Works (2)
Updated: July 5th, 2023 16:04
2011 journal article
Production of ELOVL4 transgenic pigs: a large animal model for Stargardt-like macular degeneration
British Journal of Ophthalmology, 95(12), 1749–1754.
MeSH headings : Animals; Animals, Genetically Modified; Disease Models, Animal; Electroretinography; Eye Proteins / biosynthesis; Eye Proteins / genetics; Gene Deletion; Immunohistochemistry; Macular Degeneration / metabolism; Macular Degeneration / pathology; Macular Degeneration / physiopathology; Membrane Proteins / biosynthesis; Membrane Proteins / genetics; Microscopy, Fluorescence; Mutation; Retina / metabolism; Retina / pathology; Retina / physiopathology; Swine
TL;DR:
These transgenic pigs provide unique animal models for examining macular degeneration and STGD3 pathogenesis and direct fluorescence microscopy indicated that the Y270terEYFP protein is expressed in photoreceptors and mislocalised within the cell.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
1997 journal article
Genetically engineered large animal model for studying cone photoreceptor survival and degeneration in retinitis pigmentosa
NATURE BIOTECHNOLOGY, 15(10), 965–970.
author keywords: transgenic swine; retinal degeneration; rhodopsin mutation; night blindness; eye disease
MeSH headings : Animals; Animals, Genetically Modified; Blotting, Southern; Disease Models, Animal; Electroretinography; Embryo Transfer; Gene Expression Regulation / genetics; Genetic Engineering; Microscopy, Electron; Molecular Sequence Data; Phenotype; Polymerase Chain Reaction; Retina / pathology; Retina / physiopathology; Retina / ultrastructure; Retinal Cone Photoreceptor Cells / physiopathology; Retinal Cone Photoreceptor Cells / ultrastructure; Retinal Degeneration / physiopathology; Retinitis Pigmentosa / genetics; Retinitis Pigmentosa / physiopathology; Rhodopsin / chemistry; Rhodopsin / genetics; Swine / embryology; Swine / genetics; Transgenes
TL;DR:
These transgenic pigs that express a mutated rhodopsin gene will provide a large animal model for study of the protracted phase of cone degeneration found in RP and for preclinical treatment trials.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018