Works (6)
Updated: August 16th, 2024 13:37
2006 journal article
Neutrophils do not mediate the pathophysiological sequelae of Cryptosporidium parvum infection in neonatal piglets
INFECTION AND IMMUNITY, 74(10), 5497–5505.
MeSH headings : Animals; Antibodies / pharmacology; CD18 Antigens / drug effects; Cryptosporidiosis / immunology; Cryptosporidiosis / pathology; Cryptosporidium parvum; Diarrhea / immunology; Diarrhea / microbiology; Disease Models, Animal; Ileum / immunology; Ileum / microbiology; Ileum / pathology; Immunoglobulin G / pharmacology; Intestinal Mucosa / immunology; Intestinal Mucosa / microbiology; Intestinal Mucosa / pathology; Lipid Peroxidation; Neutrophils / enzymology; Neutrophils / immunology; Peroxidase / analysis; Peroxidase / metabolism; Peroxynitrous Acid / metabolism; Prostaglandins / metabolism; Superoxides / metabolism; Swine
TL;DR:
These studies are the first to demonstrate that neutrophilic inflammation arising in response to infection by a noninvasive epithelial pathogen results in physiologic rather than pathological effects in vivo.
(via Semantic Scholar)
open access via iai.asm.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2005 journal article
Local peroxynitrite formation contributes to early control of Cryptosporidium parvum infection
INFECTION AND IMMUNITY, 73(7), 3929–3936.
MeSH headings : Animals; Cryptosporidiosis / immunology; Cryptosporidium parvum; Female; Immunohistochemistry; Lipid Peroxidation; Nitric Oxide Synthase / analysis; Nitric Oxide Synthase Type II; Peroxynitrous Acid / biosynthesis; Swine; Tyrosine / metabolism
TL;DR:
The present results are the first to demonstrate an in vivo role for peroxynitrite formation in acute mucosal defense against a noninvasive intestinal epithelial pathogen.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2005 journal article
NF-kappa B-mediated expression of iNOS promotes epithelial defense against infection by Cryptosporidium parvum in neonatal piglets
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 290(1), G164–G174.
author keywords: nitric oxide; barrier function; diarrhea; cryptosporidiosis
MeSH headings : Animals; Animals, Newborn; Body Weight; Chlorides / metabolism; Cryptosporidiosis / enzymology; Cryptosporidiosis / metabolism; Cryptosporidium parvum / immunology; Epithelial Cells / metabolism; Gene Expression Regulation, Enzymologic; Ileum / cytology; Ileum / metabolism; Ileum / ultrastructure; Intestinal Mucosa / cytology; Intestinal Mucosa / metabolism; Intestinal Mucosa / pathology; NF-kappa B / metabolism; Nitric Oxide Synthase Type II / genetics; Nitric Oxide Synthase Type II / metabolism; Swine; Swine Diseases / enzymology; Swine Diseases / metabolism; Swine Diseases / parasitology
TL;DR:
It is shown that mucosal expression of inducible nitric oxide (NO) synthase (iNOS) is increased in infected piglets and that inhibition of iNOS in vitro has no short-term effect on barrier function, suggesting that induction of i NOS represents a nonspecific response of the epithelium that mediates enterocyte defense against C. parvum infection.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2004 journal article
Nitric oxide synthase stimulates prostaglandin synthesis and barrier function in C-parvum-infected porcine ileum
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 287(3), G571–G581.
author keywords: Cryptosporidium parvum; permeability
MeSH headings : Animals; Animals, Newborn; Atrophy; Cryptosporidiosis / enzymology; Cryptosporidiosis / physiopathology; Cryptosporidium parvum; Diarrhea / microbiology; Diarrhea / pathology; Dinoprostone / biosynthesis; Eicosanoids / biosynthesis; Epoprostenol / biosynthesis; Ileum / physiopathology; Intestinal Mucosa / metabolism; Microscopy, Electron; Nitric Oxide Synthase / genetics; Nitric Oxide Synthase / physiology; Nitric Oxide Synthase Type II; Prostaglandins / biosynthesis; Reverse Transcriptase Polymerase Chain Reaction; Sodium / metabolism; Swine; Thromboxane A2 / biosynthesis
TL;DR:
Using an entire intestinal mucosa, it is demonstrated for the first time that NO serves as a proximal mediator of PGE2 synthesis and barrier function in C. parvum infection.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2002 journal article
Oral bovine serum concentrate improves cryptosporidial enteritis in calves
PEDIATRIC RESEARCH, 51(3), 370–376.
MeSH headings : Administration, Oral; Animals; Blood Proteins / pharmacology; Cattle; Cryptosporidiosis / drug therapy; Cryptosporidiosis / pathology; Cryptosporidium parvum; Diarrhea / drug therapy; Enteritis / drug therapy; Enteritis / parasitology; Enteritis / pathology; Feces / parasitology; Ileum / enzymology; Ileum / pathology; Intestinal Absorption; Lactase; Male; beta-Galactosidase / metabolism
TL;DR:
In animals receiving BSC, peak diarrheal volume and intestinal permeability were reduced 33%, fewer oocysts were shed, intestinal crypts were significantly deeper, and villous surface area returned to normal by 9 d after infection (all p ≤ 0.05).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
1997 journal article
Peptide YY inhibits intestinal Cl- secretion in experimental porcine cryptosporidiosis through a prostaglandin-activated neural pathway
Journal of Pharmacology and Experimental Therapeutics, 283(2), 692–697.
Source: NC State University Libraries
Added: August 6, 2018
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