Wen Yih Aw

Works (7)

Updated: July 21st, 2025 14:37

2025 journal article

Colloidal-Fibrillar Composite Gels Demonstrate Structural Reinforcement, Secondary Fibrillar Alignment, and Improved Vascular Healing Outcomes

Communications Engineering, 4, 67.

By: N. Moiseiwitsch n, S. Pandit n, N. Zwennes n, K. Nellenbach n, A. Sheridan n, J. LeGrand n, E. Chee n, S. Ozawa n  ...

topics (OpenAlex): Intracranial Aneurysms: Treatment and Complications; Connective tissue disorders research; Bone Tissue Engineering Materials
Sources: Web Of Science, NC State University Libraries, NC State University Libraries
Added: April 12, 2025

2025 article

Dysfunctional mechanotransduction regulates the progression of PIK3CA-driven vascular malformations

Aw, W. Y., Sawhney, A., Rathod, M., Whitworth, C. P., Doherty, E. L., Madden, E., … Polacheck, W. J. (2025, February 5). APL Bioengineering.

By: W. Aw n, A. Sawhney n, M. Rathod n, C. Whitworth  n, E. Doherty  n, E. Madden *, J. Lu  n, K. Westphal n, R. Stack n, W. Polacheck n

topics (OpenAlex): Vascular Malformations and Hemangiomas; Vascular Malformations Diagnosis and Treatment; Vascular Tumors and Angiosarcomas
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Source: Web Of Science
Added: February 24, 2025

2025 article

Microphysiological Uremia Model Reveals Biophysical Potentiators of Vascular Dysfunction

Rathod, M., Stack, R. N., Kubik, S. E., Huang, S. A., Whitworth, C. P., Aw, W. Y., … Polacheck, W. J. (2025, June 20). Advanced Science.

By: M. Rathod n, R. Stack n, S. Kubik n, S. Huang n, C. Whitworth *, W. Aw n, E. Doherty  n, S. Meehan n, P. Roy‐Chaudhury *, W. Polacheck n

author keywords: cardiovascular disease; chronic kidney disease; mechanobiology; microfluidics; organ-on-chip; uremic toxin; vascular endothelium
topics (OpenAlex): Dialysis and Renal Disease Management; Blood properties and coagulation; Erythropoietin and Anemia Treatment
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Source: Web Of Science
Added: June 30, 2025

2025 article

Understanding the Lymphatic System: Tissue-on-Chip Modeling

Polacheck, W. J., Dixon, J. B., & Aw, W. Y. (2025, January 22). Annual Review of Biomedical Engineering.

By: W. Polacheck n, J. Dixon * & W. Aw n

author keywords: lymphatics; organs-on-chip; microphysiological systems; mechanobiology; lymphatic-on-chip
MeSH headings : Humans; Lymphatic Vessels / physiology; Lymphatic Vessels / cytology; Animals; Lab-On-A-Chip Devices; Lymphatic System / physiology; Endothelial Cells / cytology; Models, Biological; Tissue Engineering / methods
topics (OpenAlex): Lymphatic System and Diseases; 3D Printing in Biomedical Research
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Source: Web Of Science
Added: May 27, 2025

2024 article

Donor‐Derived Engineered Microvessels for Cardiovascular Risk Stratification of Patients with Kidney Failure

Rathod, M. L., Aw, W. Y., Huang, S., Lu, J., Doherty, E. L., Whithworth, C. P., … Polacheck, W. J. (2024, January 7). Small.

By: M. Rathod n, W. Aw n, S. Huang n, J. Lu  n, E. Doherty  n, C. Whithworth*, P. Roy‐Chaudhury *, W. Polacheck n

author keywords: blood-derived endothelial cell; cardiovascular; chronic kidney disease; indoxyl sulfate; microfluidics; organs-on-chip; uremic toxin
MeSH headings : Humans; Microvessels / pathology; Cardiovascular Diseases; Animals; Swine; Renal Insufficiency / therapy; Risk Assessment; Tissue Donors; Tissue Engineering / methods; Indican / blood
topics (OpenAlex): Dialysis and Renal Disease Management; Erythropoietin and Anemia Treatment; 3D Printing in Biomedical Research
TL;DR: The engineered microvessels presented here have the potential to be utilized to risk stratify and to direct personalized treatments for patients with chronic kidney disease and an increase in sensitivity compared to traditional 2D assays. (via Semantic Scholar)
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Source: Web Of Science
Added: January 29, 2024

2024 article

P300 Modulates Endothelial Mechanotransduction of Fluid Shear Stress

Whitworth, C. P., Aw, W. Y., Doherty, E. L., Handler, C., Ambekar, Y., Sawhney, A., … Polacheck, W. J. (2024, June 11). Cellular and Molecular Bioengineering.

By: C. Whitworth *, W. Aw n, E. Doherty  n, C. Handler*, Y. Ambekar *, A. Sawhney n, G. Scarcelli *, W. Polacheck n

author keywords: Mechanotransduction; Vascular biology; Nuclear mechanotransduction; Cell mechanics
topics (OpenAlex): Blood properties and coagulation; Kruppel-like factors research; Cancer, Hypoxia, and Metabolism
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Source: Web Of Science
Added: June 24, 2024

2023 article

Patient-derived extracellular matrix demonstrates role of COL3A1 in blood vessel mechanics

Doherty, E. L., Aw, W. Y., Warren, E. C., Hockenberry, M., Whitworth, C. P., Krohn, G., … Polacheck, W. J. (2023, May 13). Acta Biomaterialia.

By: E. Doherty  n, W. Aw n, E. Warren  n, M. Hockenberry *, C. Whitworth *, G. Krohn  n, S. Howell *, B. Diekman n ...

author keywords: Vascular Ehlers-Danlos syndrome; Cell derived matrix; Collagen III; Mechanotransduction; ECM mechanics; Viscoelasticity
MeSH headings : Humans; Endothelial Cells / metabolism; Ehlers-Danlos Syndrome / genetics; Ehlers-Danlos Syndrome / metabolism; Mutation, Missense; Mutation / genetics; Ehlers-Danlos Syndrome, Type IV; Extracellular Matrix / metabolism; Collagen Type III / genetics; Collagen Type III / chemistry
topics (OpenAlex): Connective tissue disorders research; Aortic aneurysm repair treatments; Cell Adhesion Molecules Research
TL;DR: This work generates fibrous, collagen-rich ECM from primary donor cells from patients with vascular Ehlers-Danlos syndrome, a disease caused by mutations in the gene that encodes collagen III, and observes that ECM grown from vEDS patients is characterized by unique mechanical signatures, including altered viscoelastic properties. (via Semantic Scholar)
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3. Good Health and Well-being (OpenAlex)
Source: Web Of Science
Added: August 7, 2023

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