Wen Yih Aw

Works (2)

Updated: April 5th, 2024 17:41

2024 article

Donor-Derived Engineered Microvessels for Cardiovascular Risk Stratification of Patients with Kidney Failure

Rathod, M. L., Aw, W. Y., Huang, S., Lu, J., Doherty, E. L., Whithworth, C. P., … Polacheck, W. J. (2024, January 7). SMALL.

By: M. Rathod n, W. Aw n, S. Huang n, J. Lu  n, E. Doherty  n, C. Whithworth*, G. Xi, P. Roy-Chaudhury *, W. Polacheck n

author keywords: blood-derived endothelial cell; cardiovascular; chronic kidney disease; indoxyl sulfate; microfluidics; organs-on-chip; uremic toxin
TL;DR: The engineered microvessels presented here have the potential to be utilized to risk stratify and to direct personalized treatments for patients with chronic kidney disease and an increase in sensitivity compared to traditional 2D assays. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Web Of Science
Added: January 29, 2024

2023 journal article

Patient-derived extracellular matrix demonstrates role of COL3A1 in blood vessel mechanics

ACTA BIOMATERIALIA, 166, 346–359.

By: E. Doherty  n, W. Aw n, E. Warren  n, M. Hockenberry *, C. Whitworth *, G. Krohn  n, S. Howell *, B. Diekman n ...

author keywords: Vascular Ehlers-Danlos syndrome; Cell derived matrix; Collagen III; Mechanotransduction; ECM mechanics; Viscoelasticity
TL;DR: This work generates fibrous, collagen-rich ECM from primary donor cells from patients with vascular Ehlers-Danlos syndrome, a disease caused by mutations in the gene that encodes collagen III, and observes that ECM grown from vEDS patients is characterized by unique mechanical signatures, including altered viscoelastic properties. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Web Of Science
Added: August 7, 2023

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