Works (39)

Updated: September 15th, 2023 05:00

2023 journal article

A myristoylated alanine-rich C-kinase substrate (MARCKS) inhibitor peptide attenuates neutrophil outside-in & beta;(2)-integrin activation and signaling

A myristoylated alanine-rich C-kinase substrate (MARCKS) inhibitor peptide attenuates neutrophil outside-in & beta;(2)-integrin activation and signaling. CELL ADHESION & MIGRATION, 17(1), 1–16.

By: H. Conley n, R. Till n, A. Berglund n, S. Jones n & M. Sheats n

author keywords: Beta2-integrin; ICAM-1; MARCKS; neutrophils; outside-in; >
MeSH headings : Alanine; CD18 Antigens / metabolism; Neutrophils; Peptides / pharmacology; Signal Transduction; Myristoylated Alanine-Rich C Kinase Substrate / antagonists & inhibitors
Sources: ORCID, Web Of Science
Added: July 13, 2023

2023 review

Asthma: The Use of Animal Models and Their Translational Utility

[Review of ]. CELLS, 12(7).

author keywords: asthma; animal model; inflammation
MeSH headings : Humans; Mice; Rats; Animals; Guinea Pigs; Sheep; Horses; Dogs; Disease Models, Animal; Asthma / drug therapy; Proteins; Inflammation
Sources: ORCID, Web Of Science
Added: April 6, 2023

2023 journal article

Initial investigation of molecular phenotypes of airway mast cells and cytokine profiles in equine asthma

FRONTIERS IN VETERINARY SCIENCE, 9.

By: J. Woodrow*, M. Hines, C. Sommardahl, B. Flatland, Y. Lo, Z. Wang, M. Sheats*, E. Lennon

author keywords: equine; asthma; mast cell; cytokine; chemokine; airway
Sources: Web Of Science, ORCID
Added: February 13, 2023

2023 journal article

Investigation of a Questionnaire Used to Measure Self-Perception of Self-Regulated Learning in Veterinary Students

Journal of Veterinary Medical Education.

Source: ORCID
Added: September 14, 2023

2023 journal article

Investigation of a questionnaire used to measure self-perception of self-regulated learning in veterinary students

Journal of Veterinary Medical Education.

By: M. Sheats, O. Petritz & J. Robertson

Source: ORCID
Added: June 27, 2023

2023 journal article

Legacy and emerging per- and polyfluoroalkyl substances suppress the neutrophil respiratory burst

JOURNAL OF IMMUNOTOXICOLOGY, 20(1).

By: D. Phelps*, A. Palekar, H. Conley*, G. Ferrero, J. Driggers*, K. Linder*, S. Kullman n, D. Reif n ...

author keywords: Innate immunity; neutrophils; per- and polyfluoroalkyl substances (PFAS); reactive oxygen species; zebrafish
MeSH headings : Animals; Humans; Zebrafish; Neutrophils; Reactive Oxygen Species; Respiratory Burst; Fluorocarbons / toxicity; Alkanesulfonic Acids / toxicity; Environmental Pollutants
Sources: ORCID, Web Of Science
Added: February 15, 2023

2023 review

Targeting Neutrophil beta(2)-Integrins: A Review of Relevant Resources, Tools, and Methods

[Review of ]. BIOMOLECULES, 13(6).

author keywords: neutrophils; beta(2)-integrins; CD18; CD11; ICAM-1; innate immune cells
MeSH headings : Humans; Neutrophils / metabolism; CD18 Antigens / metabolism; Inflammation / metabolism; Signal Transduction / physiology; Cell Adhesion / physiology
Sources: ORCID, Web Of Science
Added: May 28, 2023

2022 article

Investigation of plasma cell-free DNA as a potential biomarker in horses

Bayless, R. L., Cooper, B. L., & Sheats, M. K. (2022, February 15). JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION, Vol. 2.

author keywords: biomarker; cell-free DNA; cfDNA; colic; equine; gastrointestinal
MeSH headings : Animals; Biomarkers; Cell-Free Nucleic Acids; Colic / diagnosis; Colic / veterinary; DNA; Horse Diseases / diagnosis; Horses; Humans; Plasma
Sources: Web Of Science, ORCID
Added: March 7, 2022

2022 journal article

Withaferin A Inhibits Neutrophil Adhesion, Migration, and Respiratory Burst and Promotes Timely Neutrophil Apoptosis

FRONTIERS IN VETERINARY SCIENCE, 9.

By: R. Bayless n, R. Bayless, M. Sheats n & S. Jones n

Ed(s): R. Bayless n

author keywords: neutrophil (PMN); Withaferin A (PubChem CID; 265237); equine; inflammation; phytochemical; veterinary medicine; novel therapeutic
Sources: Web Of Science, ORCID
Added: July 11, 2022

2021 journal article

Development and Formative Evaluation of a Low-Fidelity Equine Castration Model for Veterinary Education

FRONTIERS IN VETERINARY SCIENCE, 8.

By: M. Sheats n, M. Burke n, J. Robertson n, K. Fiebrandt n & C. Fogle n

author keywords: competency; veterinary education; veterinary simulators; surgical simulation and training; model development and evaluation; equine castration model; horse castration model
Sources: Web Of Science, ORCID
Added: October 12, 2021

2021 journal article

Differential gene expression and Ingenuity Pathway Analysis of bronchoalveolar lavage cells from horses with mild/moderate neutrophilic or mastocytic inflammation on BAL cytology

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 234.

author keywords: Equine asthma syndrome; Heaves; Inflammatory airway disease; Recurrent airway obstruction; Asthma phenotype; Gene expression; RNA-seq; BAL
MeSH headings : Animals; Bronchoalveolar Lavage / veterinary; Bronchoalveolar Lavage Fluid / cytology; Bronchoalveolar Lavage Fluid / immunology; Cytokines / genetics; Cytokines / immunology; Cytological Techniques; Female; Gene Expression; Horses / genetics; Inflammation / pathology; Inflammation / veterinary; Male; Mast Cells / immunology; Mast Cells / pathology; Metabolic Networks and Pathways / genetics; Metabolic Networks and Pathways / immunology; Neutrophils / immunology; Qualitative Research
Sources: ORCID, Web Of Science
Added: February 5, 2021

2021 journal article

Sulfate Import in Salmonella Typhimurium Impacts Bacterial Aggregation and the Respiratory Burst in Human Neutrophils

INFECTION AND IMMUNITY, 89(6).

By: T. Westerman n, M. Sheats n & J. Elfenbein n

author keywords: Salmonella; cysteine metabolism; flagellar motility; neutrophils; respiratory burst
MeSH headings : Cysteine / metabolism; Flagella / physiology; Genes, Bacterial; Host-Pathogen Interactions / immunology; Humans; Mutation; Neutrophils / immunology; Neutrophils / metabolism; Respiratory Burst / immunology; Salmonella Infections / immunology; Salmonella Infections / microbiology; Salmonella typhimurium / physiology; Sulfates / metabolism; Type III Secretion Systems / genetics; Type III Secretion Systems / metabolism
Sources: Web Of Science, ORCID
Added: June 10, 2021

2021 journal article

The Role of Neutrophils in the Pathophysiology of Asthma in Humans and Horses

Inflammation, 44(2), 450–465.

author keywords: asthma; neutrophils; noneosinophilic asthma; equine asthma syndrome; nonallergic asthma; horses
MeSH headings : Animals; Asthma / immunology; Asthma / metabolism; Asthma / physiopathology; Asthma / veterinary; Biomarkers / metabolism; Eosinophils / immunology; Eosinophils / metabolism; Horse Diseases / immunology; Horse Diseases / metabolism; Horse Diseases / physiopathology; Horses; Humans; Neutrophils / immunology; Neutrophils / metabolism; Phenotype; Severity of Illness Index
Source: ORCID
Added: November 5, 2020

2020 article

Multidimensional Analysis of Bronchoalveolar Lavage Cytokines and Mast Cell Proteases Reveals Interferon-γ as a Key Biomarker in Equine Asthma Syndrome

Woodrow, J. S., Hines, M., Sommardahl, C., Flatland, B., Davis, K. U., Lo, Y., … Lennon, E. M. (2020, February 25). (Vol. 2). Vol. 2.

By: J. Woodrow*, M. Hines*, C. Sommardahl*, B. Flatland*, K. Davis n, Y. Lo*, Z. Wang*, M. Sheats n, E. Lennon*

Source: ORCID
Added: February 26, 2020

2019 review

A Comparative Review of Equine SIRS, Sepsis, and Neutrophils

[Review of ]. FRONTIERS IN VETERINARY SCIENCE, 6.

author keywords: sepsis; systemic inflammatory response; neutrophil; endotoxemia; organ dysfunction
Sources: Web Of Science, ORCID
Added: May 28, 2019

2019 journal article

A Suspected Case of Rocky Mountain Spotted Fever in an Adult Horse in the Southeastern United States

JOURNAL OF EQUINE VETERINARY SCIENCE, 78, 134–137.

author keywords: Equine; Tick-borne disease; Rocky Mountain Spotted Fever; Lethargy; Fever; Rickettsia rickettsii
MeSH headings : Animals; Doxycycline / therapeutic use; Horse Diseases / diagnosis; Horse Diseases / drug therapy; Horses; Humans; Male; Rickettsia; Rickettsia rickettsii; Rocky Mountain Spotted Fever / diagnosis; Rocky Mountain Spotted Fever / drug therapy; Rocky Mountain Spotted Fever / veterinary; Southeastern United States
Sources: Web Of Science, ORCID
Added: July 1, 2019

2019 journal article

Bronchoalveolar Lavage Cytology Characteristics and Seasonal Changes in a Herd of Pastured Teaching Horses

FRONTIERS IN VETERINARY SCIENCE, 6.

By: K. Davis n & M. Sheats n

author keywords: equine asthma syndrome; heaves; inflammatory airway disease; recurrent airway obstruction; asthma phenotype; round bale hay
Sources: Web Of Science, ORCID
Added: May 28, 2019

2019 journal article

Comparative Review of Asthma in Farmers and Horses

Current Allergy and Asthma Reports, 19(11).

author keywords: Equine asthma syndrome; Occupational asthma; Organic dust; Innate immunity, neutrophilic asthma; Bronchitis
MeSH headings : Animals; Asthma / genetics; Asthma / immunology; Asthma / pathology; Asthma / veterinary; Environmental Exposure; Farmers; Horse Diseases / genetics; Horse Diseases / immunology; Horse Diseases / pathology; Horses; Humans
Source: ORCID
Added: October 11, 2019

2019 review

MARCKS and Lung Disease

[Review of ]. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 60(1), 16–27.

By: M. Sheats*, Q. Yin n, S. Fang n, J. Park n, A. Crews n, I. Parikh*, B. Dickson*, K. Adler n

author keywords: MARCKS; lung disease; inflammation; cancer
MeSH headings : Animals; Humans; Lung Diseases / metabolism; Lung Diseases / physiopathology; Myristoylated Alanine-Rich C Kinase Substrate / metabolism
Sources: Web Of Science, ORCID
Added: January 14, 2019

2018 journal article

Analysis of Final Year Veterinary Students’ Telephone Communication Skills at a Veterinary Teaching Hospital

Veterinary Sciences, 5(4), 99.

By: M. Sheats n, S. Hammond n & A. Kedrowicz n

author keywords: telephone communication; clinical communication; relationship centered care; veterinary education; telephone medicine; relationship-centered care; veterinarian-client-patient communication; communication research methods
Sources: ORCID, Crossref
Added: February 11, 2019

2018 journal article

Readability Evaluations of Veterinary Client Handouts and Implications for Patient Care

TOPICS IN COMPANION ANIMAL MEDICINE, 33(2), 58–61.

author keywords: assessment; clinical science; communications; diversity; practice/business management; public health
MeSH headings : Animals; Health Literacy / standards; Humans; Patient Care / methods; Patient Care / veterinary; Patient Education as Topic / methods; Patient Education as Topic / standards; Reading; Veterinary Medicine / methods
Sources: Web Of Science, ORCID
Added: October 16, 2018

2018 journal article

The Salmonella type-3 secretion system-1 and flagellar motility influence the neutrophil respiratory burst

PLOS ONE, 13(9).

MeSH headings : Fimbriae, Bacterial / physiology; Genotype; Granulocyte-Macrophage Colony-Stimulating Factor / pharmacology; Humans; Interleukin-8 / pharmacology; Neutrophils / cytology; Neutrophils / metabolism; Neutrophils / microbiology; Reactive Oxygen Species / metabolism; Respiratory Burst / drug effects; Salmonella / genetics; Salmonella / metabolism; Type III Secretion Systems / drug effects; Type III Secretion Systems / metabolism
Sources: Web Of Science, ORCID
Added: October 16, 2018

2018 journal article

Using readability software to enhance the health literacy of equine veterinary clients: An analysis of 17 American Association of Equine Practitioners’ newsletter and website articles

Equine Veterinary Journal, 51(4), 552–555.

By: M. Sheats n, K. Royal n & A. Kedrowicz n

author keywords: horse; literacy; horse owner; client education; readability; medical writing
MeSH headings : Animals; Comprehension; Health Literacy; Horses; Humans; Ownership; Publications; Societies, Scientific; Software; Veterinary Medicine
Sources: ORCID, Crossref
Added: February 11, 2019

2017 conference paper

Identification of Salmonella Typhimurium genes essential to induce the neutrophil oxidative burst

Poster presented at the Mid-Atlantic Microbial Pathogenesis Meeting, Nellysford, Virginia.

By: T. Westerman, M. Sheats, S. Jones & J. Elfenbein

Event: Mid-Atlantic Microbial Pathogenesis Meeting at Nellysford, Virginia on February 12-14, 2017

Source: NC State University Libraries
Added: September 8, 2019

2017 speech

Investigating the MARCKS protein as a novel therapeutic target for the treatment of equine asthma

Poster presented at the Merial National Veterinary Research Scholars Symposium, National Institutes of Health, Bethesa, MD.

By: A. Bowyer, K. Davis & M. Sheats

Event: Merial National Veterinary Research Scholars Symposium at National Institutes of Health, Bethesa, MD

Source: NC State University Libraries
Added: August 30, 2019

2017 journal article

Misoprostol Inhibits Equine Neutrophil Adhesion, Migration, and Respiratory Burst in an In Vitro Model of Inflammation

Frontiers in Veterinary Science, 4.

By: E. Martin n, R. Till n, M. Sheats n & S. Jones n

author keywords: horse; leukocyte; chemotaxis; reactive oxygen species; inflammation; anti-inflammatory; NSAID
Sources: Crossref, ORCID
Added: July 20, 2019

2017 journal article

Misoprostol Inhibits Lipopolysaccharide-Induced Pro-inflammatory Cytokine Production by Equine Leukocytes

Frontiers in Veterinary Science, 4.

By: E. Martin n, K. Messenger n, M. Sheats n & S. Jones n

author keywords: horse; leukocyte; chemokine; inflammation; anti-inflammatory; non-steroidal anti-inflammatory drug
Sources: Crossref, ORCID
Added: July 20, 2019

2016 speech

A high-throughput in vitro system to study Salmonella-neutrophil interactions

Poster presented at the 5th ASM Conference on Salmonella, Potsdam, Germany.

By: T. Westerman, M. Sheats, S. Jones & J. Elfenbein

Event: 5th ASM Conference on Salmonella at Potsdam, Germany on August 29 - September 1, 2016

Source: NC State University Libraries
Added: September 8, 2019

2016 speech

Development of a Capstone Assessment Instrument for Evaluation of Fourth Year Veterinary Student History and Examination Skills

Presented at the Veterinary Educators Collaborative, University of Calgary, Alberta, Canada.

By: C. Fogle & M. Sheats

Event: Veterinary Educators Collaborative at University of Calgary, Alberta, Canada on June 20-21, 2016

Source: NC State University Libraries
Added: September 8, 2019

2016 conference paper

Development of a neutrophil-Salmonella co-culture system to study Salmonella genes that alter the neutrophil respiratory burst

Oral presentation presented at the Duke Innate Immunity Group Symposium, Durham, North Carolina.

By: T. Westerman, M. Sheats, S. Jones & J. Elfenbein

Event: Duke Innate Immunity Group Symposium at Durham, North Carolina on June 17, 2016

Source: NC State University Libraries
Added: September 8, 2019

2016 speech

MARCKS protein as a therapeutic target in the treatment of recurrent airway obstruction in horses

Poster presented at the Merial National Veterinary Research Scholars Symposium, The Ohio State University, Columbus, Ohio.

By: C. Johnson & M. Sheats

Event: Merial National Veterinary Research Scholars Symposium at The Ohio State University, Columbus, Ohio on July 28-31, 2016

Source: NC State University Libraries
Added: September 8, 2019

2016 speech

Student Perspectives on a Newly Implemented Community-Based Model of Clinical Training in Equine Primary Care: “What’s Workings and What Could be Better?

Presented at the Scholarship of Teaching and Learning Symposium, NC State University, Raleigh, NC.

By: M. Sheats & C. Fogle

Event: Scholarship of Teaching and Learning Symposium at NC State University, Raleigh, NC on June 20-21, 2016

Source: NC State University Libraries
Added: September 8, 2019

2014 journal article

In Vitro Neutrophil Migration Requires Protein Kinase C-Delta (δ-PKC)-Mediated Myristoylated Alanine-Rich C-Kinase Substrate (MARCKS) Phosphorylation

Inflammation, 38(3), 1126–1141.

By: M. Sheats n, E. Sung n, K. Adler n, S. Jones n & Inflammation

author keywords: neutrophil; chemotaxis; adhesion; migration; innate immunity; PKC signaling
MeSH headings : Acetophenones / pharmacology; Benzopyrans / pharmacology; Cell Adhesion / immunology; Cell Movement; Cells, Cultured; Enzyme Inhibitors / pharmacology; Humans; Inflammation / immunology; Intracellular Signaling Peptides and Proteins / metabolism; Membrane Proteins / metabolism; Myristoylated Alanine-Rich C Kinase Substrate; N-Formylmethionine Leucyl-Phenylalanine / metabolism; Neutrophil Activation / immunology; Neutrophil Infiltration / immunology; Neutrophils / immunology; Phosphorylation; Protein Isoforms / antagonists & inhibitors; Protein Isoforms / metabolism; Protein Kinase C-delta / antagonists & inhibitors; Protein Kinase C-delta / metabolism
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2014 journal article

Myristoylated Alanine Rich C Kinase Substrate (MARCKS) is essential to β2-integrin dependent responses of equine neutrophils

Veterinary Immunology and Immunopathology, 160(3-4), 167–176.

By: M. Sheats*, K. Pescosolido, E. Hefner*, E. Sung, K. Adler* & S. Jones*

author keywords: Neutrophil; Migration; Adhesion; Respiratory burst; Beta2-integrin; Inflammation
MeSH headings : Amino Acid Sequence; Animals; Antigen-Antibody Complex / physiology; CD18 Antigens / immunology; CD18 Antigens / physiology; Cell Adhesion / drug effects; Cell Adhesion / physiology; Cell Movement / drug effects; Cell Movement / physiology; Conserved Sequence; Horses / immunology; Horses / physiology; In Vitro Techniques; Intracellular Signaling Peptides and Proteins / antagonists & inhibitors; Intracellular Signaling Peptides and Proteins / genetics; Intracellular Signaling Peptides and Proteins / physiology; Membrane Proteins / antagonists & inhibitors; Membrane Proteins / genetics; Membrane Proteins / physiology; Molecular Sequence Data; Myristoylated Alanine-Rich C Kinase Substrate; Neutrophil Infiltration / drug effects; Neutrophil Infiltration / immunology; Neutrophil Infiltration / physiology; Peptide Fragments / genetics; Peptide Fragments / pharmacology; Respiratory Burst / drug effects; Sequence Homology, Amino Acid; Tetradecanoylphorbol Acetate / pharmacology
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2013 journal article

Fibroblast Migration Is Regulated by Myristoylated Alanine-Rich C-Kinase Substrate (MARCKS) Protein

PLOS ONE, 8(6).

By: L. Ott n, E. Sung n, A. Melvin n, M. Sheats n, J. Haugh n, K. Adler n, S. Jones n

Ed(s): P. Aspenstrom

MeSH headings : 3T3 Cells; Animals; Becaplermin; Chemotaxis / drug effects; Chemotaxis / physiology; Collagen / metabolism; Fibroblasts / cytology; Fibronectins / metabolism; Intracellular Signaling Peptides and Proteins / metabolism; Intracellular Signaling Peptides and Proteins / physiology; Membrane Proteins / metabolism; Membrane Proteins / physiology; Mice; Myristoylated Alanine-Rich C Kinase Substrate; Phosphorylation; Proto-Oncogene Proteins c-akt / metabolism; Proto-Oncogene Proteins c-sis / pharmacology
Sources: Web Of Science, ORCID
Added: August 6, 2018

2009 journal article

Outbreak of Lawsonia intracellularis on a Standardbred breeding farm in North Carolina

EQUINE VETERINARY EDUCATION, 21(4), 179–182.

By: J. Merlo n, M. Sheats n, Y. Elce n, S. Hunter n & B. Breuhaus n

author keywords: horse; enteropathy; colic; small intestine
Sources: Web Of Science, ORCID
Added: August 6, 2018

2009 journal article

Use of ultrasound to evaluate outcome following colic surgery for equine large colon volvulus

Equine Veterinary Journal, 42(1), 47–52.

By: M. Sheats*, V. Cook n, S. Jones n, A. Blikslager n & A. Pease n

author keywords: horse; colic; large colon volvulus; ultrasound; multiple organ dysfunction syndrome; oedema
MeSH headings : Animals; Colic / diagnostic imaging; Colic / surgery; Colic / veterinary; Colonic Diseases / diagnostic imaging; Colonic Diseases / surgery; Colonic Diseases / veterinary; Female; Horse Diseases / diagnostic imaging; Horse Diseases / surgery; Horses; Intestinal Volvulus / diagnostic imaging; Intestinal Volvulus / surgery; Intestinal Volvulus / veterinary; Male; Treatment Outcome; Ultrasonography
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2008 journal article

Disseminated large granular lymphoma in a horse

EQUINE VETERINARY EDUCATION, 20(9), 459–463.

By: M. Sheats n, A. Wetter n, L. Snyder n & S. Jones n

author keywords: horse; lymphoma; weight loss; diarrhoea; T lymphocytes
Sources: Web Of Science, ORCID
Added: August 6, 2018

2004 journal article

Pharmacokinetics and Pharmacodynamics of Furosemide after Oral Administration to Horses

Journal of Veterinary Internal Medicine, 18(5), 739–743.

By: A. Johansson n, S. Gardner n, J. Levine n, M. Papich n, D. LaFevers n, R. Goldman n, M. Sheets n, C. Atkins n

Sources: Crossref, ORCID
Added: July 28, 2019

Employment

Updated: June 26th, 2023 08:35

2014 - present

NC State University Raleigh, NC, US
Associate Professor Clinical Sciences

Education

Updated: July 13th, 2023 07:11

2019 - 2020

Royal Veterinary College London, GB
Fellow Higher Education Academy

2009 - 2014

North Carolina State University Raleigh, NC, US
PhD, Comparative Biomedical Science

2001 - 2005

North Carolina State University Raleigh, NC, US
Doctor of Veterinary Medicine

1998 - 2000

North Carolina State University Raleigh, NC, US
BS, Animal Science