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Works (10)
Updated: July 31st, 2024 05:01
2024 journal article
A Functional RNA-Origami as Direct Thrombin Inhibitor with Fast-acting and Specific Single-Molecule Reversal Agents in vivo model
Molecular Therapy, 32(7), 2286–2298.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: May 17, 2024
2024 journal article
Utilizing multiscale engineered biomaterials to examine <scp>TGF‐β</scp>‐mediated myofibroblastic differentiation
Wound Repair and Regeneration, 3.
author keywords: biomaterials; DNA origami; fibrosis; mechanotransduction; microgel; TGF-beta
TL;DR:
It is found that highly viscous materials with non-fixed TGF-β-R spacing promoted increased TGF-β signalling and myofibroblastic differentiation, likely due to the ability of cells to better cluster receptors on these surfaces.
(via Semantic Scholar)
open access via doi.org (publisher)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: March 18, 2024
2022 journal article
DNA aerogels and DNA-wrapped CNT aerogels for neuromorphic applications
MATERIALS TODAY BIO, 16.
author keywords: DNA aerogel; DNA -wrapped CNT aerogel; Resistive switching; Neuromorphic application; Self -assembly
TL;DR:
The successful construction of pure DNA aerogels and DNA-wrapped carbon nanotube (CNT) composite (DNA-CNT), via a single-step freeze-drying of the respective hydrogels are described.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: September 27, 2022
2021 journal article
Mechanical and Electrical Properties of DNA Hydrogel-Based Composites Containing Self-Assembled Three-Dimensional Nanocircuits
APPLIED SCIENCES-BASEL, 11(5).
author keywords: DNA hydrogel; DNA hydrogel-based composites; self-assembly; biomaterials; DNA nanotechnology; carbon nanotubes; gold nanoparticles
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: March 22, 2021
2021 journal article
Multivalent Aptamer‐Functionalized Single‐Strand RNA Origami as Effective, Target‐Specific Anticoagulants with Corresponding Reversal Agents
Advanced Healthcare Materials, 10(11).
author keywords: anticoagulants; aptamers; direct thrombin inhibitors; nucleic acids; reversal agents; RNA nanotechnology; RNA origami
MeSH headings : Anticoagulants / pharmacology; Aptamers, Nucleotide / pharmacology; Blood Coagulation; RNA / pharmacology; Thrombin
TL;DR:
Compared to current commercial intravenous anticoagulants, RNA origami‐based molecules show promise as safer alternatives with rapid activity switching for future therapeutic applications.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: June 10, 2021
2021 review
Self-Assembling Nucleic Acid Nanostructures Functionalized with Aptamers
[Review of ]. CHEMICAL REVIEWS, 121(22), 13797–13868.
MeSH headings : Nanostructures / chemistry; Nanotechnology; Nucleic Acid Conformation; Nucleic Acids / chemistry; Oligonucleotides
TL;DR:
This review focuses on the development of self-assembling nucleic acid nanostructures that are functionalized with nucleic Acid aptamers and their great potential in wide ranging application areas.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: March 7, 2022
2019 journal article
Genetically Encoded, Functional Single-Strand RNA Origami: Anticoagulant
ADVANCED MATERIALS, 31(21).
author keywords: anticoagulants; in vitro transcription; nucleic acid nanotechnology; RNA aptamers; RNA origami
MeSH headings : Anticoagulants / chemistry; Anticoagulants / pharmacology; Aptamers, Nucleotide / chemistry; Aptamers, Nucleotide / metabolism; Aptamers, Nucleotide / pharmacology; Humans; Nucleic Acid Conformation; Partial Thromboplastin Time; RNA / chemistry; RNA / pharmacology; Thrombin / antagonists & inhibitors; Thrombin / genetics; Thrombin / metabolism
TL;DR:
A family of self‐folding, functional RNA origami molecules bearing multiple thrombin‐binding RNA aptamers and showing significantly improved anticoagulant activity is described, paving the way for development of RNA Origami for potential therapeutic applications especially as a safer surgical anticogulant.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: July 29, 2019
2018 journal article
Controlled aggregation of DNA functionalized poly(phenylene-vinylene)
CHEMICAL COMMUNICATIONS, 54(44), 5534–5537.
MeSH headings : DNA / chemistry; Molecular Structure; Polyvinyls / chemistry
TL;DR:
It is shown that polymer aggregation can be controlled in solution through ion and DNA interactions; aggregation is induced in the presence of divalent cations and can be reversed by adding sequence specific DNA.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Docking of Antibodies into the Cavities of DNA Origami Structures
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 56(46), 14423–14427.
author keywords: DNA origami; IgG antibodies; protein immobilization; self-assembly
MeSH headings : Antibodies / chemistry; Antibodies / immunology; Bacteriophage M13 / genetics; Binding Sites, Antibody; DNA, Viral / chemistry; DNA, Viral / immunology; Immunoglobulin G / chemistry; Immunoglobulin G / immunology; Microscopy, Atomic Force; Microscopy, Electron, Transmission; Nucleic Acid Conformation
TL;DR:
This method for the covalent and orientation-selective immobilization of antibodies in designed cavities in 2D and 3D DNA origami structures has the potential to direct the interactions between antibodies and targets and to provide more regular surface assemblies of antibodies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Preparation, Single-Molecule Manipulation, and Energy Transfer Investigation of a Polyfluorene-graft-DNA polymer
CHEMISTRY-A EUROPEAN JOURNAL, 23(44), 10511–10515.
author keywords: conjugated polymers; DNA graft; DNA origami; energy transfer; polyfluorene
MeSH headings : DNA, Single-Stranded / chemistry; DNA, Single-Stranded / metabolism; Fluorenes / chemistry; Fluorescence Resonance Energy Transfer; Microscopy, Atomic Force; Nanostructures / chemistry; Polymers / chemistry
TL;DR:
This study demonstrates controlled single-molecule patterning of poly(F-DNA), as well as energy transfer between two different polymer-DNA conjugates, and highly efficient DNA-directed quenching of polyfluorene fluorescence was shown.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
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