Daniel Chester

Works (8)

Updated: March 25th, 2024 08:09

2024 journal article

Utilizing multiscale engineered biomaterials to examine <scp>TGF‐β</scp>‐mediated myofibroblastic differentiation

Wound Repair and Regeneration, 3.

By: A. Simpson n, A. Krissanaprasit n, D. Chester n, C. Koehler n, T. LaBean n & A. Brown n 

author keywords: biomaterials; DNA origami; fibrosis; mechanotransduction; microgel; TGF-beta
TL;DR: It is found that highly viscous materials with non-fixed TGF-β-R spacing promoted increased TGF-β signalling and myofibroblastic differentiation, likely due to the ability of cells to better cluster receptors on these surfaces. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, Crossref
Added: March 18, 2024

2022 journal article

Elucidating the combinatorial effect of substrate stiffness and surface viscoelasticity on cellular phenotype

Journal of Biomedical Materials Research Part A, 110(6), 1224–1237.

By: D. Chester n, V. Lee  n, P. Wagner n, M. Nordberg n, M. Fisher n & A. Brown n 

author keywords: loss tangent; mechanotransduction; microgel; viscoelasticity
MeSH headings : Biocompatible Materials / chemistry; Hydrogels / chemistry; Hydrogels / pharmacology; Mechanotransduction, Cellular / physiology; Phenotype; Viscosity
TL;DR: A novel composite hydrogel system capable of decoupling and individually controlling both the bulk stiffness and surface viscoelasticity of the material by combining polyacrylamide gels with microgel thin films is characterized, allowing for a greater understanding of cellular mechanotransduction mechanisms than previously possible through current model material platforms. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref, NC State University Libraries
Added: February 7, 2022

2020 journal article

Ultrasonic Microplotting of Microgel Bioinks

ACS Applied Materials & Interfaces, 12(42), 47309–47319.

By: D. Chester n, P. Theetharappan n, T. Ngobili n, M. Daniele  n & A. Brown n 

author keywords: microgel; microplotting; patterned films; layer-by-layer fabrication; bioink
MeSH headings : Ink; Microgels / analysis; Molecular Structure; Particle Size; Surface Properties; Tissue Scaffolds / chemistry; Ultrasonic Waves
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref, NC State University Libraries
Added: December 21, 2020

2019 journal article

Mechanical properties of tissue formed in vivo are affected by 3D-bioplotted scaffold microarchitecture and correlate with ECM collagen fiber alignment

Connective Tissue Research, 61(2), 190–204.

By: P. Huebner  n, P. Warren n, D. Chester n, J. Spang *, A. Brown n , M. Fisher n, R. Shirwaiker n 

author keywords: 3D printing; atomic force microscopy; elastic modulus; tissue engineering; tissue scaffolds
MeSH headings : Animals; Bioprinting; Collagen / chemistry; Extracellular Matrix / chemistry; Male; Polyesters / chemistry; Printing, Three-Dimensional; Rats; Rats, Sprague-Dawley; Tissue Engineering; Tissue Scaffolds / chemistry
TL;DR: The findings demonstrate the significant effects of 3D-bioplotted scaffold microarchitectures in the organization and sub-tissue-level mechanical properties of ECM in vivo. (via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 26, 2019

2018 journal article

Viscoelastic properties of microgel thin films control fibroblast modes of migration and pro-fibrotic responses

Biomaterials, 185, 371–382.

By: D. Chester n, R. Kathard n, J. Nortey  n, K. Nellenbach n & A. Brown n 

author keywords: Microgels; Colloidal thin film; Fibroblasts; Mechanotransduction; Self-healing
MeSH headings : Biocompatible Materials / chemistry; Cell Adhesion; Cell Differentiation; Cell Line; Cell Movement; Elastic Modulus; Fibroblasts / cytology; Fibrosis / etiology; Gels / chemistry; Humans; Mechanotransduction, Cellular; Viscosity
TL;DR: Using microgel thin films with controllable non-linear elastic properties for investigating the role of material loss tangent on cell adhesion, migration, and myofibroblastic differentiation indicates that slight changes in tissue viscoelasticity following injury could contribute to early initiation of fibrotic related responses. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref, NC State University Libraries
Added: November 12, 2018

2017 journal article

Study of Poly(<i>N</i>-isopropylacrylamide-<i>co</i>-acrylic acid) (pNIPAM) Microgel Particle Induced Deformations of Tissue-Mimicking Phantom by Ultrasound Stimulation

Langmuir, 34(4), 1457–1465.

By: A. Joshi*, S. Nandi n, D. Chester n, A. Brown n  & M. Muller n 

MeSH headings : Acrylates / chemistry; Acrylic Resins / chemistry; Drug Delivery Systems; Gels / chemistry; Polymers / chemistry
TL;DR: It is demonstrated in tissue-mimicking phantoms that using ultrasound insonification causes deformations of ULC microgel particles, and increasing the degree of microgel cross-linking reduces the magnitude of the deformation and increases the optimal concentration required to achieve the largest amount of deformation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2017 article

Wound Healing and the Host Response in Regenerative Engineering

ENCYCLOPEDIA OF BIOMEDICAL ENGINEERING, VOL 1, pp. 707–718.

By: D. Chester n, E. Marrow n, M. Daniele n & A. Brown n 

TL;DR: The purpose of this book chapter is to highlight the cellular processes and bioactive agents that encompass the wound healing process and to discuss how these processes change in the presence of a biomaterial. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: April 14, 2020

2016 journal article

Single-platelet nanomechanics measured by high-throughput cytometry

Nature Materials, 16(2), 230–235.

By: D. Myers *, Y. Qiu *, M. Fay *, M. Tennenbaum *, D. Chester n, J. Cuadrado*, Y. Sakurai *, J. Baek* ...

MeSH headings : Blood Coagulation / physiology; Blood Flow Velocity / physiology; Blood Platelets / physiology; Cells, Cultured; Elastic Modulus / physiology; Flow Cytometry / methods; Hardness / physiology; Humans; Mechanotransduction, Cellular / physiology; Nanoparticles / chemistry; Platelet Activation / physiology; Platelet Adhesiveness / physiology
TL;DR: A high-throughput hydrogel based platelet-contraction cytometer is reported that quantifies single-platelet contraction forces in different clot microenvironments and shows that platelets, via the Rho/ROCK pathway, synergistically couple mechanical and biochemical inputs to mediate contraction. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

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