Mary Katherine Sheats
Also known as: Katie
Works (40)
Updated: April 4th, 2024 09:20
2024 journal article
MARCKS Inhibition Alters Bovine Neutrophil Responses to <i>Salmonella</i> Typhimurium
BIOMEDICINES, 12(2).
author keywords: neutrophils; Salmonella; MARCKS; respiratory burst; migration; phagocytosis
TL;DR:
This study demonstrates that MARCKS inhibition attenuated STm-induced neutrophil adhesion and chemotaxis and enhanced neutrophil phagocytosis and respiratory burst in response to STm, the first report describing the role of MARCKS protein in neutrophil antibacterial responses.
(via Semantic Scholar)
www.mdpi.com (publisher PDF)
Sources: ORCID, Web Of Science
Added: February 22, 2024
2023 journal article
A myristoylated alanine-rich C-kinase substrate (MARCKS) inhibitor peptide attenuates neutrophil outside-in & beta;(2)-integrin activation and signaling
A myristoylated alanine-rich C-kinase substrate (MARCKS) inhibitor peptide attenuates neutrophil outside-in & beta;(2)-integrin activation and signaling. CELL ADHESION & MIGRATION, 17(1), 1–16.
author keywords: Beta2-integrin; ICAM-1; MARCKS; neutrophils; outside-in; >
MeSH headings : Alanine; CD18 Antigens / metabolism; Neutrophils; Peptides / pharmacology; Signal Transduction; Myristoylated Alanine-Rich C Kinase Substrate / antagonists & inhibitors
TL;DR:
MANS treatment significantly attenuated ICAM-1/Mn2+-stimulated static adhesion, cell spreading andβ2-integrin clustering, suggesting a role for MARCKS function in outside-in β2-Integrin activation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science
Added: July 13, 2023
2023 review
Asthma: The Use of Animal Models and Their Translational Utility
[Review of ]. CELLS, 12(7).
author keywords: asthma; animal model; inflammation
MeSH headings : Humans; Mice; Rats; Animals; Guinea Pigs; Sheep; Horses; Dogs; Disease Models, Animal; Asthma / drug therapy; Proteins; Inflammation
TL;DR:
This review aims to discuss the animal models most available for asthma investigation, with an emphasis on describing the inciting antigen/allergen, inflammatory response induced, and its translation to human asthma.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science
Added: April 6, 2023
2023 journal article
Initial investigation of molecular phenotypes of airway mast cells and cytokine profiles in equine asthma
FRONTIERS IN VETERINARY SCIENCE, 9.
author keywords: equine; asthma; mast cell; cytokine; chemokine; airway
TL;DR:
Comparisons of mast cell protease mRNA expression between healthy and asthmatic horses and the cytokine profile present in BALF of currently defined equine asthma groups are analyzed to use these data to evaluate potential biomarkers of defined asthma groups.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, ORCID
Added: February 13, 2023
2023 article
Investigation of a Questionnaire Used to Measure Self-Perception of Self-Regulated Learning in Veterinary Students
Sheats, M. K., Petritz, O. A., & Robertson, J. B. (2023, September 13). JOURNAL OF VETERINARY MEDICAL EDUCATION, Vol. 9.
author keywords: lifelong learning; self-regulated learner; student motivation; reflection; professionalism; mentoring; remediation
TL;DR:
The Self-Regulated Learning Perception Scale (SRLPS) is a 41-item instrument that has been previously validated in other graduate student populations, including medical students and could have broad applications in veterinary educational practices and research, including assessing impact of courses on professional development and/or coaching/mentoring programs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
4. Quality Education
(Web of Science)
Sources: ORCID, Web Of Science
Added: September 14, 2023
2023 journal article
Investigation of a questionnaire used to measure self-perception of self-regulated learning in veterinary students
Journal of Veterinary Medical Education.
Contributors: M. Sheats, O. Petritz & J. Robertson
Source: ORCID
Added: June 27, 2023
2023 journal article
Legacy and emerging per- and polyfluoroalkyl substances suppress the neutrophil respiratory burst
JOURNAL OF IMMUNOTOXICOLOGY, 20(1).
author keywords: Innate immunity; neutrophils; per- and polyfluoroalkyl substances (PFAS); reactive oxygen species; zebrafish
MeSH headings : Animals; Humans; Zebrafish; Neutrophils; Reactive Oxygen Species; Respiratory Burst; Fluorocarbons / toxicity; Alkanesulfonic Acids / toxicity; Environmental Pollutants
TL;DR:
This report is the first to demonstrate that these PFASs suppress neutrophil function and support the utility of employing zebrafish larvae and a human cell line as screening tools to identify chemicals that may suppress human immune function.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Sources: ORCID, Web Of Science
Added: February 15, 2023
2023 review
Targeting Neutrophil beta(2)-Integrins: A Review of Relevant Resources, Tools, and Methods
[Review of ]. BIOMOLECULES, 13(6).
author keywords: neutrophils; beta(2)-integrins; CD18; CD11; ICAM-1; innate immune cells
MeSH headings : Humans; Neutrophils / metabolism; CD18 Antigens / metabolism; Inflammation / metabolism; Signal Transduction / physiology; Cell Adhesion / physiology
TL;DR:
A detailed review of resources, tools, experimental methods, and in vivo models that have been and will continue to be utilized to investigate the vitally important cell surface receptors, neutrophil β2-integrins are provided.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science
Added: May 28, 2023
2022 article
Investigation of plasma cell-free DNA as a potential biomarker in horses
Bayless, R. L., Cooper, B. L., & Sheats, M. K. (2022, February 15). JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION, Vol. 2.
author keywords: biomarker; cell-free DNA; cfDNA; colic; equine; gastrointestinal
MeSH headings : Animals; Biomarkers; Cell-Free Nucleic Acids; Colic / diagnosis; Colic / veterinary; DNA; Horse Diseases / diagnosis; Horses; Humans; Plasma
TL;DR:
The results with extracted-plasma samples provide proof of concept for further investigation of plasma cfDNA as a biomarker in horses and accuracy in neat equine plasma using a benchtop fluorometer.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: March 7, 2022
2022 journal article
Withaferin A Inhibits Neutrophil Adhesion, Migration, and Respiratory Burst and Promotes Timely Neutrophil Apoptosis
FRONTIERS IN VETERINARY SCIENCE, 9.
Contributors: R. Bayless n , R. Bayless, R. Bayless, R. Bayless, R. Bayless, R. Bayless, R. Bayless
Ed(s): R. Bayless n
author keywords: neutrophil (PMN); Withaferin A (PubChem CID; 265237); equine; inflammation; phytochemical; veterinary medicine; novel therapeutic
TL;DR:
The data demonstrate that WFA may reduce neutrophil-mediated inflammation through multiple mechanisms, including suppression of inflammatory responses and promotion of apoptosis, and additional research is needed to elucidate the molecular mechanisms for these effects.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: July 11, 2022
2021 journal article
Development and Formative Evaluation of a Low-Fidelity Equine Castration Model for Veterinary Education
FRONTIERS IN VETERINARY SCIENCE, 8.
author keywords: competency; veterinary education; veterinary simulators; surgical simulation and training; model development and evaluation; equine castration model; horse castration model
TL;DR:
This work developed an inexpensive, low-fidelity model of equine field castration and evaluated it using a mixed-methods approach, suggesting that both students and veterinary educators feel that this low- fidelity model has educational value.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
4. Quality Education
(Web of Science)
Sources: Web Of Science, ORCID
Added: October 12, 2021
2021 journal article
Differential gene expression and Ingenuity Pathway Analysis of bronchoalveolar lavage cells from horses with mild/moderate neutrophilic or mastocytic inflammation on BAL cytology
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 234.
author keywords: Equine asthma syndrome; Heaves; Inflammatory airway disease; Recurrent airway obstruction; Asthma phenotype; Gene expression; RNA-seq; BAL
MeSH headings : Animals; Bronchoalveolar Lavage / veterinary; Bronchoalveolar Lavage Fluid / cytology; Bronchoalveolar Lavage Fluid / immunology; Cytokines / genetics; Cytokines / immunology; Cytological Techniques; Female; Gene Expression; Horses / genetics; Inflammation / pathology; Inflammation / veterinary; Male; Mast Cells / immunology; Mast Cells / pathology; Metabolic Networks and Pathways / genetics; Metabolic Networks and Pathways / immunology; Neutrophils / immunology; Qualitative Research
TL;DR:
Upregulation of mRNA transcripts involved in the IL-1 family cytokine signaling axis (IL1a, IL1b, and IL1R2) in neutrophilic mEAS, as well as KIT mRNA in mastocytic mEas, are novel, potentially clinically relevant, findings of this study.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science
Added: February 5, 2021
2021 journal article
Sulfate Import in Salmonella Typhimurium Impacts Bacterial Aggregation and the Respiratory Burst in Human Neutrophils
INFECTION AND IMMUNITY, 89(6).
author keywords: Salmonella; cysteine metabolism; flagellar motility; neutrophils; respiratory burst
MeSH headings : Cysteine / metabolism; Flagella / physiology; Genes, Bacterial; Host-Pathogen Interactions / immunology; Humans; Mutation; Neutrophils / immunology; Neutrophils / metabolism; Respiratory Burst / immunology; Salmonella Infections / immunology; Salmonella Infections / microbiology; Salmonella typhimurium / physiology; Sulfates / metabolism; Type III Secretion Systems / genetics; Type III Secretion Systems / metabolism
TL;DR:
It is demonstrated that Salmonella Typhimurium has numerous mechanisms to limit the magnitude of the neutrophil respiratory burst, and this data further inform the understanding of howSalmonella may alter human neutrophIL antimicrobial defenses.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: June 10, 2021
2021 journal article
The Role of Neutrophils in the Pathophysiology of Asthma in Humans and Horses
Inflammation, 44(2), 450–465.
author keywords: asthma; neutrophils; noneosinophilic asthma; equine asthma syndrome; nonallergic asthma; horses
MeSH headings : Animals; Asthma / immunology; Asthma / metabolism; Asthma / physiopathology; Asthma / veterinary; Biomarkers / metabolism; Eosinophils / immunology; Eosinophils / metabolism; Horse Diseases / immunology; Horse Diseases / metabolism; Horse Diseases / physiopathology; Horses; Humans; Neutrophils / immunology; Neutrophils / metabolism; Phenotype; Severity of Illness Index
TL;DR:
A comparative review examines the recent literature in order to explore the role of neutrophil inflammatory functions in the pathophysiology and immunology of asthma in humans and horses.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Source: ORCID
Added: November 5, 2020
2020 article
Multidimensional Analysis of Bronchoalveolar Lavage Cytokines and Mast Cell Proteases Reveals Interferon-γ as a Key Biomarker in Equine Asthma Syndrome
Woodrow, J. S., Hines, M., Sommardahl, C., Flatland, B., Davis, K. U., Lo, Y., … Lennon, E. M. (2020, February 25). (Vol. 2). Vol. 2.
TL;DR:
Multidimensional analysis demonstrated that IFNγ differentiates severe from moderate asthma, and that TNFα and CXCL8 are key biomarkers of equine asthma subtype.
(via Semantic Scholar)
Source: ORCID
Added: February 26, 2020
2019 review
A Comparative Review of Equine SIRS, Sepsis, and Neutrophils
[Review of ]. FRONTIERS IN VETERINARY SCIENCE, 6.
author keywords: sepsis; systemic inflammatory response; neutrophil; endotoxemia; organ dysfunction
TL;DR:
This review will present both historical and updated perspectives on the systemic inflammatory response (SIRS) and sepsis; it will also discuss the impact of septicaemia on neutrophils, and theimpact of neutrophil during sepsi.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: May 28, 2019
2019 journal article
A Suspected Case of Rocky Mountain Spotted Fever in an Adult Horse in the Southeastern United States
JOURNAL OF EQUINE VETERINARY SCIENCE, 78, 134–137.
author keywords: Equine; Tick-borne disease; Rocky Mountain Spotted Fever; Lethargy; Fever; Rickettsia rickettsii
MeSH headings : Animals; Doxycycline / therapeutic use; Horse Diseases / diagnosis; Horse Diseases / drug therapy; Horses; Humans; Male; Rickettsia; Rickettsia rickettsii; Rocky Mountain Spotted Fever / diagnosis; Rocky Mountain Spotted Fever / drug therapy; Rocky Mountain Spotted Fever / veterinary; Southeastern United States
TL;DR:
The clinical and serologic features of this case are extremely consistent with clinical cases of Rocky Mountain Spotted Fever (RMSF) described in both dogs and humans.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: July 1, 2019
2019 journal article
Bronchoalveolar Lavage Cytology Characteristics and Seasonal Changes in a Herd of Pastured Teaching Horses
FRONTIERS IN VETERINARY SCIENCE, 6.
author keywords: equine asthma syndrome; heaves; inflammatory airway disease; recurrent airway obstruction; asthma phenotype; round bale hay
TL;DR:
This is the first study to use bronchoalveolar lavage (BAL) cytology to diagnose, and monitor changes in, EAS phenotype in pastured adult horses, and these results help to inform discussions regarding prevalence of EAS in pastures, adult horses in the southeastern region of North America.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, ORCID
Added: May 28, 2019
2019 journal article
Comparative Review of Asthma in Farmers and Horses
Current Allergy and Asthma Reports, 19(11).
author keywords: Equine asthma syndrome; Occupational asthma; Organic dust; Innate immunity, neutrophilic asthma; Bronchitis
MeSH headings : Animals; Asthma / genetics; Asthma / immunology; Asthma / pathology; Asthma / veterinary; Environmental Exposure; Farmers; Horse Diseases / genetics; Horse Diseases / immunology; Horse Diseases / pathology; Horses; Humans
TL;DR:
This review aims to compare the etiology, pathophysiology, and immunology of asthma in horses compared to farmers and highlights the horse as a potential translational animal model for organic dust-induced asthma in humans.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: October 11, 2019
2019 review
MARCKS and Lung Disease
[Review of ]. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 60(1), 16–27.
author keywords: MARCKS; lung disease; inflammation; cancer
MeSH headings : Animals; Humans; Lung Diseases / metabolism; Lung Diseases / physiopathology; Myristoylated Alanine-Rich C Kinase Substrate / metabolism
TL;DR:
This article summarizes the structure and cellular function of MARCKS (also including MARC KS family proteins and MARCKSL1 [MARCKS‐like protein 1]).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: January 14, 2019
2018 journal article
Analysis of Final Year Veterinary Students’ Telephone Communication Skills at a Veterinary Teaching Hospital
Veterinary Sciences, 5(4), 99.
author keywords: telephone communication; clinical communication; relationship centered care; veterinary education; telephone medicine; relationship-centered care; veterinarian-client-patient communication; communication research methods
TL;DR:
It is concluded that additional training is required to familiarize students with expectations regarding telephone communication, including reviewing the case thoroughly, preparing to answer questions and provide explanations, following organizational protocol, and incorporating open ended questions, reflective listening, and empathy.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
4. Quality Education
(OpenAlex)
Sources: ORCID, Crossref
Added: February 11, 2019
2018 journal article
Readability Evaluations of Veterinary Client Handouts and Implications for Patient Care
TOPICS IN COMPANION ANIMAL MEDICINE, 33(2), 58–61.
author keywords: assessment; clinical science; communications; diversity; practice/business management; public health
MeSH headings : Animals; Health Literacy / standards; Humans; Patient Care / methods; Patient Care / veterinary; Patient Education as Topic / methods; Patient Education as Topic / standards; Reading; Veterinary Medicine / methods
TL;DR:
Evaluating the readability levels of a sample of popular client handout materials prepared expressly for veterinarians to download and distribute to their pet-owning clients indicates that 9 of 10 client brochures were written above the recommended sixth grade reading level.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
4. Quality Education
(OpenAlex)
Sources: Web Of Science, ORCID
Added: October 16, 2018
2018 journal article
The Salmonella type-3 secretion system-1 and flagellar motility influence the neutrophil respiratory burst
PLOS ONE, 13(9).
MeSH headings : Fimbriae, Bacterial / physiology; Genotype; Granulocyte-Macrophage Colony-Stimulating Factor / pharmacology; Humans; Interleukin-8 / pharmacology; Neutrophils / cytology; Neutrophils / metabolism; Neutrophils / microbiology; Reactive Oxygen Species / metabolism; Respiratory Burst / drug effects; Salmonella / genetics; Salmonella / metabolism; Type III Secretion Systems / drug effects; Type III Secretion Systems / metabolism
TL;DR:
It is demonstrated that both the type-3 secretion system-1 and flagellar motility, which are established virulence factors in enteric salmonellosis, also appear to directly influence the magnitude of the neutrophil respiratory burst in response to STm in vitro.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: October 16, 2018
2018 journal article
Using readability software to enhance the health literacy of equine veterinary clients: An analysis of 17 American Association of Equine Practitioners’ newsletter and website articles
Equine Veterinary Journal, 51(4), 552–555.
author keywords: horse; literacy; horse owner; client education; readability; medical writing
MeSH headings : Animals; Comprehension; Health Literacy; Horses; Humans; Ownership; Publications; Societies, Scientific; Software; Veterinary Medicine
TL;DR:
awareness of the issue of client literacy and use of tools such as readability analysis software can help veterinarians provide clients with 'easy-to-read' written materials that deliver a message that clients can comprehend, thus improving their health literacy and empowering them as partners in the veterinary-client relationship.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
4. Quality Education
(OpenAlex)
Sources: ORCID, Crossref
Added: February 11, 2019
2017 conference paper
Identification of Salmonella Typhimurium genes essential to induce the neutrophil oxidative burst
Poster presented at the Mid-Atlantic Microbial Pathogenesis Meeting, Nellysford, Virginia.
Event: Mid-Atlantic Microbial Pathogenesis Meeting at Nellysford, Virginia on February 12-14, 2017
Source: NC State University Libraries
Added: September 8, 2019
2017 speech
Investigating the MARCKS protein as a novel therapeutic target for the treatment of equine asthma
Poster presented at the Merial National Veterinary Research Scholars Symposium, National Institutes of Health, Bethesa, MD.
Event: Merial National Veterinary Research Scholars Symposium at National Institutes of Health, Bethesa, MD
Source: NC State University Libraries
Added: August 30, 2019
2017 journal article
Misoprostol Inhibits Equine Neutrophil Adhesion, Migration, and Respiratory Burst in an In Vitro Model of Inflammation
Frontiers in Veterinary Science, 4.
author keywords: horse; leukocyte; chemotaxis; reactive oxygen species; inflammation; anti-inflammatory; NSAID
TL;DR:
Data indicate that misoprostol-targeting of E-prostanoid (EP) receptors potently inhibits equine neutrophil effector functions in vitro, and suggest misop frostol may hold promise as a novel anti-inflammatory therapeutic in the horse.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, ORCID
Added: July 20, 2019
2017 journal article
Misoprostol Inhibits Lipopolysaccharide-Induced Pro-inflammatory Cytokine Production by Equine Leukocytes
Frontiers in Veterinary Science, 4.
author keywords: horse; leukocyte; chemokine; inflammation; anti-inflammatory; non-steroidal anti-inflammatory drug
TL;DR:
Results indicate that misoprostol exerts anti-inflammatory effects on equine leukocytes when applied before or after a pro-inflammatory stimulus, and these effects were cytokine-specific and sometimes differed at the mRNA and protein levels.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, ORCID
Added: July 20, 2019
2016 speech
A high-throughput in vitro system to study Salmonella-neutrophil interactions
Poster presented at the 5th ASM Conference on Salmonella, Potsdam, Germany.
Event: 5th ASM Conference on Salmonella at Potsdam, Germany on August 29 - September 1, 2016
Source: NC State University Libraries
Added: September 8, 2019
2016 speech
Development of a Capstone Assessment Instrument for Evaluation of Fourth Year Veterinary Student History and Examination Skills
Presented at the Veterinary Educators Collaborative, University of Calgary, Alberta, Canada.
Event: Veterinary Educators Collaborative at University of Calgary, Alberta, Canada on June 20-21, 2016
Source: NC State University Libraries
Added: September 8, 2019
2016 conference paper
Development of a neutrophil-Salmonella co-culture system to study Salmonella genes that alter the neutrophil respiratory burst
Oral presentation presented at the Duke Innate Immunity Group Symposium, Durham, North Carolina.
Event: Duke Innate Immunity Group Symposium at Durham, North Carolina on June 17, 2016
Source: NC State University Libraries
Added: September 8, 2019
2016 speech
MARCKS protein as a therapeutic target in the treatment of recurrent airway obstruction in horses
Poster presented at the Merial National Veterinary Research Scholars Symposium, The Ohio State University, Columbus, Ohio.
Event: Merial National Veterinary Research Scholars Symposium at The Ohio State University, Columbus, Ohio on July 28-31, 2016
Source: NC State University Libraries
Added: September 8, 2019
2016 speech
Student Perspectives on a Newly Implemented Community-Based Model of Clinical Training in Equine Primary Care: “What’s Workings and What Could be Better?
Presented at the Scholarship of Teaching and Learning Symposium, NC State University, Raleigh, NC.
Event: Scholarship of Teaching and Learning Symposium at NC State University, Raleigh, NC on June 20-21, 2016
Source: NC State University Libraries
Added: September 8, 2019
2014 journal article
In Vitro Neutrophil Migration Requires Protein Kinase C-Delta (δ-PKC)-Mediated Myristoylated Alanine-Rich C-Kinase Substrate (MARCKS) Phosphorylation
Inflammation, 38(3), 1126–1141.
author keywords: neutrophil; chemotaxis; adhesion; migration; innate immunity; PKC signaling
MeSH headings : Acetophenones / pharmacology; Benzopyrans / pharmacology; Cell Adhesion / immunology; Cell Movement; Cells, Cultured; Enzyme Inhibitors / pharmacology; Humans; Inflammation / immunology; Intracellular Signaling Peptides and Proteins / metabolism; Membrane Proteins / metabolism; Myristoylated Alanine-Rich C Kinase Substrate; N-Formylmethionine Leucyl-Phenylalanine / metabolism; Neutrophil Activation / immunology; Neutrophil Infiltration / immunology; Neutrophils / immunology; Phosphorylation; Protein Isoforms / antagonists & inhibitors; Protein Isoforms / metabolism; Protein Kinase C-delta / antagonists & inhibitors; Protein Kinase C-delta / metabolism
TL;DR:
It is concluded that δ-PKC-mediated MARCKS phosphorylation is essential for human neutrophil migration and adhesion in vitro, and this results implicate €1,000,000 phosphorylated actin binding protein and protein kinase C (PKC) as a key step in the inflammatory response of neutrophils.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018
2014 journal article
Myristoylated Alanine Rich C Kinase Substrate (MARCKS) is essential to β2-integrin dependent responses of equine neutrophils
Veterinary Immunology and Immunopathology, 160(3-4), 167–176.
author keywords: Neutrophil; Migration; Adhesion; Respiratory burst; Beta2-integrin; Inflammation
MeSH headings : Amino Acid Sequence; Animals; Antigen-Antibody Complex / physiology; CD18 Antigens / immunology; CD18 Antigens / physiology; Cell Adhesion / drug effects; Cell Adhesion / physiology; Cell Movement / drug effects; Cell Movement / physiology; Conserved Sequence; Horses / immunology; Horses / physiology; In Vitro Techniques; Intracellular Signaling Peptides and Proteins / antagonists & inhibitors; Intracellular Signaling Peptides and Proteins / genetics; Intracellular Signaling Peptides and Proteins / physiology; Membrane Proteins / antagonists & inhibitors; Membrane Proteins / genetics; Membrane Proteins / physiology; Molecular Sequence Data; Myristoylated Alanine-Rich C Kinase Substrate; Neutrophil Infiltration / drug effects; Neutrophil Infiltration / immunology; Neutrophil Infiltration / physiology; Peptide Fragments / genetics; Peptide Fragments / pharmacology; Respiratory Burst / drug effects; Sequence Homology, Amino Acid; Tetradecanoylphorbol Acetate / pharmacology
TL;DR:
It is demonstrated that inhibition of MARCKS function significantly attenuates β2-integrin-dependent neutrophil functions including migration, adhesion, and immune complex-mediated respiratory burst, and strongly implicate MARC KS as a potential regulator of β 2-integrins in neutrophils.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018
2013 journal article
Fibroblast Migration Is Regulated by Myristoylated Alanine-Rich C-Kinase Substrate (MARCKS) Protein
PLOS ONE, 8(6).
Ed(s): P. Aspenstrom
MeSH headings : 3T3 Cells; Animals; Becaplermin; Chemotaxis / drug effects; Chemotaxis / physiology; Collagen / metabolism; Fibroblasts / cytology; Fibronectins / metabolism; Intracellular Signaling Peptides and Proteins / metabolism; Intracellular Signaling Peptides and Proteins / physiology; Membrane Proteins / metabolism; Membrane Proteins / physiology; Mice; Myristoylated Alanine-Rich C Kinase Substrate; Phosphorylation; Proto-Oncogene Proteins c-akt / metabolism; Proto-Oncogene Proteins c-sis / pharmacology
TL;DR:
Genetic structure-function analysis revealed that MANS peptide-mediated attenuation of NIH-3T3 cell migration does not require the presence of the myristic acid moiety on the amino-terminus, and suggests that MARCKS-mediated regulation of fibroblast migration involves the MARC KS amino- terminus.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2009 journal article
Outbreak of Lawsonia intracellularis on a Standardbred breeding farm in North Carolina
EQUINE VETERINARY EDUCATION, 21(4), 179–182.
author keywords: horse; enteropathy; colic; small intestine
TL;DR:
The cases reported here are an example of multiple foals on a single farm testing serologically positive for L. intracellularis, a cause of protein-losing enteropathy in weanling foals commonly causing signs including diarrhoea, oedema and unthrifty appearance.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2009 journal article
Use of ultrasound to evaluate outcome following colic surgery for equine large colon volvulus
Equine Veterinary Journal, 42(1), 47–52.
Contributors: * , V. Cook n, S. Jones n , A. Blikslager n & A. Pease n
author keywords: horse; colic; large colon volvulus; ultrasound; multiple organ dysfunction syndrome; oedema
MeSH headings : Animals; Colic / diagnostic imaging; Colic / surgery; Colic / veterinary; Colonic Diseases / diagnostic imaging; Colonic Diseases / surgery; Colonic Diseases / veterinary; Female; Horse Diseases / diagnostic imaging; Horse Diseases / surgery; Horses; Intestinal Volvulus / diagnostic imaging; Intestinal Volvulus / surgery; Intestinal Volvulus / veterinary; Male; Treatment Outcome; Ultrasonography
TL;DR:
A shorter time to colon wall involution was associated with decreased post operative morbidity in horses presented for surgical correction of large colon volvulus without resection and may aid in identifying those cases at risk of MODS.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018
2008 journal article
Disseminated large granular lymphoma in a horse
EQUINE VETERINARY EDUCATION, 20(9), 459–463.
author keywords: horse; lymphoma; weight loss; diarrhoea; T lymphocytes
TL;DR:
In this gelding, ante mortem diagnosis of CD3+ intestinal large granular lymphoma was made via cytology of abdominal fluid and immunohistochemistry of a rectal muscle biopsy.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2004 journal article
Pharmacokinetics and Pharmacodynamics of Furosemide after Oral Administration to Horses
Journal of Veterinary Internal Medicine, 18(5), 739–743.
TL;DR:
Furosemide at 1 mg/kg PO did not induce diuresis in horses and systemic availability of furosemid PO was poor and variable among horses.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: July 28, 2019
Employment
Updated: June 26th, 2023 08:35
2014 - present
NC State University Raleigh, NC, US
Associate Professor
Clinical Sciences
Education
Updated: July 13th, 2023 07:11
2019 - 2020
Royal Veterinary College London, GB
Fellow Higher Education Academy
2009 - 2014
North Carolina State University Raleigh, NC, US
PhD, Comparative Biomedical Science
2001 - 2005
North Carolina State University Raleigh, NC, US
Doctor of Veterinary Medicine
1998 - 2000
North Carolina State University Raleigh, NC, US
BS, Animal Science
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