Wen Yih Aw

Works (3)

Updated: June 29th, 2024 05:00

2024 article

Donor-Derived Engineered Microvessels for Cardiovascular Risk Stratification of Patients with Kidney Failure

Rathod, M. L., Aw, W. Y., Huang, S., Lu, J., Doherty, E. L., Whithworth, C. P., … Polacheck, W. J. (2024, January 7). SMALL.

By: M. Rathod n, W. Aw n, S. Huang n, J. Lu  n, E. Doherty  n, C. Whithworth*, G. Xi *, P. Roy-Chaudhury *, W. Polacheck n

author keywords: blood-derived endothelial cell; cardiovascular; chronic kidney disease; indoxyl sulfate; microfluidics; organs-on-chip; uremic toxin
TL;DR: The engineered microvessels presented here have the potential to be utilized to risk stratify and to direct personalized treatments for patients with chronic kidney disease and an increase in sensitivity compared to traditional 2D assays. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: January 29, 2024

2024 article

P300 Modulates Endothelial Mechanotransduction of Fluid Shear Stress

Whitworth, C. P., Aw, W. Y., Doherty, E. L., Handler, C., Ambekar, Y., Sawhney, A., … Polacheck, W. J. (2024, June 11). CELLULAR AND MOLECULAR BIOENGINEERING.

By: C. Whitworth *, W. Aw*, E. Doherty *, C. Handler*, Y. Ambekar *, A. Sawhney*, G. Scarcelli *, W. Polacheck n

author keywords: Mechanotransduction; Vascular biology; Nuclear mechanotransduction; Cell mechanics
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: June 24, 2024

2023 journal article

Patient-derived extracellular matrix demonstrates role of COL3A1 in blood vessel mechanics

ACTA BIOMATERIALIA, 166, 346–359.

By: E. Doherty  n, W. Aw n, E. Warren  n, M. Hockenberry *, C. Whitworth *, G. Krohn  n, S. Howell *, B. Diekman n ...

author keywords: Vascular Ehlers-Danlos syndrome; Cell derived matrix; Collagen III; Mechanotransduction; ECM mechanics; Viscoelasticity
TL;DR: This work generates fibrous, collagen-rich ECM from primary donor cells from patients with vascular Ehlers-Danlos syndrome, a disease caused by mutations in the gene that encodes collagen III, and observes that ECM grown from vEDS patients is characterized by unique mechanical signatures, including altered viscoelastic properties. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Web Of Science
Added: August 7, 2023

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