Works (17)
Updated: April 4th, 2024 08:05
2024 article
Diagnostic utility of the total nucleated cell count for differentiation of septic and sterile peritoneal effusions in dogs
Didomenico, A. E., Jacob, M. E., Stowe, D. M., & Gruber, E. J. (2024, February 6). VETERINARY CLINICAL PATHOLOGY, Vol. 2.
author keywords: abdominal effusion; bacteria; fluid analysis; peritonitis; secondary peritonitis
TL;DR:
Total nucleated cell counts and absolute neutrophil counts aid in the differentiation of septic and non-septic peritoneal effusions with similar diagnostic utility but are not sufficiently sensitive or specific to use without concurrent microscopic evaluation.
(via Semantic Scholar)
onlinelibrary.wiley.com (publisher PDF)
Sources: ORCID, Web Of Science
Added: February 8, 2024
2023 journal article
Effect of Prolonged Serum Storage Time and Varied Temperatures on Biochemical Values in African Savanna Elephants (<i>Loxodonta africana</i>)
JOURNAL OF ZOOLOGICAL AND BOTANICAL GARDENS, 4(1), 12–20.
author keywords: elephant; serum chemistry; blood storage; temperature; serum stability; Loxodonta africana
TL;DR:
It is concluded that if serum is properly separated shortly after collection, many serum biochemical analytes can be accurately measured even after suboptimal serum storage, but refrigeration and prompt evaluation are still required for some analytes.
(via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: January 2, 2024
2023 journal article
Evaluation and establishment of reference intervals using the i-STAT1 blood chemistry analyzer in turkeys
POULTRY SCIENCE, 102(8).
author keywords: blood; biochemical analysis; portable analyzer; turkey
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science
Added: May 27, 2023
2023 article
Performance of a manually operated salad spinner centrifuge for serum separation in the healthy domestic horse (Equus caballus) and southern white rhinoceros (Ceratotherium simum)
Cassady, K. R., Minter, L. J., & Gruber, E. J. (2023, July 26). VETERINARY CLINICAL PATHOLOGY, Vol. 7.
author keywords: blood; clinical chemistry; field medicine; frugal science
TL;DR:
An inexpensive, manually operated centrifuge that could accept standard laboratory tubes by modifying a consumer-grade salad spinner with low-cost materials yields diagnostic quality serum suitable for the measurement of most standard biochemistry analytes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science
Added: July 28, 2023
2023 article
What is your diagnosis? Perineal swelling in a dog
Marin, J., Ferris, K., & Gruber, E. (2023, January 8). VETERINARY CLINICAL PATHOLOGY, Vol. 1.
MeSH headings : Dogs; Animals; Dog Diseases / diagnosis; Perineum
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science
Added: January 9, 2023
2023 article
What is your diagnosis? Ulcerative shell lesions from a diamond-backed terrapin (Malaclemys terrapin)
Hastain, S. A. A., Buchy, J. M. M., Dombrowski, D. S. S., Womble, M. A. A., Armwood, A. R. R., & Gruber, E. J. J. (2023, July 27). VETERINARY CLINICAL PATHOLOGY, Vol. 7.
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
14. Life Below Water
(Web of Science; OpenAlex)
15. Life on Land
(Web of Science)
Sources: ORCID, Web Of Science
Added: July 28, 2023
2022 article
Total protein concentration as a predictor of in neoplastic peritoneal and pleural effusions of dogs
Parsley, A. L., Schnelle, A. N., Gruber, E. J., Sander, W. E., & Barger, A. M. (2022, May 10). VETERINARY CLINICAL PATHOLOGY, Vol. 5.
author keywords: albumin; non-neoplastic; ratio; refractometer; TP
MeSH headings : Animals; Ascitic Fluid / pathology; Dog Diseases / diagnosis; Dog Diseases / pathology; Dogs; Hospitals, Animal; Hospitals, Teaching; Pleural Effusion / diagnosis; Pleural Effusion / etiology; Pleural Effusion / veterinary; Retrospective Studies
TL;DR:
Fluid TP concentrations were significantly greater in neoplastic than non-neoplastic effusions; however, given the considerable overlap between groups, the diagnostic utility of this difference is low.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: May 23, 2022
2022 article
What is your diagnosis? Ovarian mass in a mare
Parsley, A. L., Rasche, B. L., Yang, T. S., & Gruber, E. J. (2022, September 9). VETERINARY CLINICAL PATHOLOGY, Vol. 9.
MeSH headings : Horses; Animals; Female; Ovarian Neoplasms / diagnosis; Ovarian Neoplasms / veterinary; Granulosa Cell Tumor / diagnosis; Granulosa Cell Tumor / surgery; Granulosa Cell Tumor / veterinary; Horse Diseases / diagnosis
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, ORCID
Added: September 19, 2022
2021 journal article
Comparison of portable and conventional laboratory analyzers for biochemical tests in chickens
POULTRY SCIENCE, 100(2), 746–754.
Contributors: F. Ruiz-Jimenez, * , M. Correa & R. Crespo*
author keywords: analyzer; biochemical analysis; broiler; conventional; portable
MeSH headings : Animals; Blood Chemical Analysis / instrumentation; Blood Chemical Analysis / veterinary; Blood Gas Analysis / instrumentation; Blood Gas Analysis / veterinary; Chickens / blood; Hematologic Tests / instrumentation; Hematologic Tests / veterinary; Laboratories / standards; Point-of-Care Testing / standards; Reference Values; Time Factors
TL;DR:
Although statistically significant differences were found for some biochemical analytes over time, the actual mean or median differences were too small to be considered of clinical importance and future studies are warranted to establish analyzer-specific reference intervals for poultry.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science
Added: December 2, 2020
2021 journal article
LACTIC ACIDOSIS INDUCED BY MANUAL RESTRAINT FOR HEALTH EVALUATION AND COMPARISON OF TWO POINT-OF-CARE ANALYZERS IN HEALTHY LOGGERHEAD SEA TURTLES (CARETTA CARETTA)
JOURNAL OF ZOO AND WILDLIFE MEDICINE, 52(4), 1195–1204.
MeSH headings : Acidosis, Lactic / etiology; Acidosis, Lactic / veterinary; Animals; Bicarbonates; Carbon Dioxide; Point-of-Care Systems; Turtles
TL;DR:
Clinicians should evaluate blood gas values and lactate at the beginning of health evaluations and interpret serial lactate values in sea turtles with caution, because even short periods of manual restraint can induce lactic acidosis and considerably influence these values.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
14. Life Below Water
(Web of Science; OpenAlex)
15. Life on Land
(Web of Science)
Sources: Web Of Science, ORCID
Added: January 3, 2022
2021 journal article
Macrophage uptake of oxidized and acetylated low-density lipoproteins and generation of reactive oxygen species are regulated by linear stiffness of the growth surface
PLOS ONE.
Ed(s): A. Zirlik
MeSH headings : Animals; Biological Transport; Lipoproteins, LDL / metabolism; Macrophages / metabolism; Macrophages / pathology; Male; Mice; Mice, Inbred C57BL; Reactive Oxygen Species / metabolism; Surface Properties; TRPV Cation Channels / metabolism
TL;DR:
Through pharmacologic inhibition and genetic deletion, it is found that transient receptor potential vanilloid 4 (TRPV4), a mechanosensitive ion channel, plays an inhibitory role in the uptake of acLDL, but not oxLDL.
(via Semantic Scholar)
Source: ORCID
Added: December 17, 2021
2020 journal article
Molecular regulation of TLR signaling in health and disease: mechano-regulation of macrophages and TLR signaling
Innate Immunity, 26(1), 15–25.
author keywords: Innate immunity; macrophage; mechanosensing; mechanotransduction; stiffness; TLR signaling
MeSH headings : Animals; Atherosclerosis / metabolism; Cellular Microenvironment; Humans; Immune System Diseases; Macrophages / immunology; Macrophages / metabolism; Mechanotransduction, Cellular / immunology; Neoplasms / metabolism; Signal Transduction; Toll-Like Receptors / metabolism
TL;DR:
This work reviews mechanotransduction in immunologically important diseases and how physical characteristics of tissues regulate immune cell function, with a specific emphasis on mechanoregulation of macrophages and TLR signaling.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, ORCID
Added: January 29, 2020
2018 journal article
Toll-like receptor signaling in macrophages is regulated by extracellular substrate stiffness and Rho-associated coiled-coil kinase (ROCK1/2)
International Immunology, 30(6), 267–278.
author keywords: cell signaling; inflammation; innate immunity; mechanosignaling; mechanotransduction
MeSH headings : Acrylic Resins / pharmacology; Animals; Cell Survival / drug effects; Macrophages / enzymology; Macrophages / immunology; Macrophages / metabolism; Mechanotransduction, Cellular / immunology; Mice; RAW 264.7 Cells; Signal Transduction / immunology; Toll-Like Receptors / immunology; Toll-Like Receptors / metabolism; Tumor Necrosis Factor-alpha / immunology; Tumor Necrosis Factor-alpha / metabolism; rho-Associated Kinases / antagonists & inhibitors; rho-Associated Kinases / metabolism
TL;DR:
The data indicate that physical cues from the extracellular environment regulate macrophage morphology and TLR signaling, which have important implications in the regulation of macrophages function in diseased tissues and offer a novel pharmacological target for the manipulation ofmacrophage function in vivo.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: September 1, 2019
2017 journal article
Evaluation of procoagulant tissue factor expression in canine hemangiosarcoma cell lines
American Journal of Veterinary Research, 78(1), 69–79.
MeSH headings : Animals; Biomarkers / metabolism; Brain Neoplasms / pathology; Brain Neoplasms / veterinary; Cell Line, Tumor; Dog Diseases / pathology; Dogs; Flow Cytometry / veterinary; Hemangiosarcoma / pathology; Hemangiosarcoma / veterinary; Mice; RNA, Messenger / chemistry; Real-Time Polymerase Chain Reaction / veterinary; Skin Neoplasms / pathology; Skin Neoplasms / veterinary; Splenic Neoplasms / pathology; Splenic Neoplasms / veterinary; Thromboplastin / metabolism
TL;DR:
Hemangiosarcoma cell lines expressed procoagulant TF in vitro, with significantly greater expression of both products in SB-HSA and Emma cells than in CnAoEC, and further research is needed to determine whether TF can be used as a biomarker for hemostatic dysfunction in dogs with hemangiosARcoma.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: September 1, 2019
2016 journal article
Role of tissue factor expression in thrombin generation by canine tumor cells
American Journal of Veterinary Research, 77(4), 404–412.
MeSH headings : Animals; Blood Coagulation Factors / metabolism; Cell Line, Tumor / metabolism; Dog Diseases / pathology; Dogs; Female; Male; Mammary Glands, Animal / cytology; Mammary Neoplasms, Animal / pathology; Osteosarcoma / pathology; Osteosarcoma / veterinary; Thrombin / metabolism; Thromboplastin / metabolism
TL;DR:
A role for TF in hypercoagulability detected in dogs with mammary gland tumors and potentially for other tumors that strongly express TF is supported, supported by findings of high TF-expressing canine mammary cancer cells generation in a plasma milieu in vitro in a factor VII- and phosphatidylserine-dependent manner.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, ORCID
Added: September 1, 2019
2016 journal article
TLR9 stability and signaling are regulated by phosphorylation and cell stress
Journal of Leukocyte Biology, 100(3), 525–533.
author keywords: CpG DNA; innate immunity; inflammation; autophagy
MeSH headings : Animals; Endoplasmic Reticulum Stress; Mice; Mice, Knockout; Phosphorylation; Protein Processing, Post-Translational; Protein Stability; Proteolysis; Signal Transduction; Toll-Like Receptor 9 / chemistry; Toll-Like Receptor 9 / physiology; Tyrosine / metabolism
TL;DR:
It is demonstrated that tyrosine phosphorylation is essential for mouse Toll‐like receptor‐9 protein stability and signaling and suggested that immune evasion mechanisms may involve targeted loss of innate sensing receptors.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: September 1, 2019
2004 journal article
Short upstream region drives dynamic expression of hypoxia-inducible factor 1α during Xenopus development
Developmental Dynamics, 230(2), 229–238.
author keywords: HIF-1 alpha; hypoxia; Xenopus; transgenesis; promoter; A6 cell line
MeSH headings : Alleles; Animals; Animals, Genetically Modified; Base Sequence; Cell Hypoxia / genetics; Cell Hypoxia / physiology; Cloning, Molecular; Conserved Sequence / genetics; Embryo, Nonmammalian / cytology; Embryo, Nonmammalian / embryology; Embryo, Nonmammalian / metabolism; Gene Expression Regulation, Developmental; Genes, Reporter / genetics; Green Fluorescent Proteins / analysis; Green Fluorescent Proteins / genetics; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Molecular Sequence Data; Promoter Regions, Genetic / genetics; RNA, Messenger / genetics; RNA, Messenger / metabolism; Sequence Analysis, DNA; Transcription Factors / genetics; Transcription, Genetic / genetics; Xenopus laevis / embryology; Xenopus laevis / genetics; Xenopus laevis / metabolism
Sources: Crossref, ORCID
Added: September 1, 2019
Employment
Updated: March 30th, 2019 17:55
2018 - present
North Carolina State University Raleigh, NC, US
Assistant Professor
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