Works (21)

Updated: November 8th, 2023 05:01

2023 journal article

Influence of Fibrinogen Concentrate on Neonatal Clot Structure When Administered Ex Vivo After Cardiopulmonary Bypass

ANESTHESIA AND ANALGESIA, 137(3), 682–690.

By: N. Moiseiwitsch n, K. Nellenbach n, L. Downey*, D. Boorman*, A. Brown n & N. Guzzetta*

TL;DR: It is suggested that FC is effective in restoring structural fibrin clot properties after CPB, and further studies after the administration of FC in vivo are needed to validate this hypothesis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: September 5, 2023

2023 article

Wound-triggered shape change microgels for the development of enhanced biomimetic function platelet-like particles

Chee, E., Mihalko, E., Nellenbach, K., Sollinger, J., Huang, K., Hon, M., … Brown, A. (2023, October 17). JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, Vol. 10.

By: E. Chee n, E. Mihalko*, K. Nellenbach n, J. Sollinger n, K. Huang n, M. Hon n, S. Pandit n, K. Cheng n, A. Brown n

author keywords: fibrin; hemostasis; synthetic platelet; trauma; wound healing
TL;DR: Thrombin-sensitive PLPs are created that exhibit a wound-triggered shape change, induce significant clot retraction following exposure to thrombin and promote hemostasis and healing in vivo after trauma. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: November 6, 2023

2022 journal article

A Unique Crustacean-Based Chitin Platform to Reduce Self-Aggregation of Polysaccharide Nanofibers

FIBERS, 10(10).

By: C. Londono-Zuluaga n, H. Jameel n, R. Gonzalez n, K. Nellenbach n, A. Brown n, G. Yang*, L. Lucia n

author keywords: polysaccharide nanofibers; crustacean shells; chitin; cellulose; self-aggregation; clotting; foams
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, ORCID
Added: October 19, 2022

2022 article

On-demand, remote and lossless manipulation of biofluid droplets

Wang, W., Sun, J., Vallabhuneni, S., Pawlowski, B., Vahabi, H., Nellenbach, K., … Kota, A. K. (2022, September 7). MATERIALS HORIZONS.

By: W. Wang n, J. Sun*, S. Vallabhuneni n, B. Pawlowski*, H. Vahabi*, K. Nellenbach n, A. Brown n, F. Scholle n, J. Zhao*, A. Kota n

MeSH headings : Humans; Pandemics / prevention & control; Saliva; Disease Outbreaks; Point-of-Care Systems; Health Personnel
TL;DR: This work presents biofluid manipulators, which allow on-demand, remote and lossless manipulation of virtually any liquid droplet, and envision that these manipulators will not only reduce manual operations and minimize exposure to infectious agents, but also pave the way for developing inexpensive, simple and portable robotic systems, which can allow point-of-care operations, particularly in developing nations. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: September 19, 2022

2022 article

Platelet-mimicking procoagulant nanoparticles: Potential strategies for mitigating blood shortages

Nellenbach, K., & Brown, A. C. (2022, April 19). JOURNAL OF THROMBOSIS AND HAEMOSTASIS.

By: K. Nellenbach n & A. Brown n

MeSH headings : Blood Platelets; Humans; Nanoparticles; Platelet Activation
TL;DR: A new study has demonstrated the creation of plateletmimicking procoagulant nanoparticles (PPNs) that have advanced platelet function compared with prior designs, and the implications for these new findings in the field of synthetic platelet design are discussed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: May 2, 2022

2021 journal article

Differential sialic acid content in adult and neonatal fibrinogen mediates differences in clot polymerization dynamics

BLOOD ADVANCES, 5(23), 5202–5214.

By: K. Nellenbach, A. Kyu, N. Guzzetta & A. Brown

MeSH headings : Adult; Fibrin; Fibrinogen; Fibrinopeptide A; Humans; Infant, Newborn; N-Acetylneuraminic Acid; Polymerization
Source: Web Of Science
Added: January 3, 2022

2021 article

Ex Vivo and In Vivo Evaluation of Fibrinogen Concentrate to Mitigate Post-Surgical Bleeding in Neonates

Moiseiwitsch, N., Nellenbach, K. A., Guzzetta, N. A., Brown, A. C., & Downey, L. (2021, November 23). BLOOD, Vol. 138.

By: N. Moiseiwitsch n, K. Nellenbach n, N. Guzzetta*, A. Brown n & L. Downey*

UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Web Of Science
Added: September 6, 2022

2021 journal article

Fibrin-modulating nanogels for treatment of disseminated intravascular coagulation

BLOOD ADVANCES, 5(3), 613–627.

By: E. Mihalko n, M. Sandry n, N. Mininni n, K. Nellenbach n, H. Deal n, M. Daniele n, K. Ghadimi*, J. Levy*, A. Brown n

MeSH headings : Disseminated Intravascular Coagulation / drug therapy; Fibrin; Humans; Microcirculation; Nanogels; Thrombosis / drug therapy
TL;DR: In vivo and in vivo, tPA-FSNs decreased the presentation of multiorgan microthrombi, recovered platelet counts, and improved bleeding outcomes in a DIC rodent model, demonstrating that a fibrinolytic agent loaded into fibrin-targeting nanogels could improve DIC outcomes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
5. Gender Equality (Web of Science)
Source: Web Of Science
Added: March 22, 2021

2021 article

Fibrin-specific poly(N-isopropylacrylamide) nanogels for targeted delivery of tissue-type plasminogen activator to treat thrombotic complications are well tolerated in vivo

Mihalko, E. P., Nellenbach, K., Krishnakumar, M., Moiseiwitsch, N., Sollinger, J., Cooley, B. C., & Brown, A. C. (2021, December 11). BIOENGINEERING & TRANSLATIONAL MEDICINE.

By: E. Mihalko n, K. Nellenbach n, M. Krishnakumar n, N. Moiseiwitsch n, J. Sollinger n, B. Cooley*, A. Brown n

author keywords: disseminated intravascular coagulation; fibrin; nanogels; pNIPAM; targeted delivery; thrombosis; tissue plasminogen activator
TL;DR: The therapeutic efficacy of targeted fibrin‐specific nanogel (FSN) design for targeted delivery of tPA to treat thrombotic complications is demonstrated and key translational parameters for tPA‐FSN therapeutics are evaluated, including optimal tPA •FSN dosage in a DIC rodent model and safety of intravenous tPA•FSN therapies. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
5. Gender Equality (Web of Science)
Source: Web Of Science
Added: December 20, 2021

2021 journal article

Modeling and Parameter Subset Selection for Fibrin Polymerization Kinetics with Applications to Wound Healing

BULLETIN OF MATHEMATICAL BIOLOGY, 83(5).

By: K. Pearce n, K. Nellenbach n, R. Smith n, A. Brown n & M. Haider n

author keywords: Wound healing; Fibrin polymerization; Kinetics model; Parameter identifiability; Subset selection
MeSH headings : Animals; Cells, Cultured; Fibrin / metabolism; Humans; Kinetics; Models, Biological; Polymerization; Wound Healing
TL;DR: The findings demonstrate the high degree of information within a single fibrin accumulation curve, and a tailored model and parameter subset selection approach for improving optimization and reducing model complexity in the context of polymerization experiments. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: March 23, 2021

2021 article

Platelet-like particles reduce coagulopathy-related and neuroinflammatory pathologies post-experimental traumatic brain injury

Todd, J., Bharadwaj, V. N., Nellenbach, K., Nandi, S., Mihalko, E., Copeland, C., … Stabenfeldt, S. E. (2021, June 11). JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS.

By: J. Todd*, V. Bharadwaj*, K. Nellenbach n, S. Nandi n, E. Mihalko n, C. Copeland*, A. Brown n, S. Stabenfeldt*

author keywords: blood-brain barrier; coagulopathy; neuroinflammation; permeability; platelet-like particles; traumatic brain injury
MeSH headings : Animals; Blood Platelets / metabolism; Blood-Brain Barrier / metabolism; Brain Injuries, Traumatic / complications; Brain Injuries, Traumatic / drug therapy; Brain Injuries, Traumatic / metabolism; Disease Models, Animal; Mice; Microglia / metabolism
TL;DR: Results suggest that PLP-treatment addressed acute hypocoagulation and decreased BBB permeability followed by decreased neuroinflammation and fold-change tissue loss by 7 days post-injury, indicating that PLPs could be a potential therapeutic modality for TBI. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: June 21, 2021

2021 journal article

Synthesis of sonicated fibrin nanoparticles that modulate fibrin clot polymerization and enhance angiogenic responses

COLLOIDS AND SURFACES B-BIOINTERFACES, 204.

By: C. Roosa n, I. Muhamed n, A. Young n, K. Nellenbach n, M. Daniele n, F. Ligler n, A. Brown n

author keywords: Fibrin; Nanoparticles; Wound healing; Regenerative medicine; Fibrin sealant
MeSH headings : Fibrin; Fibrin Tissue Adhesive; Nanoparticles; Polymerization; Wound Healing
TL;DR: It is shown that SFBNs may be a promising wound healing therapy that can be easily produced and delivered in a flowable formulation and support cell migration in an in vitro angiogenic sprouting assay, relevant for wound healing. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: July 19, 2021

2021 journal article

Synthetic Platelet Microgels Containing Fibrin Knob B Mimetic Motifs Enhance Clotting Responses

ADVANCED THERAPEUTICS, 4(5).

By: S. Nandi n, E. Mihalko n, K. Nellenbach n, M. Castaneda n, J. Schneible n, M. Harp*, H. Deal n, M. Daniele n ...

author keywords: bleeding; Clotting; fibrin; hemostasis; microgel
TL;DR: Soft microgels decorated with the peptide AHRPYAAK are found to significantly increase clot density in vitro and decrease bleeding in a rodent trauma model in vivo, indicating that FAMCYs are capable of recapitulating the platelet‐mimetic properties of previous designs while utilizing a less costly, more translational design. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: April 5, 2021

2020 journal article

Nanosilver composite pNIPAm microgels for the development of antimicrobial platelet-like particles

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, 108(6), 2599–2609.

By: E. Chee n, S. Nandi n, K. Nellenbach n, E. Mihalko n, D. Snider n, L. Morrill n, A. Bond n, E. Sproul n ...

Contributors: E. Chee n, S. Nandi n, K. Nellenbach n, E. Mihalko n, D. Snider n, L. Morrill n, A. Bond n, E. Sproul n ...

author keywords: antimicrobial; microgels; nanosilver; platelet-mimetic; wound healing
MeSH headings : Acrylic Resins / chemistry; Animals; Anti-Infective Agents / chemistry; Anti-Infective Agents / pharmacology; Bacterial Infections / drug therapy; Bacterial Infections / microbiology; Blood Platelets; Clot Retraction; Colony-Forming Units Assay; Fibrin / chemistry; Fibrin / immunology; Gels; Hemorrhage / drug therapy; Hemostasis / drug effects; Liver / injuries; Male; Metal Nanoparticles; Mice; Mice, Inbred C57BL; Microgels; Silver / administration & dosage; Silver / chemistry; Wound Healing
TL;DR: It is found that nanosilver incorporation does not affect base PLP performance while bestowing significant antimicrobial activity and enhancing infected wound healing outcomes, and Ag-PLPs have great promise for treating hemorrhage and improving healing following trauma. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: March 16, 2020

2020 article

Neonatal Fibrin Scaffolds Promote Enhanced Cell Adhesion, Migration, and Wound Healing In Vivo Compared to Adult Fibrin Scaffolds

CELLULAR AND MOLECULAR BIOENGINEERING.

By: K. Nellenbach n, S. Nandi n, C. Peeler n, A. Kyu n & A. Brown n

TL;DR: In vivo significantly smaller wound areas and greater epidermal thickness were observed when wounds were treated with neonatal fibrin compared to adultfibrin or a saline control, indicating that fibr in scaffolds sourced from neonatal plasma could improve healing outcomes compared to scaffoldsourced from adult plasma. (via Semantic Scholar)
Source: Web Of Science
Added: June 15, 2020

2020 journal article

Platelet-like particles improve fibrin network properties in a hemophilic model of provisional matrix structural defects

JOURNAL OF COLLOID AND INTERFACE SCIENCE, 577, 406–418.

author keywords: Fibrin; Biomimetic; Platelet; Hemophilia; Biomaterials
MeSH headings : Blood Coagulation; Blood Platelets; Fibrin; Plasma; Wound Healing
TL;DR: PLPs improved clot network density, force generation, and stiffness, and promoted fibroblast migration within an in vitro model of early wound healing under hemophilic conditions, indicating that PLPs could provide a biomimetic platform for improving wound healing events in disease conditions that cause deficient fibrin network formation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 24, 2020

2020 journal article

Ultrasound Enhanced Synthetic Platelet Therapy for Augmented Wound Repair

ACS BIOMATERIALS SCIENCE & ENGINEERING, 6(5), 3026–3036.

By: S. Nandi n, K. Mohanty n, K. Nellenbach n, M. Erb n, M. Muller n & A. Brown n

author keywords: biomimetic; fibrin; wound healing clot retraction; artificial platelet
MeSH headings : Blood Coagulation; Blood Platelets; Clot Retraction; Fibrin; Wound Healing
TL;DR: Application of ultrasound in combination with a subtherapeutic dosage of PLPs resulted in increased clot density and stiffness, improved fibroblast migration in vitro and increased epidermal thickness and angiogenesis in vivo, indicating that this combination therapy has potential to facilitate multiphase pro-healing outcomes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: June 8, 2020

2019 journal article

Platelet-like particles dynamically stiffen fibrin matrices and improve wound healing outcomes

BIOMATERIALS SCIENCE, 7(2), 669–682.

By: S. Nandi n, E. Sproul n, K. Nellenbach n, M. Erb n, L. Gaffney n, D. Freytes n, A. Brown n

MeSH headings : Animals; Biomimetic Materials / chemistry; Blood Platelets / metabolism; Blood Platelets / physiology; Fibrin / chemistry; Fibrin / pharmacology; Humans; Mechanical Phenomena; Mice; Platelet Activation / drug effects; Skin / drug effects; Skin / injuries; Wound Healing / drug effects
TL;DR: The utility of PLPs for enhancing wound repair is demonstrated and the role of native platelet-mediated clot retraction in wound healing is provided, to provide insight into the role in vitro and in vivo models of wound healing. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: February 18, 2019

2018 journal article

Analysis of the structural and mechanical effects of procoagulant agents on neonatal fibrin networks following cardiopulmonary bypass

JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 16(11), 2159–2167.

By: K. Nellenbach n, N. Guzzetta* & A. Brown n

author keywords: activated factor VII; cardiopulmonary bypass; fibrin; neonatal coagulation; prothrombin complex concentrate; transfusion
MeSH headings : Blood Coagulation; Blood Coagulation Factors / therapeutic use; Blood Coagulation Tests; Blood Transfusion; Cardiopulmonary Bypass; Coagulants / therapeutic use; Factor VIIa / therapeutic use; Fibrin / chemistry; Fibrinogen / chemistry; Fibrinolysis; Hemorrhage; Hemostatics / therapeutic use; Humans; Infant, Newborn; Neonatology; Recombinant Proteins / therapeutic use; Risk
TL;DR: Compared neonatal clots formed with cryoprecipitate (SOC) to two procoagulant therapies, which resulted in clots with increased stiffness and decreased fibrinolytic properties may be a viable alternative to SOC treatment for neonatal bleeding. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: December 3, 2018

2018 journal article

Viscoelastic properties of microgel thin films control fibroblast modes of migration and pro-fibrotic responses

BIOMATERIALS, 185, 371–382.

By: D. Chester n, R. Kathard n, J. Nortey n, K. Nellenbach n & A. Brown n

author keywords: Microgels; Colloidal thin film; Fibroblasts; Mechanotransduction; Self-healing
MeSH headings : Biocompatible Materials / chemistry; Cell Adhesion; Cell Differentiation; Cell Line; Cell Movement; Elastic Modulus; Fibroblasts / cytology; Fibrosis / etiology; Gels / chemistry; Humans; Mechanotransduction, Cellular; Viscosity
TL;DR: Using microgel thin films with controllable non-linear elastic properties for investigating the role of material loss tangent on cell adhesion, migration, and myofibroblastic differentiation indicates that slight changes in tissue viscoelasticity following injury could contribute to early initiation of fibrotic related responses. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: November 12, 2018

2017 journal article

Peptide Mimetic Drugs for Modulating Thrombosis and Hemostasis

DRUG DEVELOPMENT RESEARCH, 78(6), 236–244.

By: K. Nellenbach n & A. Brown n

author keywords: thrombosis; hemostasis; peptide-mimetic; fibrinogen; thrombin; platelet
MeSH headings : Animals; Blood Coagulation; Fibrinolytic Agents / pharmacology; Hemostasis / drug effects; Humans; Peptidomimetics / pharmacology; Risk Factors; Thrombosis / drug therapy
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

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