; Cell Differentiation; Cicatrix / physiopathology; Disease Models, Animal; Ependyma / physiopathology; Mice; Mice, Transgenic; Neural Stem Cells / physiology; Spinal Cord Injuries / physiopathology
topics (OpenAlex): Neurogenesis and neuroplasticity mechanisms; Nerve injury and regeneration; Spinal Cord Injury Research
TL;DR: It is shown that ependyma contribution of progeny after SCI is minimal, local and dependent on direct ependymal injury, indicating that ependedyma are not a major source of endogenous neural stem cells or neuroprotective astrocytes afterSCI. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2016 article

Developmentally defined forebrain circuits regulate appetitive and aversive olfactory learning

Muthusamy, N., Zhang, X., Johnson, C. A., Yadav, P. N., & Ghashghaei, H. T. (2016, December 5). Nature Neuroscience.

By: N. Muthusamy n, X. Zhang n, C. Johnson n, P. Yadav * & H. Ghashghaei n

MeSH headings : Animals; Appetitive Behavior / physiology; Avoidance Learning / physiology; Behavior, Animal / physiology; Conditioning, Classical / physiology; Male; Mice; Neurogenesis / physiology; Neurons / physiology; Olfactory Cortex / physiology; Smell / physiology
topics (OpenAlex): Olfactory and Sensory Function Studies; Neurobiology and Insect Physiology Research; Photoreceptor and optogenetics research
TL;DR: It is demonstrated that chemogenetic inactivation of a subset of forebrain and olfactory neurons generated at birth disrupts responses to an aversive odor, revealing that developmentally defined sets of neurons may differentially participate in hedonic aspects of sensory learning. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2016 journal article

TAK1 determines susceptibility to endoplasmic reticulum stress and leptin resistance in the hypothalamus

Journal of Cell Science, 129(9), 1855–1865.

By: K. Sai n, S. Morioka  n, G. Takaesu  n, N. Muthusamy n, H. Ghashghaei n, H. Hanafusa *, K. Matsumoto *, J. Ninomiya-Tsuji n 

Contributors: K. Sai n, S. Morioka  n, G. Takaesu  n, N. Muthusamy n, H. Ghashghaei n, H. Hanafusa *, K. Matsumoto *, J. Ninomiya-Tsuji n 

author keywords: TAK1; Endoplasmic reticulum stress; Leptin; Hypothalamus; Obesity
MeSH headings : Animals; Dietary Fats / adverse effects; Dietary Fats / pharmacology; Endoplasmic Reticulum Stress; Hyperphagia / chemically induced; Hyperphagia / genetics; Hyperphagia / metabolism; Hyperphagia / pathology; Hypothalamus / metabolism; Hypothalamus / pathology; Leptin / genetics; Leptin / metabolism; MAP Kinase Kinase Kinases / genetics; MAP Kinase Kinase Kinases / metabolism; Mice; Mice, Knockout; Obesity / chemically induced; Obesity / genetics; Obesity / metabolism; Obesity / pathology; Sterol Regulatory Element Binding Proteins / genetics; Sterol Regulatory Element Binding Proteins / metabolism
topics (OpenAlex): Endoplasmic Reticulum Stress and Disease; RNA regulation and disease; Pancreatic function and diabetes
TL;DR: It is found that deletion of Tak1 increased ER volume and facilitated ER-stress tolerance in cultured cells, which was mediated by upregulation of sterol-regulatory-element-binding protein (SREBP)-dependent lipogenesis and central nervous system (CNS) deletion upregulated SREBP-target lipogenic genes and blocked ER stress in the hypothalamus. (via Semantic Scholar)
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Sources: Web Of Science, Crossref, NC State University Libraries, ORCID
Added: August 6, 2018

2015 article

MARCKS‐dependent mucin clearance and lipid metabolism in ependymal cells are required for maintenance of forebrain homeostasis during aging

Muthusamy, N., Sommerville, L. J., Moeser, A. J., Stumpo, D. J., Sannes, P., Adler, K., … Ghashghaei, H. T. (2015, May 25). Aging Cell.

By: N. Muthusamy n, L. Sommerville n, A. Moeser n, D. Stumpo *, P. Sannes n, K. Adler n, P. Blackshear *, J. Weimer *, H. Ghashghaei n

author keywords: aging; barrier function; Clca3; cerebral cortex; ependymal cells; lipid droplets; mucin; oxidative stress
MeSH headings : Aging / metabolism; Animals; Ependyma / cytology; Ependyma / metabolism; Homeostasis; Intracellular Signaling Peptides and Proteins / deficiency; Intracellular Signaling Peptides and Proteins / metabolism; Lipid Metabolism; Membrane Proteins / deficiency; Membrane Proteins / metabolism; Mice; Mucins / metabolism; Myristoylated Alanine-Rich C Kinase Substrate; Oxidative Stress; Prosencephalon / metabolism
topics (OpenAlex): Neuroinflammation and Neurodegeneration Mechanisms; Barrier Structure and Function Studies; Alzheimer's disease research and treatments
TL;DR: It is demonstrated that metabolic and barrier functions in ECs decline significantly during aging in mice, and this work constitutes a conceptually new paradigm in the potential role of ECs in the initiation of various conditions and diseases in the aging brain. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2015 review

Complementary roles of the neuron-enriched endosomal proteins NEEP21 and calcyon in neuronal vesicle trafficking

[Review of ]. Journal of Neurochemistry, 132(1), 20–31.

By: N. Muthusamy, Y. Chen, D. Yin, L. Mei & C. Bergson

Source: NC State University Libraries
Added: August 6, 2018

2014 article

A Knock‐in Foxj1CreERT2::GFP mouse for recombination in epithelial cells with motile cilia

Muthusamy, N., Vijayakumar, A., Cheng, G., & Ghashghaei, H. T. (2014, February 18). Genesis.

By: N. Muthusamy n, A. Vijayakumar n, G. Cheng * & H. Ghashghaei n

author keywords: Foxj1; CreERT2::GFP; knock-in; ependymal cells; motile cilia; epithelial cells
MeSH headings : Animals; Cell Lineage; Choroid Plexus / cytology; Choroid Plexus / metabolism; Cilia / physiology; Epithelial Cells / metabolism; Epithelial Cells / ultrastructure; Female; Forkhead Transcription Factors / biosynthesis; Forkhead Transcription Factors / genetics; Gene Expression; Gene Knock-In Techniques; Green Fluorescent Proteins / biosynthesis; Green Fluorescent Proteins / genetics; Integrases / genetics; Male; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Transgenic; Recombination, Genetic; Tamoxifen / pharmacology; Transcriptional Activation / drug effects
topics (OpenAlex): Genetic and Kidney Cyst Diseases; Renal and related cancers; Fetal and Pediatric Neurological Disorders
TL;DR: The generation of an inducible knock-in Foxj1CreERT2::GFP knock‐in mouse is reported, which reliably induces Cre‐mediated recombination for genetic studies in epithelial cells with motile cilia throughout embryonic and postnatal development. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2011 article

Specification of a Foxj1-Dependent Lineage in the Forebrain Is Required for Embryonic-to-Postnatal Transition of Neurogenesis in the Olfactory Bulb

Jacquet, B. V., Muthusamy, N., Sommerville, L. J., Xiao, G., Liang, H., Zhang, Y., … Ghashghaei, H. T. (2011, June 22). Journal of Neuroscience.

By: B. Jacquet n, N. Muthusamy n, L. Sommerville n, G. Xiao n, H. Liang n, Y. Zhang *, M. Holtzman *, H. Ghashghaei n

MeSH headings : Animals; Forkhead Transcription Factors / metabolism; Mice; Mice, Knockout; Neurogenesis / physiology; Neurons / physiology; Olfactory Bulb / embryology; Olfactory Bulb / physiology; Prosencephalon / embryology; Prosencephalon / physiology
topics (OpenAlex): Neurogenesis and neuroplasticity mechanisms; Axon Guidance and Neuronal Signaling; Developmental Biology and Gene Regulation
TL;DR: For the first time, this study identifies the time- and region-specific activity of a perinatal progenitor domain that is required for transition and progression of OB neurogenesis from the embryonic-to-postnatal periods. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

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