Robert A. Argenzio

Works (48)

Updated: April 4th, 2024 18:29

2009 journal article

Influence of diet and water supply on mineral content and pH within the large intestine of horses with enterolithiasis

VETERINARY JOURNAL, 182(1), 44–49.

By: D. Hassel*, S. Spier*, B. Aldridge*, M. Watnick*, R. Argenzio n & J. Snyder*

author keywords: Horse; Enterolithiasis; Nutrition; Water; Minerals
MeSH headings : Animal Feed / adverse effects; Animal Feed / analysis; Animals; Case-Control Studies; Colon / chemistry; Female; Horse Diseases / diet therapy; Horse Diseases / etiology; Horse Diseases / metabolism; Horse Diseases / prevention & control; Horses; Hydrogen-Ion Concentration; Intestinal Diseases / etiology; Intestinal Diseases / metabolism; Intestinal Diseases / prevention & control; Intestinal Diseases / veterinary; Lithiasis / etiology; Lithiasis / metabolism; Lithiasis / prevention & control; Lithiasis / veterinary; Magnesium Compounds / analysis; Magnesium Compounds / metabolism; Male; Minerals / analysis; Minerals / metabolism; Phosphates / analysis; Phosphates / metabolism; Risk Factors; Struvite; Water Supply / analysis; Water Supply / standards
TL;DR: Under controlled dietary and management conditions, horses with enterolithiasis have differences in colonic mineral and pH parameters that may be consistent with physiological differences between horses with and without the disease. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2004 journal article

Arginine stimulates intestinal cell migration through a focal adhesion kinase dependent mechanism

Gut, 53(4), 514–522.

By: J. Rhoads*, W. Chen*, J. Gookin n, G. Wu*, Q. Fu*, A. Blikslager n, R. Rippe, R. Argenzio n ...

Contributors: J. Rhoads*, W. Chen*, J. Gookin n, G. Wu*, Q. Fu*, A. Blikslager n, R. Rippe, R. Argenzio n ...

MeSH headings : Animals; Arginine / pharmacology; Cell Movement / drug effects; Cells, Cultured; Dietary Supplements; Dose-Response Relationship, Drug; Enterocytes / drug effects; Enterocytes / physiology; Enzyme Inhibitors / pharmacology; Focal Adhesion Protein-Tyrosine Kinases; Nitric Oxide / metabolism; Ornithine Decarboxylase / physiology; Ornithine Decarboxylase Inhibitors; Phosphorylation / drug effects; Polyamines / pharmacology; Protein-Tyrosine Kinases / physiology; Swine; Transfection; Tyrosine / physiology
TL;DR: Results showed that l-arginine stimulates cell migration through NO and FAK dependent pathways and that combination therapy with arginine and BSC may enhance intestinal restitution via separate and convergent pathways. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: August 6, 2018

2004 journal article

Nitric oxide synthase stimulates prostaglandin synthesis and barrier function in C-parvum-infected porcine ileum

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 287(3), G571–G581.

By: J. Gookin*, L. Duckett, M. Armstrong*, S. Stauffer, C. Finnegan*, M. Murtaugh, R. Argenzio*

author keywords: Cryptosporidium parvum; permeability
MeSH headings : Animals; Animals, Newborn; Atrophy; Cryptosporidiosis / enzymology; Cryptosporidiosis / physiopathology; Cryptosporidium parvum; Diarrhea / microbiology; Diarrhea / pathology; Dinoprostone / biosynthesis; Eicosanoids / biosynthesis; Epoprostenol / biosynthesis; Ileum / physiopathology; Intestinal Mucosa / metabolism; Microscopy, Electron; Nitric Oxide Synthase / genetics; Nitric Oxide Synthase / physiology; Nitric Oxide Synthase Type II; Prostaglandins / biosynthesis; Reverse Transcriptase Polymerase Chain Reaction; Sodium / metabolism; Swine; Thromboxane A2 / biosynthesis
TL;DR: Using an entire intestinal mucosa, it is demonstrated for the first time that NO serves as a proximal mediator of PGE2 synthesis and barrier function in C. parvum infection. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2004 journal article

Physiological responses in swine treated with water containing sodium bicarbonate as a prophylactic for gastric ulcers

Journal of Animal Science, 82(9), 2757–2763.

By: J. Cole n, R. Argenzio n & J. Eisemann n

MeSH headings : Acid-Base Equilibrium / drug effects; Acid-Base Equilibrium / physiology; Adaptation, Physiological; Animals; Anti-Ulcer Agents / pharmacology; Drinking; Hydrogen-Ion Concentration; Male; Random Allocation; Sodium / urine; Sodium Bicarbonate / metabolism; Sodium Bicarbonate / pharmacology; Stomach / chemistry; Stomach Ulcer / prevention & control; Stomach Ulcer / veterinary; Swine / metabolism; Swine / physiology; Swine Diseases / prevention & control
TL;DR: Results indicate that sodium bicarbonate can safely be added to the water supply for pigs, with no clinically relevant alterations in acid-base balance because the animals readily compensate for buffer intake. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: NC State University Libraries
Added: August 6, 2018

2003 journal article

Cyclooxygenase blockade and exogenous glutamine enhance sodium absorption in infected bovine ileum

American Journal of Physiology-Gastrointestinal and Liver Physiology, 284(3), G516–G524.

By: J. Cole*, A. Blikslager*, E. Hunt n, J. Gookin* & R. Argenzio*

author keywords: Cryptosporidium parvum; Na/H exchanger 3; cyclooxygenase-2; diarrhea
MeSH headings : Animals; Biological Transport, Active; Blotting, Western; Cattle; Chlorine; Cryptosporidiosis / metabolism; Cryptosporidiosis / parasitology; Cryptosporidium parvum; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors / pharmacology; Glutamine / pharmacology; Ileum / metabolism; Ileum / parasitology; Ileum / pathology; Inflammation / pathology; Intestinal Absorption / drug effects; Intestinal Absorption / physiology; Isoenzymes / metabolism; Male; Prostaglandin-Endoperoxide Synthases / metabolism; Radioisotopes; Sodium / metabolism; Sodium Radioisotopes; Tissue Fixation
TL;DR: It is shown that prostanoids inhibit electroneneutral sodium absorption in Cryptosporidium parvum-infected porcine ileum, whereas glutamine stimulates electroneutral sodium absorption via a cyclooxygenase (COX)-dependent pathway, and glutamine increases sodium uptake by an electrogenic mechanism in this same tissue. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2003 journal article

Effects of hvdrochloric, valeric, and other volatile fatty acids on pathogenesis of ulcers in the nonglandular portion of the stomach of horses

AMERICAN JOURNAL OF VETERINARY RESEARCH, 64(4), 413–417.

By: J. Nadeau, F. Andrews, C. Patton, R. Argenzio*, A. Mathew & A. Saxton

MeSH headings : Animals; Culture Techniques; Electric Conductivity; Fatty Acids, Volatile / adverse effects; Female; Horse Diseases / physiopathology; Horses; Hydrochloric Acid / adverse effects; Hydrogen-Ion Concentration; Male; Membrane Potentials / drug effects; Pentanoic Acids / adverse effects; Sodium / metabolism; Stomach / drug effects; Stomach / pathology; Stomach Ulcer / chemically induced; Stomach Ulcer / pathology; Stomach Ulcer / veterinary; Time Factors
TL;DR: In vitro effects of hydrochloric acid, valeric acid, and other volatile fatty acids (VFAs) on the pathogenesis of ulcers in the nonglandular portion of the equine stomach were identified and changes in barrier function attributable to exposure to Valeric acid were associated with histopathologic evidence of cellular swelling in all layers of the nONGlandular mucosa. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2003 journal article

Effects of hydrochloric, acetic, butyric, and propionic acids on pathogenesis of ulcers in the nonglandular portion of the stomach of horses

AMERICAN JOURNAL OF VETERINARY RESEARCH, 64(4), 404–412.

By: J. Nadeau n, F. Andrews n, C. Patton n, R. Argenzio n, A. Mathew n & A. Saxton n

MeSH headings : Acetic Acid / adverse effects; Animals; Butyric Acid / adverse effects; Culture Techniques; Fatty Acids, Volatile / adverse effects; Female; Gastric Mucosa / drug effects; Gastric Mucosa / pathology; Horse Diseases / chemically induced; Horse Diseases / etiology; Horse Diseases / pathology; Horses; Hydrochloric Acid / adverse effects; Hydrogen-Ion Concentration; Male; Membrane Potentials / drug effects; Propionates / adverse effects; Stomach / drug effects; Stomach / pathology; Stomach Ulcer / chemically induced; Stomach Ulcer / etiology; Stomach Ulcer / pathology; Stomach Ulcer / veterinary; Time Factors
TL;DR: Results indicate that HCl alone or in combination with VFAs at gastric pH < or = 4.0 may be important in the pathogenesis of gastric ulcers in the nonglandular portion of the stomach of horses. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2003 journal article

PG-mediated closure of paracellular pathway and not restitution is the primary determinant of barrier recovery in acutely injured porcine ileum

American Journal of Physiology-Gastrointestinal and Liver Physiology, 285(5), G967–G979.

By: J. Gookin n, J. Galanko*, A. Blikslager n & R. Argenzio n

author keywords: resistance; permeability; tight junction; deoxycholate
MeSH headings : Animals; Deoxycholic Acid / pharmacology; Detergents / pharmacology; Gastrointestinal Motility; Ileum / drug effects; Ileum / metabolism; Ileum / pathology; Intestinal Mucosa / drug effects; Intestinal Mucosa / metabolism; Intestinal Mucosa / pathology; Intestinal Mucosa / physiopathology; Microscopy, Electron; Microvilli; Permeability / drug effects; Prostaglandins / metabolism; Recovery of Function; Swine; Wound Healing
TL;DR: These studies are the first to clearly distinguish the relative contribution of paracellular resistance vs. restitution to acute recovery of epithelial barrier function and underlie barrier failure resulting from NSAID use in patients with underlying enteropathy. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2002 journal article

Endoscopy via a gastric cannula to monitor the development of ulcers in the pars esophagea in pigs after consumption of a finely ground feed combined with a period of withholding of feed

AMERICAN JOURNAL OF VETERINARY RESEARCH, 63(8), 1076–1082.

By: J. Cole n, J. Gookin n, J. Gayle n, J. Eisemann n, R. Argenzio n & A. Blikslager n

MeSH headings : Animal Feed / adverse effects; Animals; Catheterization / veterinary; Endoscopy, Digestive System / instrumentation; Endoscopy, Digestive System / veterinary; Food Deprivation / physiology; Male; Particle Size; Stomach Ulcer / etiology; Stomach Ulcer / metabolism; Stomach Ulcer / pathology; Stomach Ulcer / veterinary; Swine; Swine Diseases / etiology; Swine Diseases / metabolism; Swine Diseases / pathology
TL;DR: Endoscopic examination via a gastric cannula was an effective means of monitoring ulcer development in the pars esophagea of pigs and direct visual examination during necropsy confirmed the accuracy of endoscopic examination. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2002 review

Host responses to Cryptosporidium infection

[Review of ]. JOURNAL OF VETERINARY INTERNAL MEDICINE, 16(1), 12–21.

By: J. Gookin n, S. Nordone n & R. Argenzio n

author keywords: cryptosporidiosis; diarrhea; immunity; intestinal epithelium; pathogenesis
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2002 article

Inducible nitric oxide synthase mediates early epithelial repair of porcine ileum

Gookin, J. L., Rhoads, J. M., & Argenzio, R. A. (2002, July). AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, Vol. 283, pp. G157–G168.

By: J. Gookin n, J. Rhoads* & R. Argenzio n

author keywords: restitution; epithelium; serum; deoxycholate
MeSH headings : Animals; Arginine / pharmacology; Deoxycholic Acid; Detergents; Enterocytes / physiology; Female; Ileum / enzymology; Ileum / physiopathology; Intestinal Diseases / chemically induced; Intestinal Diseases / physiopathology; Intestinal Mucosa / physiopathology; Microvilli / enzymology; Microvilli / physiology; Nitric Oxide / biosynthesis; Nitric Oxide Synthase / physiology; Nitric Oxide Synthase Type II; Swine; Wound Healing
TL;DR: It is demonstrated that iNOS-derived NO is a key mediator of early villous reepithelialization following acute mucosal injury. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2002 journal article

Neutrophils increase paracellular permeability of restituted ischemic-injured porcine ileum

SURGERY, 132(3), 461–470.

By: J. Gayle*, S. Jones*, R. Argenzio*, A. Blikslager* & Surgery

MeSH headings : Animals; Antibodies, Monoclonal / immunology; CD11 Antigens / physiology; CD18 Antigens / physiology; Electric Impedance; Ileum / blood supply; Ileum / metabolism; Ileum / pathology; Ischemia / metabolism; Ischemia / pathology; Neutrophils / physiology; Permeability; Polyethylene Glycols / pharmacology; Superoxide Dismutase / pharmacology; Swine
TL;DR: Pretreatment with anti-CD11/CD18 monoclonal antibody and superoxide dismutase-polyethylene glycol significantly reduced neutrophil infiltration and normalized transepithelial electrical resistance and mannitol fluxes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2002 journal article

Oral bovine serum concentrate improves cryptosporidial enteritis in calves

PEDIATRIC RESEARCH, 51(3), 370–376.

By: E. Hunt n, Q. Fu*, M. Armstrong n, D. Rennix n, D. Webster n, J. Galanko*, W. Chen*, E. Weaver*, R. Argenzio*, J. Rhoads

MeSH headings : Administration, Oral; Animals; Blood Proteins / pharmacology; Cattle; Cryptosporidiosis / drug therapy; Cryptosporidiosis / pathology; Cryptosporidium parvum; Diarrhea / drug therapy; Enteritis / drug therapy; Enteritis / parasitology; Enteritis / pathology; Feces / parasitology; Ileum / enzymology; Ileum / pathology; Intestinal Absorption; Lactase; Male; beta-Galactosidase / metabolism
TL;DR: In animals receiving BSC, peak diarrheal volume and intestinal permeability were reduced 33%, fewer oocysts were shed, intestinal crypts were significantly deeper, and villous surface area returned to normal by 9 d after infection (all p ≤ 0.05). (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2002 journal article

Prostaglandin E-2 and reactive oxygen metabolite damage in the cecum in a pony model of acute colitis

Canadian Journal of Veterinary Research, 66(1), 50–54.

By: R. McConnico, R. Argenzio & M. Roberts

Source: NC State University Libraries
Added: August 6, 2018

2002 journal article

Recovery of ischaemic injured porcine ileum: evidence for a contributory role of COX-1 and COX-2

Gut, 50(5), 615–623.

By: A. Blikslager n, D. Zimmel*, K. Young*, N. Campbell, D. Little* & R. Argenzio*

Contributors: A. Blikslager n, D. Zimmel*, K. Young*, N. Campbell, D. Little* & R. Argenzio*

MeSH headings : Animals; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors / pharmacology; Diffusion Chambers, Culture; Dose-Response Relationship, Drug; Eicosanoids / biosynthesis; Female; Ileum / blood supply; Ileum / drug effects; Indomethacin / pharmacology; Intestinal Mucosa / blood supply; Intestinal Mucosa / drug effects; Intestinal Mucosa / pathology; Ischemia / enzymology; Ischemia / pathology; Isoenzymes / antagonists & inhibitors; Isoenzymes / physiology; Male; Nitrobenzenes / pharmacology; Permeability; Prostaglandin-Endoperoxide Synthases / physiology; Sulfonamides / pharmacology; Swine
TL;DR: The results suggest that recovery of resistance is triggered by PGE and PGI2, which may be elaborated by either COX-1 orCOX-2. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2001 journal article

Glutamine transporter in crypts compensates for loss of villus absorption in bovine cryptosporidiosis

American Journal of Physiology-Gastrointestinal and Liver Physiology, 281(3), G645–G653.

By: A. Blikslager*, E. Hunt n, R. Guerrant*, M. Rhoads* & R. Argenzio*

author keywords: sodium absorption; sodium/hydrogen exchanger; villous atrophy; crypt hyperplasia; prostaglandin E-2
MeSH headings : Amino Acid Transport Systems; Amino Acid Transport Systems, Basic; Animals; Blotting, Western; Carrier Proteins / metabolism; Cattle; Chlorides / metabolism; Cryptosporidiosis / drug therapy; Cryptosporidiosis / pathology; Cryptosporidiosis / physiopathology; Cyclooxygenase Inhibitors / pharmacology; Dinoprostone / pharmacology; Dipeptides / pharmacology; Disease Models, Animal; Drug Synergism; Glutamine / pharmacology; Ileum / parasitology; Ileum / pathology; Ileum / physiopathology; Immunohistochemistry; In Vitro Techniques; Indomethacin / antagonists & inhibitors; Indomethacin / pharmacology; Intestinal Absorption / drug effects; Ion Transport / drug effects; Sodium / metabolism
TL;DR: It is illustrated that the combined use of a PG synthesis inhibitor and glutamine can fully stimulate Na(+) and Cl(-) absorption despite the severe villous atrophy, an effect associated with increased expression of a Na(+)-dependent amino acid transporter in infected crypts. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, Crossref
Added: August 6, 2018

2001 chapter

The excretory system

In H. J. M. W. G. Pond (Ed.), Biology of the domestic pig (Vol. 13, pp. 585–624). Ithaca, NY: Comstock Pub. Associates/Cornell University Press.

By: N. Monteiro-Riviere & R. Argenzio

Ed(s): H. W. G. Pond

Source: NC State University Libraries
Added: August 6, 2018

2000 journal article

Effects of feed physical form and buffering solutes on water disappearance and proximal stomach pH in swine.

Journal of Animal Science, 78(9), 2344.

By: K. Ange n, J. Eisemann n, R. Argenzio n, G. Almond n & A. Blikslager n

Contributors: K. Ange n, J. Eisemann n, R. Argenzio n, G. Almond n & A. Blikslager n

MeSH headings : Animal Feed; Animals; Buffers; Gastric Mucosa / metabolism; Hydrogen-Ion Concentration; Solutions; Swine / metabolism; Water / metabolism; Water Supply
TL;DR: The effects of the physical form of feed on water disappearance and the effects of buffered water on proximal stomach pH in swine were determined in two experiments and the proximal pH of the stomach was increased by adding buffers to the water supply. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: NC State University Libraries, Crossref, NC State University Libraries, ORCID
Added: August 6, 2018

2000 journal article

Evaluation of diet as a cause of gastric ulcers in horses

AMERICAN JOURNAL OF VETERINARY RESEARCH, 61(7), 784–790.

By: J. Nadeau, F. Andrews, A. Mathew, R. Argenzio*, J. Blackford, M. Sohtell, A. Saxton

MeSH headings : Animal Feed / adverse effects; Animal Feed / analysis; Animals; Chromatography, Gas / veterinary; Cross-Over Studies; Endoscopy, Digestive System / veterinary; Fatty Acids, Volatile / analysis; Female; Gastric Mucosa / pathology; Gastrointestinal Contents / chemistry; Horse Diseases / etiology; Horse Diseases / pathology; Horses; Hydrogen-Ion Concentration; Lactic Acid / analysis; Random Allocation; Regression Analysis; Stomach Ulcer / etiology; Stomach Ulcer / pathology; Stomach Ulcer / veterinary
TL;DR: Concentrations of acetic, propionic, and isovaleric acid were significantly higher in gastric juice, and number and severity of nonglandular squamous gastric lesions were significantly lower in horses fed alfalfa hay-grain, whereas valeric acid concentrations and butyric acid were useful in predicting severity of those lesions in Horses fed bromegrass hay. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2000 article

Evaluation of intestinal permeability and gluten sensitivity in Soft-Coated Wheaten Terriers with familial protein-losing enteropathy, protein-losing nephropathy, or both

Vaden, S. L., Sellon, R. K., Melgarejo, L. T., Williams, D. A., Trogdon, M. M., VanCamp, S. D., & Argenzio, R. A. (2000, May). AMERICAN JOURNAL OF VETERINARY RESEARCH, Vol. 61, pp. 518–524.

By: S. Vaden n, R. Sellon n, L. Melgarejo n, D. Williams n, M. Trogdon n, S. VanCamp n, R. Argenzio n

MeSH headings : Animals; Biopsy / veterinary; Blood Cell Count / veterinary; Chlorides / pharmacology; Chlorides / urine; Chromium Compounds / pharmacology; Chromium Compounds / urine; Creatinine / urine; Dog Diseases / genetics; Dog Diseases / pathology; Dog Diseases / physiopathology; Dogs; Duodenum / pathology; Duodenum / physiopathology; Feces / chemistry; Female; Food Hypersensitivity / etiology; Food Hypersensitivity / physiopathology; Food Hypersensitivity / veterinary; Glutens / immunology; Glutens / metabolism; Kidney Diseases / genetics; Kidney Diseases / physiopathology; Kidney Diseases / veterinary; Male; Permeability; Protein-Losing Enteropathies / genetics; Protein-Losing Enteropathies / physiopathology; Protein-Losing Enteropathies / veterinary; Serum Albumin / analysis; Serum Globulins / analysis; Spectrophotometry, Atomic / veterinary; Statistics, Nonparametric; alpha 1-Antitrypsin / analysis
TL;DR: Although enhanced wheat-gluten sensitivity may be one factor involved in the pathogenesis of PLE or PLN in SCWT, this syndrome does not appear to be the result of a specific sensitivity to gluten. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2000 journal article

Genistein augments prostaglandin-induced recovery of barrier function in ischemia-injured porcine ileum

American Journal of Physiology-Gastrointestinal and Liver Physiology, 278(2), G207–G216.

By: A. Blikslager*, M. Roberts*, K. Young*, J. Rhoads* & R. Argenzio n

author keywords: mucosa; chloride secretion; transmucosal resistance; tyrosine kinase
MeSH headings : 8-Bromo Cyclic Adenosine Monophosphate / pharmacology; Animals; Chlorides / metabolism; Cyclic GMP / pharmacology; Dinoprostone / pharmacology; Drug Synergism; Electric Impedance; Female; Genistein / pharmacology; Ileum / blood supply; Ileum / drug effects; Ileum / physiopathology; Intestinal Mucosa / physiopathology; Ischemia / physiopathology; Male; Mannitol / metabolism; N-Formylmethionine Leucyl-Phenylalanine / pharmacology; Swine / physiology; Tetradecanoylphorbol Acetate / pharmacology; Tritium
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref
Added: August 6, 2018

2000 journal article

Glutamine metabolism stimulates intestinal cell MAPKs by a cAMP-inhibitable, Raf-independent mechanism

GASTROENTEROLOGY, 118(1), 90–100.

By: J. Rhoads n, R. Argenzio n, W. Chen n, L. Graves n, L. Licato n, A. Blikslager n, J. Smith n, J. Gatzy n, D. Brenner n

MeSH headings : Cell Division / drug effects; Cell Line; Cyclic AMP / analogs & derivatives; Cyclic AMP / metabolism; Cyclic AMP / pharmacology; DNA / biosynthesis; DNA / drug effects; Enzyme Activation / drug effects; Enzyme Inhibitors / pharmacology; Epidermal Growth Factor / metabolism; Epidermal Growth Factor / pharmacology; Flavonoids / pharmacology; Glutamine / metabolism; Glutamine / pharmacology; Intestinal Mucosa / metabolism; Intestines / cytology; MAP Kinase Signaling System / drug effects; Mitogen-Activated Protein Kinases / antagonists & inhibitors; Mitogen-Activated Protein Kinases / metabolism; Oxygen Consumption / drug effects; Thionucleotides / pharmacology; Thymidine / metabolism
TL;DR: In vitro kinase assays showed that glutamine signaling requires an intact ERK (extracellular signal-related kinase) pathway in unstarved cells and increased levels of intracellular cAMP inhibit ERKs but only partially reduce glutamine-stimulated proliferation in enterocytes adapted to low glutamine. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2000 journal article

Low endogenous prostaglandin E-2 predisposes to relapsing inflammation in experimental rat enterocolitis

DIGESTIVE DISEASES AND SCIENCES, 45(11), 2091–2099.

By: H. Kandil n, R. Argenzio & R. Sartor

author keywords: experimental colitis; enterocolitis; prostaglandin E-2; inflammation
MeSH headings : Animals; Chronic Disease; Cytokines / blood; Dinoprostone / deficiency; Enterocolitis / genetics; Enterocolitis / immunology; Female; Genetic Predisposition to Disease; Interleukin-1 / blood; Rats; Rats, Inbred F344; Rats, Inbred Lew; Recurrence
TL;DR: Increased endogenous PG may be protective against relapsing inflammation in PG-PS induced enterocolitis, at least partially via inhibition of proinflammatory cytokines. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1999 journal article

Changes in gastric contents in pigs fed a finely ground and pelleted or coarsely ground meal diet

Journal of Animal Science, 77(10), 2721–2729.

By: D. Regina n, J. Eisemann n, J. Lang n & R. Argenzio n

MeSH headings : Ammonia / metabolism; Animal Feed; Animals; Diet; Fermentation; Gastrointestinal Contents / chemistry; Surface Properties; Swine / metabolism; Time Factors
TL;DR: Data show that components secreted in the distal region, such as acid and pepsin, may play a role in initiating damage to the stratified squamous mucosa in pigs consuming a finely ground and pelleted (FGP) or coarsely ground meal (CGM) diet. (via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018

1999 journal article

Comparative pathophysiology of nonglandular ulcer disease: A review of experimental studies

Equine Veterinary Journal, 19.

By: R. Argenzio n

MeSH headings : Animal Feed; Animals; Bile Acids and Salts / physiology; Fasting / physiology; Gastric Mucosa / physiology; Horse Diseases / physiopathology; Horses; Peptic Ulcer / physiopathology; Peptic Ulcer / veterinary; Rabbits; Swine; Swine Diseases / physiopathology
TL;DR: Studies of the equine stomach have shown a similar proximal to distal pH gradient in the fed stomach, a significant duodenal-gastric reflux, and induction of squamous ulcers with fasting, thereby illustrating that similar conditions may be responsible for damage to theEquine nonglandular mucosa. (via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018

1999 chapter

Comparative pathophysiology of nonglandular ulcer disease: A review of experimental studies

In P. D. R. T. S. Mair & A. M. Merritt (Eds.), Equine gastric ulceration (Equine veterinary journal supplement) (pp. 19–23). Suffolk, UK: British Equine Veterinary Association.

By: R. Argenzio

Ed(s): P. T. S. Mair & A. Merritt

Source: NC State University Libraries
Added: August 6, 2018

1999 journal article

Effects of diet and housing density on growth and stomach morphology in pigs

Journal of Animal Science, 77(10), 2709–2714.

By: J. Eisemann n & R. Argenzio n

MeSH headings : Animals; Diet; Female; Housing, Animal; Male; Stomach / pathology; Stomach Ulcer / pathology; Stomach Ulcer / veterinary; Stress, Physiological / pathology; Swine; Swine Diseases / pathology
TL;DR: The data show the major effect of diet type on stomach lesions with no interaction with space restriction with no effect of space restriction on stomach morphology. (via Semantic Scholar)
UN Sustainable Development Goal Categories
11. Sustainable Cities and Communities (OpenAlex)
Source: NC State University Libraries
Added: August 6, 2018

1999 journal article

Effects of diets differing in propensity to promote gastric lesions on defense systems in gastric mucosae

Journal of Animal Science, 77(10), 2715–2720.

By: J. Eisemann n & R. Argenzio n

MeSH headings : Animals; Body Weight; Diet; Dinoprostone / pharmacology; Female; Gastric Mucosa / drug effects; Gastric Mucosa / pathology; Gastrointestinal Contents / chemistry; Male; Stomach Ulcer / pathology; Stomach Ulcer / veterinary; Swine; Swine Diseases / pathology; Thiobarbituric Acid Reactive Substances / metabolism
TL;DR: Generation of prooxidants and the antioxidant defense system may play a role in the predilection of ulcers for the stratified squamous mucosal region of the pig stomach in pigs fed diets with differing propensity to promote gastric lesions. (via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018

1999 journal article

Glutamine and transforming growth factor-α stimulate extracellular regulated kinases and enhance recovery of villous surface area in porcine ischemic-injured intestine

Surgery, 125(2), 186–194.

By: A. Blikslager*, J. Rhoads, D. Bristol*, M. Roberts* & R. Argenzio*

Contributors: A. Blikslager*, J. Rhoads, D. Bristol*, M. Roberts* & R. Argenzio*

TL;DR: Glutamine plus TGF-alpha treatment restored mucosal architecture within 72 hours of severe ischemic injury associated with sustained elevations in ERK activity. (via Semantic Scholar)
Sources: NC State University Libraries, ORCID, NC State University Libraries
Added: August 6, 2018

1999 journal article

Low endogenous prostaglandin E-2 predisposes to relapsing inflammation in experimental rat enterocolitis

Digestive Diseases and Sciences, 44(10), 2110–2118.

By: H. Kandil, R. Argenzio & R. Sartor

Source: NC State University Libraries
Added: August 6, 2018

1999 conference paper

New therapies for calf diarrhea: therapy and prevention for the new millennium

Proceedings of the thirty second annual conference, American Association of Bovine Practitioners: September 23-26, 1999, Nashville, TN, 32, 118–122. Stillwater, OK: American Association of Bovine Practitioners.

By: E. Hunt, R. Argenzio & A. Blikslager

Source: NC State University Libraries
Added: August 6, 2018

1999 journal article

Prostaglandin-induced recovery of barrier function in porcine ileum is triggered by chloride secretion

American Journal of Physiology-Gastrointestinal and Liver Physiology, 276(1), G28–G36.

By: A. Blikslager*, M. Roberts* & R. Argenzio n

author keywords: tight junction; ischemia; mucosa
MeSH headings : 16,16-Dimethylprostaglandin E2 / pharmacology; Amiloride / pharmacology; Animals; Bumetanide / pharmacology; Chlorides / antagonists & inhibitors; Chlorides / metabolism; Cyclic GMP / analogs & derivatives; Cyclic GMP / pharmacology; Cyclooxygenase Inhibitors / pharmacology; Electric Conductivity; Electric Impedance; Enzyme Inhibitors / pharmacology; Epoprostenol / analogs & derivatives; Epoprostenol / pharmacology; Female; Ileum / drug effects; Ileum / metabolism; Ileum / physiology; Indomethacin / pharmacology; Male; Ouabain / pharmacology; Permeability / drug effects; Sodium-Potassium-Exchanging ATPase / antagonists & inhibitors; Swine
TL;DR: PGs signal recovery of R via induction of Cl- secretion and inhibition of Na+ absorption, possibly by establishing a transmucosal osmotic gradient. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref
Added: August 6, 2018

1999 journal article

The characteristics of intestinal injury peripheral to strangulating obstruction lesions in the equine small intestine

EQUINE VETERINARY JOURNAL, 31(4), 331–335.

By: M. Gerard*, A. Blikslager n, M. Roberts n, L. Tate n & R. Argenzio n

author keywords: horse; intestine; ischaemia; myeloperoxidase; lipid peroxidation
MeSH headings : Anastomosis, Surgical / veterinary; Animals; Follow-Up Studies; Horse Diseases / etiology; Horse Diseases / pathology; Horse Diseases / surgery; Horses; Intestinal Mucosa / enzymology; Intestinal Mucosa / metabolism; Intestinal Mucosa / pathology; Intestinal Obstruction / complications; Intestinal Obstruction / pathology; Intestinal Obstruction / surgery; Intestinal Obstruction / veterinary; Intestine, Small / metabolism; Intestine, Small / pathology; Intestine, Small / surgery; Lipid Peroxidation; Peroxidase / metabolism; Reperfusion Injury / etiology; Reperfusion Injury / pathology; Reperfusion Injury / veterinary
TL;DR: Evidence of serosal injury and neutrophil infiltration in the proximal jejunal resection margins may predispose horses to post operative adhesions. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

1998 review

Feeding strategy and water homeostasis in equids: the role of the hind gut

[Review of ]. JOURNAL OF ARID ENVIRONMENTS, 38(3), 493–509.

By: J. Sneddon* & R. Argenzio n

author keywords: horses; feeding strategy; hind gut; water homeostasis
TL;DR: Feed and digestive strategies of ruminants and hind gut fermenters are compared with respect to body size and evidence for the existence of a gastrointestinal fluid reservoir in equids is provided. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1998 journal article

L-Glutamine and Transforming Growth Factor-α Enhance Recovery of Monoacylglycerol Acyltransferase and Diacylglycerol Acyltransferase Activity in Porcine Postischemic Ileum

Pediatric Research, 43(2), 227–233.

By: N. Ahdieh*, A. Blikslager n, B. Bhat*, R. Coleman*, R. Argenzio n & J. Rhoads*

MeSH headings : Acyltransferases / metabolism; Animals; Diacylglycerol O-Acyltransferase; Duodenum / enzymology; Glutamine / pharmacology; Ileum / blood supply; Ileum / drug effects; Ileum / enzymology; Ileum / pathology; Intestinal Mucosa / drug effects; Intestinal Mucosa / pathology; Ischemia / enzymology; Jejunum / enzymology; Male; Swine; Transforming Growth Factor alpha / pharmacology
TL;DR: It is shown that intestinal MGAT and DGAT activities decrease after ischemic damage, yet recover rapidly in bowel exposed to Gln and/or TGF-α, which could improve the efficacy of enteral feeding in infants recovering from bowel damage. (via Semantic Scholar)
Sources: Web Of Science, Crossref
Added: August 6, 2018

1998 journal article

Production of gastroesophageal erosions and ulcers (GEU) in gnotobiotic swine monoinfected with fermentative commensal bacteria and fed high-carbohydrate diet

VETERINARY PATHOLOGY, 35(4), 274–282.

By: S. Krakowka*, K. Eaton*, D. Rings* & R. Argenzio n

author keywords: diet; Gastrospirillum; gnotobiology; Helicobacter; Lactobacillus; swine; ulcers
MeSH headings : Animals; Bacillus / isolation & purification; Bacillus / pathogenicity; Cell Division; Dietary Carbohydrates / administration & dosage; Epithelium / microbiology; Epithelium / pathology; Esophageal Diseases / microbiology; Esophageal Diseases / pathology; Esophageal Diseases / veterinary; Esophagogastric Junction / microbiology; Esophagogastric Junction / pathology; Gastric Mucosa / microbiology; Gastric Mucosa / pathology; Germ-Free Life; Helicobacter / isolation & purification; Helicobacter / pathogenicity; Hydrogen-Ion Concentration; Lactobacillus / isolation & purification; Lactobacillus / pathogenicity; Stomach Ulcer / microbiology; Stomach Ulcer / pathology; Stomach Ulcer / veterinary; Swine; Swine Diseases / microbiology; Swine Diseases / pathology
TL;DR: Experimental GEU likely develops secondary to epithelial damage mediated by microbial-origin acids whose production is potentiated by high dietary carbohydrate and parietal cell-origin hydrochloric acid. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

1998 journal article

Synergistic effect of hydrochloric acid and bile acids on the pars esophageal mucosa of the porcine stomach

American Journal of Veterinary Research, 59(9), 1170–1176.

By: J. Lang, A. Blikslager, D. Regina, J. Eisemann & R. Argenzio

Source: NC State University Libraries
Added: August 6, 2018

1997 journal article

How important is intestinal reperfusion injury in horses?

Journal of the American Veterinary Medical Association, 211(11), 1387–1389.

By: A. Blikslager, M. Roberts, M. Gerard & R. Argenzio

Source: NC State University Libraries
Added: August 6, 2018

1997 journal article

Is reperfusion injury an important cause of mucosal damage after porcine intestinal ischemia?

SURGERY, 121(5), 526–534.

By: A. Blikslager n, M. Roberts n, J. Rhoads n & R. Argenzio n

MeSH headings : Animals; Female; Intestinal Mucosa / enzymology; Intestinal Mucosa / pathology; Intestines / blood supply; Intestines / enzymology; Ischemia / complications; Ischemia / metabolism; Male; Peroxidases / metabolism; Reperfusion Injury / complications; Reperfusion Injury / metabolism; Swine; Xanthine Dehydrogenase / metabolism; Xanthine Oxidase / metabolism
TL;DR: Reperfusion injury may not play an important role in intestinal injury under conditions of complete mesenteric ischemia and low-flow states in the pig, which may result from low xanthine oxidase-xanthine dehydrogenase levels, which are similar to those found in the human being. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1997 journal article

L-glutamine stimulates intestinal cell proliferation and activates mitogen-activated protein kinases

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 272(5), G943–G953.

By: J. Rhoads*, R. Argenzio*, W. Chen*, R. Rippe*, J. Westwick*, A. Cox*, H. Berschneider*, D. Brenner*

author keywords: Jun nuclear kinase; IEC-6 cells; enterocyte; epidermal growth factor; c-Jun; extracellular signal-related kinase; Elk-1; diarrhea; insulin-like growth factor I
MeSH headings : Animals; Calcium-Calmodulin-Dependent Protein Kinases / metabolism; Cell Division / drug effects; DNA-Binding Proteins / metabolism; Enzyme Activation; Epidermal Growth Factor / pharmacology; Genes, Reporter; Glutamine / pharmacology; Intestines / cytology; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins c-jun / genetics; RNA, Messenger / metabolism; Rats; Swine; Transcription Factor AP-1 / physiology; Transcription, Genetic / drug effects
TL;DR: Gln may be a unique nutrient for enterocytes, capable of dual signaling and augmenting the effects of growth factors that govern cellular proliferation and repair. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
Source: Web Of Science
Added: August 6, 2018

1997 chapter

Neuro-immune pathobiology of infectious enteric disease

In D. H. F. P. S. Paul & D. A. Benfield (Eds.), Mechanisms in the pathogenesis of enteric diseases (Advances in experimental medicine and biology ; v. 412) (Vol. 412, pp. 21–29).

By: R. Argenzio n

Ed(s): D. P. S. Paul & D. Benfield

MeSH headings : Acute Disease; Anaphylaxis / immunology; Animals; Diarrhea / immunology; Diarrhea / physiopathology; Humans; Inflammation / physiopathology; Intestinal Absorption; Intestinal Diseases / immunology; Intestinal Diseases / physiopathology; Intestines / immunology; Intestines / innervation; Mast Cells / immunology; Phagocytes / physiology; Signal Transduction; Structure-Activity Relationship; Water-Electrolyte Balance
TL;DR: The signalling network mediated by cells in the lamina propria provides new points of control for pharmacological therapy and may mediate the majority of the secretory response induced by enterotoxins or phagocytes. (via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018

1997 journal article

Peptide YY inhibits intestinal Cl- secretion in experimental porcine cryptosporidiosis through a prostaglandin-activated neural pathway

Journal of Pharmacology and Experimental Therapeutics, 283(2), 692–697.

By: R. Argenzio, M. Armstrong, A. Blikslager & J. Rhoads

Source: NC State University Libraries
Added: August 6, 2018

1997 journal article

Prostaglandins I2 and E2 have a synergistic role in rescuing epithelial barrier function in porcine ileum.

Journal of Clinical Investigation, 100(8), 1928–1933.

By: A. Blikslager*, M. Roberts*, J. Rhoads* & R. Argenzio*

author keywords: intestinal mucosa; ischemia; cAMP; calcium; tight junctions
MeSH headings : Animals; Cytoprotection; Dinoprostone / pharmacology; Drug Synergism; Electric Impedance; Epithelium / drug effects; Epithelium / metabolism; Epoprostenol / analogs & derivatives; Epoprostenol / pharmacology; Female; Ileum / drug effects; Ileum / metabolism; In Vitro Techniques; Indomethacin / pharmacology; Intestinal Mucosa / drug effects; Intestinal Mucosa / metabolism; Inulin / metabolism; Male; Permeability / drug effects; Reperfusion Injury / drug therapy; Swine
TL;DR: It is concluded that PGE2 and PGI2 have a synergistic role in restoration of intestinal barrier function by increasing intracellular cAMP and Ca2+, respectively, which in turn signal cytoskeletal-mediated tight junction closure. (via Semantic Scholar)
Sources: Web Of Science, Crossref
Added: August 6, 2018

1997 journal article

Reactive oxygen metabolites in piglet cryptosporidiosis

PEDIATRIC RESEARCH, 41(4), 521–526.

By: R. Argenzio n & J. Rhoads*

MeSH headings : Animals; Animals, Newborn; Biological Transport / physiology; Catalase / metabolism; Cryptosporidiosis / complications; Cryptosporidiosis / drug therapy; Cryptosporidiosis / metabolism; Diarrhea / drug therapy; Diarrhea / etiology; Diarrhea / metabolism; Electrolytes / metabolism; Ileum / metabolism; Indomethacin / therapeutic use; Lipid Peroxidation / physiology; Malondialdehyde / metabolism; Prostaglandins / metabolism; Reactive Oxygen Species / metabolism; Swine; Tetrodotoxin / therapeutic use
TL;DR: There is evidence of increased ROM production in cryptosporidial infection and that intestinal PG synthesis and inhibited NaCl absorption may be mediated partially by ROM in this model, suggesting additional, cooperative factors are likely needed to induce the alterations in ion transport seen in this infection. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

1996 journal article

Mechanisms of acid injury in porcine gastroesophageal mucosa

American Journal of Veterinary Research, 57(4), 564.

By: R. Argenzio & J. Eisemann

Source: NC State University Libraries
Added: August 6, 2018

1993 journal article

PROSTANOIDS INHIBIT INTESTINAL NACL ABSORPTION IN EXPERIMENTAL PORCINE CRYPTOSPORIDIOSIS

GASTROENTEROLOGY, 104(2), 440–447.

By: R. Argenzio n, J. Lecce n & D. Powell n

MeSH headings : Animals; Chlorides / metabolism; Cryptosporidiosis / metabolism; Dinoprostone / analysis; Dinoprostone / pharmacology; Glucose / pharmacology; Indomethacin / pharmacology; Intestinal Absorption / drug effects; Intestinal Absorption / physiology; Perfusion; Prostaglandins / physiology; Sodium Chloride / metabolism; Swine
TL;DR: Data indicate that in addition to the Na-glucose malabsorption arising from structural damage, part of the diarrhea of these infected animals must be attributed to local prostanoid production. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

1991 journal article

SHORT-CHAIN FATTY-ACIDS INDUCE REVERSIBLE INJURY OF PORCINE COLON

DIGESTIVE DISEASES AND SCIENCES, 36(10), 1459–1468.

By: R. Argenzio n & D. Meuten n

author keywords: RESTITUTION; ACETATE; LACTATE; H-ION; MUCOSAL DEFENSE; EPITHELIAL CELL MIGRATION
MeSH headings : Acetates / pharmacology; Animals; Colon / drug effects; Colon / metabolism; Colon / pathology; Dose-Response Relationship, Drug; Fatty Acids, Volatile / metabolism; Female; Hydrogen-Ion Concentration; In Vitro Techniques; Intestinal Absorption / physiology; Intestinal Mucosa / drug effects; Intestinal Mucosa / metabolism; Intestinal Mucosa / pathology; Ion Exchange; Lactates / pharmacology; Mannitol / pharmacokinetics; Permeability / drug effects; Sodium Chloride / pharmacology; Swine; Theophylline / pharmacology
TL;DR: The results suggest that colonic mucosal injury is possible under conditions that may be present during carbohydrate malabsorption syndromes and provide evidence that the process of surface reepithelialization may be of central importance in the defense and repair of the Colonic mucosa during such acid-induced injury. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1989 journal article

Electrolyte and water absorption in the hind gut of herbivores

Acta Veterinaria Scandinavica, 159.

By: R. Argenzio & L. Clarke

Source: NC State University Libraries
Added: August 6, 2018

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