Nagendran Muthusamy

Works (7)

Updated: July 13th, 2023 21:19

2017 journal article

Ependymal cell contribution to scar formation after spinal cord injury is minimal, local and dependent on direct ependymal injury

SCIENTIFIC REPORTS, 7.

By: Y. Ren *, Y. Ao*, . Timothy M. O'Shea *, J. Burda *, A. Bernstein*, A. Brumm*, N. Muthusamy n, H. Ghashghaei  n ...

MeSH headings : Animals; Astrocytes / physiology; Cell Differentiation; Cicatrix / physiopathology; Disease Models, Animal; Ependyma / physiopathology; Mice; Mice, Transgenic; Neural Stem Cells / physiology; Spinal Cord Injuries / physiopathology
TL;DR: It is shown that ependyma contribution of progeny after SCI is minimal, local and dependent on direct ependymal injury, indicating that ependedyma are not a major source of endogenous neural stem cells or neuroprotective astrocytes afterSCI. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Developmentally defined forebrain circuits regulate appetitive and aversive olfactory learning

NATURE NEUROSCIENCE, 20(1), 20–23.

By: N. Muthusamy n, X. Zhang n, C. Johnson n, P. Yadav * & H. Ghashghaei  n

MeSH headings : Animals; Appetitive Behavior / physiology; Avoidance Learning / physiology; Behavior, Animal / physiology; Conditioning, Classical / physiology; Male; Mice; Neurogenesis / physiology; Neurons / physiology; Olfactory Cortex / physiology; Smell / physiology
TL;DR: It is demonstrated that chemogenetic inactivation of a subset of forebrain and olfactory neurons generated at birth disrupts responses to an aversive odor, revealing that developmentally defined sets of neurons may differentially participate in hedonic aspects of sensory learning. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2016 journal article

TAK1 determines susceptibility to endoplasmic reticulum stress and leptin resistance in the hypothalamus

Journal of Cell Science, 129(9), 1855–1865.

By: K. Sai n, S. Morioka  n, G. Takaesu  n, N. Muthusamy n, H. Ghashghaei  n, H. Hanafusa *, K. Matsumoto *, J. Ninomiya-Tsuji n 

Contributors: K. Sai n, S. Morioka  n, G. Takaesu  n, N. Muthusamy n, H. Ghashghaei  n, H. Hanafusa *, K. Matsumoto *, J. Ninomiya-Tsuji n 

author keywords: TAK1; Endoplasmic reticulum stress; Leptin; Hypothalamus; Obesity
MeSH headings : Animals; Dietary Fats / adverse effects; Dietary Fats / pharmacology; Endoplasmic Reticulum Stress; Hyperphagia / chemically induced; Hyperphagia / genetics; Hyperphagia / metabolism; Hyperphagia / pathology; Hypothalamus / metabolism; Hypothalamus / pathology; Leptin / genetics; Leptin / metabolism; MAP Kinase Kinase Kinases / genetics; MAP Kinase Kinase Kinases / metabolism; Mice; Mice, Knockout; Obesity / chemically induced; Obesity / genetics; Obesity / metabolism; Obesity / pathology; Sterol Regulatory Element Binding Proteins / genetics; Sterol Regulatory Element Binding Proteins / metabolism
TL;DR: It is found that deletion of Tak1 increased ER volume and facilitated ER-stress tolerance in cultured cells, which was mediated by upregulation of sterol-regulatory-element-binding protein (SREBP)-dependent lipogenesis and central nervous system (CNS) deletion upregulated SREBP-target lipogenic genes and blocked ER stress in the hypothalamus. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries, ORCID
Added: August 6, 2018

2015 review

Complementary roles of the neuron-enriched endosomal proteins NEEP21 and calcyon in neuronal vesicle trafficking

[Review of ]. Journal of Neurochemistry, 132(1), 20–31.

By: N. Muthusamy, Y. Chen, D. Yin, L. Mei & C. Bergson

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

MARCKS-dependent mucin clearance and lipid metabolism in ependymal cells are required for maintenance of forebrain homeostasis during aging

AGING CELL, 14(5), 764–773.

By: N. Muthusamy n, L. Sommerville n, A. Moeser n, D. Stumpo *, P. Sannes n, K. Adler n, P. Blackshear *, J. Weimer *, H. Ghashghaei  n

author keywords: aging; barrier function; Clca3; cerebral cortex; ependymal cells; lipid droplets; mucin; oxidative stress
MeSH headings : Aging / metabolism; Animals; Ependyma / cytology; Ependyma / metabolism; Homeostasis; Intracellular Signaling Peptides and Proteins / deficiency; Intracellular Signaling Peptides and Proteins / metabolism; Lipid Metabolism; Membrane Proteins / deficiency; Membrane Proteins / metabolism; Mice; Mucins / metabolism; Myristoylated Alanine-Rich C Kinase Substrate; Oxidative Stress; Prosencephalon / metabolism
TL;DR: It is demonstrated that metabolic and barrier functions in ECs decline significantly during aging in mice, and this work constitutes a conceptually new paradigm in the potential role of ECs in the initiation of various conditions and diseases in the aging brain. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2014 journal article

A Knock-in Foxj1(CreERT2:: GFP)Mouse for Recombination in Epithelial Cells with Motile Cilia

GENESIS, 52(4), 350–358.

By: N. Muthusamy n, A. Vijayakumar n, G. Cheng * & H. Ghashghaei  n

author keywords: Foxj1; CreERT2::GFP; knock-in; ependymal cells; motile cilia; epithelial cells
MeSH headings : Animals; Cell Lineage; Choroid Plexus / cytology; Choroid Plexus / metabolism; Cilia / physiology; Epithelial Cells / metabolism; Epithelial Cells / ultrastructure; Female; Forkhead Transcription Factors / biosynthesis; Forkhead Transcription Factors / genetics; Gene Expression; Gene Knock-In Techniques; Green Fluorescent Proteins / biosynthesis; Green Fluorescent Proteins / genetics; Integrases / genetics; Male; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Transgenic; Recombination, Genetic; Tamoxifen / pharmacology; Transcriptional Activation / drug effects
TL;DR: The generation of an inducible knock-in Foxj1CreERT2::GFP knock‐in mouse is reported, which reliably induces Cre‐mediated recombination for genetic studies in epithelial cells with motile cilia throughout embryonic and postnatal development. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Specification of a Foxj1-Dependent Lineage in the Forebrain Is Required for Embryonic-to-Postnatal Transition of Neurogenesis in the Olfactory Bulb

JOURNAL OF NEUROSCIENCE, 31(25), 9368–9382.

By: B. Jacquet n, N. Muthusamy n, L. Sommerville n, G. Xiao n, H. Liang n, Y. Zhang *, M. Holtzman *, H. Ghashghaei  n

MeSH headings : Animals; Forkhead Transcription Factors / metabolism; Mice; Mice, Knockout; Neurogenesis / physiology; Neurons / physiology; Olfactory Bulb / embryology; Olfactory Bulb / physiology; Prosencephalon / embryology; Prosencephalon / physiology
TL;DR: For the first time, this study identifies the time- and region-specific activity of a perinatal progenitor domain that is required for transition and progression of OB neurogenesis from the embryonic-to-postnatal periods. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

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