Kyoungju Choi
Works (6)
Updated: July 5th, 2023 15:55
2013 journal article
Human Variation and Risk Assessment: Microarray and Other Studies Utilizing Human Hepatocytes and Human Liver Subcellular Preparations
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 28(1), 1–10.
author keywords: Cytotoxicity; Human Hepatocytes; Human Variation; Microarrays; RNAseq; Toxicant Metabolism; Toxicant Interactions
MeSH headings : Enzyme Activation; Enzyme Inhibitors / pharmacology; Genetic Variation; Hepatocytes / enzymology; Hepatocytes / metabolism; Humans; Liver / metabolism; Oligonucleotide Array Sequence Analysis; Risk Assessment; Subcellular Fractions / metabolism
TL;DR:
This review summarizes the use of primary human hepatocytes and hepatocyte subcellular preparations for the investigation of the metabolism and metabolic interactions of environmental chemicals.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Rapid decreases in salinity, but not increases, lead to immune dysregulation in Nile tilapia,Oreochromis niloticus(L.)
Journal of Fish Diseases, 36(4), 389–399.
author keywords: IL-1; immunopathology; phagocytosis assay; salinity stress; TGF-; tilapia
MeSH headings : Animals; Cichlids / immunology; Cytokines; Dose-Response Relationship, Drug; Gene Expression Regulation / drug effects; Gene Expression Regulation / immunology; Interleukin-1beta / genetics; Interleukin-1beta / metabolism; RNA, Messenger / genetics; RNA, Messenger / metabolism; Salinity; Sodium Chloride / administration & dosage; Sodium Chloride / toxicity; Time Factors; Transforming Growth Factor beta / genetics; Transforming Growth Factor beta / metabolism; Water / chemistry
TL;DR:
In total, acute salinity changes appeared to trigger reactive dysregulation of the immune response in tilapia, a situation which, when combined with additional co-occurring stressors such as sudden changes in temperature and/or dissolved oxygen, could make fish more susceptible to infectious diseases.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2010 journal article
Human metabolism of atrazine
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, 98(1), 73–79.
author keywords: Atrazine; Human liver microsomes; Cytochrome P450; Human liver S9 fractions; Human metabolism; Phase I metabolism; Phase II metabolism; Glutathione conjugation; LC/MS/MS
TL;DR:
Atrazine (ATZ) metabolism by human liver microsomes, cytochrome P450 (CYP) isoforms, and human liver S9 fractions, was investigated using HPLC/PDA and LC/MS/MS.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2007 journal article
Acute hypoxia-reperfusion triggers immunocompromise in Nile tilapia
JOURNAL OF AQUATIC ANIMAL HEALTH, 19(2), 128–140.
MeSH headings : Animals; Aquaculture; Blood Chemical Analysis / veterinary; Blood Gas Analysis; Cichlids / blood; Cichlids / immunology; Cytokines / biosynthesis; Female; Hematologic Tests / veterinary; Hydrocortisone / blood; Hypoxia / blood; Hypoxia / immunology; Hypoxia / veterinary; Interleukin-1beta / biosynthesis; Male; Oxygen / pharmacology; Phagocytosis / drug effects; Reperfusion / veterinary; Time Factors; Transforming Growth Factor beta / biosynthesis
TL;DR:
It is concluded that acute hypoxia triggered an overall downregulation of the immune system in the test fish, suggesting a possible factor in the pathogenesis of disease outbreaks in fish in which repeated, sublethal bouts of environmentally induced hypoxIA lead to increased disease susceptibility and individual mortalities rather than massive fish kills.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2007 journal article
Inhibition of fipronil and nonane metabolism in human liver microsomes and human cytochrome P450 isoforms by chlorpyrifos
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 21(2), 76–80.
author keywords: fipronil; nonane; human liver microsomes; cytochrome P450; CYP2B6; CYP3A4
MeSH headings : Alkanes / pharmacology; Aryl Hydrocarbon Hydroxylases / antagonists & inhibitors; Aryl Hydrocarbon Hydroxylases / metabolism; Chlorpyrifos / pharmacology; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System / metabolism; Enzyme Activation / drug effects; Female; Humans; Insecticides / pharmacology; Isoenzymes / antagonists & inhibitors; Isoenzymes / metabolism; Male; Microsomes, Liver / enzymology; Oxidoreductases, N-Demethylating / antagonists & inhibitors; Oxidoreductases, N-Demethylating / metabolism; Pyrazoles / pharmacology
TL;DR:
In both co‐ and preincubation experiments, CPS significantly inhibited the metabolism of fipronil or nonane by HLM although CPS inhibited the metabolization of fIPronil more effectively than that of nonane.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2006 journal article
Metabolism of chlorpyrifos and chlorpyrifos oxon by human hepatocytes
Journal of Biochemical and Molecular Toxicology, 20(6), 279–291.
MeSH headings : Adult; Biotransformation; Chlorpyrifos / analogs & derivatives; Chlorpyrifos / analysis; Chlorpyrifos / chemistry; Chlorpyrifos / metabolism; Chlorpyrifos / toxicity; Chromatography, High Pressure Liquid; Female; Hepatocytes / drug effects; Hepatocytes / metabolism; Humans; Male; Mass Spectrometry; Middle Aged; Subcellular Fractions
TL;DR:
The results suggest that human liver plays an important role in detoxification, rather than activation, of CPS, and phase II‐related conjugates, including O‐ and S‐glucuronides, were identified in CPS‐treated human hepatocytes, although the O‐sulfate of TCP conjugate was found only when human liver S9 fractions were used as the enzyme source.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: NC State University Libraries
Added: August 6, 2018