Abhichart Krissanaprasit

Works (10)

Updated: April 25th, 2025 19:40

2024 journal article

A Functional RNA-Origami as Direct Thrombin Inhibitor with Fast-acting and Specific Single-Molecule Reversal Agents in vivo model

Molecular Therapy, 5.

By: A. Krissanaprasit*, E. Mihalko*, K. Meinhold n, A. Simpson*, J. Sollinger*, S. Pandit*, D. Dupont *, J. Kjems *, A. Brown* , T. LaBean*

MeSH headings : Animals; Mice; Humans; Aptamers, Nucleotide / pharmacology; Aptamers, Nucleotide / chemistry; Thrombin / metabolism; Blood Coagulation / drug effects; Tissue Distribution; RNA; Disease Models, Animal; Liver / metabolism; Liver / drug effects; Anticoagulants / pharmacology; Anticoagulants / chemistry; Antithrombins / pharmacology; Antidotes / pharmacology; Antidotes / chemistry
topics (OpenAlex): Advanced biosensing and bioanalysis techniques; RNA Interference and Gene Delivery; Bacteriophages and microbial interactions; Extracellular vesicles in disease
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Sources: Web Of Science, Crossref, NC State University Libraries
Added: May 17, 2024

2024 journal article

Utilizing multiscale engineered biomaterials to examine TGF‐β‐mediated myofibroblastic differentiation

Wound Repair and Regeneration, 3.

By: A. Simpson n, A. Krissanaprasit n, D. Chester n, C. Koehler n, T. LaBean n & A. Brown n 

author keywords: biomaterials; DNA origami; fibrosis; mechanotransduction; microgel; TGF-beta
MeSH headings : Cell Differentiation; Biocompatible Materials / pharmacology; Myofibroblasts / metabolism; Myofibroblasts / physiology; Transforming Growth Factor beta / metabolism; Extracellular Matrix / metabolism; Humans; Signal Transduction; Receptors, Transforming Growth Factor beta / metabolism; Cells, Cultured; Tissue Engineering / methods; Viscosity
topics (OpenAlex): Cellular Mechanics and Interactions; Cell Adhesion Molecules Research; 3D Printing in Biomedical Research
TL;DR: It is found that highly viscous materials with non-fixed TGF-β-R spacing promoted increased TGF-β signalling and myofibroblastic differentiation, likely due to the ability of cells to better cluster receptors on these surfaces. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, Crossref
Added: March 18, 2024

2022 article

DNA aerogels and DNA-wrapped CNT aerogels for neuromorphic applications

Hosseini, M., Rahmanian, V., Pirzada, T., Frick, N., Krissanaprasit, A., Khan, S. A., & LaBean, T. H. (2022, September 26). Materials Today Bio, Vol. 12.

By: M. Hosseini n, V. Rahmanian n, T. Pirzada n , N. Frick n, A. Krissanaprasit n, S. Khan n , T. LaBean n

author keywords: DNA aerogel; DNA -wrapped CNT aerogel; Resistive switching; Neuromorphic application; Self -assembly
topics (OpenAlex): Advanced biosensing and bioanalysis techniques; Advanced Memory and Neural Computing; Conducting polymers and applications
TL;DR: The successful construction of pure DNA aerogels and DNA-wrapped carbon nanotube (CNT) composite (DNA-CNT), via a single-step freeze-drying of the respective hydrogels are described. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: September 27, 2022

2021 article

Mechanical and Electrical Properties of DNA Hydrogel-Based Composites Containing Self-Assembled Three-Dimensional Nanocircuits

Gao, M., Krissanaprasit, A., Miles, A., Hsiao, L. C., & LaBean, T. H. (2021, March 3). Applied Sciences, Vol. 11.

By: M. Gao n, A. Krissanaprasit n, A. Miles*, L. Hsiao n  & T. LaBean n

author keywords: DNA hydrogel; DNA hydrogel-based composites; self-assembly; biomaterials; DNA nanotechnology; carbon nanotubes; gold nanoparticles
topics (OpenAlex): Advanced biosensing and bioanalysis techniques; DNA and Nucleic Acid Chemistry; RNA Interference and Gene Delivery
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: March 22, 2021

2021 journal article

Multivalent Aptamer‐Functionalized Single‐Strand RNA Origami as Effective, Target‐Specific Anticoagulants with Corresponding Reversal Agents

Advanced Healthcare Materials, 10(11).

By: A. Krissanaprasit n, C. Key n, K. Froehlich n, S. Pontula, E. Mihalko n, D. Dupont *, E. Andersen *, J. Kjems *, A. Brown n , T. LaBean n

author keywords: anticoagulants; aptamers; direct thrombin inhibitors; nucleic acids; reversal agents; RNA nanotechnology; RNA origami
MeSH headings : Anticoagulants / pharmacology; Aptamers, Nucleotide / pharmacology; Blood Coagulation; RNA / pharmacology; Thrombin
topics (OpenAlex): Advanced biosensing and bioanalysis techniques; RNA Interference and Gene Delivery; Extracellular vesicles in disease; Biosensors and Analytical Detection
TL;DR: Compared to current commercial intravenous anticoagulants, RNA origami‐based molecules show promise as safer alternatives with rapid activity switching for future therapeutic applications. (via Semantic Scholar)
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Sources: Web Of Science, Crossref, NC State University Libraries
Added: June 10, 2021

2021 article

Self-Assembling Nucleic Acid Nanostructures Functionalized with Aptamers

Krissanaprasit, A., Key, C. M., Pontula, S., & LaBean, T. H. (2021, June 22). Chemical Reviews.

By: A. Krissanaprasit n, C. Key*, S. Pontula * & T. LaBean n

MeSH headings : Nanostructures / chemistry; Nanotechnology; Nucleic Acid Conformation; Nucleic Acids / chemistry; Oligonucleotides
topics (OpenAlex): Advanced biosensing and bioanalysis techniques; DNA and Nucleic Acid Chemistry; RNA Interference and Gene Delivery
TL;DR: This review focuses on the development of self-assembling nucleic acid nanostructures that are functionalized with nucleic Acid aptamers and their great potential in wide ranging application areas. (via Semantic Scholar)
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Source: Web Of Science
Added: March 7, 2022

2019 article

Genetically Encoded, Functional Single‐Strand RNA Origami: Anticoagulant

Krissanaprasit, A., Key, C., Fergione, M., Froehlich, K., Pontula, S., Hart, M., … LaBean, T. H. (2019, April 10). Advanced Materials.

By: A. Krissanaprasit n, C. Key n, M. Fergione n, K. Froehlich n, S. Pontula *, M. Hart n, P. Carriel n, J. Kjems *, E. Andersen *, T. LaBean n

author keywords: anticoagulants; in vitro transcription; nucleic acid nanotechnology; RNA aptamers; RNA origami
MeSH headings : Anticoagulants / chemistry; Anticoagulants / pharmacology; Aptamers, Nucleotide / chemistry; Aptamers, Nucleotide / metabolism; Aptamers, Nucleotide / pharmacology; Humans; Nucleic Acid Conformation; Partial Thromboplastin Time; RNA / chemistry; RNA / pharmacology; Thrombin / antagonists & inhibitors; Thrombin / genetics; Thrombin / metabolism
topics (OpenAlex): Advanced biosensing and bioanalysis techniques; RNA Interference and Gene Delivery; Extracellular vesicles in disease; Single-cell and spatial transcriptomics; Nanowire Synthesis and Applications
TL;DR: A family of self‐folding, functional RNA origami molecules bearing multiple thrombin‐binding RNA aptamers and showing significantly improved anticoagulant activity is described, paving the way for development of RNA Origami for potential therapeutic applications especially as a safer surgical anticogulant. (via Semantic Scholar)
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Source: Web Of Science
Added: July 29, 2019

2018 article

Controlled aggregation of DNA functionalized poly(phenylene-vinylene)

Gudnason, D., Madsen, M., Krissanaprasit, A., Gothelf, K. V., & Birkedal, V. (2018, January 1). Chemical Communications.

By: D. Gudnason*, M. Madsen*, A. Krissanaprasit*, K. Gothelf * & V. Birkedal *

MeSH headings : DNA / chemistry; Molecular Structure; Polyvinyls / chemistry
topics (OpenAlex): Luminescence and Fluorescent Materials; Advanced biosensing and bioanalysis techniques; Molecular Sensors and Ion Detection; Conducting polymers and applications
TL;DR: It is shown that polymer aggregation can be controlled in solution through ion and DNA interactions; aggregation is induced in the presence of divalent cations and can be reversed by adding sequence specific DNA. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2017 article

Docking of Antibodies into the Cavities of DNA Origami Structures

Ouyang, X., De Stefano, M., Krissanaprasit, A., Bank Kodal, A. L., Bech Rosen, C., Liu, T., … Gothelf, K. V. (2017, September 5). Angewandte Chemie International Edition.

By: X. Ouyang *, M. De Stefano*, A. Krissanaprasit n, A. Bank Kodal *, C. Bech Rosen*, T. Liu *, S. Helmig*, C. Fan *, K. Gothelf *

author keywords: DNA origami; IgG antibodies; protein immobilization; self-assembly
MeSH headings : Antibodies / chemistry; Antibodies / immunology; Bacteriophage M13 / genetics; Binding Sites, Antibody; DNA, Viral / chemistry; DNA, Viral / immunology; Immunoglobulin G / chemistry; Immunoglobulin G / immunology; Microscopy, Atomic Force; Microscopy, Electron, Transmission; Nucleic Acid Conformation
topics (OpenAlex): Advanced biosensing and bioanalysis techniques; Advanced Biosensing Techniques and Applications; Monoclonal and Polyclonal Antibodies Research; Biosensors and Analytical Detection
TL;DR: This method for the covalent and orientation-selective immobilization of antibodies in designed cavities in 2D and 3D DNA origami structures has the potential to direct the interactions between antibodies and targets and to provide more regular surface assemblies of antibodies. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2017 article

Preparation, Single‐Molecule Manipulation, and Energy Transfer Investigation of a Polyfluorene‐graft‐DNA polymer

Madsen, M., Christensen, R. S., Krissanaprasit, A., Bakke, M. R., Riber, C. F., Nielsen, K. S., … Gothelf, K. V. (2017, June 22). Chemistry - A European Journal.

By: M. Madsen*, R. Christensen *, A. Krissanaprasit n, M. Bakke*, C. Riber *, K. Nielsen*, A. Zelikin *, K. Gothelf *

author keywords: conjugated polymers; DNA graft; DNA origami; energy transfer; polyfluorene
MeSH headings : DNA, Single-Stranded / chemistry; DNA, Single-Stranded / metabolism; Fluorenes / chemistry; Fluorescence Resonance Energy Transfer; Microscopy, Atomic Force; Nanostructures / chemistry; Polymers / chemistry
topics (OpenAlex): Advanced biosensing and bioanalysis techniques; Molecular Junctions and Nanostructures; Luminescence and Fluorescent Materials; RNA Interference and Gene Delivery
TL;DR: This study demonstrates controlled single-molecule patterning of poly(F-DNA), as well as energy transfer between two different polymer-DNA conjugates, and highly efficient DNA-directed quenching of polyfluorene fluorescence was shown. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

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