Martha U. Armstrong

Works (6)

Updated: August 16th, 2024 13:37

2006 journal article

Neutrophils do not mediate the pathophysiological sequelae of Cryptosporidium parvum infection in neonatal piglets

INFECTION AND IMMUNITY, 74(10), 5497–5505.

By: L. Zadrozny n, S. Stauffer*, M. Armstrong*, S. Jones n  & J. Gookin* 

MeSH headings : Animals; Antibodies / pharmacology; CD18 Antigens / drug effects; Cryptosporidiosis / immunology; Cryptosporidiosis / pathology; Cryptosporidium parvum; Diarrhea / immunology; Diarrhea / microbiology; Disease Models, Animal; Ileum / immunology; Ileum / microbiology; Ileum / pathology; Immunoglobulin G / pharmacology; Intestinal Mucosa / immunology; Intestinal Mucosa / microbiology; Intestinal Mucosa / pathology; Lipid Peroxidation; Neutrophils / enzymology; Neutrophils / immunology; Peroxidase / analysis; Peroxidase / metabolism; Peroxynitrous Acid / metabolism; Prostaglandins / metabolism; Superoxides / metabolism; Swine
TL;DR: These studies are the first to demonstrate that neutrophilic inflammation arising in response to infection by a noninvasive epithelial pathogen results in physiologic rather than pathological effects in vivo. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2005 journal article

Local peroxynitrite formation contributes to early control of Cryptosporidium parvum infection

INFECTION AND IMMUNITY, 73(7), 3929–3936.

By: J. Gookin n , J. Allen n, S. Chiang n, L. Duckett n & M. Armstrong n

MeSH headings : Animals; Cryptosporidiosis / immunology; Cryptosporidium parvum; Female; Immunohistochemistry; Lipid Peroxidation; Nitric Oxide Synthase / analysis; Nitric Oxide Synthase Type II; Peroxynitrous Acid / biosynthesis; Swine; Tyrosine / metabolism
TL;DR: The present results are the first to demonstrate an in vivo role for peroxynitrite formation in acute mucosal defense against a noninvasive intestinal epithelial pathogen. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2005 journal article

NF-kappa B-mediated expression of iNOS promotes epithelial defense against infection by Cryptosporidium parvum in neonatal piglets

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 290(1), G164–G174.

By: J. Gookin n , S. Chiang n, J. Allen n, M. Armstrong n, S. Stauffer n, C. Finnegan*, M. Murtaugh

author keywords: nitric oxide; barrier function; diarrhea; cryptosporidiosis
MeSH headings : Animals; Animals, Newborn; Body Weight; Chlorides / metabolism; Cryptosporidiosis / enzymology; Cryptosporidiosis / metabolism; Cryptosporidium parvum / immunology; Epithelial Cells / metabolism; Gene Expression Regulation, Enzymologic; Ileum / cytology; Ileum / metabolism; Ileum / ultrastructure; Intestinal Mucosa / cytology; Intestinal Mucosa / metabolism; Intestinal Mucosa / pathology; NF-kappa B / metabolism; Nitric Oxide Synthase Type II / genetics; Nitric Oxide Synthase Type II / metabolism; Swine; Swine Diseases / enzymology; Swine Diseases / metabolism; Swine Diseases / parasitology
TL;DR: It is shown that mucosal expression of inducible nitric oxide (NO) synthase (iNOS) is increased in infected piglets and that inhibition of iNOS in vitro has no short-term effect on barrier function, suggesting that induction of i NOS represents a nonspecific response of the epithelium that mediates enterocyte defense against C. parvum infection. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2004 journal article

Nitric oxide synthase stimulates prostaglandin synthesis and barrier function in C-parvum-infected porcine ileum

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 287(3), G571–G581.

By: J. Gookin* , L. Duckett, M. Armstrong*, S. Stauffer, C. Finnegan*, M. Murtaugh, R. Argenzio*

author keywords: Cryptosporidium parvum; permeability
MeSH headings : Animals; Animals, Newborn; Atrophy; Cryptosporidiosis / enzymology; Cryptosporidiosis / physiopathology; Cryptosporidium parvum; Diarrhea / microbiology; Diarrhea / pathology; Dinoprostone / biosynthesis; Eicosanoids / biosynthesis; Epoprostenol / biosynthesis; Ileum / physiopathology; Intestinal Mucosa / metabolism; Microscopy, Electron; Nitric Oxide Synthase / genetics; Nitric Oxide Synthase / physiology; Nitric Oxide Synthase Type II; Prostaglandins / biosynthesis; Reverse Transcriptase Polymerase Chain Reaction; Sodium / metabolism; Swine; Thromboxane A2 / biosynthesis
TL;DR: Using an entire intestinal mucosa, it is demonstrated for the first time that NO serves as a proximal mediator of PGE2 synthesis and barrier function in C. parvum infection. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2002 journal article

Oral bovine serum concentrate improves cryptosporidial enteritis in calves

PEDIATRIC RESEARCH, 51(3), 370–376.

By: E. Hunt n, Q. Fu *, M. Armstrong n, D. Rennix n, D. Webster n, J. Galanko *, W. Chen*, E. Weaver *, R. Argenzio*, J. Rhoads

MeSH headings : Administration, Oral; Animals; Blood Proteins / pharmacology; Cattle; Cryptosporidiosis / drug therapy; Cryptosporidiosis / pathology; Cryptosporidium parvum; Diarrhea / drug therapy; Enteritis / drug therapy; Enteritis / parasitology; Enteritis / pathology; Feces / parasitology; Ileum / enzymology; Ileum / pathology; Intestinal Absorption; Lactase; Male; beta-Galactosidase / metabolism
TL;DR: In animals receiving BSC, peak diarrheal volume and intestinal permeability were reduced 33%, fewer oocysts were shed, intestinal crypts were significantly deeper, and villous surface area returned to normal by 9 d after infection (all p ≤ 0.05). (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

1997 journal article

Peptide YY inhibits intestinal Cl- secretion in experimental porcine cryptosporidiosis through a prostaglandin-activated neural pathway

Journal of Pharmacology and Experimental Therapeutics, 283(2), 692–697.

By: R. Argenzio, M. Armstrong, A. Blikslager  & J. Rhoads

Source: NC State University Libraries
Added: August 6, 2018

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