Works (37)

2021 article

Submonomer synthesis of peptoids containing trans-inducing N-imino- and N-alkylamino-glycines

Davern, C. M., Lowe, B. D., Rosfi, A., Ison, E. A., & Proulx, C. (2021, May 10). CHEMICAL SCIENCE, Vol. 5.

By: C. Davern, B. Lowe, A. Rosfi, E. Ison & C. Proulx

Sources: Web Of Science, ORCID
Added: June 10, 2021

2020 journal article

Atheroprotective and atheroregressive potential of azapeptide derivatives of GHRP-6 as selective CD36 ligands in apolipoprotein E-deficient mice

ATHEROSCLEROSIS, 307, 52–62.

By: G. Fregeau, R. Sarduy, H. Elimam, C. Esposito, K. Mellal, L. Menard, S. Graca, C. Proulx ...

Sources: Web Of Science, ORCID
Added: September 28, 2020

2020 article

Catching up to nature's ribosomes

SCIENCE, Vol. 368, pp. 941–941.

By: C. Proulx

Sources: Web Of Science, ORCID
Added: June 22, 2020

2020 journal article

N-Arylation of Amino Acid Esters to Expand Side Chain Diversity in Ketoxime Peptide Ligations

JOURNAL OF ORGANIC CHEMISTRY, 85(3), 1748–1755.

By: H. Young, Q. Guthrie & C. Proulx

Sources: Web Of Science, ORCID
Added: March 16, 2020

2020 review

Peptide science: A "rule model" for new generations of peptidomimetics

[Review of ]. ACTA BIOMATERIALIA, 102, 35–74.

By: H. Reese, C. Shanahan, C. Proulx & S. Menegatti

Sources: Web Of Science, ORCID
Added: February 27, 2020

2020 review

Synthesis and Biomedical Potential of Azapeptide Modulators of the Cluster of Differentiation 36 Receptor (CD36)

[Review of ]. BIOMEDICINES, 8(8).

By: C. Proulx, J. Zhang, D. Sabatino, S. Chemtob, H. Ong & W. Lubell

Sources: Web Of Science, ORCID
Added: November 2, 2020

2019 speech

Aerobic oxidation of N-aryl peptides for catalyst-free oxime ligations

Proulx, C. (2019, November). Presented at the Appalachian State University, Boone, NC.

By: C. Proulx

Event: Appalachian State University at Boone, NC on November 1, 2019

Source: NC State University Libraries
Added: March 4, 2021

2019 conference paper

Aerobic oxidation of N-phenylglycinyl peptides for catalyst-free oxime ligations

American Chemical Society (ACS) meeting. Presented at the American Chemical Society (ACS) meeting, Orlando, Florida.

By: Q. Guthrie & C. Proulx

Event: American Chemical Society (ACS) meeting at Orlando, Florida on March 31 - April 4, 2019

Source: NC State University Libraries
Added: March 8, 2021

2019 journal article

Aza-Amino Acids Disrupt -Sheet Secondary Structures

MOLECULES, 24(10).

By: M. McMechen, E. Willis, P. Gourville & C. Proulx

Sources: Web Of Science, ORCID
Added: July 1, 2019

2019 conference paper

In situ oxidation of N-phenylglycinyl peptides for oxime bond formation at neutral pH

American Peptide Symposium 2019. Presented at the American Peptide Symposium, Monterey, CA.

By: C. Proulx

Event: American Peptide Symposium at Monterey, CA on June 22-27, 2019

Source: NC State University Libraries
Added: March 8, 2021

2019 journal article

Ketoxime peptide ligations: oxidative couplings of alkoxyamines to N-aryl peptides

CHEMICAL SCIENCE, 10(41), 9506–9512.

By: Q. Guthrie, H. Young & C. Proulx

Sources: Web Of Science, ORCID
Added: November 18, 2019

2019 conference paper

New strategies for Ketoxime peptide ligations

Boulder Peptide Symposium 2019. Presented at the Boulder Peptide Symposium 2019, Boulder, CO.

By: C. Proulx

Event: Boulder Peptide Symposium 2019 at Boulder, CO on September 23-26, 2019

Source: NC State University Libraries
Added: March 4, 2021

2019 speech

Oxime ligation via in situ oxidation of N-phenylglycinyl peptides

Proulx, C. (2019, April). Presented at the Seton Hall University, South Orange, NJ.

By: C. Proulx

Event: Seton Hall University at South Orange, NJ on April 9, 2019

Source: NC State University Libraries
Added: March 4, 2021

2018 journal article

Adiponectin has a pivotal role in the cardioprotective effect of CP-3(iv), a selective CD36 azapeptide ligand, after transient coronary artery occlusion in mice

FASEB Journal, 32(2), 807–818.

By: D. Huynh, V. Bessi, L. Menard, J. Piquereau, C. Proulx, M. Febbraio, W. Lubell, A. Carpentier ...

Sources: NC State University Libraries, ORCID
Added: August 6, 2018

2018 journal article

Glycosylated Peptoid Nanosheets as a Multivalent Scaffold for Protein Recognition

ACS Nano, 12(3), 2455–2465.

By: A. Battigelli, J. Kim, D. Dehigaspitiya, C. Proulx, E. Robertson, D. Murray, B. Rad, K. Kirshenbaum, R. Zuckermann

Sources: Crossref, ORCID
Added: February 24, 2020

2018 journal article

Oxime ligation via in situ oxidation of N-phenylglycinyl peptides

Organic Letters, 20(9), 2564–2567.

By: Q. Guthrie & C. Proulx

Sources: NC State University Libraries, ORCID
Added: August 6, 2018

2018 conference paper

Oxime ligation via in situ oxidation of N-phenylglycinyl peptides

Guthrie, Q. A., & Proulx, C. (2018, February 11). Presented at the Chemistry and Biology of Peptides Gordon Research Conference (GRC), Ventura, California.

By: Q. Guthrie & C. Proulx

Event: Chemistry and Biology of Peptides Gordon Research Conference (GRC) at Ventura, California on February 11-16, 2018

Source: NC State University Libraries
Added: March 4, 2021

2017 article

Azapeptide synthesis methods for expanding side-chain diversity for biomedical applications

Accounts of Chemical Research, Vol. 50, pp. 1541–1556.

By: R. Chingle, C. Proulx & W. Lubell

Sources: NC State University Libraries, ORCID
Added: August 6, 2018

2016 journal article

Design, Synthesis, Assembly, and Engineering of Peptoid Nanosheets

Accounts of Chemical Research, 49(3), 379–389.

By: E. Robertson, A. Battigelli, C. Proulx, R. Mannige, T. Haxton, L. Yun, S. Whitelam, R. Zuckermann

Sources: Crossref, ORCID
Added: February 24, 2020

2016 journal article

Improved chemical and mechanical stability of peptoid nanosheets by photo-crosslinking the hydrophobic core

Chemical Communications, 52(26), 4753–4756.

By: D. Flood, C. Proulx, E. Robertson, A. Battigelli, S. Wang, A. Schwartzberg, R. Zuckermann

Sources: Crossref, ORCID
Added: February 24, 2020

2016 journal article

Molecular Engineering of the Peptoid Nanosheet Hydrophobic Core

Langmuir, 32(45), 11946–11957.

By: E. Robertson, C. Proulx, J. Su, R. Garcia, S. Yoo, E. Nehls, M. Connolly, L. Taravati, R. Zuckermann

Sources: Crossref, ORCID
Added: February 24, 2020

2016 journal article

On-resin N -terminal peptoid degradation: Toward mild sequencing conditions

Biopolymers, 106(5), 726–736.

By: C. Proulx, F. Noë, S. Yoo, M. Connolly & R. Zuckermann

Sources: Crossref, ORCID
Added: August 28, 2020

2015 journal article

Accelerated Submonomer Solid-Phase Synthesis of Peptoids Incorporating Multiple Substituted N-Aryl Glycine Monomers

The Journal of Organic Chemistry, 80(21), 10490–10497.

By: C. Proulx, S. Yoo, M. Connolly & R. Zuckermann

Sources: Crossref, ORCID
Added: August 28, 2020

2015 journal article

Peptoid nanosheets exhibit a new secondary-structure motif

Nature, 526(7573), 415–420.

By: R. Mannige, T. Haxton, C. Proulx, E. Robertson, A. Battigelli, G. Butterfoss, R. Zuckermann, S. Whitelam

Sources: Crossref, ORCID
Added: February 24, 2020

2014 journal article

Analysis of N-amino-imidazolin-2-one peptide turn mimic 4-position substituent effects on conformation by X-ray crystallography

Biopolymers, 102(1), 7–15.

By: C. Proulx & W. Lubell

Sources: Crossref, ORCID
Added: October 29, 2020

2014 journal article

Assembly and molecular order of two-dimensional peptoid nanosheets through the oil–water interface

Proceedings of the National Academy of Sciences, 111(37), 13284–13289.

By: E. Robertson, G. Olivier, M. Qian, C. Proulx, R. Zuckermann & G. Richmond

Sources: Crossref, ORCID
Added: August 28, 2020

2014 journal article

Multicomponent Diversity-Oriented Synthesis of Aza-Lysine-Peptide Mimics

Organic Letters, 16(1), 298–301.

By: J. Zhang, C. Proulx, A. Tomberg & W. Lubell

Sources: Crossref, ORCID
Added: October 29, 2020

2014 chapter

Precision Sequence Control in Bioinspired Peptoid Polymers

In ACS Symposium Series (pp. 35–53).

By: J. Sun, C. Proulx & R. Zuckermann

Sources: Crossref, ORCID
Added: June 24, 2021

2014 journal article

Structure-Determining Step in the Hierarchical Assembly of Peptoid Nanosheets

ACS Nano, 8(11), 11674–11684.

By: B. Sanii, T. Haxton, G. Olivier, A. Cho, B. Barton, C. Proulx, S. Whitelam, R. Zuckermann

Sources: Crossref, ORCID
Added: August 28, 2020

2012 journal article

Azapeptide Analogues of the Growth Hormone Releasing Peptide 6 as Cluster of Differentiation 36 Receptor Ligands with Reduced Affinity for the Growth Hormone Secretagogue Receptor 1a

Journal of Medicinal Chemistry, 55(14), 6502–6511.

By: C. Proulx, É. Picard, D. Boeglin, P. Pohankova, S. Chemtob, H. Ong, W. Lubell

Sources: Crossref, ORCID
Added: October 29, 2020

2012 journal article

N-Amino-imidazolin-2-one Peptide Mimic Synthesis and Conformational Analysis

Organic Letters, 14(17), 4552–4555.

By: C. Proulx & W. Lubell

Sources: Crossref, ORCID
Added: August 28, 2020

2011 journal article

Modified peptide monolayer binding His-tagged biomolecules for small ligand screening with SPR biosensors

The Analyst, 136(15), 3142.

By: O. Bolduc, P. Lambert-Lanteigne, D. Colin, S. Zhao, C. Proulx, D. Boeglin, W. Lubell, J. Pelletier ...

Sources: Crossref, ORCID
Added: August 28, 2020

2011 journal article

Structure–Activity Relationships of GHRP-6 Azapeptide Ligands of the CD36 Scavenger Receptor by Solid-Phase Submonomer Azapeptide Synthesis

Journal of the American Chemical Society, 133(32), 12493–12506.

By: D. Sabatino, C. Proulx, P. Pohankova, H. Ong & W. Lubell

Sources: Crossref, ORCID
Added: August 28, 2020

2010 journal article

Aza-1,2,3-triazole-3-alanine Synthesis via Copper-Catalyzed 1,3-Dipolar Cycloaddition on Aza-progargylglycine

The Journal of Organic Chemistry, 75(15), 5385–5387.

By: C. Proulx & W. Lubell

Sources: Crossref, ORCID
Added: August 28, 2020

2010 journal article

Copper-Catalyzed N-Arylation of Semicarbazones for the Synthesis of Aza-Arylglycine-Containing Aza-Peptides

Organic Letters, 12(13), 2916–2919.

By: C. Proulx & W. Lubell

Sources: Crossref, ORCID
Added: October 29, 2020

2010 journal article

Solution-phase submonomer diversification of aza-dipeptide building blocks and their application in aza-peptide and aza-DKP synthesis

Journal of Peptide Science, 16(6), 284–296.

By: C. Bourguet, C. Proulx, S. Klocek, D. Sabatino & W. Lubell

Sources: Crossref, ORCID
Added: August 28, 2020

2009 journal article

Exploring Side-Chain Diversity by Submonomer Solid-Phase Aza-Peptide Synthesis

Organic Letters, 11(16), 3650–3653.

By: D. Sabatino, C. Proulx, S. Klocek, C. Bourguet, D. Boeglin, H. Ong, W. Lubell

Sources: Crossref, ORCID
Added: August 28, 2020

Employment

2016 - present

North Carolina State University Raleigh, NC, US
Assistant Professor Department of Chemistry

2012 - 2016

Lawrence Berkeley National Laboratory CA, CA, US
Postdoctoral Fellow Molecular Foundry

Education

2007 - 2012

Université de Montréal Montreal, QC, CA
Ph.D Departement de Chimie

2003 - 2007

University of Ottawa Ottawa, ON, CA
B.Sc. Department of Chemistry